The role of the CD40 pathway in the pathogenesis and treatment of cancer

Current Opinion in Pharmacology

Volumn 4, Issue 4, 2004, Pages 360-367

  Eliopoulos, Aristides G ^a   Young, Lawrence S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD40 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CERAMIDE; CISPLATIN; CYTOKINE; CYTOTOXIC AGENT; FAS LIGAND; FLICE INHIBITORY PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CARCINOGENESIS; CARCINOMA; CELL ACTIVITY; CLINICAL OBSERVATION; CLINICAL TRIAL; DENDRITIC CELL; DRUG POTENTIATION; DRUG SENSITIZATION; HUMAN; IMMUNOREGULATION; LEUKEMIA; LYMPHOMA; MITOSIS INHIBITION; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIDE EFFECT; TUMOR IMMUNITY; VIRAL GENE DELIVERY SYSTEM;

EID: 3343015039     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2004.02.008     Document Type: Review

References (80)

1. Paulie S. Ehlin-Henriksson B. Mellstedt H. Koho H. Ben-Aissa H. Perlmann P. A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes Cancer Immunol Immunother 20 1985 23-28
2. Stamenkovic I. Clark E.A. Seed B. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas EMBO J 8 1989 1403-1410
3. Armitage R.J. Fanslow W.C. Strockbine L. Sato T.A. Clifford K.N. Macduff B.M. Anderson D.M. Gimpel S.D. Davis-Smith T. Maliszewski C.R. et al. Molecular and biological characterisation of a murine ligand for CD40 Nature 357 1992 80-82
4. Callard R.E. Armitage R.J. Fanslow W.C. Spriggs M.K. CD40 ligand and its role in X-linked hyper-IgM syndrome Immunol Today 14 1993 559-564
5. Hayward A.R. Levy J. Facchetti F. Notarangelo L. Ochs H.D. Etzioni A. Bonnefoy J.-Y. Cosyns M. Weinberg A. Cholangiopathy and tumours of the pancreas, liver and biliary tree in boys with X-linked immunodeficiency with hyper-IgM J Immunol 158 1997 977-983
6. Tan J. Town T. Mori T. Obregon D. Wu Y. Delle-Donne A. Rojiani A. Crawford F. Flavell R.A. Mullan M. CD40 is expressed and functional on neuronal cells EMBO J 21 2002 643-652
7. Young L.S. Dawson C.W. Brown K.W. Rickinson A.B. Identification of a human epithelial cell surface protein sharing an epitope with C3d/Epstein-Barr virus receptor molecule of B lymphocytes Int J Cancer 43 1989 786-794
8. Hollenbaugh D. Mischel-Petty N. Edwards C.P. Simon J.C. Denfield R.W. Kiener P.A. Aruffo A. Expression of functional CD40 by vascular endothelial cells J Exp Med 182 1995 33-40
9. Wang Y. Kelly C.G. Karttunen J.T. Whittall T. Lehner P.J. Duncan L. MacAry P. Younson J.S. Singh M. Oehlmann W. et al. CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines Immunity 15 2001 971-983
10. Brodeur S.R. Angelini F. Bacharier L.B. Blom A.M. Mizoguchi E. Fujiwara H. Plebani A. Notarangelo L.D. Dahlback B. Tsitsikov E. et al. C4b-binding protein (C4BP) activates B cells through the CD40 receptor Immunity 18 2003 837-848
11. Tsukamoto N. Kobayashi N. Azuma S. Yamamoto T. Inoue J.-I. Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40 Proc Natl Acad Sci USA 96 1999 1234-1239
12. Eliopoulos A.G. Wang C.C. Dumitru C.D. Tsichlis P.N. Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40 EMBO J 22 2003 3855-3864
13. Hanissian S.H. Geha R.S. JAK3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells Immunity 6 1997 379-387
14. Davies C.C. Mason J. Wakelam M.J. Young L.S. Eliopoulos A.G. Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells J Biol Chem 279 2004 1010-1019
15. Karmann K. Hughes C.C.W. Schechner J. Fanslow W.C. Pober J.S. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression Proc Natl Acad Sci USA 92 1995 4342-4346
16. Young L.S. Eliopoulos A.G. Gallagher N.J. Dawson C.W. CD40 and epithelial cells: across the great divide Immunol Today 19 1998 502-506
17. Koho H. Paulie S. Ben-Aissa H. Jonsdottir I. Hansson Y. Lundblad M.-L. Perlmann P. Monoclonal antibodies to antigens associated with transitional cell carcinoma of the human urinary bladder Cancer Immunol Immunother 17 1984 165-172
