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Volumn 40, Issue 6, 2005, Pages 455-465

The essential mechanisms of aging: Irreparable damage accumulation of biochemical side-reactions

Author keywords

Age pigments; Aging mechanisms; Carbonyl stress; Entropy; Free radical oxidation; Non enzymatic glycosylation

Indexed keywords

CARBONYL DERIVATIVE; FREE RADICAL; LIPID; PIGMENT;

EID: 21244486584     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2005.03.012     Document Type: Note
Times cited : (179)

References (115)
  • 1
    • 0035978878 scopus 로고    scopus 로고
    • Molecular mechanisms of ageing in connective tissues
    • A.J. Bailey Molecular mechanisms of ageing in connective tissues Mech. Ageing Dev. 122 2001 735 755
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 735-755
    • Bailey, A.J.1
  • 2
    • 0034571077 scopus 로고    scopus 로고
    • From life to death - The struggle between chemistry and biology during aging: The Maillard reaction as an amplifier of genomic damage
    • J.W. Baynes From life to death - the struggle between chemistry and biology during aging: the Maillard reaction as an amplifier of genomic damage Biogerontol. 1 2000 235 246
    • (2000) Biogerontol. , vol.1 , pp. 235-246
    • Baynes, J.W.1
  • 3
    • 0034893715 scopus 로고    scopus 로고
    • The role of AGEs in aging: Causation or correlation
    • J.W. Baynes The role of AGEs in aging: causation or correlation Exp. Gerontol. 36 2001 1527 1537
    • (2001) Exp. Gerontol. , vol.36 , pp. 1527-1537
    • Baynes, J.W.1
  • 6
    • 0014271005 scopus 로고
    • The crosslinkage theory of aging
    • J. Bjorksten The crosslinkage theory of aging J. Am. Geriatric. Soc. 16 1968 408 427
    • (1968) J. Am. Geriatric. Soc. , vol.16 , pp. 408-427
    • Bjorksten, J.1
  • 7
    • 0035990297 scopus 로고    scopus 로고
    • DNA damage and its processing: Relation to human disease
    • V.A. Bohr DNA damage and its processing: relation to human disease J. Inherit. Metab. Dis. 25 3 2002 215 222
    • (2002) J. Inherit. Metab. Dis. , vol.25 , Issue.3 , pp. 215-222
    • Bohr, V.A.1
  • 8
    • 0023009451 scopus 로고
    • Aging as entropy
    • W. Bortz Aging as entropy Exp. Gerontol. 21 1986 321 328
    • (1986) Exp. Gerontol. , vol.21 , pp. 321-328
    • Bortz, W.1
  • 9
    • 0036236006 scopus 로고    scopus 로고
    • The mitochondrial-lysosomal axis theory of aging
    • U.T. Brunk, and A. Terman The mitochondrial-lysosomal axis theory of aging Eur. J. Biochem. 269 2002 1996 2002
    • (2002) Eur. J. Biochem. , vol.269 , pp. 1996-2002
    • Brunk, U.T.1    Terman, A.2
  • 10
    • 0022339852 scopus 로고
    • Hypothesis: Glucose as a mediator of aging
    • A. Cerami Hypothesis: glucose as a mediator of aging J. Am. Geriatr. Soc. 33 1985 626 634
    • (1985) J. Am. Geriatr. Soc. , vol.33 , pp. 626-634
    • Cerami, A.1
  • 11
    • 5644256969 scopus 로고    scopus 로고
    • RAGE (receptor for advanced glycation end products): A central player in the inflammatory response
    • T. Chavakis, A. Bierhaus, and P.P. Nawroth RAGE (receptor for advanced glycation end products): a central player in the inflammatory response Microbes Infect. 6 13 2004 1219 1225
    • (2004) Microbes Infect. , vol.6 , Issue.13 , pp. 1219-1225
    • Chavakis, T.1    Bierhaus, A.2    Nawroth, P.P.3
  • 12
    • 72949134211 scopus 로고
    • The modification by X-irradiation of the life span of haploids and diploids of the wasp Habrobracon sp
    • A.M. Clark, and M.A. Rubin The modification by X-irradiation of the life span of haploids and diploids of the wasp Habrobracon sp Radiation Res. 15 1961 244 253
    • (1961) Radiation Res. , vol.15 , pp. 244-253
