Synthesis of novel 5-fluorouracil derivatives with 1,4-oxaheteroepane moieties

Tetrahedron

Volumn 54, Issue 43, 1998, Pages 13295-13312

  Gómez, Jose A ^a   Trujillo, María A ^a   Campos, Joaquín ^a   Gallo, Miguel A ^a   Espinosa, Antonio ^a  

^a Facultad de Farmacia   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL DERIVATIVE; TEGAFUR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 0032558654     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(98)00815-1     Document Type: Article

References (36)

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28. 22. We now know the experimental conditions needed to direct the 5-FU nucleophilic-mediated tin (IV) chloride attack to the seven-membered methyl O,O-acetals 5 towards either the cyclic O,N-acetals type 3 or the acyclic ones type 4 (see ref. 12).
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