18. Kato K. Cantwell M.J. Sharma S. Kipps T.J. Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells J Clin Invest 101 1998 1133-1141
19. Pellat-Deceunynck C. Amiot M. Robillard N. Wijdenes J. Bataille R. CD11a-CD18 and CD102 interactions mediate human myeloma cell growth arrest induced by CD40 Cancer Res 56 1996 1909-1916
20. Teoh G. Tai Y.-T. Urashima M. Shirahama S. Matsuzaki M. Chauhan D. Treon S.P. Raje N. Hideshima T. Shima Y. et al. CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines Blood 95 2000 1039-1046
21. Aldinucci D. Poletto D. Nanni P. Degan M. Rupolo M. Pinto A. Gattei V. Exp Hematol 30 2002 1283-1292
22. von Leoprechting A. van der Bruggen P. Pahl H.L. Aruffo A. Simon J.C. Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis Cancer Res 59 1999 1287-1294
23. Kennedy M.M. Biddolph S. Lucas S.B. Howells D.D.Picton S. McGee J.O. O'Leary J.J. CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma Mol Pathol 52 1999 32-36
24. Ottaiano A. Pisano C. De Chiara A. Barletta E. Ascierto A.P. Botti G. Napolitano M. Apice G. Iaffaioli R.V. Expression of CD40 has no predictive value in soft tissue sarcomas Anticancer Res 23 2003 1597-1604
25. Cooke P.W. James N.D. Ganesan R. Wallace M. Burton A. Young L.S. CD40 expression in bladder cancer J Pathol 188 1999 38-43
26. Altenburg A. Baldus S.E. Smola H. Pfister H. Hess S. CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-γ J Immunol 162 1999 4140-4147
27. Gallagher N.J. Eliopoulos A.G. Agathangelo A. Oates J. Crocker J. Young L.S. CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion Mol Pathol 55 2002 110-120
28. Agathanggelou A. Niedobitek G. Chen R.W. Nicholls J. Yin W.B. Young L.S. Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma - evidence for a functional interaction between epithelial tumour cells and infiltrating lymphoid cells Am J Pathol 147 1995 1152-1160
29. Hirano A. Longo D.L. Taub D.D. Ferris D.K. Young L.S. Eliopoulos A.G. Agathanggelou A. Cullen N. Macartney J. Fanslow W.C. et al. Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand Blood 93 1999 2999-3007
30. Ghosh M. Crocker J. Morris A.G. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors J Pathol 189 1999 363-367
31. Sabel M.S. Yamada M. Kawaguchi Y. Chen F.-A. Takita H. Bankert R.B. CD40 expression on human lung cancer correlates with metastatic spread Cancer Immunol Immunother 49 2000 101-108
32. Viac J. Schmitt D. Claudy A. CD40 expression in epidermal tumours Anticancer Res 17 1997 569-572
33. Wrone-Smith T. Johnson T. Nelson B. Boise L.H. Thompson C.B. Nunez G. Nickoloff B.J. Discordant expression of Bcl-X and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo Am J Pathol 146 1995 1079-1088
34. Denfeld R.W. Hollenbaugh D. Fehrenbach A. Weiss J.M. von Leoprechting A. Mai B. Voith U. Schopf E. Aruffo A. Simon J.C. CD40 is functionally expressed on human keratinocytes Eur J Immunol 26 1996 2329-2334
35. Tone M. Tone Y. Fairchild P.J. Wykes M. Waldmann H. Regulation of CD40 function by its isoforms generated through alternative splicing Proc Natl Acad Sci USA 98 2001 1751-1756
36. Pham L.V. Tamayo A.T. Yoshimura L.C. Lo P. Terry N. Reid P.S. Ford R.J. A CD40 signalosome anchored in lipid rafts leads to constitutive activation of NFκB and autonomous cell growth in B cell lymphomas Immunity 16 2002 37-50
37. Challa A. Eliopoulos A.G. Holder M.J. Burguete A.S. Pound J.D. Chamba A. Grafton G. Armitage R.J. Gregory C.D. Martinez-Valdez H. et al. Population depletion activates autonomous CD154-dependent survival in biopsy-like Burkitt lymphoma cells Blood 99 2002 3411-3418
38. Furman R.R. Asgary Z. Mascarenhas J.O. Liou H.-C. Schattner E.J. Modulation of NF-κB activity and apoptosis in chronic lymphocytic leukaemia B cells J Immunol 164 2000 2200-2206
39. Tong A.W. Papayoti M.H. Netto G. Armstrong D.T. Ordonez G. Lawson J.M. Stone M.J. Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer Clin Cancer Res 7 2001 691-703
