메뉴 건너뛰기




Volumn 14, Issue 12, 2005, Pages 1699-1708

Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; HISTONE H2A; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN P21; PROTEIN P53; SERINE; TEMPOL;

EID: 21244453856     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddi181     Document Type: Article
Times cited : (45)

References (67)
  • 2
    • 0026246632 scopus 로고
    • Vegetables, fruit, and cancer. II. Mechanisms
    • Steinmetz, K.A. and Potter, J.D. (1991) Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control, 2, 429-442.
    • (1991) Cancer Causes Control , vol.2 , pp. 429-442
    • Steinmetz, K.A.1    Potter, J.D.2
  • 4
    • 4444310761 scopus 로고    scopus 로고
    • Diet and cancer prevention
    • McCullough, M. and Giovannucci, E. (2004) Diet and cancer prevention. Oncogene, 23, 6349-6364.
    • (2004) Oncogene , vol.23 , pp. 6349-6364
    • McCullough, M.1    Giovannucci, E.2
  • 8
    • 0035266308 scopus 로고    scopus 로고
    • Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
    • Kamsler, A., Daily, D., Hochman, A., Stern, N., Shiloh, Y., Rotman, G. and Barzilai, A. (2001) Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. Cancer Res., 61, 1849-1854.
    • (2001) Cancer Res. , vol.61 , pp. 1849-1854
    • Kamsler, A.1    Daily, D.2    Hochman, A.3    Stern, N.4    Shiloh, Y.5    Rotman, G.6    Barzilai, A.7
  • 9
    • 0031259793 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress?
    • Rotman, G. and Shiloh, Y. (1997) Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress? Bioessays, 19, 911-917.
    • (1997) Bioessays , vol.19 , pp. 911-917
    • Rotman, G.1    Shiloh, Y.2
  • 13
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh, Y. (2003) ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer, 3, 155-168.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 14
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan, M.B. and Lim, D.S. (2000) The many substrates and functions of ATM. Nat. Rev. Mol. Cell. Biol. 1, 179-186.
    • (2000) Nat. Rev. Mol. Cell. Biol. , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 15
    • 0033592868 scopus 로고    scopus 로고
    • Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
    • Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y. and Shkedy, D. (1999) Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc. Natl Acad. Sci. USA, 96, 14973-14977.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14973-14977
    • Khosravi, R.1    Maya, R.2    Gottlieb, T.3    Oren, M.4    Shiloh, Y.5    Shkedy, D.6
  • 16
    • 0034306332 scopus 로고    scopus 로고
    • Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
    • Melchionna, R., Chrn, X.B., Blasina, A. and McGowan, C.H. (2000) Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nat. Cell Biol., 2, 762-765.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 762-765
    • Melchionna, R.1    Chrn, X.B.2    Blasina, A.3    McGowan, C.H.4
  • 17
    • 0031752481 scopus 로고    scopus 로고
    • Analysis of the interaction between the p53 binding domain and the p21/CiP1 DNA response element: A novel architectural organization
    • Appella, E., Nagaich, A.K., Zhurkin, V.B. and Harrington, R.E. (1998) Analysis of the interaction between the p53 binding domain and the p21/CiP1 DNA response element: a novel architectural organization. J. Protein Chem., 17, 527-528.
    • (1998) J. Protein Chem. , vol.17 , pp. 527-528
    • Appella, E.1    Nagaich, A.K.2    Zhurkin, V.B.3    Harrington, R.E.4
  • 18
    • 0028868527 scopus 로고
    • p53: A cell cycle regulator activated by DNA damage
    • Selivanova, G. and Wiman, K.G. (1995) p53: a cell cycle regulator activated by DNA damage. Adv. Cancer Res., 66, 143-180.
