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Volumn 3, Issue 2, 2003, Pages 227-236

T cell costimulatory pathways: Blockade for autoimmunity

Author keywords

Autoimmunity; CD28; Costimulation; CTLA 4; ICOS; PD 1

Indexed keywords

ANTIBODY; B7 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 IMMUNOGLOBULIN FUSION PROTEIN; HYBRID PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 0037393460     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.3.2.227     Document Type: Review
Times cited : (30)

References (80)
  • 1
    • 0029851224 scopus 로고    scopus 로고
    • Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases
    • REISER H, STADECKER MJ: Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases. N. Engl. J. Med. (1996) 335:1369-1377.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1369-1377
    • Reiser, H.1    Stadecker, M.J.2
  • 2
    • 0032543306 scopus 로고    scopus 로고
    • The role of T-cell costimulatory activation pathways in transplant rejection
    • SAYEGH MH, TURKA LA: The role of T-cell costimulatory activation pathways in transplant rejection. N. Engl. J. Med (1998) 338:1813-1821.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1813-1821
    • Sayegh, M.H.1    Turka, L.A.2
  • 3
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination
    • BRETCHER P, COHN M: A theory of self-nonself discrimination. Science (1970) 169:1042-1049.
    • (1970) Science , vol.169 , pp. 1042-1049
    • Bretcher, P.1    Cohn, M.2
  • 4
    • 0036156661 scopus 로고    scopus 로고
    • The role of novel T cell costimulatory pathways in autoimmunity and transplantation
    • YAMADA A, SALAMA AD, SAYEGH MH: The role of novel T cell costimulatory pathways in autoimmunity and transplantation. J. Am. Soc. Nephrol. (2002) 13:559-575.
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 559-575
    • Yamada, A.1    Salama, A.D.2    Sayegh, M.H.3
  • 5
    • 0027403299 scopus 로고
    • The role of the CD28 receptor during T cell responses to antigen
    • LINSLEY PS, LEDBETTER JA: The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. (1993) 11:191-212.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 191-212
    • Linsley, P.S.1    Ledbetter, J.A.2
  • 7
    • 0033865436 scopus 로고    scopus 로고
    • CTLA4-Ig: A novel immunosuppressive agent
    • A thorough review of CTLA-4-Ig
    • NAJAFIAN N, SAYEGH MH: CTLA4-Ig: a novel immunosuppressive agent. Expert Opin. Investig. Drugs (2000) 9:2147-2157. A thorough review of CTLA-4-Ig.
    • (2000) Expert Opin. Investig. Drugs , vol.9 , pp. 2147-2157
    • Najafian, N.1    Sayegh, M.H.2
  • 8
    • 0037015055 scopus 로고    scopus 로고
    • Modulation of TOR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
    • RILEY J, MAO M, KOBA YASHI S et al.: Modulation of TOR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc. Natl. Acad. Sci. USA (2002) 99:11796-11801.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11796-11801
    • Riley, J.1    Mao, M.2    Koba Yashi, S.3
  • 9
    • 0037015038 scopus 로고    scopus 로고
    • Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
    • Gene expression studies to evaluate the role of CD28 costimulation in T cell activation
    • DIEHN M, ALIZADEH AA, RANDO OJ et al: Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc. Natl. Acad Sci. USA (2002) 99:11790-11795. Gene expression studies to evaluate the role of CD28 costimulation in T cell activation.
    • (2002) Proc. Natl. Acad Sci. USA , vol.99 , pp. 11790-11795
    • Diehn, M.1    Alizadeh, A.A.2    Rando, O.J.3
  • 11
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • published erratum appears in J. Exp. Med. (1996) 184(1):301
    • WALUNAS TL, BAKKER CY, BLUESTONE JA: CTLA-4 ligation blocks CD28-dependent T cell activation [published erratum appears in J. Exp. Med. (1996) 184(1):301] J. Exp. Med. (1996) 183:2541-2550.
    • (1996) J. Exp. Med. , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 12
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • TIVOL EA, BORRIELLO F, SCHWEIZER AN, LYNCH WP, BLUESTONE JA, SHARPE AH: Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity (1995) 3:541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweizer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 13
    • 0027942023 scopus 로고
    • Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity
    • GUINAN EC, GRIBBEN JG, BOUSSIOTIS VA, FREEMAN GJ, NADLER LM: Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood (1994) 84:3261-3282.