40. Bussolati B. Russo S. Deambrosis I. Cantaluppi V. Volpe A. Ferrando U. Camussi G. Expression of CD154 on renal cell carcinomas and effect on cell proliferation, motility and platelet-activating factor synthesis Int J Cancer 100 2002 654-661
41. Eliopoulos A.G. Young L.S. LMP1 structure and signal transduction Semin Cancer Biol 11 2001 435-444
42. Dirmeier U. Neuhierl B. Kilger E. Reisbach G. Sandberg M.L. Hammerschmidt W. Latent membrane protein 1 is critical for efficient growth transformation of human B cells by Epstein-Barr virus Cancer Res 63 2003 2982-2989
43. Mehling A. Loser K. Varga G. Metze D. Luger T.A. Schwarz T. Grabbe S. Beissert S. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity J Exp Med 194 2001 615-628
44. Wilson J.B. Weinberg W. Johnson R. Yuspa S. Levine A.J. Cell 61 1990 1315-1327
45. Funakoshi S. Longo D.L. Beckwith M. Conley D.K. Tsarfaty G. Tsarfaty I. Armitage R.J. Fanslow W.C. Spriggs M.K. Murphy W.J. Inhibition of human B-cell lymphoma growth by CD40 stimulation Blood 83 1994 2787-2794
46. Planken E.V. Dijkstra N.H. Willemze R. Kluin-Nelemans J.C. Proliferation of B cell malignancies in all stages of differentiation upon stimulation in the 'CD40 system' Leukemia 10 1996 488-493
47. Lee H.H. Dadgostart H. Cheng Q. Shu J. Cheng G. NK-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signalling in B lymphocytes Proc Natl Acad Sci USA 96 1999 9136-9141
48. Hennino A. Berard M. Krammer P.H. Defrance T. FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis J Exp Med 193 2001 447-458
49. Wang D. Freeman G.J. Levine H. Ritz J. Robertson M.J. Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies Br J Haematol 97 1997 409-417
50. Chu P. Deforce D. Pedersen I.M. Kim Y. Kitada S. Reed J.C. Kipps T.J. Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia Proc Natl Acad Sci USA 99 2002 3854-3859
51. Eliopoulos A.G. Dawson C.W. Mosialos G. Floettmann J.E. Rowe M. Armitage R.J. Dawson J. Zapata J.M. Kerr D.J. Wakelam M.J.O. et al. CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr virus-encoded LMP1: Involvement of TRAF3 as a common mediator Oncogene 13 1996 2243-2254
52. Ghamande S. Hylander B.L. Oflazoglu E. Lele S. Fanslow W.C. Repasky E.A. Recombinant CD40 ligand therapy has significant anti-tumour effects on CD40-positive ovarian tumour xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin Cancer Res 61 2001 7556-7562
53. Hess S. Engelmann H. A novel function of CD40: induction of cell death in transformed cells J Exp Med 183 1996 159-167
54. Eliopoulos A.G. Davies C. Knox P.G. Gallagher N.J. Afford S.C. Adams D.H. Young L.S. CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumour necrosis factor superfamily Mol Cell Biol 20 2000 5503-5515
55. Afford S.C. Randhawa S. Eliopoulos A.G. Hubscher S.G. Young L.S. Adams D.H. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface Fas ligand expression and amplifies Fas-mediated hepatocyte death during allograft rejection J Exp Med 189 1999 441-446
56. Grell M. Zimmermann G. Gottfried E. Chen C.-M. Grunwald U. Huang D.C.S. Y-HW L. Durkop H. Engelmann H. Scheurich P. et al. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF EMBO J 18 1999 3034-3043
57. + T-helper and a T-killer cell Nature 393 1998 474-478
58. Bennett S.R.M. Carbone F.R. Karamalis F. Flavell R.A. Miller J.F.A.P. Heath W.R. Help for cytotoxic-T-cell responses is mediated by CD40 signalling Nature 393 1998 478-480
59. Schoenberg S.P. Toes R.E.M. van der Voort E.I.H. Offringa R. Melief C.J.M. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions Nature 393 1998 480-483
60. Mackey M.F. Gunn J.R. Ting P.P. Kikutani H. Dranoff G. Noelle R.J. Barth R.J.J. Protective immunity induced by tumour vaccines requires interaction between CD40 and its ligand, CD154 Cancer Res 57 1997 2569-2574
