New regulatory co-receptors: Inducible co-stimulator and PD-1

Current Opinion in Immunology

Volumn 14, Issue 6, 2002, Pages 779-782

  Okazaki, Taku ^a   Iwai, Yoshiko ^a   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INDUCIBLE CO RECEPTOR; LIGAND; PROTEIN; PROTEIN PD1; RECEPTOR; UNCLASSIFIED DRUG; ABATACEPT; ANTIBODY CONJUGATE; APOPTOSIS REGULATORY PROTEIN; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; INDUCIBLE T CELL CO STIMULATOR; INDUCIBLE T-CELL CO-STIMULATOR; LEUKOCYTE ANTIGEN; MEMBRANE ANTIGEN; PDCD1 PROTEIN, MOUSE; T LYMPHOCYTE ANTIGEN;

ARTHRITIS; AUTOIMMUNE DISEASE; CYTOKINE PRODUCTION; HUMAN; IMMUNE SYSTEM; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN STRUCTURE; REVIEW; T LYMPHOCYTE; ANIMAL; AUTOIMMUNITY; BAGG ALBINO MOUSE; C57BL MOUSE; IMMUNOLOGY; LYMPHOCYTE; MOUSE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; IMMUNOCONJUGATES; LIGANDS; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTEINS;

EID: 0036888554     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00398-9     Document Type: Review

References (38)