    • Clark, A.M.1    Rubin, M.A.2
  • 13
    • 0348099030 scopus 로고    scopus 로고
    • Aging as a war between chemical and biochemical processes: Protein methylation and the recognition of age-damaged proteins for repair
    • S. Clarke Aging as a war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair Ageing Res. Rev. 2 2003 263 285
    • (2003) Ageing Res. Rev. , vol.2 , pp. 263-285
    • Clarke, S.1
  • 15
    • 0022393345 scopus 로고
    • Biology of disease, lipid peroxidation and cellular damage in toxic liver injury
    • M. Comporti Biology of disease, lipid peroxidation and cellular damage in toxic liver injury Lab. Invest. 53 1985 599 623
    • (1985) Lab. Invest. , vol.53 , pp. 599-623
    • Comporti, M.1
  • 18
    • 11144324518 scopus 로고    scopus 로고
    • Open-minded scepticism: Inferring the causal mechanisms of human ageing from genetic perturbations
    • J.P. de Magalhaes Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations Ageing Res. Rev. 4 2005 1 22
    • (2005) Ageing Res. Rev. , vol.4 , pp. 1-22
    • De Magalhaes, J.P.1
  • 19
    • 0042671376 scopus 로고    scopus 로고
    • 4-Hydroxynonenal from pathology to physiology
    • M.U. Dianzani 4-Hydroxynonenal from pathology to physiology Mol. Asp. Med. 24 2003 263 272
    • (2003) Mol. Asp. Med. , vol.24 , pp. 263-272
    • Dianzani, M.U.1
  • 20
    • 0042671405 scopus 로고    scopus 로고
    • Genotoxicity of HNE
    • P.M. Eckl Genotoxicity of HNE Mol. Asp. Med. 24 2003 161 165
    • (2003) Mol. Asp. Med. , vol.24 , pp. 161-165
    • Eckl, P.M.1
  • 21
    • 0018387608 scopus 로고
    • Aging, genetics and the environment. Potential of errors introduced into genetic information transfer by metal ions
    • G.L. Eichhorn Aging, genetics and the environment. Potential of errors introduced into genetic information transfer by metal ions Mech. Ageing Dev. 9 1979 291 301
    • (1979) Mech. Ageing Dev. , vol.9 , pp. 291-301
    • Eichhorn, G.L.1
  • 22
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxy-nonenal, malondialdehyde and related aldehydes
    • H. Esterbauer, R.J. Schaur, and H. Zollner Chemistry and biochemistry of 4-hydroxy-nonenal, malondialdehyde and related aldehydes Free Radic. Biol. Med. 11 1 1991 81 128
    • (1991) Free Radic. Biol. Med. , vol.11 , Issue.1 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 23
    • 0030713963 scopus 로고    scopus 로고
    • Genetics of aging
    • C.E. Finch, and R.E. Tanzi Genetics of aging Science 278 5337 1997 407 411
    • (1997) Science , vol.278 , Issue.5337 , pp. 407-411
    • Finch, C.E.1    Tanzi, R.E.2
  • 24
    • 0018411145 scopus 로고
    • Error propagation in viable cells
    • J. Gallant, and L. Palmer Error propagation in viable cells Mech. Ageing Dev. 10 1979 27 38
    • (1979) Mech. Ageing Dev. , vol.10 , pp. 27-38
    • Gallant, J.1    Palmer, L.2
  • 25
    • 0025948114 scopus 로고
    • Mechanism of formation of the Maillard protein cross-link pentosidine
    • S.K. Grandhee, and V.M. Monnier Mechanism of formation of the Maillard protein cross-link pentosidine J. Biol. Chem. 266 1991 11649 11653
    • (1991) J. Biol. Chem. , vol.266 , pp. 11649-11653
    • Grandhee, S.K.1    Monnier, V.M.2
  • 27
    • 0242334033 scopus 로고    scopus 로고
    • Genes of aging
    • P. Hamet, and J. Tremblay Genes of aging Metabolism 52 10 2003 5 9
    • (2003) Metabolism , vol.52 , Issue.10 , pp. 5-9
    • Hamet, P.1    Tremblay, J.2
  • 29
    • 77049308856 scopus 로고
    • Ageing: A theory based on free radical and radiation chemistry
    • D. Harman Ageing: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 31
    • 0142213542 scopus 로고    scopus 로고
    • The free radical theory of aging
