Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM

Nuclear Medicine and Biology

Volumn 32, Issue 6, 2005, Pages 623-630

  Burgman, Paul ^a   O'Donoghue, Joseph A ^a   Lewis, Jason S ^b   Welch, Michael J ^b   Humm, John L ^a   Ling, C Clifton ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cu ATSM; Hypoxia; Nuclear imaging; PET

Indexed keywords

COPPER DERIVATIVE; DIACETYLBIS(N 4 METHYLTHIOSEMICARBAZONE) CU 64; SEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANOXIA; ARTICLE; CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; DRUG ACCUMULATION; DRUG METABOLISM; DRUG RETENTION; DRUG UPTAKE; HUMAN; HUMAN CELL; HYPOXIA; INCUBATION TIME; NONHUMAN; OXYGENATION; POSITRON EMISSION TOMOGRAPHY; RODENT; STATISTICAL SIGNIFICANCE; TIME SERIES ANALYSIS;

ANIMALS; CELL HYPOXIA; COPPER; COPPER RADIOISOTOPES; FEMALE; HUMANS; NEOPLASMS; ORGANOMETALLIC COMPOUNDS; OXYGEN; RATS; THIOSEMICARBAZONES; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 22144449210     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2005.05.003     Document Type: Article

References (46)

1. 18F]fluoromisonidazole: a pretherapy study of 37 patients Int J Radiat Oncol Biol Phys 36 1996 417 428
2. D.M. Brizel, S.P. Scully, J.M. Harrelson, L.J. Layfield, J.M. Bean, and L.R. Prosnitz Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma Cancer Res 56 1996 941 943
3. A.W. Fyles, M. Milosevic, R. Wong, M.-C. Kavanagh, M. Pintilie, and A. Sun Oxygenation predicts radiation response and survival in patients with cervix cancer Radiother Oncol 48 1998 149 156
4. J.D. Chapman, E.L. Engelhardt, C.C. Stobbe, R.F. Schneider, and G.E. Hanks Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays Radiother Oncol 46 1998 229 237
5. J.D. Chapman, L.R. Coia, C.C. Stobbe, E.L. Engelhardt, M.C. Fenning, and R.F. Schneider Prediction of tumour hypoxia and radioresistance with nuclear medicine markers Br J Cancer 74 1996 204 208
6. B. Movsas, J.D. Chapman, E.M. Horwitz, W.H. Pinover, R.E. Greenberg, and A.L. Hanlon Hypoxic regions exist in human prostate carcinoma Urology 53 1999 11 18
7. J.E. Moulder, and S. Rockwell Hypoxic fractions in solid tumors: experimental techniques, methods of analysis and a survey of existing data Int J Radiat Oncol Biol Phys 10 1984 695 712
8. M. Nordsmark, M. Overgaard, and J. Overgaard Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck Radiother Oncol 41 1996 31 39
9. T.G. Graeber, C. Osmanian, T. Jacks, D.E. Housman, C.J. Koch, and S.W. Lowe Hypoxia-mediated selection of cells with diminished apoptotic potential in tumors Nature 379 1996 88 91
10. M. Höckel, K. Schlenger, B. Aral, M. Mitze, U. Schäffer, and P. Vaupel Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res 56 1996 4509 4515
11. M. Höckel, K. Schlenger, M. Mitze, U. Schaffer, and P. Vaupel Hypoxia and radiation response in human tumors Semin Radiat Oncol 6 1996 3 9
12. M. Höckel, K. Schlenger, S. Höckel, and P. Vaupel Hypoxic cervical cancers with low apoptotic index are highly aggressive Cancer Res 59 1999 4525 4528
13. A. Kondo, R. Safaei, M. Mishima, H. Niedner, X. Lin, and B. Howell Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair Cancer Res 61 2001 7603 7607
14. B. Movsas, J.D. Chapman, R.E. Greenberg, A.L. Hanlon, E.M. Horwitz, and W.H. Pinover Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age Cancer 89 2000 2018 2024
15. E.K. Rofstad, and E.F. Halsor Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8 Br J Cancer 86 2002 301 308
16. E.K. Rofstad, H. Rasmussen, K. Galappathi, B. Mathiesen, K. Nilsen, and B.A. Graff Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor Cancer Res 62 2002 1847 1853
17. K. Lehtio, V. Oikonen, T. Gronroos, O. Eskola, K. Kalliokoski, and J. Bergman Imaging of blood flow and hypoxia in head and neck cancer: initial evaluation with [(15)O]H(2)O and [(18)F]fluoroerythronitroimidazole PET J Nucl Med 42 2001 1653 1655
18. 18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure Appl Radiat Isot 54 2001 73 80
