Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax

Journal of Comparative Neurology

Volumn 433, Issue 3, 2001, Pages 299-311

  Martin, Lee J ^a   Kaiser, Adeel ^a   Yu, Jonathan W ^a   Natale, Joanne E ^a   Al Abdulla, Nael A ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; DNA damage; Head trauma; Programmed cell death; Tumor suppressor protein

Indexed keywords

CASPASE 3; PROTEIN BAX; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN INJURY; CONTROLLED STUDY; DNA DAMAGE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LATERAL GENICULATE NUCLEUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN INJURIES; CASPASE 3; CASPASES; CELL NUCLEUS; DNA; ENZYME ACTIVATION; GENES, P53; GENES, TUMOR SUPPRESSOR; GENICULATE BODIES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURONS; OCCIPITAL LOBE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; THALAMUS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035821429     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.1141     Document Type: Article

References (56)

1. The neuropathology of the vegetative state after an acute brain insult
2. Axotomy-induced neuronal death and reactive astrogliosis in the lateral geniculate nucleus following a lesion of the visual cortex in the rat
3. Apoptosis of retrogradely degenerating neurons occurs in association with the accumulation of perikaryal mitochondria and oxidative damage to the nucleus
4. Occipital cortex ablation in adult rat causes retrograde neuronal death in the lateral geniculate nucleus that resembles apoptosis
5. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-jun immunoreactivity, relationship to brain area, and effect of postmortem delay
6. Inhibition of bax channel-forming activity by bcl-2
7. Apoptosis: The role of endonuclease
8. Comparative evaluation of synaptophysin-based methods for quantification of synapses
9. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
10. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
11. Bax is required for neuronal death after trophic factor deprivation and during development
12. Comparative analysis of p73 and p53 regulation and effector functions
13. Cell deaths in normal vertebrate ontogeny
14. Alzheimer's disease: Neurofibrillary tangles in nuclei that project to the cerebral cortex
15. Differential requirement for caspase 9 in apoptotic pathways in vivo
16. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
17. Inhibition of CPP-32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo
18. Activation of caspase-3 in axotomized rat ganglion cell in vivo
19. Definition and incidence of apoptosis: An historical perspective
20. Apoptotic cell death in neurons and glial cells: Implications for Alzheimer's disease
21. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
22. Identification and characterization of a spinal muscular atrophy-determining gene
23. p53, the cellular gatekeeper for growth and division
24. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
25. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
26. Neuronal and glial apoptosis after traumatic spinal cord injury
27. Motor neurons rapidly accumulate DNA single-strand breaks after in vitro exposure to nitric oxide and peroxynitrite and in vivo axotomy
28. Detection of higher-order 50- and 10-kbp DNA fragments before apoptotic internucleosomal cleavage after transient cerebral ischemia
29. In vivo ubiquitination and proteasome-mediated degradation of p53
30. Neuronal death in amyotrophic lateral sclerosis is apoptosis: Possible contribution of a programmed cell death mechanism
31. p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis
32. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
33. Motor neuron degeneration after sciatic nerve avulsion in adult rat evolves with oxidative stress and is apoptosis
34. Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death
35. Apoptosis and necrosis occur in separate neuronal populations in hippocampus and cerebellum after ischemia and are associated with differential alterations in metabotropic glutamate signaling pathways
36. Bcl-2 gene family in the nervous system
37. p63 is a p53 homologue required for limb and epidermal morphogenesis
38. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
39. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
40. Tumor suppressor p53 is a regulator of Bcl-2 and bax gene expression in vitro and in vivo
41. Expression of Bcl-2, Bax, and caspase-3 in the brain of the developing rat
42. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death
43. Cell death during development of the nervous system
44. The neuroanatomy of Alzheimer's disease
45. A model for p53-induced apoptosis
46. Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum
47. Bax translocation is a critical event in neuronal apoptosis: Regulation by neuroprotectants, Bcl-2, and caspases
48. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
49. p53-deficient mice are protected against adrenalectomy-induced apoptosis
50. Neuronal pathology in the nucleus basali and associated cell groups in senile dementia of the Alzheimer's type: Possible role in cell loss
51. p53 function and dysfunction
52. DNA damage enables p73
53. Movement of Bax from the cytosol to mitochondria during apoptosis
54. The role of free radicals and p53 in neuron apoptosis in vivo
55. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumors
56. An Apaf-1-cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9