Dietary intervention at middle age: Caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice

Cancer Research

Volumn 59, Issue 7, 1999, Pages 1642-1648

  Pugh, Thomas D ^a,c   Oberley, Terry D ^a,c   Weindruch, Richard ^b,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRASTERONE; PRASTERONE SULFATE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; CONTROLLED STUDY; DIET; HORMONE SUBSTITUTION; LIFESPAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT;

AGE FACTORS; ANIMALS; BODY WEIGHT; DEHYDROEPIANDROSTERONE SULFATE; ENERGY INTAKE; INCIDENCE; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; NEOPLASMS;

EID: 0033119046     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Weindruch, R., and Walford, R. L. The Retardation of Aging and Disease by Dietary Restriction. Springfield, IL: Charles C. Thomas, 1988.
2. Tannenbaum, A. Genesis and growth of tumors. II. Effects of caloric restriction per se. Cancer Res., 2: 460-467, 1942.
3. Ross, M. H., and Bras, G. Tumor incidence patterns and nutrition in the rat. J. Nutr., 87: 245-260, 1961.
4. Cheney, K. E., Liu, R. K., Smith, G. S., Leung, R. E., Mickey, M. R., and Walford, R. L. Survival and disease patterns in C57BI/6J mice subjected to undernutrition. Exp. Gerontol., 15: 237-258, 1980.
5. Orentreich, N., Brind, J. L., Riser, R. L., and Vogelman, J. H. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood J. Clin. Endocrinol. Metab., 59: 551-555, 1984.
6. Belanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J. L., and Labrie, F. Changes in scrum concentrations of conjugated and unconjugated steroids in 40-to 80-year-old men. J. Clin. Endocrinol. Metab., 79: 1086-1090, 1994.
7. Barrett-Conner, E., Khaw, K. T., and Yen, S. S. A prospective study of dehydroepiandrostcrone sulfate, mortality and cardiovascular disease. N. Engl. J. Med., 315: 1519-1524, 1986.
8. Zumoff, B., Levin, J., Rosenfeld, R. S., Markham, M. Strain, G. W., and Fukushima, D. K. Abnormal 24-hr mean plasma concentrations of dehydroepiandrosterone and dehydroisoandrosterone sulfate in women with primary operable breast cancer. Cancer Res., 41: 3360-3363, 1981.
9. Stahl, F., Schnorr, D., Pilz, C., and Dorner, G. Dehydroepiandrosterone (DHEA) levels in patients with prostatic cancer, heart diseases and under surgery stress. Exp. Clin. Endocrinol., 99: 68-70, 1992.
10. Suzuki, T., Suzuki, N., Daynes, R. A., and Engleman, E. G. Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells. Clin. Immunol. Immunopathol., 61: 202-211, 1991.
11. Daynes, R. A., and Araneo, B. A. Prevention and reversal of some age-associated changes in immunologic responses by supplemental dehydroepiandrosterone sulfate therapy. Aging Immunol. Infect. Dis., 3: 135-154, 1992.
12. Danenberg, H. D., Ben-Yehuda, A., Zakay-Rones, Z., and Friedman, G. Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection. Vaccine, 13: 1445-1448, 1995.
13. v/a) mice by long-term treatment with dehydroepiandrosterone. Cancer Res., 39: 1129-1132, 1979.
14. Schwartz, A. G., Pashko, L., and Whitcomb, J. M. Inhibition of tumor development by dehydroepiandrosterone and related steroids. Toxicol. Pathol., 14: 357-362, 1986.
15. Coleman, D. L. Therapeutic effects of dehydroepiandrosterone (DHEA) and its metabolites in obese-hyperglycemic mutant mice. Prog. Clin. Biol. Res., 265: 161-175, 1988.
16. vy/a mice by dehydroepiandrosterone. Lipids, 12: 409-413, 1977.
17. Cleary, M. P. The antiobesity effect of dehydroepiandrosterone in rats. Proc. Soc. Exp. Biol. Med., 196: 8-15, 1991
18. Macewen, E. G., and Kurzman, I. D. Obesity in the dog: role of the adrenal steroid dehydroepiandrosterone (DHEA). J. Nutr., 121 (Suppl.): S51-S55, 1991.
19. Arad, Y., Badimon, J. J., Badimon, L., Hembree, W. C., and Ginsberg, H. N. Dehydroepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbit. Arteriosclerosis, 9: 159-166, 1989.
20. Volk, M., Pugh, T. D., Kim, M. J. Frith, C. H., Daynes, R. A., Ershler, W. B., and Weindruch, R. Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57Bi/6 mice. Cancer Res., 54: 3054-3061, 1994.
21. Brunning, R. D. Bone marrow. In: J. Rosai (ed.), Ackerman's Surgical Pathology, Ed. 8, Vol. 2, pp. 1797-1916. St. Louis: Mosby-Yearbook, 1996.
22. Gompertz, B. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. Phil. Trans. R. Soc. Lond., 115: 513-585, 1825.
23. Doubal, S., and Kiemera, P. Practical methodology of evaluation of mortality curves and detection of aging-related interventions. Age, 20: 229-234, 1998.
24. Sundberg, J. P., Brown, K. S., and McMahan, W. M. Chronic ulcerative dermatitis in black mice. In: JP Sundberg (ed.), Handbook Of Mouse Mutations With Skin And Hair Abnormalities, pp. 485-492. Boca Raton, FL: CRC Press, 1994.
