Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors

Oncogene

Volumn 24, Issue 11, 2005, Pages 1882-1894

  Di Vizio, Dolores ^a   Cito, Letizia ^a   Boccia, Angelo ^a   Chieffi, Paolo ^b   Insabato, Luigi ^a   Pettinato, Guido ^a   Motti, Maria Letizia ^a   Schepis, Filippo ^c   D'Amico, Wanda ^c   Fabiani, Fernanda ^c   Tavernise, Barbara ^c   Venuta, Salvatore ^c   Fusco, Alfredo ^a   Viglietto, Giuseppe ^a,d  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c 88100 Univ 'M Graecia' Catanzaro   (Italy)

^d Dipto di Med Sperim e Clinica   (Italy)

Author keywords

Germ cell tumors; ITGCN; p27kip1; PTEN

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MESSENGER RNA; MICROSATELLITE DNA; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL MIGRATION; CELL SURVIVAL; CHROMOSOME 10Q; CONTROLLED STUDY; EMBRYO; EMBRYONAL CARCINOMA; GENE DELETION; GENE MUTATION; GERM CELL TUMOR; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; INTRATUBULAR GERM CELL NEOPLASIA; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMINOMA; SIGNAL TRANSDUCTION; TERATOCARCINOMA; TERATOMA; TESTIS BIOPSY; TUMOR SUPPRESSOR GENE; ANIMAL; BREAST TUMOR; CELL TRANSFORMATION; CHROMOSOME 10; CYTOLOGY; FEMALE; FLOW CYTOMETRY; GENETICS; HETEROZYGOSITY LOSS; PATHOLOGY; PRENATAL DEVELOPMENT; TESTIS; TESTIS TUMOR; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 10; FEMALE; FLOW CYTOMETRY; GENES, TUMOR SUPPRESSOR; GERMINOMA; HUMANS; IN SITU HYBRIDIZATION; LOSS OF HETEROZYGOSITY; MALE; MICE; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; TESTICULAR NEOPLASMS; TESTIS; TUMOR SUPPRESSOR PROTEINS;

EID: 20144386807     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208368     Document Type: Article

References (59)

