In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat

Neuroscience Letters

Volumn 304, Issue 3, 2001, Pages 199-203

  Usuki, Fusako ^a   Yasutake, Akira ^a   Umehara, Fujio ^b   Tokunaga, Hidehiro ^c   Matsumoto, Miyuki ^a   Eto, Komyo ^a   Ishiura, Shoichi ^d   Higuchi, Itsuro ^b  

^a Natl Inst Minamata D   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Antioxidant; Apoptosis; In vivo protection; Methylmercury intoxication; Mitochondrial electron transport system; Oxidative stress; Trolox (6 hydroxy 2,5,7,8 tetramethylchroman 2 carboxylic acid)

Indexed keywords

CATALASE; CYTOCHROME C OXIDASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; METHYLMERCURY; SUCCINATE DEHYDROGENASE; TROLOX C;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; ELECTRON TRANSPORT; ENERGY METABOLISM; ENZYME ACTIVITY; MALE; MITOCHONDRION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TISSUE DISTRIBUTION; TISSUE LEVEL; WEIGHT REDUCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN; CEREBELLUM; CHROMANS; ELECTRON TRANSPORT; MALE; MERCURY; METHYLMERCURY COMPOUNDS; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXIDOREDUCTASES; RATS; RATS, WISTAR; SOLUBILITY; WATER;

EID: 0035947450     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01764-5     Document Type: Article

References (19)

1. Aschner M., Clarkson T.W. Uptake of methylmercury in the rat brain: effects of amino acids. Brain Res. 462:1988;31-39.
2. Castle L., Perkins M.J. Inhibition kinetics of chain-breaking phenolic antioxidants in SDS micelles. Evidence that intermicellar diffusion rates may be rate-limiting for hydrophobic inhibitors such as α-tocopherol. J. Am. Chem. Soc. 108:1986;6381-6382.
3. Grandjean P., Weiche P., White R.F., Debes F., Araki S., Yokoyama K., Murata K., Sorensen N., Dahl R., Jorgensen P.J. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol. Teratol. 19:1997;417-428.
4. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
5. Hamada R., Osame M. Minamata disease and other mercury syndromes. Chang L.W. Toxicology of Metals. 1996;337-351 CRC Press, London.
6. Harada M. Neurotoxicity of methylmercury: Minamata and the Amazon. Yasui M., Strong M.J., Ota K., Verity M.A. Mineral and Metal Neurotoxicology. 1997;177-188 CRC Press, London.
7. Hirayama K. Effects of combined administration of thiol compounds and methylmercury chloride on mercury distribution in rats. Biochem. Pharmacol. 34:1985;2030-2032.
8. Koseki T., Inohara N., Chen S., Nunez G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc. Natl. Acad. Sci. USA. 95:1998;5156-5160.
9. Lawrence R.A., Burk R.F. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71:1976;952-958.
10. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
11. Morel Y., Barouki R. Repression of gene expression by oxidative stress. Biochem. J. 342:1999;481-496.
12. Naganuma A., Miura N., Kaneko S., Mishina T., Hosoya S., Miyairi S., Furuchi T., Kuge S. GFAT as a target molecule of methylmercury toxicity in Saccharomyces cerevisiae. FASEB J. 14:2000;968-972.
13. Ohkawa T., Uenoyama H., Tanida K., Ohmae T. Ultra trace mercury analysis by dry thermal decomposition in almina porcelain tube. J. Hyg. Chem. 23:1977;13-22.
14. Sugiyama Y., Suzuki A., Kishikawa M., Akutsu R., Hirose T., Waye M.M.Y., Tsui S.K.W., Yoshida S., Ohno S. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. J. Biol. Chem. 275:2000;1095-1104.
15. Thompson J.F., Nance S.L., Tollakson S.L. Spectrophotometric assay of catalase with perborate as substrate. Proc. Soc. Exp. Biol. Med. 157:1978;33-35.
16. Usuki F., Yasutake A., Matsumoto M., Umehara F., Higuchi I. The effect of methylmercury on skeletal muscle in the rat: a histopathological study. Toxicol. Lett. 94:1998;227-232.
17. Usuki F., Ishiura S. Expanded CTG repeats in myotonin protein kinase increase susceptibility to oxidative stress. NeuroReport. 9:1998;2291-2296.
18. Usuki F., Takahashi N., Sasagawa N., Ishiura S. Differential signaling pathways following oxidative stress in mutant myotonin protein kinase cDNA-transfected C2C12 cell lines. Biochem. Biophys. Res. Comm. 267:2000;739-743.
19. Yasutake A., Hirayama K. Selective quantification of inorganic mercury in tissues of methylmercury-treated rats. Bull. Environ. Contam. Toxicol. 45:1990;662-666.