    • (1994) Blood , vol.84 , pp. 3261-3282
    • Guinan, E.C.1    Gribben, J.G.2    Boussiotis, V.A.3    Freeman, G.J.4    Nadler, L.M.5
  • 14
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • WALUNAS TL, LENSCHOW DJ, BAKKER CY et al.: CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 1:405-413.
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.L.1    Lenschow, D.J.2    Bakker, C.Y.3
  • 15
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • LINSLEY PS, GREENE JL, BRADY W, BAJORATH J, LEDBETTER JA, PEACH R: Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity (1994) 1:793-801.
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3    Bajorath, J.4    Ledbetter, J.A.5    Peach, R.6
  • 16
    • 0030006733 scopus 로고    scopus 로고
    • CD28 costimulation prevents cell death during primary T cell activation
    • NOEL PJ, BOISE LH, GREEN JM, THOMPSON CB: CD28 costimulation prevents cell death during primary T cell activation. J. Immunol. (1996) 157:636-642.
    • (1996) J. Immunol. , vol.157 , pp. 636-642
    • Noel, P.J.1    Boise, L.H.2    Green, J.M.3    Thompson, C.B.4
  • 17
    • 0027284230 scopus 로고
    • Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation
    • GIMMI CD, FREEMAN GJ, GRIBBEN JG, GRAY G, NADLER LM: Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc. Natl. Acad. Sci. USA (1993) 90:6586-6590.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6586-6590
    • Gimmi, C.D.1    Freeman, G.J.2    Gribben, J.G.3    Gray, G.4    Nadler, L.M.5
  • 18
    • 0032502801 scopus 로고    scopus 로고
    • Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
    • VAN PARIJS L, ABBAS AK: Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science (1998) 280:243-248.
    • (1998) Science , vol.280 , pp. 243-248
    • Van Parijs, L.1    Abbas, A.K.2
  • 20
    • 2642655282 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
    • LUHDER F, HOGLUND P, ALLISON JP, BENOIST C, MATHIS D: Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. (1998) 187:427-432.
    • (1998) J. Exp. Med. , vol.187 , pp. 427-432
    • Luhder, F.1    Hoglund, P.2    Allison, J.P.3    Benoist, C.4    Mathis, D.5
  • 22
    • 0036604902 scopus 로고    scopus 로고
    • Negative co-receptors on lymphocytes
    • Excellent review of negative costimulatory pathways on lymphocytes
    • GREENWALD RS, LATCHMAN YE, SHARPE AH: Negative co-receptors on lymphocytes. Curr. Opin. Immunol. (2002) 14:390-396. Excellent review of negative costimulatory pathways on lymphocytes.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 390-396
    • Greenwald, R.S.1    Latchman, Y.E.2    Sharpe, A.H.3
  • 23
    • 0028365499 scopus 로고
    • Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice
    • GUERDER S, PICARELLA DE, LINSLEY PS, FLAVELL RA: Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. Proc. Natl. Acad. Sci. USA (1994) 91:5138-5142.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5138-5142
    • Guerder, S.1    Picarella, D.E.2    Linsley, P.S.3    Flavell, R.A.4
  • 24
    • 0028199631 scopus 로고
    • Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness
    • HARLAN DM, HENGARTNER H, HUANG ML et al.: Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc. Natl. Acad. Sci. USA (1994) 91:3137-3141.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3137-3141
    • Harlan, D.M.1    Hengartner, H.2    Huang, M.L.3
  • 25
    • 0028556917 scopus 로고
    • Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens
    • WILLIAMS IR, ORT RJ, KUPPER TS: Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens. Proc. Natl. Acad. Sci. USA (1994) 91:12780-12784.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12780-12784
    • Williams, I.R.1    Ort, R.J.2    Kupper, T.S.3
  • 26
    • 0028809507 scopus 로고
    • Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions
    • WINDHAGEN A, NEWCOMBE J, DANGOND F et al.: Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J. Exp. Med. (1995) 182:1985-1996.