1. Andrews PW. (1984). Dev. Biol., 103, 285-293.
2. Baldassarre G, Barone MV, Belletti B, Sandomenico C, Bruni P, Spiezia S, Boccia A, Vento MT, Romano A, Pepe S, Fusco A and Viglietto G. (1999). Oncogene, 18, 6241-6251.
3. Baldassarre G, Boccia A, Bruni P, Sandomenico C, Barone MV, Pepe S, Angrisano T, Belletti B, Motti ML, Fusco A and Viglietto G. (2000). Cell Growth Differ., 11, 517-526.
4. Baldassarre G, Romano A, Armenante F, Rambaldi M, Paoletti I, Sandomenico C, Pepe S, Staibano S, Salvatore G, De Rosa G, Persico MG and Viglietto G. (1997). Oncogene, 15, 927-936.
5. Bruni P, Boccia A, Baldassarre G, Trapasso F, Santoro M, Chiappetta G, Fusco A and Viglietto G. (2000). Oncogene, 19, 3146-3155.
6. Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG, Jen J, Isaacs WB, Bova GS and Sidransky D. (1997). Cancer Res., 57, 4997-5000.
7. Chaganti RSK and Houldsworth J. (2000). Cancer Res., 60, 1475-1482.
8. Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T and Hay N. (2001). Genes Dev., 15, 2203-2208.
9. Da-Ming L and Hong S. (1998). Proc. Natl. Acad. Sci. USA, 95, 15406-15411.
10. Datta SR, Brunei A and Greemberg ME. (1999). Genes Dev., 13, 2905-2927.
11. Di Cristofano A, Pesce B, Cordon-Cardo C and Pandolfi PP. (1998). Nat. Genet., 19, 348-355.
12. Diehl JA, Cheng M, Roussel MF and Sherr CJ. (1998). Genes Dev., 12, 3499-3511.
13. Furnari FB, Lin H, Huang HS and Cavenee WK. (1997). Proc. Natl. Acad. Sci. USA, 94, 12479-12484.
14. Gimm O, Perren A, Weng LP, Marsh DJ, Yeh JJ, Ziebold U, Gil E, Hinze R, Delbridge L, Lees JA, Mutter GL, Robinson BG, Komminoth P, Dralle H and Eng C. (2000). Am. J. Pathol., 156, 1693-1700.
15. Grimaldi P, Piscitelli D, Albanesi C, Blasi F, Geremia R and Rossi P. (1993). Mol. Endocrinol., 7, 1217-1225.
16. Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G and Stokoe D. (1998). Curr. Biol., 8, 1195-1198.
17. Houldsworth J, Reuter V, Bosl GJ and Chaganti RS. (1997). Cell Growth Differ., 8, 293-299.
18. Iqbal UA. (2000). J. Natl. Cancer Inst., 92, 861-862.
19. Kimura T, Suzuki A, Fujita Y, Yomogida K, Lomeli H, Asada N, Ikeuchi M, Nagy A, Mak TW and Nakano T. (2003). Development, 130, 1691-1700.
20. Li DM and Sun H. (1997). Cancer Res., 57, 2124-2129.
21. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Pue J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH and Parsons R. (1997). Science, 275, 1943-1947.
22. Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C and Parsons R. (1997). Nat. Genet., 16, 64-67.
23. Lu Y, Lin YZ, LaPushin R, Cuevas B, Fang X, Yu SX, Davies MA, Khan H, Furui T, Mao M, Zinner R, Hung MC, Steck P, Siminovitch K and Mills GB. (1999). Oncogene, 18, 7034-7045.
24. Luukko K, Ylikorkala A, Tiainen M and Makela TP. (1999). Mech. Dev., 83, 187-190.
25. Maehama T and Dixon JE. (1998). J. Biol. Chem., 273, 13375-13378.
26. Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ and Eng C. (1997). Nat. Genet., 16, 333-334.
27. Marte BM and Downward J. (1997). Trends Biochem. Sci., 22, 355-358.
28. Matsui Y. (1998). Acta. Pathol. Microbiol. Immunol. Scand., 106, 142-148.
29. McMenamin ME, Soung P, Perera S, Kaplan I, Loda M and Sellers WR. (1999). Cancer Res., 59, 4291-4296.
30. Meistrich ML. (1977). Methods Cell Biol., 15, 15-54.
31. Mertens F, Johansson B, Hoglund M and Mitelman F. (1997). Cancer Res., 57, 2765-2780.
32. Moe-Behrens GH, Klinger FG, Eskild W, Grotmol T, Haugen TB and De Felici M. (2003). Mol. Endocrinol. Dec., 17, 2630-2638.
33. Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JP, Lees JA, Weng LP and Eng CJ. (2000). Natl. Cancer Inst., 92, 924-930.
34. Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP and Tonks NK. (1997). Proc. Natl. Acad. Sci. USA, 94, 9052-9057.
35. Nelen MR, van Staveren WC, Peeters EA, Hassel MB, Gorlin RJ, Hamm H, Lindboe CF, Fryns JP, Sijmons RH, Woods DG, Mariman EC, Padberg GW and Kremer H. (1997). Mol. Genet., 6, 1383-1387.
36. Okahara F, Ikawa H, Kanaho Y and Maehama T. (2004). J. Biol. Chem., 279, 45300-45303.
37. Perren A, Komminoth P, Saremasiani P, Matter C, Feurer S, Lees JA, Heitz PU and Eng C. (2000). Am. J. Pathol., 157, 1097-1103.
38. Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE and Parsons R. (1999). Proc. Natl. Acad. Sci. USA, 96, 1563-1568.
39. Rasheed BK, Stenzel TT, McLendon RE, Parsons R, Friedman AH, Friedman HS, Bigner DD and Bigner SH. (1997). Cancer Res., 57, 4187-4190.
40. Risinger JI, Hayes AK, Berchuck A and Barrett JC. (1997). Cancer Res., 57, 4736-4738.
41. Rossi P, Dolci S, Albanesi C, Grimaldi P, Ricca R and Geremia R. (1993). Dev. Biol., 155, 68-74.
42. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B and Velculescu VE. (2004). Science, 304, 554-558.
43. Scala S, Bruni P, Lo Muzio L, Mignogna M, