Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule

Journal of Leukocyte Biology

Volumn 74, Issue 6, 2003, Pages 992-997

  Kipnis, Andre ^a   Basaraba, Randall J ^a   Turner, Joanne ^b   Orme, Ian M ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Cell recruitment; Lung; Lung inflammation; Mouse; Tuberculosis infection

Indexed keywords

HERMES ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROTECTION; CONTROLLED STUDY; GENE DISRUPTION; HELPER CELL; IMMUNOPATHOLOGY; LYMPHOCYTE; MOLECULAR DYNAMICS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TUBERCULOSIS;

ANIMALS; ANTIGENS, CD44; FLOW CYTOMETRY; IMMUNITY, CELLULAR; INTERFERON TYPE II; LUNG; LYMPHOCYTE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM TUBERCULOSIS; NEUTROPHILS; SPLEEN; T-LYMPHOCYTES; TUBERCULOSIS, PULMONARY;

ACTINOBACTERIA (CLASS); ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0347416905     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0603301     Document Type: Article

References (21)

1. Bean, A. G., Roach, D. R., Briscoe, H., France, M. P., Korner, H., Sedgwick, J. D., Britton, W. J. (1999) Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J. Immunol. 162, 3504-3511.
2. Peters, W., Scott, H. M., Chambers, H. F., Flynn, J. L., Charo, I. F., Ernst, J. D. (2001) Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 98, 7958-7963.
3. Kipnis, A., Basaraba, R. J., Orme, I. M., Cooper, A. M. (2003) Role of chemokine CCL2 in the protective response to early murine pulmonary tuberculosis. Immunology 109, 547-551.
4. Saunders, B. M., Cooper, A. M. (2000) Restraining mycobacteria: role of granulomas in mycobacterial infections. Immunol. Cell Biol. 78, 334-341.
5. Johnson, C. M., Cooper, A. M., Frank, A. A., Orme, I. M. (1998) Adequate expression of protective immunity in the absence of granuloma formation in Mycobacterium tuberculosis-infected mice with a disruption in the intracellular adhesion molecule I gene. Infect. Immun. 66, 1666-1670.
6. Cooper, A. M., Flynn, J. L. (1995) The protective immune response to Mycobacterium tuberculosis. Curr. Opin. Immunol. 7, 512-516.
7. Cooper, A. M., Dalton, D. K., Stewart, T. A., Griffin, J. P., Russell, D. G., Orme, I. M. (1993) Disseminated tuberculosis in interferon gamma gene-disrupted mice. J. Exp. Med. 178, 2243-2247.
8. Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A., Bloom, B. R. (1993) An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178, 2249-2254.
9. Ponta, H., Sherman, L., Herrlich, P. A. (2003) CD44: from adhesion molecules to signalling regulators. Nat. Rev. Mol. Cell Biol. 4, 33-45.
10. Teder, P., Vandivier, R. W., Jiang, D., Liang, J., Cohn, L., Pure, E., Henson, P. M., Noble, P. W. (2002) Resolution of lung inflammation by CD44. Science 296, 155-158.
11. Cosulich, M. E., Rubartelli, A., Risso, A., Cozzolino, F., Bargellesi, A. (1987) Functional characterization of an antigen involved in an early step of T-cell activation. Proc. Natl. Acad. Sci. USA 84, 4205-4209.
12. Serbina, N. V., Flynn, J. L. (1999) Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice. Infect. Immun. 67, 3980-3988.
13. Feng, C. G., Bean, A. G., Hooi, H., Briscoe, H., Britton, W. J. (1999) Increase in gamma interferon-secreting CD8(+), as well as CD4(+), T cells in lungs following aerosol infection with Mycobacterium tuberculosis. Infect. Immun. 67, 3242-3247.
14. Maiti, A., Maki, G., Johnson, P. (1998) TNF-alpha induction of CD44-mediated leukocyte adhesion by sulfation. Science 282, 941-943.
15. Mohamadzadeh, M., DeGrendele, H., Arizpe, H., Estess, P., Siegelman, M. (1998) Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion. J. Clin. Invest. 101, 97-108.
16. Rhoades, E. R., Frank, A. A., Orme, I. M. (1997) Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis. Tuber. Lung Dis. 78, 57-66.
17. Si-Tahar, M., Sitaraman, S., Shibahara, T., Madara, J. L. (2001) Negative regulation of epithelium-neutrophil interactions via activation of CD44. Am. J. Physiol. Cell Physiol. 280, C423-C432.
18. Wang, Q., Teder, P., Judd, N. P., Noble, P. W., Doerschuk, C. M. (2002) CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice. Am. J. Pathol. 161, 2219-2228.
19. D'Souza, C. D., Cooper, A. M., Frank, A. A., Mazzaccaro, R. J., Bloom, B. R., Orme, I. M. (1997) An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis. J. Immunol. 158, 1217-1221.
20. Leemans, J. C., Florquin, S., Heikens, M., Pals, S. T., van der Neut, R., Van Der Poll, T. (2003) CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis. J. Clin. Invest. 111, 681-689.
21. Scott, H. M., Flynn, J. L. (2002) Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Infect. Immun. 70, 5946-5954.