Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: Relationship to therapeutic response - A preliminary report

International Journal of Radiation Oncology Biology Physics

Volumn 55, Issue 5, 2003, Pages 1233-1238

  Dehdashti, Farrokh ^a,b   Grigsby, Perry W ^a,b   Mintun, Mark A ^a,b   Lewis, Jason S ^a,b   Siegel, Barry A ^a,b   Welch, Michael J ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b USA   (United States)

Author keywords

60Cu ATSM; Cervical cancer; Hypoxia; Positron emission tomography; Response to therapy

Indexed keywords

BIOPSY; POSITRON EMISSION TOMOGRAPHY; RADIOTHERAPY; TUMORS;

TUMOR HYPOXIA;

ONCOLOGY;

COPPER; COPPER 60; DIACETYL BIS(N 4 METHYLTHIOSEMICARBAZONE); FLUORODEOXYGLUCOSE F 18; SEMICARBAZONE DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLOW UP; HUMAN; HYPOXIA; METASTASIS; OXYGENATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECURRENT DISEASE; TREATMENT OUTCOME; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA;

EID: 0242417596     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)04477-2     Document Type: Article

References (33)

1. Brown J.M., Giaccia A.J. The unique physiology of solid tumors Opportunities (and problems) for cancer therapy. Cancer Res. 58:1998;1408-1416.
2. Brown J.M. The hypoxic cell A target for selective cancer therapy. Eighteenth Bruce F. Cain Memorial Award Lecture. Cancer Res. 59:1999;5863-5870.
3. Brizel D.M., Scully S.P., Harrelson J.M., et al. Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Res. 56:1996;5347-5350.
4. Höckel M., Schlenger K., Aral B., et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:1996;4509-4515.
5. Rofstad E.K., Sundfor K., Lyng H., et al. Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br J Cancer. 83:2000;354-359.
6. Shweiki D., Itin A., Soffer D., et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 359:1992;843-845.
7. Graeber T.G., Osmaninan C., Jacks T., et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature. 379:1996;88-91.
8. 2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol. 26:1993;45-50.
9. Höckel M., Schlenger K., Höckel S., et al. Tumor hypoxia in pelvic recurrences of cervical cancer. Int J Cancer. 79:1998;365-369.
10. Pitson G., Fyles A., Milosevic M., et al. Tumor size and oxygenation are independent predictors of nodal disease in patients with cervix cancer. Int J Radiat Oncol Biol Phys. 51:2001;699-703.
11. Nunn A., Linder K., Strauss H.W. Nitroimidazoles and imaging hypoxia. Eur J Nucl Med. 22:1995;265-280.
12. Fujibayshi Y., Taniuchi H., Yonekura Y., et al. Copper-62-ATSM A new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med. 38:1997;1155-1160.
13. 64Cu-ATSM) in vitro and in vivo in a hypoxic tumor model. J Nucl Med. 40:1999;177-183.
14. Grigsby P.W., Siegel B.A., Dehdashti F. Prognostic significance of lymph node staging by positron emission tomography in patients with carcinoma of the cervix. J Clin Oncol. 19:2001;3745-3749.
15. Perez C.A. Uterine cervix. Perez C.A., Brady L.W. Principles and practice of radiation oncology. 3rd ed:1998;1733-1834 Lippincott-Raven Publishers, Philadelphia.
16. Grigsby P.W. Modification of the radiation response of patients with carcinoma of the uterine cervix. Cancer Control. 6:1999;343-351.
17. Bass L.A., McCarthy D.W., Jones L.A., et al. High purity production and potential applications of copper-60 and copper-61. J Labelled Compd Rad. 40:1997;325-327.
18. McCarthy D.W., Bass L.A., Cutler P.D., et al. High purity production and potential applications of copper-60 and copper-61. Nucl Med Biol. 26:1999;351-358.
19. Young H., Carnochan P., Zweit J., et al. Evaluation of copper(II)-pyruvaldehyde bis(N-4-methylthiosemicarbazone) for tissue blood flow using a trapped tracer model. J Nucl Med. 21:1994;336-341.
20. Adam, Zaers J., Ostertag H., et al. Performance evaluation of the whole-body PET scanner ECAT EXAT HR+ following the IEC standard. IEEE Trans Nucl Sci. 44:1997;1172-1179.
21. Kubota K., Matsuzawa T., Ito M., et al. Lung tumor imaging by positron emission tomography using C-11 L-methionine. J Nucl Med. 26:1985;37-42.
22. Overgaard J., Horsman M.R. Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol. 6:1996;10-21.
23. Fyles A.W., Milosevic M., Pintilie M., et al. Cervix cancer oxygenation measured following external radiation therapy. Int J Radiat Oncol Biol Phys. 42:1998;751-753.
24. Rasey J.S., Nelson N.J., Chin L., et al. Characteristics of the binding of labeled fluoromisonidazole in cells in vitro. Radiat Res. 122:1990;301-308.
25. Koh W.-J., Rasey J.S., Evans M.L. Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole. Int J Radiat Oncol Biol Phys. 22:1992;199-212.
26. 18F]fluoromisonidazole A pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys. 25:1996;417-428.
27. 4-methythiosemicarbazone) Effect of changes in tissue oxygenation. J Nucl Med. 42:2001;655-661.
28. 64Cu using a biomedical cyclotron. Nucl Med Biol. 24:1997;35-43.
29. 62Cu-PTSM. J Nucl Med. 41:2000;309-314.
30. 18F-fluoro-2-deoxy-glucose positron emission tomography scan in non-small-cell lung cancer An analysis of 125 cases. J Clin Oncol. 17:1999;3201-3206.
31. 18F]-D-glucose. Cancer. 82:1998;2227-2234.
32. Clavo A.C., Brown R.S., Wahl R.L. Fluorodeoxyglucose uptake in human cancer cell lines increased by hypoxia. J Nucl Med. 36:1995;1625-1632.
33. Burgman P., Odonoghue J.A., Humm J.L., et al. Hypoxia-induced increase in FDG uptake in MCF7 cells. J Nucl Med. 42:2001;170-175.