    • D. Harman The free radical theory of aging Antioxid. Redox Signal. 5 5 2003 557 561
    • (2003) Antioxid. Redox Signal. , vol.5 , Issue.5 , pp. 557-561
    • Harman, D.1
  • 32
    • 0024511940 scopus 로고
    • Aging of proteins: Immunological detection of a glucose-derived pyrrole formed during Maillard reaction in vivo
    • F. Hayase, R.H. Nagaraj, S. Miyata, F.G. Njoroge, and V.M. Monnier Aging of proteins: Immunological detection of a glucose-derived pyrrole formed during Maillard reaction in vivo J. Biol. Chem. 263 1989 3758 3764
    • (1989) J. Biol. Chem. , vol.263 , pp. 3758-3764
    • Hayase, F.1    Nagaraj, R.H.2    Miyata, S.3    Njoroge, F.G.4    Monnier, V.M.5
  • 33
    • 0032434055 scopus 로고    scopus 로고
    • How and why we age
    • L. Hayflick How and why we age Exp. Gerontol. 33 7-8 1998 639 653
    • (1998) Exp. Gerontol. , vol.33 , Issue.7-8 , pp. 639-653
    • Hayflick, L.1
  • 34
    • 0034646822 scopus 로고    scopus 로고
    • The probable involvement of soluble and deposited melanins, their intermediates and the reactive oxygen side-products in human diseases and aging
    • Z.L. Hegedus The probable involvement of soluble and deposited melanins, their intermediates and the reactive oxygen side-products in human diseases and aging Toxicology 145 2000 85 101
    • (2000) Toxicology , vol.145 , pp. 85-101
    • Hegedus, Z.L.1
  • 35
    • 33947448299 scopus 로고
    • Dehydrated foods, chemistry of browning reactions in model systems
    • J.E. Hodge Dehydrated foods, chemistry of browning reactions in model systems J. Agric. Food Chem. 1 1953 928 943
    • (1953) J. Agric. Food Chem. , vol.1 , pp. 928-943
    • Hodge, J.E.1
  • 36
    • 0033804699 scopus 로고    scopus 로고
    • Somatic mutations and ageing
    • R. Holliday Somatic mutations and ageing Mutat. Res. 463 2000 173 178
    • (2000) Mutat. Res. , vol.463 , pp. 173-178
    • Holliday, R.1
  • 37
    • 0024546310 scopus 로고
    • DNA, mutations and aging
    • T.B.L. Kirkwood DNA, mutations and aging Mutat. Res. 219 1989 1 7
    • (1989) Mutat. Res. , vol.219 , pp. 1-7
    • Kirkwood, T.B.L.1
  • 40
    • 0028569044 scopus 로고
    • Variations in the level of urinary thiobarbituric acid reactant in healthy humans under different physiological conditions
    • H. Kosugi, H. Enomoto, Y. Ishizuka, and K. Kikugawa Variations in the level of urinary thiobarbituric acid reactant in healthy humans under different physiological conditions Biol. Pharm. Bull. 17 1994 1645 1650
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 1645-1650
    • Kosugi, H.1    Enomoto, H.2    Ishizuka, Y.3    Kikugawa, K.4
  • 41
    • 0028271046 scopus 로고
    • Towards a network theory of ageing: A model combining the free radical theory and the protein error theory
    • A. Kowald, and T.B. Kirkwood Towards a network theory of ageing: a model combining the free radical theory and the protein error theory J. Theor. Biol. 168 1 1994 75 94
    • (1994) J. Theor. Biol. , vol.168 , Issue.1 , pp. 75-94
    • Kowald, A.1    Kirkwood, T.B.2
  • 42
    • 0026781030 scopus 로고
    • An emerging hypothesis: Synergistic induction of aging by free radicals and Maillard reactions
    • B.S. Kristal, and B.P. Yu An emerging hypothesis: synergistic induction of aging by free radicals and Maillard reactions J. Gerontol. 47 4 1992 B107 B114
    • (1992) J. Gerontol. , vol.47 , Issue.4
    • Kristal, B.S.1    Yu, B.P.2
  • 43
    • 21244468764 scopus 로고
    • The effects of X-irradiation on the longevity of triploid and diploid female Drosophila melanogaster
    • M.J. Lamb The effects of X-irradiation on the longevity of triploid and diploid female Drosophila melanogaster Exp. Gerontol. 1 1965 181 187
    • (1965) Exp. Gerontol. , vol.1 , pp. 181-187
    • Lamb, M.J.1
  • 44
    • 0034725085 scopus 로고    scopus 로고
    • Extension of cell life-span and telomere length in animals cloned from senescent somatic cells
    • R.P. Lanza, J.B. Cibelli, and C. Blachwell Extension of cell life-span and telomere length in animals cloned from senescent somatic cells Science 288 5466 2000 665 669
    • (2000) Science , vol.288 , Issue.5466 , pp. 665-669
    • Lanza, R.P.1    Cibelli, J.B.2    Blachwell, C.3
  • 45
    • 0000916315 scopus 로고
    • Action des acides amines sur les sucres: Formation des melanoidines par voie methodique
    • L.C. Maillard Action des acides amines sur les sucres: Formation des melanoidines par voie methodique C.R. Hebd. Seances Acad. Sci. 154 1912 66 68
    • (1912) C.R. Hebd. Seances Acad. Sci. , vol.154 , pp. 66-68
    • Maillard, L.C.1
  • 46
    • 0025117953 scopus 로고
    • An attempt at a rational classification of theories of aging
    • Z.A. Medvedev An attempt at a rational classification of theories of aging Biol. Rev. 65 1990 375 398
    • (1990) Biol. Rev. , vol.65 , pp. 375-398
    • Medvedev, Z.A.1
  • 48
    • 0142058743 scopus 로고    scopus 로고
    • Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: A novel therapy for treatment of diabetic complications
    • T.O. Metz, N.L. Alderson, S.R. Thorpe, and J.W. Baynes Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications Arch. Biochem. Biophys. 419 2003 41 49
    • (2003) Arch. Biochem. Biophys. , vol.419 , pp. 41-49
    • Metz, T.O.1    Alderson, N.L.2    Thorpe, S.R.3    Baynes, J.W.4
  • 50
    • 0033865719 scopus 로고    scopus 로고
    • Relevance of oxidative and carbonyl stress to long-term uremic complications
    • T. Miyata, K. Kurokawa, and C.Y. de Strihou Relevance of oxidative and carbonyl stress to long-term uremic complications Kidney Int. 58 2000 S120 S125
    • (2000) Kidney Int. , vol.58
    • Miyata, T.1    Kurokawa, K.2    De Strihou, C.Y.3
  • 52
    • 0025373091 scopus 로고
    • Nonenzymatic glycosylation, the Maillard reaction and aging process
    • V.M. Monnier Nonenzymatic glycosylation, the Maillard reaction and aging process J. Gerontol. 45 1990 B105 B111
    • (1990) J. Gerontol. , vol.45
    • Monnier, V.M.1
  • 53
    • 0026708910 scopus 로고
    • Crosslines a and B as candidates for the fluorophores in age- and diabetes-related cross-linked proteins, and their diacetates produced by Maillard reaction of N-acetyl-L-lysine with o-Glucose
    • K. Nakamura, T. Hasegawa, Y. Fukunaga, and K. Ienaga Crosslines A and B as candidates for the fluorophores in age- and diabetes-related cross-linked proteins, and their diacetates produced by Maillard reaction of N-acetyl-L-lysine with o-Glucose J. Chem. Soc. Chem. Commun. 14 1992 992 994
    • (1992) J. Chem. Soc. Chem. Commun. , vol.14 , pp. 992-994
    • Nakamura, K.1    Hasegawa, T.2    Fukunaga, Y.3    Ienaga, K.4
  • 54
    • 0343967481 scopus 로고
    • Reactions of amino acids with 4-hydroxy-2,3-trans-pentenal and therapy of Ehrlich ascites tumors with the amino acid adducts
    • S. Napetschnig Reactions of amino acids with 4-hydroxy-2,3-trans-pentenal and therapy of Ehrlich ascites tumors with the amino acid adducts Austria Univ. Graz. Thesis. 1981
    • (1981) Austria Univ. Graz. Thesis.
    • Napetschnig, S.1
  • 55
    • 0030631569 scopus 로고    scopus 로고
    • Preparation of artificial ceroid/lipofuscin by UV-oxidation of subcellular organelles
    • Nilsson, E., Yin, D., Preparation of artificial ceroid/lipofuscin by UV-oxidation of subcellular organelles. Mech. Ageing Dev. 99, 61-78.
