Extension of cell life-span and telomere length in animals cloned from senescent somatic cells

Science

Volumn 288, Issue 5466, 2000, Pages 665-669

  Lanza, Robert P ^a   Cibelli, Jose B ^a   Blackwell, Catherine ^a   Cristofalo, Vincent J ^b,c   Francis, Mary Kay ^b,c   Baerlocher, Gabriela M ^d   Mak, Jennifer ^d   Schertzer, Michael ^d   Chavez, Elizabeth A ^d   Sawyer, Nancy ^a   Lansdorp, Peter M ^d,e   West, Michael D ^a  

^a Advanced Cell Technology   (United States)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL CELL; ARTICLE; CATTLE; CELL CYCLE; CLONING; LIFESPAN; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; TELOMERE; TISSUE REGENERATION;

ANIMALS; BLOTTING, SOUTHERN; CATTLE; CELL AGING; CELL DIVISION; CELLS, CULTURED; CLONE CELLS; CLONING, ORGANISM; DNA, COMPLEMENTARY; EMBRYO TRANSFER; EYE PROTEINS; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LONGEVITY; MATCHED-PAIR ANALYSIS; NERVE GROWTH FACTORS; NUCLEAR TRANSFER TECHNIQUES; PROTEINS; RNA, MESSENGER; SERPINS; TELOMERE;

ANIMALIA; BOS TAURUS; MAMMALIA;

EID: 0034725085     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5466.665     Document Type: Article

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43. We thank P. Damiani, J. Kane, K. Delegge, K. Cunniff, C. Malcuit, and E. Milano (Advanced Cell Technology) and the staff at Trans Ova Genetics, particularly the Genetic Advancement Center Team. We also thank A. P. Soler for his help with the electron microscopy studies and K. Chapman for helpful criticism. This work was supported in part by NIH grants AG00378, AI29524, and GM56162, a grant from the National Cancer Institute of Canada, and funds from the Terry Fox Run and the Lankenau Foundation. G.M.B. is supported by the Swiss National Science Foundation.