Cytotoxic potential of proinflammatory cytokines: Combined deletion of TNF receptors TNFR1 and TNFR2 prevents motoneuron cell death after facial axotomy in adult mouse

Experimental Neurology

Volumn 178, Issue 2, 2002, Pages 186-193

  Raivich, G ^a,b   Liu, Z Q ^a   Kloss, C U A ^a   Labow, M ^c,d   Bluethmann, H ^c,d   Bohatschek, M ^a  

^a MPI Neurobiology ^*  (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d HOFFMANN LA ROCHE INC   (United States)

Author keywords

AlphaX beta2, CD11c CD18 integrin; Cell death; Cytokine receptor; Microglia; Motoneuron; Phagocytosis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTEGRIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL LOSS; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; FACIAL NERVE; GENE DELETION; HOMOZYGOSITY; KNOCKOUT MOUSE; MICROGLIA; MOTONEURON; MOUSE; NERVE CELL DEGENERATION; NERVE CELL INHIBITION; NERVE CELL LESION; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; TRANSGENIC MOUSE; WILD TYPE;

EID: 0036934895     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.8024     Document Type: Article

References (49)

1. Abercrombie, M. 1946. Estimation of nuclear populations from microtome sections. Anat. Rec. 94: 239-247.
2. Allan, S. M., L. C. Parker, B. Collins, R. Davies, G. N. Luheshi, and N. J. Rothwell. 2000. Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat. Proc. Natl. Acad. Sci. USA 97: 5580-5585.
3. Banati, R. B., J. Gehrmann, P. Schubert, and G. W. Kreutzberg. 1993. Cytotoxicity of microglia. Glia 7: 111-118.
4. Berezovskaya, O., D. Maysinger, and S. Fedoroff. 1995. The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: Congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury. Int. J. Dev. Neurosci. 13: 285-299.
5. Bernardes-Silva, M., D. C. Anthony, A. C. Issekutz, and V. H. Perry. 2001. Recruitment of neutrophils across the blood-brain barrier: The role of E- and P-selectins. J. Cereb. Blood Flow Metab. 21: 1115-1124.
6. Bethea, J. R., H. Nagashima, M. C. Acosta, C. Briceno, F. Gomez, A. E. Marcillo, K. Loor, J. Green, and W. D. Dietrich. 1999. Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. J. Neurotrauma 16: 851-863.
7. Bohatschek, M., A. Gschwendtner, X. von Maltzan, C. U. A. Kloss, K. Pfeffer, M. Labow, H. Bluthmann, G. W. Kreutzberg, and G. Raivich. 1999. Cytokine-mediated regulation of MHC1, MHC2 and B7-2, in the axotomized mouse facial motor nucleus. Soc. Neurosci. Abs. 25: 1535.
8. Bohatschek, M., C. U. Kloss, R. Kalla, and G. Raivich. 2001. In vitro model of microglial deramification: Ramified microglia transform into amoeboid phagocytes following addition of brain cell membranes to microglia-astrocyte cocultures. J. Neurosci. Res. 64: 508-522.
9. Bohatschek, M., A. Werner, and G. Raivich. 2001. Systemic lipopolysaccharide injection leads to granulocyte influx into normal and injured brain: Effects of ICAM-1 deficiency. Exp. Neurol. 172: 137-152.
10. Boutin, H., R. A. LeFeuvre, R. Horai, M. Asano, Y. Iwakura, and N. J. Rothwell. 2001. Role of IL-1alpha and IL-1beta in ischemic brain damage. J. Neurosci. 21: 5528-5534.
11. Bruce, A. J., W. Boling, M. S. Kindy, J. Peschon, P. J. Kraemer, M. K. Carpenter, F. W. Holtsberg, and M. P. Mattson. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nature Med. 2: 788-794.
12. Erickson, S. L., F. J. de Sauvage, K. Kikly, K. Carver-Moore, S. Pitts-Meek, N. Gillett, K. C. Sheehan, R. D. Schreiber, D. V. Goeddel, and M. W. Moore. 1994. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature 372: 560-563.
13. Fernandes, K. J. L., J. L. Vanderluit, and W. Tetzlaff. 2000. Stimulation of regenerative cell body responses in chronically axotomized motoneurons by a second axon injury: Evidence for positive injury signals. Soc. Neurosci. Abs. 26: 122.14.
