Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor α agonists

Biochemical and Biophysical Research Communications

Volumn 290, Issue 3, 2002, Pages 1114-1122

  Yamazaki, Kazuto ^a   Kuromitsu, Junro ^a   Tanaka, Isao ^a  

^a EISAI CO LTD   (Japan)

Author keywords

Liver; Microarray; Mouse; Peroxisome proliferator activated receptor agonist; Serum amyloid A

Indexed keywords

FENOFIBRATE; MESSENGER RNA; METALLOTHIONEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIRINIXIC ACID; PROTEIN; PROTEIN VANIN 1; RECA PROTEIN; RETINOL; SERUM AMYLOID A; UNCLASSIFIED DRUG;

AMYLOIDOSIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DRUG EFFECT; FATTY ACID OXIDATION; GENE EXPRESSION; LIPID METABOLISM; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RNA EXTRACTION; UNINDEXED SEQUENCE;

EID: 0036289332     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6319     Document Type: Article

References (51)

1. Fibric acids: Effects on lipids and lipoprotein metabolism
2. Effects of fibrates on serum lipids and atherosclerosis
3. Gemfibrozil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia
4. Fenofibrate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipidaemia
5. Increase in lipoprotein lipase during clofibrate treatment of hypertriglyceridemia in patients on hemodialysis
6. Effects of bezafibrate on the serum lipoprotein lipid and apolipoprotein composition, lipoprotein triglyceride removal capacity and the fatty acid composition of the plasma lipid esters
7. Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects
8. Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: A potential physiologic basis for their mode of action
9. Fibrates down-regulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates
10. Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat
11. Apolipoprotein A-IV messenger ribonucleic acid abundance is regulated in a tissue-specific manner
12. Down-regulation of hepatic lipase gene expression and activity by fenofibrate
13. Lecithin: Cholesterol acyltransferase gene expression is regulated in a tissue-selective manner by fibrates
14. Perturbation of developmental gene expression in rat liver by fibric acid derivatives: Lipoprotein lipase and α-fetoprotein as models
15. Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation
16. Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators
17. Biochemical mechanisms of induction of hepatic peroxisome proliferation
18. Biochemistry of peroxisomes
19. Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens
20. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
21. The PPARs: From orphan receptors to drug discovery
22. Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element
23. Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids
24. Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells
25. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
26. High density synthetic oligonucleotide arrays
27. Analysis of drug pharmacology towards predicting drug behavior by expression profiling using high-density oligonucleotide arrays
28. Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays
29. Protection against acetaminophen hepatotoxicity by a single dose of clofibrate: Effects on selective protein arylation and glutathione depletion
30. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue- and inducer-specific manner
31. Human peroxisome proliferator-activated receptor α (PPARα) supports the induction of peroxisome proliferation in PPARα deficient mouse liver
32. Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate
33. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants
34. Regulation of hepatocytic glycoprotein sialylation and sialyltransferases by peroxisome proliferators
35. Down regulation of epidermal growth factor receptors in rat hepatocytes treated with clofibric acid
36. PPARα agonists reduce 11β-hydroxysteroid dehydrogenase type 1 in the liver
37. cDNA cloning and characterization of a cis-retinol/3α-hydroxysterol short-chain dehydrogenase
38. Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing
39. Pantetheinase activity of membrane-bound Vanin-1: Lack of free cysteamine in tissues of Vanin-1 deficient mice
40. Effect of thiols on lipid peroxidation in rat liver microsomes
41. Experimental acetaminophen-induced hepatic necrosis: Biochemical and electron microscopic study of cysteamine protection
42. Preclinical and clinical studies with cysteamine and pantethine related to the central nervous system
43. Long-term effects of hypolipidemic peroxisome proliferator administration on hepatic hydrogen peroxide metabolism in rats
44. Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis
45. Differential expression of the amyloid SAA 3 gene in liver and peritoneal macrophages of mice undergoing dissimilar inflammatory episodes
46. Serum amyloid A (SAA): An acute phase protein and apolipoprotein
47. The association of c-reactive protein, serum amyloid a and fibrinogen with prevalent coronary heart disease - Baseline findings of the PAIS project
48. Amyloid precursors and amyloidosis in inflammatory arthritis
49. Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signaling, and reduces inflammatory cytokine production in aging
50. Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1
51. Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein