Number of activated T-helper cells and NK cells in peripheral blood is decreased in severe Crohn's disease

APMIS

Volumn 104, Issue 5, 1996, Pages 355-361

  Kontiainen, Sirkka ^a,c   Scheinin, Tom ^b   Halme, Leena ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c Aurora Hospital   (Finland)

Author keywords

Activated T helper cells; Activity of Crohn's disease; NK cells

Indexed keywords

MONOCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; BLOOD; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DISEASE ACTIVITY; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL;

EID: 0029933956     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1996.tb00727.x     Document Type: Article

References (25)

1. Beeken, W. L., Gundel, R. M., St. Andre-Ukena, S. & McAuliffe, T.: In vitro cellular cytotoxicity for a human colon cancer cell line by mucosal mononuclear cells of patients with colon cancer and other disorders. Cancer 55: 1024-1029, 1982.
2. Breese, E., Braegger, C. P., Corrigan, C. J., Walker-Smith, J. A. & Macdonald, T. T.: Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 78: 127 131, 1993.
3. Boyum, A.: Isolation of leucocytes from human blood. A two phase system for the removal of red cells with methyl cellulose as erythrocyte aggregating agent. Scand. J. Clin. Lab. Invest. 21 (Suppl.): 77-89, 1968.
4. Choy, M. Y., Walker-Smith, J. A., Williams, C. B. & MacDonald, T. T.: Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn s disease and ulcerative colitis. Gut 31: 1365-1370, 1990.
5. Cuvelier, C. A., de Wever, N., Mielants, H., de Vos, M., Veys, E. M. & Roels, H.: Expression of T cell receptors alpha/beta and gamma/delta in the ileal mucosa of patients with Crohn's disease and with spondylarthropathy. Clin. Exp. Immunol. 90: 275-279, 1992.
6. De Berardinis, P., Londei, M., James, R. F. L., Lake, S. P., Wise, P. H. & Feldmann, M.: Do CD4-positive cytotoxic T cells damage islet beta cells in type 1 diabetes? Lancet ii: 823-824, 1988.
7. Fantry, C. T. & James, S. P.: Cellular and molecular immunology and biochemistry of IBD. Curr. Opin. Gastroenterol. 9: 544-551, 1993.
8. Fiocchi, C.: Inflammatory bowel disease: an immunological overview. Clin. Immunol. 12: 162-167, 1992.
9. Gibson, P. R. & Jewell, D. P.: The nature of the natural killer (NK) cell of human intestinal mucosa and mesenteric lymph node. Clin. Exp. Immunol. 61: 160-168, 1985.
10. Giorgi, J. V., Kesson, A. M. & Chou, C.-C.: Immunodeficiency and infectious diseases. In: Rose, N. R., de Macario, E. C., Fahey, J. L., Friedman, H. & Penn, G. M. (Eds.): Manual of Clinical Laboratory Immunology. Fourth Edition. American Society for Microbiology, Washington, D.C. 1992, pp. 174-181.
11. James, S. P., Fiocchi, C, Graeff, A. S. & Strober, W.: Phenotypic analysis of lamina propria lymphocytes. Predominance of helper-inducer and cytolytic T-cell phenotypes and deficiency of suppressor-inducer phenotypes in Crohn's disease and control patients. Gastroenterology 91: 1483-1489, 1986.
12. Kontiainen, S., Toomath, R., Lowder, J. & Feldmann, M: Selective activation of T cells in newly diagnosed insulin-dependent diabetic patients: evidence for heterogeneity of T cell receptor usage. Clin. Exp. Immunol. 83: 347-351, 1991.
13. Lanier, L. L. & Jackson, A. L.: Monoclonal antibodies: Differentiation antigens expressed on leukocytes. In: Rose, N. R., de Macario, E. C., Fahey, J. L. Friedman, H. & Penn, G. M (Eds.): Manual of Clinical Laboratory Immunology. Fourth Edition. American Society for Microbiology, Washington, D.C. 1992, pp. 157-163.
14. Lennard-Jones, J. E.: Classification of inflammatory bowel disease. Scand. J. Gastroenterol. 24 (Suppl. 170): 2-5, 1989.
15. Londei, M., Bottazzo, F. & Feldmann, M.: Human T-cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science 228: 85-89, 1985.
16. MacDermott, R. P.: Alterations in the mucosal immune system in ulcerative colitis and in Crohn's disease. Med. Clin. North Am. 78: 1207-1231, 1994.
17. MacDermott, R. P., Franklin, G. O., Jenkins, K. M., Kodner, I. J., Nash, G. S. & Weinrieb, I. J.: Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities. Gastroenterology 78: 47-66, 1980.
18. Myren, J., Bouchier, I. A. D., Watkinson, G., Clam, S. E. & deCombal, F. T.: The OMGE multinational inflammatory bowel disease survey 1976-1982. A further report on 2657 cases. Scand. J. Gastroenterol. 19 (Suppl. 95): 1-27, 1984.
19. Pirzer, U., Schönhaar, A., Fleisher, B., Hermann, E. & Meyerzum Büschenfelde, K.-H.: Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease. Lancet 338: 1238-1239, 1991.
20. Sauer, D., Sauer, H. & Fiebig, H.: Circulating lymphocyte populations in patients with Crohn's disease. Gastroenterology J. 51: 27-32, 1991.
21. Selby, W. S., Janossy, G., Bofill, M. & Jewell, D. P.: Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin. Exp. Immunol. 52: 219-228, 1983.
22. Selby, W. S., Janossy, G., Bofill, M. & Jewell, D. P.: Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistochemical and cell isolation techniques. Gut 25: 32-40, 1984.
23. Senju, M., Hulstaert, F., Lowder, J. & Jewell, D. P.: Flow cytometric analysis of peripheral blood lymphocytes in ulcerative colitis and Crohn's disease. Gut 32: 779-783, 1991.
24. Targan, S., Britvan, L., Kendal, R., Vimadalal, S. & Soll, A.: Isolation of spontaneous and interferon inducible natural killer-like cells from human colonic mucosa: lysis of lymphoid and autologous epithelial target cells. Clin. Exp. Immunol. 54: 14-22, 1983.
25. Van Tol, E. A. F., Verspaget, H. W., Pena, A. S., Kraemer, C. V. E. & Lamers, C. B. H. W.: The CD56 adhesion molecule is the major determinant for detecting non-major histocompatibility complex-restricted cytotoxic mononuclear cells from the intestinal lamina propria. Eur. J. Immunol. 22: 23-29, 1992.