New medium oxacyclic O,N-acetals and related open analogues: Biological activities

Current Medicinal Chemistry

Volumn 12, Issue 12, 2005, Pages 1423-1438

  Campos, Joaquín ^a   Saniger, Estrella ^a   Marchal, Juan A ^b   Aiello, Stefania ^a   Súarez, Inés ^c   Boulaiz, Houria ^c   Aránega, Antonia ^c   Gallo, Miguel Á ^a   Espinosa, Antonio ^a  

^a Facultad de Farmacia   (Spain)

^b Facultad de CC Experimentales   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

1 3 (hydroxymethyl) 1,4 dioxepan 5 y1 pyrimidines; Anti tumour drugs; Benzodioxepins; Breast cancer; Cell cycle; Lipophilicity; Neighbouring group participation; Programmed cell death

Indexed keywords

1 (2 OXEPANYL) 5 FLUOROURACIL; 1 (2,3 DIHYDROBENZOXEPIN 2 YL) 5 FLUOROURACIL; 1 [2 (2 HYDROXYMETHYL 4 NITROPHENOXY) 1 METHOXYETHYL] 5 FLUOROURACIL; 2 (HYDROXYMETHYL)PHENOXYACETALDEHYDE DIMETHYLACETAL DERIVATIVE; 2 HYDROXY 5 METHOXYBENZYL ALCOHOL; 2 HYDROXYPHENOXYPROPANAL DIMETHYLACETAL; 2 METHOXY 2,3 DIHYDRO 2H 1,5 BENZDIOXEPIN; 2 METHOXY 2,3 DIHYDROBENZOXEPIN; 3 METHOXY 2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN DERIVATIVE; 4 METHOXY 8 CHROMANOL; 5 BROMOURACIL; 5 TRIFLUOROMETHYLURACIL; ACETAL DERIVATIVE; BENZODIOXEPIN DERIVATIVE; CYTOSINE; CYTOTOXIC AGENT; DIDANOSINE; FLUOROURACIL; FLUOROURACIL DERIVATIVE; NUCLEOSIDE ANALOG; PACLITAXEL; PRODRUG; TEGAFUR; THYMINE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BENZYLATION; BONE MARROW TOXICITY; BREAST CANCER; CANCER THERAPY; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL STIMULATION; CELL STRAIN MCF 7; CHEMICAL MODIFICATION; DRUG EFFICACY; DRUG POTENCY; DRUG RESPONSE; DRUG TARGETING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; LIPOPHILICITY; LIVER TOXICITY; MITOSIS INHIBITION; NONHUMAN; PANCREATITIS; PERIPHERAL NEUROPATHY; REVIEW; STRUCTURE ACTIVITY RELATION;

ACETALS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CRYSTALLOGRAPHY, X-RAY; FLUOROURACIL; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 21144445551     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867054020927     Document Type: Review

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