Assessment of regional tumor hypoxia using 18F- fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4- methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models

International Journal of Radiation Oncology Biology Physics

Volumn 61, Issue 5, 2005, Pages 1493-1502

  O'Donoghue, Joseph A ^a   Zanzonico, Pat ^a   Pugachev, Andrei ^a   Wen, Bixiu ^a   Smith Jones, Peter ^a   Cai, Shangde ^a   Burnazi, Eva ^a   Finn, Ronald D ^a   Burgman, Paul ^a   Ruan, Shutian ^a   Lewis, Jason S ^b   Welch, Michael J ^b   Ling, C Clifton ^a   Humm, John L ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Correlative study; Hoechst 33342; Oxygen probe; Pimonidazole; Positron emission tomography; Tumor hypoxia

Indexed keywords

BIODIVERSITY; CARCINOGENS; CELLS; MEDICAL IMAGING; MICROSCOPIC EXAMINATION; POSITRON EMISSION TOMOGRAPHY;

ANIMAL MODELS; CARCINOMA CELL; FLUORESCENT MICROSCOPY; TUMOR HYPOXIA;

TUMORS;

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; COPPER 64; DIACETYL BIS(N4 METHYLTHIOSEMICARBAZONE) CU 64; FLUORINE 18; HOE 33342; PIMONIDAZOLE; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; CANCER GRAFT; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION FUNCTION; DRUG DISTRIBUTION; DRUG RETENTION; DRUG UPTAKE; FLUORESCENCE MICROSCOPY; HYPOXIA; IMAGING SYSTEM; INTERMETHOD COMPARISON; MICROPOSITRON EMISSION TOMOGRAPHY; NONHUMAN; OXYGEN TENSION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE TUMOR; RAT; RAT STRAIN; SQUAMOUS CELL CARCINOMA; TUMOR; TUMOR MODEL; XENOGRAFT;

EID: 20144387807     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2004.12.057     Document Type: Article

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