    • (1995) Adv. Cancer Res. , vol.66 , pp. 143-180
    • Selivanova, G.1    Wiman, K.G.2
  • 19
    • 0032510115 scopus 로고    scopus 로고
    • Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints
    • Xie, G., Habbersett, R.C., Jia, Y., Peterson, S.R., Lehnert, B.E., Bradbury, E.M. and D'Anna, J.A. (1998) Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints. Oncogene, 16, 721-736.
    • (1998) Oncogene , vol.16 , pp. 721-736
    • Xie, G.1    Habbersett, R.C.2    Jia, Y.3    Peterson, S.R.4    Lehnert, B.E.5    Bradbury, E.M.6    D'Anna, J.A.7
  • 20
    • 0031465731 scopus 로고    scopus 로고
    • p21/p53, cellular growth control and genomic integrity
    • El-Deiry, W.S. (1998) p21/p53, cellular growth control and genomic integrity. Curr. Top. Microbiol. Immunol., 227, 121-137.
    • (1998) Curr. Top. Microbiol. Immunol. , vol.227 , pp. 121-137
    • El-Deiry, W.S.1
  • 22
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown, E.J. and Baltimore, D. (2000) ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev., 14, 397-402.
    • (2000) Genes Dev. , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 26
    • 0029941651 scopus 로고    scopus 로고
    • p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts
    • Huang, L.C., Clarkin, K.C. and Wahl, G.M. (1996) p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res., 56, 2940-2944.
    • (1996) Cancer Res. , vol.56 , pp. 2940-2944
    • Huang, L.C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 27
    • 0030446964 scopus 로고    scopus 로고
    • p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice
    • Gurley, K.E. and Kemp, C.J. (1996) p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice. Carcinogenesis, 17, 2537-2542.
    • (1996) Carcinogenesis , vol.17 , pp. 2537-2542
    • Gurley, K.E.1    Kemp, C.J.2
  • 28
    • 0842304283 scopus 로고    scopus 로고
    • Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: Implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species
    • Ito, K., Nakazato, T., Yamato, K., Miyakawa, Y., Yamada, T., Hozumi, N., Segawa, K., Ikeda, Y. and Kizaki, M. (2004) Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res., 64, 1071-1078.
    • (2004) Cancer Res. , vol.64 , pp. 1071-1078
    • Ito, K.1    Nakazato, T.2    Yamato, K.3    Miyakawa, Y.4    Yamada, T.5    Hozumi, N.6    Segawa, K.7    Ikeda, Y.8    Kizaki, M.9
  • 29
    • 0032053876 scopus 로고    scopus 로고
    • Antiproliferative effect of the piperidine nitroxide TEMPOL on neoplastic and nonneoplastic mammalian cell lines
    • Gariboldi, M.B., Lucchi, S., Caserini, C., Supino, R., Oliva, C. and Monti, E. (1998) Antiproliferative effect of the piperidine nitroxide TEMPOL on neoplastic and nonneoplastic mammalian cell lines. Free Radic. Biol. Med., 24, 913-923.
    • (1998) Free Radic. Biol. Med. , vol.24 , pp. 913-923
    • Gariboldi, M.B.1    Lucchi, S.2    Caserini, C.3    Supino, R.4    Oliva, C.5    Monti, E.6
  • 30
    • 0037444791 scopus 로고    scopus 로고
    • Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis
    • Cheng, W.H., Zheng, X., Quimby, F.R., Roneker, C.A. and Lei, X.G. (2003) Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis. Biochem. J., 370, 927-934.
    • (2003) Biochem. J. , vol.370 , pp. 927-934
    • Cheng, W.H.1    Zheng, X.2    Quimby, F.R.3    Roneker, C.A.4    Lei, X.G.5
  • 32
    • 0033119046 scopus 로고    scopus 로고
    • Dietary intervention at middle age: Caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice
    • Pugh, T.D., Oberley, T.D. and Weindruch, R. (1999) Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res., 59, 1642-1648.