1. Lenschow D.J., Walunas T.L., Bluestone J.A. CD28/B7 system of T cell costimulation. Annu Rev Immunol. 14:1996;233-258.
2. Grewal I.S., Flavell R.A. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol. 16:1998;111-135.
3. Chambers C.A., Kuhns M.S., Egen J.G., Allison J.P. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol. 19:2001;565-594.
4. Hutloff A., Dittrich A.M., Beier K.C., Eljaschewitsch B., Kraft R., Anagnostopoulos I., Kroczek R.A. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 397:1999;263-266.
5. Tezuka K., Tsuji T., Hirano D., Tamatani T., Sakamaki K., Kobayashi Y., Kamada M. Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family. Biochem Biophys Res Commun. 276:2000;335-345.
6. Yoshinaga S.K., Whoriskey J.S., Khare S.D., Sarmiento U., Guo J., Horan T., Shih G., Zhang M., Coccia M.A., Kohno T., et al. T-cell co-stimulation through B7RP-1 and ICOS. Nature. 402:1999;827-832.
7. Swallow M.M., Wallin J.J., Sha W.C. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity. 11:1999;423-432.
8. Wang S., Zhu G., Chapoval A.I., Dong H., Tamada K., Ni J., Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood. 96:2000;2808-2813.
9. Ling V., Wu P.W., Finnerty H.F., Bean K.M., Spaulding V., Fouser L.A., Leonard J.P., Hunter S.E., Zollner R., Thomas J.L., et al. Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol. 164:2000;1653-1657.
10. Aicher A., Hayden-Ledbetter M., Brady W.A., Pezzutto A., Richter G., Magaletti D., Buckwalter S., Ledbetter J.A., Clark E.A. Characterization of human inducible costimulator ligand expression and function. J Immunol. 164:2000;4689-4696.
11. Brodie D., Collins A.V., Iaboni A., Fennelly J.A., Sparks L.M., Xu X.N., van der Merwe P.A., Davis S.J. LICOS, a primordial costimulatory ligand? Curr Biol. 10:2000;333-336.
12. Ishida Y., Agata Y., Shibahara K., Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11:1992;3887-3895.
13. Agata Y., Kawasaki A., Nishimura H., Ishida Y., Tsubata T., Yagita H., Honjo T. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol. 8:1996;765-772.
14. Nishimura H., Honjo T. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol. 22:2001;265-268.
15. Okazaki T., Maeda A., Nishimura H., Kurosaki T., Honjo T. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl Acad Sci USA. 98:2001;13866-13871. In this article, PD-1 is shown to inhibit B cell activation by competing B cell receptor signaling. PD-1 is shown to recruit SHP-2 upon coligation with B cell receptor and dephosphorylate key molecules in B cell activation. Thus, this article provides the first molecular basis for inhibitory effects of PD-1 on activation of lymphocytes.
16. Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., Fitz L.J., Malenkovich N., Okazaki T., Byrne M.C., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 192:2000;1027-1034. Together with [18•], these articles describe identification of ligands of PD-1, PD-L1 and PD-L2. These ligands belong to the B7 family and inhibit T cell proliferation and cytokine production in vitro.
17. Dong H., Zhu G., Tamada K., Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med. 5:1999;1365-1369.
18. Latchman Y., Wood C.R., Chernova T., Chaudhary D., Borde M., Chernova I., Iwai Y., Long A.J., Brown J.A., Nunes R., et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2:2001;261-268. See annotation to [16•] .
19. Tseng S.Y., Otsuji M., Gorski K., Huang X., Slansky J.E., Pai S.I., Shalabi A., Shin T., Pardoll D.M., Tsuchiya H. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med. 193:2001;839-846.
20. Nishimura H., Nose M., Hiai H., Minato N., Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 11:1999;141-151.
21. Nishimura H., Okazaki T., Tanaka Y., Nakatani K., Hara M., Matsumori A., Sasayama S., Mizoguchi A., Hiai H., Minato N., et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 291:2001;319-322. PD1 deficient mice on the BALB/c background are shown to develop fatal dilated cardiomyopathy. This disease involves high-titered heart specific IgG autoantibodies in sera and their deposition on the surface of cardiomyocytes. This is the first animal model for the dilated cardiomyopathy caused by autoimmunity.
22. Iwai Y., Ishida M., Tanaka Y., Okazaki T., Honjo T., Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 bockade. Proc Natl Acad Sci USA. 99:2002;12293-12297.
23. Carter L., Fouser L., Jussif J., Fitz L., Deng B., Wood C., Collins M., Honjo T., Freeman G., Carreno B. PD-1: PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol. 32:2002;634-643.
24. Tamura H., Dong H., Zhu G., Sica G.L., Flies D.B., Tamada K., Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood. 97:2001;1809-1816.
25. + T cells. ICOS is shown to have a stronger influence on secondary response rather than primary response.
26. Coyle A.J., Lehar S., Lloyd C., Tian J., Delaney T., Manning S., Nguyen T., Burwell T., Schneider H., Gonzalo J.A., et al. The CD28-related molecule ICOS is required for effective T cell- dependent immune responses. Immunity. 13:2000;95-105.
27. Rottman J.B., Smith T., Tonra J.R., Ganley K., Bloom T., Silva R., Pierce B., Gutierrez-Ramos J.C., Ozkaynak E., Coyle A.J. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat Immunol. 2:2001;605-611. ICOS blockade is shown to either protect or facilitate EAE, depending on the timing of blockade. ICOS blockade at the induction phase of EAE exacerbates the disease and ICOS blockade at the effector phase abrogates the disease.
28. McAdam A.J., Chang T.T., Lumelsky A.E., Greenfield E.A., Boussiotis V.A., Duke-Cohan J.S., Chernova T., Malenkovich N., Jabs C., Kuchroo V.K., et al. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol. 165:2000;5035-5040.
29. Kopf M., Coyle A.J., Schmitz N., Barner M., Oxenius A., Gallimore A., Gutierrez-Ramos J.C., Bachmann M.F. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection. J Exp Med. 192:2000;53-61.
30. Dong C., Temann U.A., Flavell R.A. Cutting edge: critical role of inducible costimulator in germinal center reactions. J Immunol. 166:2001;3659-3662.
31. Dong C., Juedes A.E., Temann U.A., Shresta S., Allison J.P., Ruddle N.H., Flavell R.A. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 409:2001;97-101.
32. McAdam A.J., Greenwald R.J., Levin M.A., Chernova T., Malenkovich N., Ling V., Freeman G.J., Sharpe A.H. ICOS is critical for CD40-mediated antibody class switching. Nature. 409:2001;102-105.
33. Tafuri A., Shahinian A., Bladt F., Yoshinaga S.K., Jordana M., Wakeham A., Boucher L.M., Bouchard D., Chan V.S., Duncan G., et al. ICOS is essential for effective T-helper-cell responses. Nature. 409:2001;105-109.
34. Chapoval A.I., Ni J., Lau J.S., Wilcox R.A., Flies D.B., Liu D., Dong H., Sica G.L., Zhu G., Tamada K., et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol. 2:2001;269-274.
35. Nishimura H., Minato N., Nakano T., Honjo T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol. 10:1998;1563-1572.
36. Chang T.T., Jabs C., Sobel R.A., Kuchroo V.K., Sharpe A.H. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J Exp Med. 190:1999;733-740.
37. Marelli-Berg F.M., Lechler R.I. Antigen presentation by parenchymal cells: a route to peripheral tolerance? Immunol Rev. 172:1999;297-314.
38. Dong H., Strome S.E., Salomao D.R., Tamura H., Hirano F., Flies D.B., Roche P.C., Lu J., Zu G., Tamada K., et al. Tumor-associated B7-H1 promotes T cell apoptosis: a potential mechanism of immune invasion. Nat Med. 8:2002;793-800.