    • Mech. Ageing Dev. , vol.99 , pp. 61-78
    • Nilsson, E.1    Yin, D.2
  • 56
    • 0036605411 scopus 로고    scopus 로고
    • No truth to the fountain of youth
    • S.J. Olshansky, L. Hayflick, and B.A. Carnes No truth to the fountain of youth Sci. Am. 286 6 2002 92 95
    • (2002) Sci. Am. , vol.286 , Issue.6 , pp. 92-95
    • Olshansky, S.J.1    Hayflick, L.2    Carnes, B.A.3
  • 57
    • 73649150958 scopus 로고
    • The maintenance of the accuracy of protein synthesis and its relevance to ageing
    • L.E. Orgel The maintenance of the accuracy of protein synthesis and its relevance to ageing Proc. Natl Acad. Sci. USA 49 1963 517 521
    • (1963) Proc. Natl Acad. Sci. USA , vol.49 , pp. 517-521
    • Orgel, L.E.1
  • 58
    • 0028220114 scopus 로고
    • Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
    • W.C. Orr, and R.S. Sohal Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster Science 263 1994 1128
    • (1994) Science , vol.263 , pp. 1128
    • Orr, W.C.1    Sohal, R.S.2
  • 59
    • 14544268189 scopus 로고    scopus 로고
    • DNA repair defects in stem cell function and aging
    • Y. Park, and S.L. Gerson DNA repair defects in stem cell function and aging Annu. Rev. Med. 56 2005 495 508
    • (2005) Annu. Rev. Med. , vol.56 , pp. 495-508
    • Park, Y.1    Gerson, S.L.2
  • 60
    • 0001112738 scopus 로고
    • Aging of proteins: Isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose
    • S. Pongor, P.C. Ulrich, F.A. Bencsath, and A. Cerami Aging of proteins: Isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose Proc. Natl Acad. Sci. USA 81 1984 2684 2688
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 2684-2688
    • Pongor, S.1    Ulrich, P.C.2    Bencsath, F.A.3    Cerami, A.4
  • 62
    • 9644283367 scopus 로고    scopus 로고
    • Age impairments in sleep, metabolic and immune functions
    • P.N. Prinz Age impairments in sleep, metabolic and immune functions Exp. Gerontol. 39 11-12 2004 1739 1743
    • (2004) Exp. Gerontol. , vol.39 , Issue.11-12 , pp. 1739-1743
    • Prinz, P.N.1
  • 63
    • 0029983808 scopus 로고    scopus 로고
    • Synthesis, modification, and turnover of proteins during aging
    • S.I. Rattan Synthesis, modification, and turnover of proteins during aging Exp. Gerontol. 31 1-2 1996 33 47
    • (1996) Exp. Gerontol. , vol.31 , Issue.1-2 , pp. 33-47
    • Rattan, S.I.1
  • 64
    • 7144251582 scopus 로고
    • Are free radicals causes or effects of aging? the entropy theory
    • G.S. Roth Are free radicals causes or effects of aging? the entropy theory Aging Clin. Exp. Res. 5 3 1993 241 242
    • (1993) Aging Clin. Exp. Res. , vol.5 , Issue.3 , pp. 241-242
    • Roth, G.S.1
  • 65
    • 0036132470 scopus 로고    scopus 로고
    • Protein turnover plays a key role in aging
    • A.G. Ryazanov, and B.S. Nefsky Protein turnover plays a key role in aging Mech. Ageing Dev. 123 2-3 2002 207 213
    • (2002) Mech. Ageing Dev. , vol.123 , Issue.2-3 , pp. 207-213
    • Ryazanov, A.G.1    Nefsky, B.S.2
  • 66
    • 21244466026 scopus 로고
    • Abnutzungstheorie
    • N.W. Shock Thomas, C.C. Springfield, Ill
    • G.A. Sacher Abnutzungstheorie N.W. Shock Perspectives in Experimental Gerontology 1966 Thomas, C.C. Springfield, Ill 326 335
    • (1966) Perspectives in Experimental Gerontology , pp. 326-335
    • Sacher, G.A.1
  • 67
    • 84980131081 scopus 로고
    • The complementarity of entropy terms for the temperature dependence of development and aging
    • G.A. Sacher The complementarity of entropy terms for the temperature dependence of development and aging Ann. NY Acad. Sci. 138 1967 680 712
    • (1967) Ann. NY Acad. Sci. , vol.138 , pp. 680-712
    • Sacher, G.A.1
  • 69
    • 0018055280 scopus 로고
    • Formation and properties of reactive aldehydes
    • E. Schauenstein, and H. Esterbauer Formation and properties of reactive aldehydes Ciba Found. Symp. 67 1979 225 244
    • (1979) Ciba Found. Symp. , vol.67 , pp. 225-244
    • Schauenstein, E.1    Esterbauer, H.2
  • 70
    • 0043172509 scopus 로고    scopus 로고
    • Basic aspects of the biochemical reactivity of 4-hydroxynonenal
    • R.J. Schaur Basic aspects of the biochemical reactivity of 4-hydroxynonenal Mol. Asp. Med. 24 2003 149 159
    • (2003) Mol. Asp. Med. , vol.24 , pp. 149-159
    • Schaur, R.J.1
  • 72
    • 0000353211 scopus 로고
    • Aging of long-lived proteins: Extracellular matrix (collagens, elastins, proteoglycans) and lens crystallins
    • E.J. Masoro Oxford University Press New York
    • D.R. Sell, and V.M. Monnier Aging of long-lived proteins: extracellular matrix (collagens, elastins, proteoglycans) and lens crystallins E.J. Masoro Handbook of Physiology 1995 Oxford University Press New York 235 305
    • (1995) Handbook of Physiology , pp. 235-305
    • Sell, D.R.1    Monnier, V.M.2
  • 75
    • 0004276105 scopus 로고
    • Elsevier/North-Holland Biomedical Press New York
    • R.S. Sohal Age Pigments 1981 Elsevier/North-Holland Biomedical Press New York
    • (1981) Age Pigments
    • Sohal, R.S.1
  • 76
    • 0036709816 scopus 로고    scopus 로고
    • Oxidative stress hypothesis of aging
    • R.S. Sohal Oxidative stress hypothesis of aging Free Radic. Biol. Med. 33 5 2002 573 574
    • (2002) Free Radic. Biol. Med. , vol.33 , Issue.5 , pp. 573-574
    • Sohal, R.S.1
  • 77
    • 0025614206 scopus 로고
    • Oxidative stress as a causal factor in differentiation and aging: A unifying hypothesis
    • R.S. Sohal, and R.G. Allen Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis Exp. Gerontol. 25 6 1990 499 522
    • (1990) Exp. Gerontol. , vol.25 , Issue.6 , pp. 499-522
    • Sohal, R.S.1    Allen, R.G.2
  • 78
    • 0036710886 scopus 로고    scopus 로고
    • Mechanisms of aging: An appraisal of the oxidative stress hypothesis
    • R.S. Sohal, R.J. Mokett, and W.C. Orr Mechanisms of aging: an appraisal of the oxidative stress hypothesis Free Radic. Biol. Med. 33 5 2002 575 586
    • (2002) Free Radic. Biol. Med. , vol.33 , Issue.5 , pp. 575-586
    • Sohal, R.S.1    Mokett, R.J.2    Orr, W.C.3
  • 79
    • 0026795635 scopus 로고
    • Protein oxidation and aging
    • E.R. Stadtman Protein oxidation and aging Science 257 5074 1992 1220 1224
    • (1992) Science , vol.257 , Issue.5074 , pp. 1220-1224
    • Stadtman, E.R.1
  • 80
    • 0346100345 scopus 로고    scopus 로고
    • Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
    • E.R. Stadtman, and R.L. Levine Free radical-mediated oxidation of free amino acids and amino acid residues in proteins Amino Acids 25 3-4 2003 207 218
    • (2003) Amino Acids , vol.25 , Issue.3-4 , pp. 207-218
    • Stadtman, E.R.1    Levine, R.L.2
  • 82
    • 0002235236 scopus 로고
    • On the nature of the aging process
    • L. Szilard On the nature of the aging process Proc. Natl Acad. Sci. USA 45 1959 30 45
    • (1959) Proc. Natl Acad. Sci. USA , vol.45 , pp. 30-45
    • Szilard, L.1
  • 83
    • 0141650806 scopus 로고    scopus 로고
    • Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems
    • P.A. Szweda, M. Camouse, K.C. Lundberg, T.D. Oberley, and L.I. Szweda Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems Ageing Res. Rev. 2 4 2003 383 405
    • (2003) Ageing Res. Rev. , vol.2 , Issue.4 , pp. 383-405
    • Szweda, P.A.1    Camouse, M.2    Lundberg, K.C.3    Oberley, T.D.4    Szweda, L.I.5
  • 84
    • 0035063178 scopus 로고    scopus 로고
    • Garbage catastrophe theory of aging: Imperfect removal of oxidative damage?
    • A. Terman Garbage catastrophe theory of aging: imperfect removal of oxidative damage? Redox. Report. 6 2001 15 26
    • (2001) Redox. Report. , vol.6 , pp. 15-26
    • Terman, A.1
  • 85
    • 0033597866 scopus 로고    scopus 로고
    • Structure and mechanism of formation of human lens fluorophore LM-1. Relationship to vesperlysine a and the advanced Maillard reaction in aging, diabetes, and cataractogenesis
    • F. Tessier, M. Obrenovich, and V.M. Monnier Structure and mechanism of formation of human lens fluorophore LM-1. Relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataractogenesis J. Biol. Chem. 274 30 1999 20796 20804
    • (1999) J. Biol. Chem. , vol.274 , Issue.30 , pp. 20796-20804
    • Tessier, F.1    Obrenovich, M.2    Monnier, V.M.3
  • 86
    • 0033571012 scopus 로고    scopus 로고
    • Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
    • P.J. Thornalley, A. Langborg, and H.S. Minhas Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose Biochem. J. 344 Pt 1 1999 109 116
    • (1999) Biochem. J. , vol.344 , Issue.1 SUPPL. , pp. 109-116
    • Thornalley, P.J.1    Langborg, A.2    Minhas, H.S.3
  • 88
    • 0000305880 scopus 로고
    • The effect of vitamin e and beta-carotene on the incidence of lung cancer and other cancers in male smokers
    • Tochopherol Group
    • Tochopherol Group The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers New Eng. J. Med. 330 1994 1329 1335
    • (1994) New Eng. J. Med. , vol.330 , pp. 1329-1335
  • 89
    • 12344308106 scopus 로고    scopus 로고
    • Nitric oxide as a unique bioactive signaling messenger in physiology and pathophysiology
    • N. Tuteja, M. Chandra, R. Tuteja, and M.K. Misra Nitric oxide as a unique bioactive signaling messenger in physiology and pathophysiology J. Biomed. Biotechnol. 4 2004 227 237
    • (2004) J. Biomed. Biotechnol. , Issue.4 , pp. 227-237
    • Tuteja, N.1    Chandra, M.2    Tuteja, R.3    Misra, M.K.4
  • 90
    • 0018069570 scopus 로고
    • Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
    • M. Uchiyama, and M. Mihara Determination of malonaldehyde precursor in tissues by thiobarbituric acid test Anal. Biochem. 86 1978 271 278
    • (1978) Anal. Biochem. , vol.86 , pp. 271-278
    • Uchiyama, M.1    Mihara, M.2
  • 92
    • 0346786307 scopus 로고    scopus 로고
    • Replicative senescence and the art of counting
    • T. von Zglinicki Replicative senescence and the art of counting Exp. Gerontol. 38 2003 1259 1264
    • (2003) Exp. Gerontol. , vol.38 , pp. 1259-1264
    • Von Zglinicki, T.1
  • 96
    • 0035966101 scopus 로고    scopus 로고
    • Characterization of regulatory elements on the promoter region of p16 (INK4a) that contribute to overexpression of p16 in senescent fibroblasts
    • W. Wang, J. Wu, Z. Zhang, and T. Tong Characterization of regulatory elements on the promoter region of p16 (INK4a) that contribute to overexpression of p16 in senescent fibroblasts J. Biol. Chem. 276 52 2001 48655 48661
    • (2001) J. Biol. Chem. , vol.276 , Issue.52 , pp. 48655-48661
    • Wang, W.1    Wu, J.2    Zhang, Z.3    Tong, T.4
  • 97
    • 11144308949 scopus 로고    scopus 로고
    • Longivity genes: From primitive organisms to humans
    • H.R. Warner Longivity genes: from primitive organisms to humans Mech. Ageing Dev. 126 2005 235 242
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 235-242
    • Warner, H.R.1
  • 98
    • 0023009007 scopus 로고
    • Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro
    • C.K. Winter, H.J. Segall, and W.F. Haddon Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro Cancer Res. 46 1986 5682 5686
    • (1986) Cancer Res. , vol.46 , pp. 5682-5686
    • Winter, C.K.1    Segall, H.J.2    Haddon, W.F.3
  • 99
    • 0019270984 scopus 로고
    • Lipid pigments (chromolipids): Their origin, nature, and significance
    • M. Wolman Lipid pigments (chromolipids): their origin, nature, and significance Pathobiol. Annu. 10 1980 253 267
    • (1980) Pathobiol. Annu. , vol.10 , pp. 253-267
    • Wolman, M.1
  • 100
    • 0000877330 scopus 로고
    • Assay for serum lipid peroxide level and its clinic significance
    • K. Yagi Academic Press New York
    • K. Yagi Assay for serum lipid peroxide level and its clinic significance K. Yagi Lipid Peroxides in Biology and Medicine 1982 Academic Press New York 223 243
    • (1982) Lipid Peroxides in Biology and Medicine , pp. 223-243
    • Yagi, K.1
  • 101
    • 3042637228 scopus 로고    scopus 로고
    • Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy
    • S. Yamagishi, M. Takeuchi, Y. Inagaki, K. Nakamura, and T. Imaizumi Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy Int. J. Clin. Pharmacol. Res. 23 4 2003 129 134
    • (2003) Int. J. Clin. Pharmacol. Res. , vol.23 , Issue.4 , pp. 129-134
    • Yamagishi, S.1    Takeuchi, M.2    Inagaki, Y.3    Nakamura, K.4    Imaizumi, T.5
  • 102
    • 0347381138 scopus 로고    scopus 로고
    • Glycation, inflammation, and RAGE: A scaffold for the macrovascular complications of diabetes and beyond
    • S.F. Yan, R. Ramasamy, Y. Naka, and A.M. Schmidt Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond Circ. Res. 93 12 2003 1159 1169
    • (2003) Circ. Res. , vol.93 , Issue.12 , pp. 1159-1169
    • Yan, S.F.1    Ramasamy, R.2    Naka, Y.3    Schmidt, A.M.4
  • 103
    • 0026515974 scopus 로고
    • Lipofuscin-like fluorophores can result from reactions between oxidized ascorbic acid and glutamine; Carbonyl-protein cross-linking may represent a common reaction in oxygen radical and glycosylation-related ageing processes
    • D. Yin Lipofuscin-like fluorophores can result from reactions between oxidized ascorbic acid and glutamine; carbonyl-protein cross-linking may represent a common reaction in oxygen radical and glycosylation-related ageing processes Mech. Ageing Dev. 62 1 1992 35 46
    • (1992) Mech. Ageing Dev. , vol.62 , Issue.1 , pp. 35-46
    • Yin, D.1
  • 104
    • 0029597858 scopus 로고
    • Studies of age pigments evolving into a new theory of aging
    • D. Yin Studies of age pigments evolving into a new theory of aging Gerontology 41 Suppl. 2 1995 159 172
    • (1995) Gerontology , vol.41 , Issue.2 SUPPL. , pp. 159-172
    • Yin, D.1
  • 105
    • 0029972278 scopus 로고    scopus 로고
    • Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores
    • D. Yin Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores Free Radic. Biol. Med. 21 6 1996 871 888
    • (1996) Free Radic. Biol. Med. , vol.21 , Issue.6 , pp. 871-888
    • Yin, D.1
  • 106
    • 0034070867 scopus 로고    scopus 로고
    • Is carbonyl detoxification an important antiaging process during sleep?
    • D. Yin Is carbonyl detoxification an important antiaging process during sleep? Med. Hypoth. 54 2000 519 522
    • (2000) Med. Hypoth. , vol.54 , pp. 519-522
    • Yin, D.1
  • 108
    • 21244434413 scopus 로고    scopus 로고
    • Aging: A war between life and entropy
    • D. Yin Aging: a war between life and entropy Chi. J. Gerontol. 23 2003 555 559
    • (2003) Chi. J. Gerontol. , vol.23 , pp. 555-559
    • Yin, D.1
  • 109
    • 85053510623 scopus 로고
    • Carbonyl toxification hypothesis of biological aging
    • A. Macieira-Coelho CRC Press, Inc. New York
    • D. Yin, and U.F. Brunk Carbonyl toxification hypothesis of biological aging A. Macieira-Coelho Molecular Basis of Aging 1995 CRC Press, Inc. New York 421 436
    • (1995) Molecular Basis of Aging , pp. 421-436
    • Yin, D.1    Brunk, U.F.2
  • 110
    • 21244463207 scopus 로고    scopus 로고
    • Aging mechanisms: Irreparable accumulation of impairments caused by various biochemical side-reactions
    • D. Yin, and K.J. Chen Aging mechanisms: irreparable accumulation of impairments caused by various biochemical side-reactions Chi. J. Gerontol. 25 2005 1 6
    • (2005) Chi. J. Gerontol. , vol.25 , pp. 1-6
    • Yin, D.1    Chen, K.J.2
  • 111
    • 0029759443 scopus 로고    scopus 로고
    • Aging and oxidative stress: Modulation by dietary restriction
    • B.P. Yu Aging and oxidative stress: modulation by dietary restriction Free Radic. Biol. Med. 21 1996 651 668
    • (1996) Free Radic. Biol. Med. , vol.21 , pp. 651-668
    • Yu, B.P.1
  • 112
    • 0029785583 scopus 로고    scopus 로고
    • A critical evaluation of free radical theory of aging: A proposal for the oxidative stress hypothesis
    • B.P. Yu, and Y. Yang A critical evaluation of free radical theory of aging: A proposal for the oxidative stress hypothesis Ann. NY Acad. Sci. 786 1996 1 11
    • (1996) Ann. NY Acad. Sci. , vol.786 , pp. 1-11
    • Yu, B.P.1    Yang, Y.2
  • 113
    • 0043172468 scopus 로고    scopus 로고
    • 4-Hydroxynonenal and neurodegenerative diseases
    • K. Zarkovic 4-Hydroxynonenal and neurodegenerative diseases Mol. Asp. Med. 24 2003 293 303
    • (2003) Mol. Asp. Med. , vol.24 , pp. 293-303
    • Zarkovic, K.1
  • 114
    • 0018160746 scopus 로고
    • A membrane hypothesis of aging
    • I. Zs.-Nagy A membrane hypothesis of aging J. Theor. Biol. 75 1978 189 195
    • (1978) J. Theor. Biol. , vol.75 , pp. 189-195
    • Zs.-Nagy, I.1
  • 115
    • 0025778703 scopus 로고
    • The horizons of an interdisciplinary synthesis in experimental gerontology
    • I. Zs.-Nagy The horizons of an interdisciplinary synthesis in experimental gerontology Arch. Gerontol. Geriatr. 12 1991 329 349
    • (1991) Arch. Gerontol. Geriatr. , vol.12 , pp. 329-349
    • Zs.-Nagy, I.1


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