14. Flugel, A., M. Bradl, G. W. Kreutzberg, and M. B. Graeber. 2001. Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. J. Neurosci. Res. 66: 74-82.
15. Fontaine, V., S. Mohand-Said, N. Hanoteau, C. Fuchs, K. Pfizenmaier, and U. Eisel. 2002. Neurodegenerative and neuro-protective effects of tumor Necrosis factor (TNF) in retinal ischemia: Opposite roles of TNF receptor 1 and TNF receptor 2. J. Neurosci. 22: RC216.
16. Frei, K., T. P. Leist, A. Meager, P. Gallo, D. Leppert, R. M. Zinkernagel, and A. Fontana. 1988. Production of B cell stimulatory factor-2 and interferon-γ in the central nervous system during viral meningitis and encephalitis. J. Exp. Med. 168: 449-453.
17. Galiano, M., Z. Q. Liu, R. Kalla, M. Bohatschek, A. Koppius, A. Gschwendtner, S. L. Xu, A. Werner, C. Kloss, H. Bluethmann, and G. Raivich. 2001. Interleukin-6 (IL6) and the cellular response following facial nerve injury: Effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6-deficient mice. Eur. J. Neurosci. 14: 327-341.
18. Gary, D. S., A. J. Bruce-Keller, M. S. Kindy, and M. P. Mattson. 1998. Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor. J. Cereb. Blood Flow Metab. 18: 1283-1287.
19. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-gamma receptor. Science 259: 1742-1745.
20. Imai, Y., I. Ibata, D. Ito, K. Ohsawa, and S. Kohsaka. 1996. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem. Biophys. Res. Commun. 224: 855-862.
21. Ito, D., Y. Imai, K. Ohsawa, K. Nakajima, Y. Fukuuchi, and S. Kohsaka. 1998. Microglia-specific localisation of a novel calcium binding protein, lba1. Brain Res. Mol. Brain Res. 57: 1-9.
22. Kalla, R., Z. Q. Liu, S. L. Xu, A. Koppius, Y. Imai, C. U. A. Kloss, S. Kohsaka, G. Gschwendtner, C. J. Möller, A. Werner, and G. Raivich. 2001. Microglia and the early phase of immune surveillance in the injured axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in the MCSF-deficient mice. J. Comp. Neurol. 436: 182-201.
23. Kiefer, R., D. Lindholm, and G. W. Kreutzberg. 1993. Interleukin-6 and transforming growth factor-beta 1 mRNAs are induced in rat facial nucleus following motoneuron axotomy. Eur. J. Neurosci. 5: 775-781.
24. Klein, M. A., J. C. Moller, L. L. Jones, H. Bluethmann, G. W. Kreutzberg, and G. Raivich. 1997. Impaired neuroglial activation in interleukin-6 deficient mice. Glia 19: 227-233.
25. Kloss, C. U. A., A. Werner, J. Shen, M. A. Klein, G. W. Kreutzberg, and G. Raivich. 1999. The integrin family of cell adhesion molecules in the injured brain: Regulation and cellular localization in the normal and regenerating mouse facial nucleus. J. Comp. Neurol. 441: 162-178.
26. Krieglstein, K., S. Richter, L. Farkas, N. Schuster, N. Dunker, R. W. Oppenheim, and K. Unsicker. 2000. Reduction of endogenous transforming growth factors beta prevents ontogenetic neuron death. Nature Neurosci. 3: 1085-1090.
27. Labow, M., D. Shuster, M. Zetterstrom, P. Nunes, R. Terry, E. B. Cullinan, T. Bartfai, C. Solorzano, L. L. Moldawer, R. Chizzonite, and K. W. McIntyre. 1997. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J. Immunol. 159: 2452-2461.
28. Matsuda, S., T. C. Wen, F. Morita, H. Otsuka, K. Igase, H. Yoshimura, and M. Sakanaka. 1996. Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils. Neurosci. Lett. 204: 109-112.
29. Merril, J. E., D. H. Kono, J. Clayton, D. G. Ando, D. R. Hinton, and F. M. Hofman. 1992. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proc. Natl. Acad. Sci. USA 89: 574-578.
30. Möller, J. C., M. A. Klein, S. Haas, L. L. Jones, G. W. Kreutzberg, and G. Raivich. 1996. Regulation of thrombospondin in the regenerating mouse facial motor nucleus. Glia 17: 121-132.