    • (1995) J. Exp. Med. , vol.182 , pp. 1985-1996
    • Windhagen, A.1    Newcombe, J.2    Dangond, F.3
  • 27
    • 0027996295 scopus 로고
    • Elevated expression of CD80 (B7/BB1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis
    • RANHEIM EA, KIPPS TJ: Elevated expression of CD80 (B7/BB1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis [see comments]. Arthritis Rheum. (1994) 37:1637-1646.
    • (1994) Arthritis Rheum. , vol.37 , pp. 1637-1646
    • Ranheim, E.A.1    Kipps, T.J.2
  • 28
    • 0028073590 scopus 로고
    • Expression of the B7/BB1 activation antigen and its ligand CD28 in T-cell-mediated skin diseases
    • SIMON JC, DIETRICH A, MIELKE V et al.: Expression of the B7/BB1 activation antigen and its ligand CD28 in T-cell-mediated skin diseases. J. Invest. Dermatol. (1994) 103:539-543.
    • (1994) J. Invest. Dermatol. , vol.103 , pp. 539-543
    • Simon, J.C.1    Dietrich, A.2    Mielke, V.3
  • 29
    • 0028316121 scopus 로고
    • T lymphocytes in skin lesions of psoriasis and mycosis fungoides express B7-1: A ligand for CD28
    • NICKOLOFF BJ, NESTLE FO, ZHENG XG, TURKA LA: T lymphocytes in skin lesions of psoriasis and mycosis fungoides express B7-1: a ligand for CD28. Blood (1994) 83:2580-2586.
    • (1994) Blood , vol.83 , pp. 2580-2586
    • Nickoloff, B.J.1    Nestle, F.O.2    Zheng, X.G.3    Turka, L.A.4
  • 30
    • 0026753204 scopus 로고
    • Organ injury associated with extrathymic induction of immune tolerance in doubly transgenic mice
    • FIELDS LE, LOH DY: Organ injury associated with extrathymic induction of immune tolerance in doubly transgenic mice. Proc. Natl. Acad. Sci. USA (1992) 89:5730-5734.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5730-5734
    • Fields, L.E.1    Loh, D.Y.2
  • 31
    • 0025872395 scopus 로고
    • Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction
    • SCHONRICH G, KALINKE U, MOMBURG F et al.: Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell(1991) 65:293-304.
    • (1991) Cell , vol.65 , pp. 293-304
    • Schonrich, G.1    Kalinke, U.2    Momburg, F.3
  • 32
    • 0024281396 scopus 로고
    • Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells
    • LO D, BURKLY LC, WIDERA G et al.: Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell (1988) 53:159-168.
    • (1988) Cell , vol.53 , pp. 159-168
    • Lo, D.1    Burkly, L.C.2    Widera, G.3
  • 33
    • 0024402836 scopus 로고
    • Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells
    • LO D, BURKLY LC, FLAVELL RA, PALMITER RD, BRINSTER RL: Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells. J. Exp. Med. (1989) 170:87-104.
    • (1989) J. Exp. Med. , vol.170 , pp. 87-104
    • Lo, D.1    Burkly, L.C.2    Flavell, R.A.3    Palmiter, R.D.4    Brinster, R.L.5
  • 35
    • 0030474264 scopus 로고    scopus 로고
    • Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    • HANCOCK WW, SAYEGH MH, ZHENG XG, PEACH R, LINSLY PS, TURKA LA: Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc. Natl. Acad. Sci. USA (1996) 93:13967-13972.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13967-13972
    • Hancock, W.W.1    Sayegh, M.H.2    Zheng, X.G.3    Peach, R.4    Linsly, P.S.5    Turka, L.A.6
  • 36
    • 0027499535 scopus 로고
    • Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
    • RANHEIM EA, KIPPS TJ: Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J. Exp. Med. (1993) 177:925-935.
    • (1993) J. Exp. Med. , vol.177 , pp. 925-935
    • Ranheim, E.A.1    Kipps, T.J.2
  • 37
    • 0029787322 scopus 로고    scopus 로고
    • Identification of a costimulatory molecule rapidly induced by CD40L as CD44H
    • GUO Y, WU Y, SHINDE S, SY MS, ARUFFO A, LIU Y: Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J. Exp. Med (1996) 184:955-961.
    • (1996) J. Exp. Med. , vol.184 , pp. 955-961
    • Guo, Y.1    Wu, Y.2    Shinde, S.3    Sy, M.S.4    Aruffo, A.5    Liu, Y.6
  • 38
    • 0031027019 scopus 로고    scopus 로고
    • Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides
    • YELLIN MJ, D'AGATI V, PARKINSON G et al.: Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides. Arthritis Rheum. (1997) 40:124-134.
    • (1997) Arthritis Rheum. , vol.40 , pp. 124-134
    • Yellin, M.J.1    D'agati, V.2    Parkinson, G.3
  • 39
    • 0034088163 scopus 로고    scopus 로고
    • Costimulation in antiviral immunity: Differential requirements for CD4(+) and CD8(+) T cell responses
    • WHITMIRE JK, AHMED R: Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responses. Curr. Opin. Immunol. (2000) 12:448-455.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 448-455
    • Whitmire, J.K.1    Ahmed, R.2
  • 40
    • 16044371193 scopus 로고    scopus 로고
    • CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
    • published erratum appears in Immunity (1997) 6(2):following 215
    • LENSHOW DJ, HEROLD KC, RHEE L et al.: CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes [published erratum appears in Immunity (1997) 6(2):following 215]. Immunity (1996) 5:285-293.
    • (1996) Immunity , vol.5 , pp. 285-293
    • Lenshow, D.J.1    Herold, K.C.2    Rhee, L.3
  • 41
    • 0032843342 scopus 로고    scopus 로고
    • Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis
    • CHANG TT, JABS C, SOBEL RA, KUCHROO VK, SHARPE AH: Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J. Exp. Med. (1999) 190:733-740.
    • (1999) J. Exp. Med. , vol.190 , pp. 733-740
    • Chang, T.T.1    Jabs, C.2    Sobel, R.A.3    Kuchroo, V.K.4    Sharpe, A.H.5
  • 42
    • 0033975857 scopus 로고    scopus 로고
    • Functional responses and costimulator dependence of memory CD4+ T cells
    • LONDON CA, LODGE MP, ABBAS AK: Functional responses and costimulator dependence of memory CD4+ T cells. J. Immunol. (2000) 164:265-272.
    • (2000) J. Immunol. , vol.164 , pp. 265-272
    • London, C.A.1    Lodge, M.P.2    Abbas, A.K.3
  • 43
    • 0035292756 scopus 로고    scopus 로고
    • The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function
    • COYLE AJ, GUTIERREZ-RAMOS JC: The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. (2001) 2:203-209.
    • (2001) Nat. Immunol. , vol.2 , pp. 203-209
    • Coyle, A.J.1    Gutierrez-Ramos, J.C.2
  • 44
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    • Identifies ICOS as a CD28 homologue on activated human T cells and shows that, in conjuction with a TCR signal, ICOS crosslinking upregulates cytokine production, particularly of IL-10, but not IL-2
    • HUTLOFF A, DITTRICH AM, BEIER KC et al.: ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature (1999) 397:263-266. Identifies ICOS as a CD28 homologue on activated human T cells and shows that, in conjuction with a TCR signal, ICOS crosslinking upregulates cytokine production, particularly of IL-10, but not IL-2.
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1    Dittrich, A.M.2    Beier, K.C.3
  • 45
    • 0035804254 scopus 로고    scopus 로고
    • ICOS co-stimulatory receptor is essential for T-cell activation and function
    • Shows that myelin oligodendrocyte glycoprotein-induced EAE is greatly exacerbated in ICOS knockout mice as compared with wild type mice
    • DONG C, JUEDES AE, TEMANN UA et al.: ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature (2001) 409:97-101. Shows that myelin oligodendrocyte glycoprotein-induced EAE is greatly exacerbated in ICOS knockout mice as compared with wild type mice.
