Measurement of MAP kinase activation by flow cytometry using phospho-specific antibodies to MEK and ERK: Potential for pharmacodynamic monitoring of signal transduction inhibitors

Communications in Clinical Cytometry

Volumn 46, Issue 2, 2001, Pages 72-78

  Chow, Sue ^a   Patel, Harshna ^a   Hedley, David W ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

MAP kinase; Pharmacodynamics; Phospho specific antibody; Signal transduction

Indexed keywords

ANTIBODY; BAY 37 9751; FORMALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG; UO 126;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MONITORING; ENZYME ACTIVATION; ENZYME ANALYSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PHARMACODYNAMICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

BLOTTING, WESTERN; BUTADIENES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; PHOSPHORYLATION; TETRADECANOYLPHORBOL ACETATE;

EID: 0035870575     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/cyto.1067     Document Type: Article

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