    • (1999) Cancer Res. , vol.59 , pp. 1642-1648
    • Pugh, T.D.1    Oberley, T.D.2    Weindruch, R.3
  • 33
    • 0030746765 scopus 로고    scopus 로고
    • Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice
    • Hursting, S.D., Perkins, S.N., Brown, C.C., Haines, D.C. and Phang, J.M. (1997) Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice. Cancer Res., 57, 2843-2846.
    • (1997) Cancer Res. , vol.57 , pp. 2843-2846
    • Hursting, S.D.1    Perkins, S.N.2    Brown, C.C.3    Haines, D.C.4    Phang, J.M.5
  • 34
    • 0036265047 scopus 로고    scopus 로고
    • Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice
    • Berrigan, D., Perkins, S.N., Haines, D.C. and Hursting, S.D. (2002) Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice. Carcinogenesis, 23, 817-822.
    • (2002) Carcinogenesis , vol.23 , pp. 817-822
    • Berrigan, D.1    Perkins, S.N.2    Haines, D.C.3    Hursting, S.D.4
  • 36
    • 0023097347 scopus 로고
    • Flow-cytometric characterization of stimulation, free radical formation, peroxidase activity and phagocytosis of human granulocytes with 2,7-dichlorofluorescein (DCF)
    • Burow, S. and Valet, G. (1987) Flow-cytometric characterization of stimulation, free radical formation, peroxidase activity and phagocytosis of human granulocytes with 2,7-dichlorofluorescein (DCF). Eur. J. Cell Biol., 43, 128-133.
    • (1987) Eur. J. Cell Biol. , vol.43 , pp. 128-133
    • Burow, S.1    Valet, G.2
  • 37
    • 0031878733 scopus 로고    scopus 로고
    • In vivo fluorometric measurement of cerebral oxidative stress using 2′-7′-dichlorofluorescein (DCF)
    • Watanabe, S. (1998) In vivo fluorometric measurement of cerebral oxidative stress using 2′-7′-dichlorofluorescein (DCF). Keio J. Med., 47, 92-98.
    • (1998) Keio J. Med. , vol.47 , pp. 92-98
    • Watanabe, S.1
  • 38
    • 0036233805 scopus 로고    scopus 로고
    • Therapeutics against mitochondrial oxidative stress in animal models of aging
    • Melov, S. (2002) Therapeutics against mitochondrial oxidative stress in animal models of aging. Ann. N. Y. Acad. Sci., 959, 330-340.
    • (2002) Ann. N. Y. Acad. Sci. , vol.959 , pp. 330-340
    • Melov, S.1
  • 39
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth survival: Application to proliferation and cytotoxicity assays
    • Mossmann, T. (1983) Rapid colorimetric assay for cellular growth survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mossmann, T.1
  • 40
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff, T., O'Driscoll, M., Rief, N., Iwabuchi, K., Lobrich, M. and Jeggo, P.A. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res., 64, 2390-2396.
    • (2004) Cancer Res. , vol.64 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 41
    • 0019496249 scopus 로고
    • Normal rejoining of DNA strand breaks in ataxia telangiectasia fibroblast lines after low x-ray exposure
    • Hariharan, P.V., Eleczko, S., Smith, B.P. and Paterson, M.C. (1981) Normal rejoining of DNA strand breaks in ataxia telangiectasia fibroblast lines after low x-ray exposure. Radiat. Res., 86, 589-597.
    • (1981) Radiat. Res. , vol.86 , pp. 589-597
    • Hariharan, P.V.1    Eleczko, S.2    Smith, B.P.3    Paterson, M.C.4
  • 42
    • 0035155661 scopus 로고    scopus 로고
    • ATM, a central controller of cellular responses to DNA damage
    • Khanna, K.K., Lavin, M.F., Jackson, S.P. and Mulhern, T.D. (2001) ATM, a central controller of cellular responses to DNA damage. Cell Death Differ., 8, 1052-1065.