61. van Mierlo G.J.D. den Boer A.T. Medema J.P. van der Voort E.I.H. Fransen M.F. Offringa R. Melief C.J.M. Toes R.E.M. CD40 stimulation leads to effective therapy of CD40-tumours through induction of strong systemic cytotoxic T lymphocyte immunity Proc Natl Acad Sci USA 99 2002 5561-5566
62. Khanna R. Cooper L. Kienzle N. Moss D.J. Burrows S.R.Khanna K.K. Cutting edge: engagement of CD40 antigen with soluble CD40 ligand up-regulates peptide transporter expression and restores endogenous processing function in Burkitt's lymphoma cells J Immunol 159 1997 5782-5785
63. Carbone E. Ruggiero G. Terrazzano G. Palomba C. Manzo C. Fontana S. Spits H. Karre K. Zappacosta S. A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction J Exp Med 185 1997 2053-2060
64. French R.R. Chan H.T.C. Tutt A.L. Glennie M.J. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help Nat Med 5 1999 548-553
65. Tutt A.L. O'Brien L. Hussain A. Crowther G.R. French R.R. Glennie M.J. T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody J Immunol 168 2002 2720-2728
66. Turner J.G. Rakhmilevich A.L. Burdelya L. Neal Z. Imboden M. Sondel P.M. Yu H. Anti-CD40 antibody induces antitumour and antimetastatic effects: the role of NK cells J Immunol 166 2001 89-94
67. + T cells in the absence of tumour-antigen vaccination Proc Natl Acad Sci USA 98 2001 10811-10816
68. Ribas A. Butterfield L.H. Amarnani S.N. Dissette V.B. Kim D. Meng W.S. Miranda G.A. Wang H.-J. McBride W.H. Glaspy J.A. et al. CD40 cross-linking bypasses the absolute requirement for CD4 T cells during immunisation with melanoma antigen gene-modified dendritic cells Cancer Res 61 2001 8787-8793
69. Grossman M.E. Brown M.P. Brenner M.K. Antitumour responses induced by transgenic expression of CD40 ligand Hum Gene Ther 8 1997 1935-1943
70. Kikuchi T. Crystal R.G. Anti-tumour immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumour cells Hum Gene Ther 10 1999 1375-1387
71. Kikuchi T. Moore M.A.S. Crystal R.G. Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against pre-existing murine tumours Gene Ther 96 2000 91-99
72. Sun Y. Peng D. Lecanda J. Schmitz V. Barajas M. Qian C. Prieto J. In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumour eradication and protective anti-tumour immunity Gene Ther 7 2000 1467-1476
73. Schmitz V. Barajas M. Wang L. Peng D. Duarte M. Prieto J. Qian C. Adenovirus-mediated CD40 ligand gene therapy in a rat model or orthotopic hepatocellular carcinoma Hepatology 34 2001 72-81
74. Noguchi M. Imaizumi K. Kawabe T. Wakayama H. Horio Y. Sekido Y. Hara T. Hashimoto N. Takahashi M. Shimokata K. et al. Induction of anti-tumour immunity by transduction of CD40 ligand gene and interferon-γ gene into lung cancer Cancer Gene Ther 8 2001 421-429
75. Brown M.P. Topham D.J. Sangster M.Y. Zhao J. Flynn K.J. Surman S.L. Woodland D.L. Doherty P.C. Farr A.G. Pattengale P.K. et al. Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice Nat Med 4 1998 1253-1260
76. Vonderheide R.H. Dutcher J.P. Anderson J.E. Eckhardt S.G. Stephans K.F. Razvillas B. Garl S. Butine M.D. Perry V.P. Armitage R.J. et al. Phase I study of recombinant human CD40 ligand in cancer patients J Clin Oncol 19 2001 3280-3287
77. Wierda W.G. Cantwell M.J. Woods S.J. Rassenti L.Z. Prussak C.E. Kipps T.J. CD40-ligand (CD154) gene therapy for chronic lymphocytic leukaemia Blood 96 2000 2917-2924
78. Gurunathan S. Irvine K.R. Wu C.-Y. Cohen J.I. Thomas E. Prussin C. Restifo N.P. Seder R.A. CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumour challenge J Immunol 161 1998 4563-4571
79. Huang H.-I. Wu P.-Y. Teo C.-Y. Chen M.-N. Chen Y.-C. Silin D. Tao M.-H. Improved immunogenicity of a self tumour antigen by covalent linkage to CD40 ligand Int J Cancer 108 2004 696-703
80. Zhang L. Tang Y. Akbulut H. Zelterman D. Linton P.-J. Deisseroth A.B. An adenoviral vector cancer vaccine that delivers a tumour-associated antigen/CD40-ligand fusion protein to dendritic cells Proc Natl Acad Sci USA 100 2003 15101-15106