19. R.C. Urtasun, M.B. Parliament, A.J. McEwan, J.R. Mercer, R.H. Mannan, and L.I. Wiebe Measurement of hypoxia in human tumours by non-invasive SPECT imaging of iodoazomycin arabinoside Br J Cancer 74 1996 S209 S212
20. P. Zanzonico, J. O'Donoghue, J.D. Chapman, R. Schneider, S. Cai, and S. Larson Iodine-124-labeled iodo-azomycin-galactoside imaging of tumor hypoxia in mice with serial microPET scanning Eur J Nucl Med Mol Imaging 31 2004 117 128
21. Y. Fujibayashi, H. Taniuchi, Y. Yonekura, H. Ohtani, J. Konishi, and A. Yokoyama Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential J Nucl Med 38 1997 1155 1160
22. Y. Fujibayashi, C.S. Cutler, C.J. Anderson, D.W. McCarthy, L.A. Jones, and T. Sharp Comparative studies of Cu-64-ATSM and C-11-acetate in an acute myocardial infarction model: ex vivo imaging of hypoxia in rats Nucl Med Biol 26 1999 117 121
23. N. Takahashi, Y. Fujibayashi, Y. Yonekura, M.J. Welch, A. Waki, and T. Tsuchida Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia Ann Nucl Med 15 2001 293 296
24. 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model J Nucl Med 40 1999 177 183
25. 4-methylthiosemicarbazone): effect of changes in tissue oxygenation J Nucl Med 42 2001 655 661
26. 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents Nucl Med Biol 32 2005 147 156
27. 4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells Ann Nucl Med 15 2001 499 504
28. 64Cu-ATSM as a radiotherapy agent Nucl Med Biol 32 2005 21 28
29. 60Cu-ATSM: relationship to therapeutic response - a preliminary report Int J Radiat Oncol Biol Phys 55 2003 1233 1238
30. 60Cu-ATSM Eur J Nucl Med Mol Imaging 30 2003 844 850
31. 64Cu using a biomedical cyclotron Nucl Med Biol 24 1997 35 43
32. 2 probe measurement, autoradiography and fluorescent microscopy in the R3327-AT and FaDu rat tumor models Int J Radiat Oncol Biol Phys 61 2005 1493 1502
33. J.L.J. Dearling, J.S. Lewis, G.E.D. Mullen, M.J. Welch, and P.J. Blower Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships J Biol Inorg Chem 7 2002 249 259
34. B.A. Gingras, T. Suprunchuk, and C.H. Bayley The preparation of some thiosemicarbazones and their copper complexes: Part III Can J Chem 40 1962 1053 1059
35. E.J. Hall Radiobiology for the radiologist 5th ed. 2000 Lippincott Williams & Wilkins Philadelphia
36. 4-methylthiosemicarbazone) J Nucl Med 43 2002 1557 1569
37. R.I. Maurer, P.J. Blower, J.R. Dilworth, C.A. Reynolds, Y. Zheng, and G.E.D. Mullen Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals J Med Chem 45 2002 1420 1431
38. A.R. Cowley, J.R. Dilworth, P.S. Donnelly, E. Labisbal, and A. Sousa An unusual dimeric structure of a Cu(I) bis(thiosemicarbazone) complex: implications for the mechanism of hypoxic selectivity of the Cu(II) derivatives J Am Chem Soc 124 2002 5270 5271
39. E.K. John, and M.A. Green Structure-activity relationships for metal-labeled blood flow tracers: comparison of ketoaldehyde bis(thiosemicarbazonato) copper(II) derivatives J Med Chem 33 1990 1764 1770
40. D.T. Minkel, and D.H. Petering Initial reaction of 3-ethoxy-2- oxobuteraldehyde bis(thiosemicarbazonato)-copper(II) with Ehrlich ascites tumor cells Cancer Res 38 1978 117 123
41. D.T. Minkel, L.A. Saryan, and D.H. Petering Structure-function correlations in the reaction of bis(thiosemicarbazonato)-copper(II) complexes with Ehrlich ascites tumor cells Cancer Res 38 1978 124 129
42. E.D. Harris Copper homeostasis: the role of cellular transporters Nutr Rev 59 2001 281 285
43. M. Wessling-Resnick Understanding copper uptake at the molecular level Nutr Rev 60 2002 177 179
44. M. Solioz, and C. Vulpe CPx-type ATPases: a class of P-type ATPases that pump heavy metals Trends Biochem Sci 21 1996 237 241
45. E.D. Harris Cellular copper transport and metabolism Annu Rev Nutr 20 2000 291 310
46. K. Katano, R. Safaei, G. Samimi, A. Holzer, M. Rochdi, and S.B. Howell The copper export pump ATP7B modulates the cellular pharmacology of carboplatin in ovarian carcinoma cells Mol Pharmacol 64 2003 466 473