The SREBP pathway in Drosophila: Regulation by palmitate, not sterols

Developmental Cell

Volumn 2, Issue 2, 2002, Pages 229-238

  Seegmiller, Adam C ^a   Dobrosotskaya, Irina ^a   Goldstein, Joseph L ^a   Ho, Y K ^a   Brown, Michael S ^a   Rawson, Robert B ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; DNA BINDING PROTEIN; DOUBLE STRANDED RNA; FATTY ACID; MEMBRANE PROTEIN; MESSENGER RNA; PALMITIC ACID; PEPTIDE FRAGMENT; PYRUVIC ACID; SIGNAL PEPTIDE; SREBF1 PROTEIN, HUMAN; SREBP CLEAVAGE ACTIVATING PROTEIN; SREBP CLEAVAGE-ACTIVATING PROTEIN; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR; DROSOPHILA PROTEIN; PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DROSOPHILA; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MUTATION; POLYMERASE CHAIN REACTION; PROTEIN PROCESSING; SEQUENCE HOMOLOGY; WESTERN BLOTTING; ANIMAL CELL; CELL CULTURE; CELL NUCLEUS; CELL STRAIN; CONTROLLED STUDY; FATTY ACID SYNTHESIS; GENETIC CODE; HOMEOSTASIS; LIPID METABOLISM; MEMBRANE STRUCTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION;

ANIMALS; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; DNA-BINDING PROTEINS; DROSOPHILA; FATTY ACIDS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MUTATION; PALMITIC ACID; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRUVIC ACID; RNA, DOUBLE-STRANDED; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 0036480346     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(01)00119-8     Document Type: Article

References (44)