    • (2001) Nature , vol.409 , pp. 97-101
    • Dong, C.1    Juedes, A.E.2    Temann, U.A.3
  • 46
    • 0035804268 scopus 로고    scopus 로고
    • ICOS is critical for CD40-mediated antibody class switching
    • Shows the crucial role for ICOS in regulating immunoglobulin isotype class switching and in germinal centre formation
    • MCADAM AJ, GREENWALD RJ, LEVIN MA et al.: ICOS is critical for CD40-mediated antibody class switching. Nature (2001) 409:102-105. Shows the crucial role for ICOS in regulating immunoglobulin isotype class switching and in germinal centre formation.
    • (2001) Nature , vol.409 , pp. 102-105
    • Mcadam, A.J.1    Greenwald, R.J.2    Levin, M.A.3
  • 47
    • 0035804269 scopus 로고    scopus 로고
    • ICOS is essential for effective T-helper-cell responses
    • TAFURI A, SHAHINIAN A, BLADT F et al.: ICOS is essential for effective T-helper-cell responses. Nature (2001) 409:105-109.
    • (2001) Nature , vol.409 , pp. 105-109
    • Tafuri, A.1    Shahinian, A.2    Bladt, F.3
  • 48
    • 0033212778 scopus 로고    scopus 로고
    • B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha
    • SWALLOW MM, WALLIN JJ, SHA WC: B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity (1999) 11:423-432.
    • (1999) Immunity , vol.11 , pp. 423-432
    • Swallow, M.M.1    Wallin, J.J.2    Sha, W.C.3
  • 49
    • 0033809736 scopus 로고    scopus 로고
    • Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS
    • YOSHINAGA SK, ZHANG M, PISTILLO J et al.: Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. Int. Immunol. (2000) 12:1439-1447.
    • (2000) Int. Immunol. , vol.12 , pp. 1439-1447
    • Yoshinaga, S.K.1    Zhang, M.2    Pistillo, J.3
  • 50
    • 0034193043 scopus 로고    scopus 로고
    • Characterization of human inducible costimulator ligand expression and function
    • AICHER A, HAYDEN-LEDBETTER M, BRADY WA et al.: Characterization of human inducible costimulator ligand expression and function. J. Immunol. (2000) 164:4689-4696.
    • (2000) J. Immunol. , vol.164 , pp. 4689-4696
    • Aicher, A.1    Hayden-Ledbetter, M.2    Brady, W.A.3
  • 51
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
    • AGATA Y, KAWASAKI A, NISHIMURA H et al.: Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. (1996) 8:765-772.
    • (1996) Int. Immunol. , vol.8 , pp. 765-772
    • Agata, Y.1    Kawasaki, A.2    Nishimura, H.3
  • 52
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Identifies a B7 homologue as a second receptor for PD-1
    • LATCHMAN Y, WOOD CR, CHERNOVA T et al.: PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. (2001) 2:261-268. Identifies a B7 homologue as a second receptor for PD-1.
    • (2001) Nat. Immunol. , vol.2 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 53
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • FREEMAN GJ, LONG AJ, IWAI Y et al.: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. (2000) 192:1027-1034. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
    • (2000) J. Exp. Med. , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 54
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • NISHIMURA H, NOSE M, HIAI H, MINATO N, HONJO T: Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity (1999) 11:141-151.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 57
    • 0028921849 scopus 로고
    • Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion
    • HARLAN DM, ABE R, LEE KP, JUNE CH: Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion. Clin. Immunol. Immunopathol. (1995) 75:99-111.
    • (1995) Clin. Immunol. Immunopathol. , vol.75 , pp. 99-111
    • Harlan, D.M.1    Abe, R.2    Lee, K.P.3    June, C.H.4
  • 58
    • 0028483990 scopus 로고
    • Treatment of murine lupus with CTLA4Ig
    • FINCK BK, LINSLEY PS, WOFSY D: Treatment of murine lupus with CTLA4Ig. Science (1994) 2651:1225-1227.
    • (1994) Science , vol.2651 , pp. 1225-1227
    • Finck, B.K.1    Linsley, P.S.2    Wofsy, D.3
  • 59
    • 0034101827 scopus 로고    scopus 로고
    • CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis
    • REYNOLDS J, TAM FW, CHANDRAKER A et al.: CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. J. Clin. Invest. (2000) 105:643-651.
    • (2000) J. Clin. Invest. , vol.105 , pp. 643-651
    • Reynolds, J.1    Tam, F.W.2    Chandraker, A.3
  • 60
    • 0028900297 scopus 로고
    • Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
    • LENSCHOW DJ, HO SC, SATTAR H et al.: Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. (1995) 181:1145-1155.
    • (1995) J. Exp. Med. , vol.181 , pp. 1145-1155
    • Lenschow, D.J.1    Ho, S.C.2    Sattar, H.3
  • 61
    • 0028785417 scopus 로고
    • Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis
    • RACKE MK, SCOTT DE, QUIGLEY L et al.: Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. J. Clin. Invest. (1995) 96:2195-2203.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2195-2203
    • Racke, M.K.1    Scott, D.E.2    Quigley, L.3
  • 63
    • 0028868424 scopus 로고
    • CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system
    • KHOURY SJ, AKALIN E, CHANDRAKER A et al.: CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J. Immunol. (1995) 155:4521-4524.
    • (1995) J. Immunol. , vol.155 , pp. 4521-4524
    • Khoury, S.J.1    Akalin, E.2    Chandraker, A.3
  • 64
    • 0029898878 scopus 로고    scopus 로고
    • Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand
    • TANG A, JUDGE TA, NICKOLOFF BJ, TURKA LA: Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand. J. Immunol. (1996) 157:117-125.
    • (1996) J. Immunol. , vol.157 , pp. 117-125
    • Tang, A.1    Judge, T.A.2    Nickoloff, B.J.3    Turka, L.A.4
  • 65
    • 0031458130 scopus 로고    scopus 로고
    • Blockade of CD40-CD40 ligand pathway induces tolerance in murine contact hypersensitivity
    • TANG A, JUDGE TA, TURKA LA: Blockade of CD40-CD40 ligand pathway induces tolerance in murine contact hypersensitivity. Eur. J. Immunol. (1997) 27:3143-3150.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3143-3150
    • Tang, A.1    Judge, T.A.2    Turka, L.A.3
  • 66
    • 0029100024 scopus 로고
    • Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4
    • KEARNEY ER, WLUNAS TL, KARR RW et al.: Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. (1995) 155:1032-1036.
    • (1995) J. Immunol. , vol.155 , pp. 1032-1036
    • Kearney, E.R.1    Wlunas, T.L.2    Karr, R.W.3
  • 67
    • 0033557716 scopus 로고    scopus 로고
    • The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival
    • JUDGE TA, WU Z, ZHENG XG, SHARPE AH, SAYEGH MH, TURKA LA: The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J. Immunol (1999) 162:1947-1951.
    • (1999) J. Immunol. , vol.162 , pp. 1947-1951
    • Judge, T.A.1    Wu, Z.2    Zheng, X.G.3    Sharpe, A.H.4    Sayegh, M.H.5    Turka, L.A.6
  • 68
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules differentially activate the TH1/ TH2 developmental pathways: Application to autoimmune disease therapy
    • KUCHROO VK, DAS MP, BROWN JA et al.: B7-1 and B7-2 costimulatory molecules differentially activate the TH1/ TH2 developmental pathways: application to autoimmune disease therapy. Cell (1995) 80:707-718.
    • (1995) Cell , vol.80 , pp. 707-718
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3
  • 69
    • 0033104777 scopus 로고    scopus 로고
    • Effects of anti-B7 monoclonal antibodies on humoral immune responses
    • DAIKH DI, WOFSY D: Effects of anti-B7 monoclonal antibodies on humoral immune responses. J. Autoimmunity (1999) 12:101-108.
    • (1999) J. Autoimmunity , vol.12 , pp. 101-108
    • Daikh, D.I.1    Wofsy, D.2
  • 70
    • 0031279105 scopus 로고    scopus 로고
    • CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice
    • BALASA B, KRAHL T, PATSTONE G et al.: CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J. Immunol. (1997) 159:4620-4627.
