Neighbouring-group participation as the key step in the reactivity of acyclic and cyclic salicyl-derived O,O-acetals with 5-fluorouracil. Antiproliferative activity, cell cycle dysregulation and apoptotic induction of new O,N-acetals against breast cancer cells

Tetrahedron

Volumn 59, Issue 40, 2003, Pages 8017-8026

  Saniger, Estrella ^a   Campos, Joaquín M ^a   Entrena, Antonio ^a   Marchal, Juan A ^b   Boulaiz, Houria ^c   Aránega, Antonia ^c   Gallo, Miguel Á ^a   Espinosa, Antonio ^a  

^a Facultad de Farmacia   (Spain)

^b UNIVERSITY OF JAÉN   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Acetals; Antitumour compounds; Benzodioxepins; Mechanisms; Neighbouring group effects

Indexed keywords

1 (HYDROXYMETHYL) 5 BROMO 2 PHENOXYACETALDEHYDE DIMETHYL ACETAL; 1 (HYDROXYMETHYL) 5 CHLORO 2 PHENOXYACETALDEHYDE DIMETHYL ACETAL; 1 (HYDROXYMETHYL) 5 NITRO 2 PHENOXYACETALDEHYDE DIMETHYL ACETAL; 1 [2 (2 HYDROXYMETHYL 4 NITROPHENOXY) 1 METHOXYETHYL] 5 FLUOROURACIL; 1 [2 (2 HYDROXYMETHYL 6 METHOXYPHENOXY) 1 METHOXYETHYL] 5 FLUOROURACIL; 1 [2 (2 HYDROXYMETHYLPHENOXY) 1 METHOXYETHYL] 5 FLUOROURACIL; 1 [2 (4 CHLORO 2 HYDROXYMETHYLPHENOXY) 1 METHOXYETHYL] 5 FLUOROURACIL; 3 METHOXY 7 NITRO 2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN; 3 [2 (4 AMINO 2 HYDROXYMETHYLPHENOXY) 1 METHOXYETHYL] 5 FLUOROURACIL; 3 [2 (4 BROMO 2 HYDROXYMETHYLPHENOXY) 1 METHOXYETHYL] 5 FLUOROURACIL; 4,10 BIS[5 (FLUOROURACIL 1 YL)] 2,5,8,11 TETRAOXA 1,7(1,2) DIBENZENADODECAPHANE; 7 BROMO 3 METHOXY 2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN; 7 CHLORO 3 METHOXY 2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN; ACETAL DERIVATIVE; FLUOROURACIL DERIVATIVE; OXEPINE DERIVATIVE; TEGAFUR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DISRUPTION; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; METASTASIS INHIBITION; PRIORITY JOURNAL; SILYLATION;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0141652001     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2003.08.016     Document Type: Article

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