25. Finch, C. E., and Girgis, F. G. Enlarged seminal vesicles of senescent C57BI/6J mice. J. Gerontol., 29: 134-138, 1974.
26. Cleary, M. P., Shepherd, A., Zisk, J., and Schwartz, A. Effect of dehydroepiantrosterone on body weight and food intake in rats. Nutr. Behav., 1: 127-136, 1983.
27. Weindruch, R., McFeeters, G., and Walford, R. L. Food intake reduction and immunologic alterations in mice fed dehydroepandrosterone. Exp. Gerontol., 19: 297-304, 1984.
28. Rao, M. S., Subbarao, V., Yeldandi, A. V., and Reddy, J. K. Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Res., 52: 2977-2979, 1992.
29. Frenkel, T. A., Slaughter, C. A., Orth, K., Moomaw, C. R., Hicks, S. H., Snyder, J. M., Bennett, M., Prough, R. A., Putnam, R. S., and Milewich, L. Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rale liver by dehydroepiandrosterone feeding. J. Steroid Biochem., 35: 333-342, 1990.
30. McIntosh, M. K., Goldfarb, A. H., Curtis, L. N., and Cote, P. S. Vitamin E alters hepatic antioxidant enzymes in rats treated with dehydroepiandroslerone (DHEA). J. Nutr., 123: 216-224, 1993.
31. Goldfarb, A. H., McIntosh, M. K., Boyer, B. T., and Fatouros, J. Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rats. J. Appl. Physiol., 76: 1630-1635, 1994.
32. Fishbein, L. Biological Effects of Dietary Restriction. New York: Springer-Verlag, 1991.
33. Weindruch, R., and Walford, R. L. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (Washington DC) 215: 1415-1418, 1982.
34. Frith, C. H., and Ward, J. M. Color Atlas of Neoplastic and Non-Neoplastic Lesions in Aging Mice, pp. 77-81. Amsterdam: Elsevier, 1988.
35. Radl, J., Croese, J. W., Zurcher, C., van den Enden-Vieveen, M. M., and de Leeuw, A. M. Animal model of human disease: multiple myeloma. Am. J. Pathol., 132: 593-597, 1988.
36. Garrett, I. R., Dallas, S., Radl, J., and Mundy, G. R. A murine model of human myeloma bone disease. Bone, 20: 515-520, 1997.
37. Tannenbaum, A. The dependence of tumor formation on the degree of caloric restriction. Cancer Res., 5: 609-615, 1945.
38. Rehm, S., Wcislo, A., and Deerberg, F. Non-neoplastic lesions of female virgin Han:NMRI mice, incidence and influence of food restriction throughout life span. II: Respiratory tract. Lab. Anim., 19: 224-235, 1985.
39. Cartee, G. D., and Dean, D. J. Glucose transport with brief dietary restriction: heterogeneous responses in muscles. Am. J. Physiol., 266: E946-E952, 1994.
40. Dubey, A., Forster, M. J., Lal, H., and Sohal, R. S. Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch. Biochem. Biophys., 333: 189-197, 1996.
41. Sohal, R. S., and Weindruch, R. Oxidative stress, caloric restriction, and aging. Science (Washington DC), 273: 59-63, 1996.
42. Sohal, R. S., Ku, H-H., Agarwal, S., Forster, M. J., and Lal, I. Oxidative damage, mitochondrial oxidant generation and amioxidant defenses during aging and in response to food restriction in the mouse. Mech. Ageing Dev., 74: 121-133, 1994.
43. Lass, A., Sohal, B. H., Weindruch, R., Forster, M. I., and Sohal, R. S. Caloric restriction prevents age-associated accrual of Oxidative damage to mouse skeletal muscle mitochondria. Free Radic. Biol. Med., 25: 1089-1097, 1998.
44. Grasl-Kraupp, B., Bursch, W., Ruttkay-Nedecky, B., Wagner, A., Lauer, B., and Schulte-Herman, R. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc. Natl. Acad. Sci. USA, 91: 9995-9999, 1994.
45. Muskhelishvili, L., Hart, R. W., Turturro, A., and James, S. J. Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice. Am. J. Pathol., 147: 20-24, 1995.
46. Spaulding, C. C., Walford, R. L., and Effros, R. B. The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech. Ageing Dev., 93: 25-33, 1997.
47. Higami, Y., Shimokawa, I., Tomita, M., Okimoto, T., Koji, T., Kobayashi, N., and Ikeda, T. Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes. Am. J. Pathol., 151: 659-663, 1997.
48. Weindruch, R. Immunogerontologic outcomes of dietary restriction started in adulthood. Nutr. Rev., 53(Suppl.): S66-S71, 1995.
49. Aspnes, L. E., Lee, C. M., Weindruch, R., Chung, S. S., Roecker, E. B., and Aiken, J. M. Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J., 11: 573-581, 1997.
50. Kemnitz, J. W., Roecker, E. B., Weindruch, R., Elson, D. F., Baum, S. T., and Bergman, R. N. Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am. J. Physiol., 266; E540-E547, 1994.
51. Lane, M. A., Baer, D. J., Rumpler, W. V., Weindruch, R., Ingram, D. K., Tilmont, E. M., Cutler, R. G., and Roth, G. S. Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc. Natl. Acad. Sci. USA, 93: 4159-4164, 1996.