31. Morganti-Kossmann, M. C., T. Kossmann, and S. M. Wahl. 1992. Cytokines and neuropathology. Trends Pharmacol. Sci. 13: 286-291.
32. Morganti-Kossmann, M. C., T. Kossmann, and S. M. Wahl. 1992. Cytokines and neuropathology. Trends Pharmacol. Sci. 13: 286-291.
33. Penkowa, M., M. Giralt, J. Carrasco, H. Hadberg, and J. Hidalgo. 2000. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia 32: 271-285.
34. Raivich, G., J. Gehrmann, and G. W. Kreutzberg. 1991. Increase of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor receptors in the regenerating rat facial nucleus. J. Neurosci. Res. 30: 682-686.
35. Raivich, G., M. T. Moreno-Flores, J. C. Moller, and G. W. Kreutzberg. 1994. Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse. Eur. J. Neurosci. 6: 1615-1618.
36. Raivich, G., L. L. Jones, C. U. A. Kloss, A. Werner, H. Neumann, and G. W. Kreutzberg. 1998. Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration. J. Neurosci. 18: 5804-5816.
37. Raivich, G., S. Haas, A. Werner, M. A. Klein, C. Kloss, and G. W. Kreutzberg. 1998. Regulation of MCSF receptors on microglia in the normal and injured mouse central nervous system: A quantitative immunofluorescence study using confocal laser microscopy. J. Comp. Neurol. 395: 342-358.
38. Raivich, G., M. Bohatschek, C. U. A. Kloss, A. Werner, L. L. Jones, and G. W. Kreutzberg. 1999. Neuroglial activation in the injured brain: Graded response, molecular mechanisms and cues to physiological function. Brain Res. Rev. 30: 77-105.
39. Rothe, J., W. Lesslauer, H. Loetscher, Y. Lang, P. Koebel, F. Kontgen, A. Althage, R. Zinkernagel, M. Steinmetz, and H. Bluethmann. 1993. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364: 798-802.
40. Rothwell, N. J., and S. J. Hopkins. 1996. Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci. 18: 130-136.
41. Seilhean, D., K. Kobayashi, Y. He, T. Uchihara, O. Rosenblum, C. Katlama, F. Bricaire, C. Duyckaerts, and J. J. Hauw. 1997. Tumor necrosis factor-alpha, microglia and astrocytes in aids dementia complex. Acta Neuropathol. 93: 508-517.
42. Selmaj, K., C. S. Raine, B. Cannella, and C. F. Brosnan. 1991. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J. Clin. Invest. 87: 949-954.
43. Sharma, K., R. X. Wang, L. Y. Zhang, D. L. Yin, X. Y. Luo, J. C. Solomon, R. F. Jiang, K. Markos, W. Davidson, D. W. Scott, and Y. F. Shi. 2000. Death the Fas way: Regulation and pathophysiology of CD95 and its ligand. Pharmacol. Ther. 88: 333-347.
44. Singh, A., J. Ni, and B. B. Aggarwal. 1998. Death domain receptors and their role in cell demise. J. Interferon Cytokine Res. 18: 439-450.
45. Streit, W. J., and G. W. Kreutzberg. 1988. Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin. J. Comp. Neurol. 268: 248-263.
46. Streit, W. J., S. L. Semple-Rowland, S. D. Hurley, R. C. Miller, P. G. Popovich, and B. T. Stokes. 1998. Cytokine mRNA profiles in confused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp. Neurol. 152: 74-87.
47. Terrado, J., D. Monnier, D. Perrelet, D. Vesin, S. Jemelin, W. A. Buurman, L. Mattenberger, B. King, A. C. Kato, and I. Garcia. 2000. Soluble TNF receptors partially protect injured motoneurons in the postnatal CNS. Eur. J. Neurosci. 12: 3443-3447.
48. Torvik, A., and F. Skjorten. 1971. Electron microscopic observations on nerve cell regeneration and degeneration after axon lesions. II. Changes in the glial cells. Acta Neuropathol. 17: 265-282.
49. Uno, H., T. Matsuyama, H. Akita, H. Nishimura, and M. Sugita. 1997. Induction of tumor necrosis factor-alpha in the mouse hippocampus following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 17: 491-499.