1. Brown M.S. Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 1997 331-340
2. Brown M.S. Goldstein J.L. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc. Natl. Acad. Sci. USA 96 1999 11041-11048
3. Brown M.S. Faust J.R. Goldstein J.L. Kaneko I. Endo A. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase J. Biol. Chem. 253 1978 1121-1128
4. Brown M.S. Ye J. Rawson R.B. Goldstein J.L. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans Cell 100 2000 391-398
5. Clark A.J. Bloch K. The absence of sterol synthesis in insects J. Biol. Chem. 234 1959 2578-2588
6. Clemens J.C. Worby C.A. Simonson-Leff N. Muda M. Maehama T. Hemmings B.A. Dixon J.E. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways Proc. Natl. Acad. Sci. USA 97 2000 6499-6503
7. DeBose-Boyd R.A. Brown M.S. Li W.-P. Nohturfft A. Goldstein J.L. Espenshade P.J. Transport-dependent proteolysis of SREBP: relocation of Site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi Cell 99 1999 703-712
8. De Renobales M. Blomquist G.J. Biosynthesis of medium chain fatty acids in Drosophila melanogaster. Arch. Biochem. Biophys. 228 1984 407-414
9. Duncan E.A. Brown M.S. Goldstein J.L. Sakai J. Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in lumenal loop of sterol regulatory element binding protein-2 J. Biol. Chem. 272 1997 12778-12785
10. Duncan E.A. Davé U.P. Sakai J. Goldstein J.L. Brown M.S. Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning J. Biol. Chem. 273 1998 17801-17809
11. Gielkens A.L.J. VanZaane D. Bloemers H.P.J. Bloemendal H. Synthesis of Rauscher murine leukemia virus-specific polypeptides in vitro. Proc. Natl. Acad. Sci. USA 73 1976 356-360
12. Hannah V.C. Ou J. Luong A. Goldstein J.L. Brown M.S. Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells J. Biol. Chem. 276 2001 4365-4372
13. Heid C.A. Stevens J. Livak K.J. Williams P.M. Real time quantitative PCR Genome Res. 6 1996 986-994
14. Herz J. Kowal R.C. Ho Y.K. Brown M.S. Goldstein J.L. Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver J. Biol. Chem. 265 1990 21355-21362
15. Horton J.D. Shimomura I. Brown M.S. Hammer R.E. Goldstein J.L. Shimano H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2 J. Clin. Invest. 101 1998 2331-2339
16. Hua X. Sakai J. Ho Y.K. Goldstein J.L. Brown M.S. Hairpin orientation of sterol regulatory element binding protein-2 in cell membranes as determined by protease protection J. Biol. Chem. 270 1995 29422-29427
17. Hua X. Nohturfft A. Goldstein J.L. Brown M.S. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage activating protein (SCAP) Cell 87 1996 415-426
18. Isola V.J. Eisenberg R.J. Siebert G.R. Heilman C.J. Wilcox W.C. Cohen G.H. Fine mapping of antigenic site 11 of herpes simplex virus glycoprotein D J. Virol. 63 1989 2325-2334
19. Kim J.B. Spiegelman B.M. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism Genes Dev. 10 1996 1096-1107
20. Kim J.B. Spotts G.D. Halvorsen Y.-D. Shih H.-M. Ellenberger T. Towle H.C. Spiegelman B.M. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain Mol. Cell. Biol. 15 1995 2582-2588
21. Kyte J. Doolittle R.F. A simple method for displaying the hydropathic character of a protein J. Mol. Biol. 157 1982 105-132
22. Lowry O.H. Rosebrough N.J. Farr A.L. Randall R.J. Protein measurement with the folin phenol reagent J. Biol. Chem. 193 1951 265-275
23. Luong A. Hannah V.C. Brown M.S. Goldstein J.L. Molecular characterization of human acetyl CoA synthetase, an enzyme regulated by SREBPs J. Biol. Chem. 275 2000 26458-26466
24. Matsuda M. Korn B.S. Hammer R.E. Moon Y.-A. Komuro R. Horton J.D. Goldstein J.L. Brown M.S. Shimomura I. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation Genes Dev. 15 2001 1206-1216
25. Nohturfft A. Hua X. Brown M.S. Goldstein J.L. Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant CHO cell lines Proc. Natl. Acad. Sci. USA 93 1996 13709-13714
26. Nohturfft A. Brown M.S. Goldstein J.L. Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N Proc. Natl. Acad. Sci. USA 95 1998 12848-12853
27. Nohturfft A. Yabe D. Goldstein J.L. Brown M.S. Espenshade P.J. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes Cell 102 2000 315-323
28. O'Connell P. Rosbash M. Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 gene Nucleic Acids Res. 12 1984 5495-5513
29. Rawson R.B. DeBose-Boyd R. Goldstein J.L. Brown M.S. Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein J. Biol. Chem. 274 1999 28549-28556
30. Rosenfeld J.M. Osborne T.F. HLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph J. Biol. Chem. 273 1998 16112-16121
31. Sakai J. Duncan E.A. Rawson R.B. Hua X. Brown M.S. Goldstein J.L. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment Cell 85 1996 1037-1046
32. Sakai J. Nohturfft A. Goldstein J.L. Brown M.S. Cleavage of sterol regulatory element binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies J. Biol. Chem. 273 1998a 5785-5793
33. Sakai J. Rawson R.B. Espenshade P.J. Cheng D. Seegmiller A.C. Goldstein J.L. Brown M.S. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells Mol. Cell 2 1998b 505-514
34. Schneider I. Cell lines derived from late embryonic stages of Drosophila melanogaster J. Embryol. Exp. Morphol. 27 1972 353-365
35. Shimano H. Horton J.D. Hammer R.E. Shimomura I. Brown M.S. Goldstein J.L. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a J. Clin. Invest. 98 1996 1575-1584
36. Shimomura I. Shimano H. Korn B.S. Bashmakov Y. Horton J.D. Nuclear sterol regulatory element binding proteins activate genes responsible for entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver J. Biol. Chem. 273 1998 35299-35306
37. Shimomura I. Bashmakov Y. Horton J.D. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus J. Biol. Chem. 274 1999 30028-30032
38. Theopold U. Ekengren S. Hultmark D. HLH106, a Drosophila transcription factor with similarity to the vertebrate sterol responsive element binding protein Proc. Natl. Acad. Sci. USA 93 1996 1195-1199
39. Thewke D.P. Panini S.R. Sinensky M. Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins J. Biol. Chem. 273 1998 21402-21407
40. Wang X. Sato R. Brown M.S. Hua X. Goldstein J.L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Cell 77 1994 53-62
41. Worgall T.S. Sturley S.L. Seo T. Osborne T.F. Deckelbaum R.J. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein J. Biol. Chem. 273 1998 25537-25540
42. Ye J. Dave U.P. Grishin N.V. Goldstein J.L. Brown M.S. Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by Site-2 protease Proc. Natl. Acad. Sci. USA 97 2000 5123-5128
43. Yokoyama C. Wang X. Briggs M.R. Admon A. Wu J. Hua X. Goldstein J.L. Brown M.S. SREBP-1, a basic helix-loop-helix leucine zipper protein that controls transcription of the LDL receptor gene Cell 75 1993 187-197
44. Zelenski N.G. Rawson R.B. Brown M.S. Goldstein J.L. Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins J. Biol. Chem. 274 1999 21973-21980