    • (2001) Cell Death Differ. , vol.8 , pp. 1052-1065
    • Khanna, K.K.1    Lavin, M.F.2    Jackson, S.P.3    Mulhern, T.D.4
  • 43
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma, S., Chen, B.P., Murphy, M., Kurimasa, A. and Chen, D.J. (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem., 276, 42462-42467.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 44
    • 0030814125 scopus 로고    scopus 로고
    • Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay
    • Rosenzweig, K.E., Youmell, M.B., Palayoor, S.T. and Price, B.D. (1997) Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin. Cancer Res., 3, 1149-1156.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1149-1156
    • Rosenzweig, K.E.1    Youmell, M.B.2    Palayoor, S.T.3    Price, B.D.4
  • 45
    • 0033152759 scopus 로고    scopus 로고
    • Competitive and noncompetitive inhibition of the DNA-dependent protein kinase
    • Izzard, R.A., Jackson, S.P. and Smith, G.C. (1999) Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. Cancer Res., 59, 2581-2586.
    • (1999) Cancer Res. , vol.59 , pp. 2581-2586
    • Izzard, R.A.1    Jackson, S.P.2    Smith, G.C.3
  • 46
    • 0028918334 scopus 로고
    • Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
    • Burdon, R.H. (1995) Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med., 18, 775-794.
    • (1995) Free Radic. Biol. Med. , vol.18 , pp. 775-794
    • Burdon, R.H.1
  • 50
    • 0027932734 scopus 로고
    • Ras proteins regulate multiple mitogenic pathways in A10 vascular smooth muscle cells
    • Irani, K., Herzlinger, S. and Finkel, T. (1994) Ras proteins regulate multiple mitogenic pathways in A10 vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 202, 1252-1258.
    • (1994) Biochem. Biophys. Res. Commun. , vol.202 , pp. 1252-1258
    • Irani, K.1    Herzlinger, S.2    Finkel, T.3
  • 51
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel, T. and Holbrook, N.J. (2000) Oxidants, oxidative stress and the biology of ageing. Nature, 408, 239-247.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 52
    • 0035796023 scopus 로고    scopus 로고
    • The contribution of endogenous sources of DNA damage to the multiple mutations in cancer
    • Jackson, A.L. and Loeb, L.A. (2001) The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat. Res., 477, 7-21.
    • (2001) Mutat. Res. , vol.477 , pp. 7-21
    • Jackson, A.L.1    Loeb, L.A.2
  • 53
    • 0033378084 scopus 로고    scopus 로고
    • Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes. A comet assay study
    • Benitez-Bribiesca, L. and Sanchez-Suarez, P. (1999) Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes. A comet assay study. Ann. N. Y. Acad. Sci., 887, 133-149.
    • (1999) Ann. N. Y. Acad. Sci. , vol.887 , pp. 133-149
    • Benitez-Bribiesca, L.1    Sanchez-Suarez, P.2
  • 56
    • 0027254621 scopus 로고
    • Molecular and biochemical reprogramming of oncogenesis through the activity of prooxidants and antioxidants
    • Schwartz, J.L., Antoniades, D.Z. and Zhao, S. (1993) Molecular and biochemical reprogramming of oncogenesis through the activity of prooxidants and antioxidants. Ann. N. Y. Acad. Sci., 686, 262-278.
    • (1993) Ann. N. Y. Acad. Sci. , vol.686 , pp. 262-278
    • Schwartz, J.L.1    Antoniades, D.Z.2    Zhao, S.3
  • 57
    • 1242342067 scopus 로고    scopus 로고
    • Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: Relevance in cell proliferation
    • Pozo-Guisado, E., Lorenzo-Benayas, M.J. and Fernandez-Salguero, P.M. (2004) Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int. J. Cancer, 109, 167-173.