    • (1997) J. Immunol. , vol.159 , pp. 4620-4627
    • Balasa, B.1    Krahl, T.2    Patstone, G.3
  • 71
    • 0029978178 scopus 로고    scopus 로고
    • CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis
    • GERRITSE K, LAMAN JD, NOELLE RJ et al.: CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. USA (1996) 93:2499-2504.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2499-2504
    • Gerritse, K.1    Laman, J.D.2    Noelle, R.J.3
  • 72
    • 0032953939 scopus 로고    scopus 로고
    • Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
    • HOWARD LM, MIGA AJ, VANDERLUGT CL et al.: Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis. J. Clin. Invest. (1999) 103:281-290.
    • (1999) J. Clin. Invest. , vol.103 , pp. 281-290
    • Howard, L.M.1    Miga, A.J.2    Vanderlugt, C.L.3
  • 73
    • 0029862164 scopus 로고    scopus 로고
    • Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes
    • KOSHY M, BERGER D, CROW MK: Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J. Clin. Invest. (1996) 98:826-837.
    • (1996) J. Clin. Invest. , vol.98 , pp. 826-837
    • Koshy, M.1    Berger, D.2    Crow, M.K.3
  • 74
    • 0031253956 scopus 로고    scopus 로고
    • Longterm inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways
    • DAIKH DI, FINCK BK, LINSLEY PS, HOLLENBAUGH D, WOFSY D: Longterm inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways. J. Immunol. (1997) 159:3104-3108.
    • (1997) J. Immunol. , vol.159 , pp. 3104-3108
    • Daikh, D.I.1    Finck, B.K.2    Linsley, P.S.3    Hollenbaugh, D.4    Wofsy, D.5
  • 75
    • 0034870102 scopus 로고    scopus 로고
    • ICOS ligand costimulation is required for T-cell encephalitogenicity
    • SPORICI RA, BESWICK RL, VON ALLMAN C et al.: ICOS ligand costimulation is required for T-cell encephalitogenicity. Clin. Immunol. (2001) 100:277-288.
    • (2001) Clin. Immunol. , vol.100 , pp. 277-288
    • Sporici, R.A.1    Beswick, R.L.2    Von Allman, C.3
  • 76
    • 0033135564 scopus 로고    scopus 로고
    • CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris
    • ABRAMS JR, LEBWOHL MG, GUZZO CA et al.: CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J. Clin. Invest. (1999) 103:1243-1252.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1243-1252
    • Abrams, J.R.1    Lebwohl, M.G.2    Guzzo, C.A.3
  • 77
    • 0036275436 scopus 로고    scopus 로고
    • Costimulatory blockade in patients with rheumatoid arthritis
    • MORELAND LW, ALTEN R, VAN DEN BOSCH F et al.: Costimulatory blockade in patients with rheumatoid arthritis. Arthritis Rheum. (2002) 46:1470-1479.
    • (2002) Arthritis Rheum. , vol.46 , pp. 1470-1479
    • Moreland, L.W.1    Alten, R.2    Van Den Bosch, F.3
  • 78
    • 0033965079 scopus 로고    scopus 로고
    • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand
    • KAWAI T, ANDREWS D, COLVIN RB, SACHS DH, COSIMI AB: Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat. Med. (2000) 6:114.
    • (2000) Nat. Med. , vol.6 , pp. 114
    • Kawai, T.1    Andrews, D.2    Colvin, R.B.3    Sachs, D.H.4    Cosimi, A.B.5
  • 79
    • 0036899589 scopus 로고    scopus 로고
    • Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154
    • First clinical study that evaluates the safety and efficacy of a humanised mAb against CD154 in patients with active SLE
    • KALUNIAN KC, DAVIS JC, MERRILL JT, TOTORITIS MC, WOFSY D: Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154. Arthritis Rheum. (2002) 12:3251-3258. First clinical study that evaluates the safety and efficacy of a humanised mAb against CD154 in patients with active SLE.
    • (2002) Arthritis Rheum. , vol.12 , pp. 3251-3258
    • Kalunian, K.C.1    Davis, J.C.2    Merrill, J.T.3    Totoritis, M.C.4    Wofsy, D.5
  • 80
    • 0033134624 scopus 로고    scopus 로고
    • Finally, CTLA4Ig graduates to the clinic
    • SAYEGH MH: Finally, CTLA4Ig graduates to the clinic. J. Clin. Invest. (1999) 103:1223-1225.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1223-1225
    • Sayegh, M.H.1


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