    • (2004) Int. J. Cancer , vol.109 , pp. 167-173
    • Pozo-Guisado, E.1    Lorenzo-Benayas, M.J.2    Fernandez-Salguero, P.M.3
  • 58
    • 0033797023 scopus 로고    scopus 로고
    • The nitroxide tempol induces oxidative stress, p21 (WAF1/CIP1), and cell death in HL60 cells
    • Gariboldi, M.B., Rimoldi, V., Supino, R., Favini, E. and Monti, E. (2000) The nitroxide tempol induces oxidative stress, p21 (WAF1/CIP1), and cell death in HL60 cells. Free Radic. Biol. Med., 29, 633-641.
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 633-641
    • Gariboldi, M.B.1    Rimoldi, V.2    Supino, R.3    Favini, E.4    Monti, E.5
  • 59
    • 0035933889 scopus 로고    scopus 로고
    • Cloning of a novel phosphatidylinositol kinase-related kinase: Characterization of the human SMG-1 RNA surveillance protein
    • Denning, G., Jamieson, L., Maquat, L.E., Thompson, E.A. and Fields, A.P. (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J. Biol. Chem., 276, 22709-22714.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22709-22714
    • Denning, G.1    Jamieson, L.2    Maquat, L.E.3    Thompson, E.A.4    Fields, A.P.5
  • 60
    • 0035449691 scopus 로고    scopus 로고
    • Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
    • Yamashita, A., Ohnishi, T., Kashima, I., Taya, Y. and Ohno, S. (2001) Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev., 15, 2215-2228.
    • (2001) Genes Dev. , vol.15 , pp. 2215-2228
    • Yamashita, A.1    Ohnishi, T.2    Kashima, I.3    Taya, Y.4    Ohno, S.5
  • 62
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of teh human bax gene
    • Miyashita, T. and Reed, J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of teh human bax gene. Cell, 80, 293 -299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 63
    • 0036594890 scopus 로고    scopus 로고
    • The role of cyclin-dependent kinase inhibitor p21 in apoptosis
    • Gartel, A. and Tyner, A. (2002) The role of cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther., 1, 639-649.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 639-649
    • Gartel, A.1    Tyner, A.2
  • 64
    • 0034284341 scopus 로고    scopus 로고
    • Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice
    • Liyanage, M., Weaver, Z., Barlow, C., Coleman, A., Pankratz, D.G., Anderson, S., Wynshaw-Boris, A. and Ried, T. (2000) Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice. Blood, 96, 1940-1946.
    • (2000) Blood , vol.96 , pp. 1940-1946
    • Liyanage, M.1    Weaver, Z.2    Barlow, C.3    Coleman, A.4    Pankratz, D.G.5    Anderson, S.6    Wynshaw-Boris, A.7    Ried, T.8
  • 65
    • 0036308716 scopus 로고    scopus 로고
    • Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion
    • Singhal, A.B., Wang, X., Sumii, T., Mori, T. and Lo, E.H. (2002) Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J. Cereb. Blood Flow Metab., 22, 861-868.
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 861-868
    • Singhal, A.B.1    Wang, X.2    Sumii, T.3    Mori, T.4    Lo, E.H.5
  • 67
    • 0035031809 scopus 로고    scopus 로고
    • Evaluation of the mutagenic and genotoxic activities of anti-hepatitis B analogs of beta-L-adenosine by the Ames test and the Comet assay
    • Placidi, L., De Meo, M., Gosselin, G., Imbach, J.L., Bryant, M.L., Dumenil, G. and Sommadossi, J.P. (2001) Evaluation of the mutagenic and genotoxic activities of anti-hepatitis B analogs of beta-L-adenosine by the Ames test and the Comet assay. Antiviral Res., 50, 139-145.
    • (2001) Antiviral Res. , vol.50 , pp. 139-145
    • Placidi, L.1    De Meo, M.2    Gosselin, G.3    Imbach, J.L.4    Bryant, M.L.5    Dumenil, G.6    Sommadossi, J.P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.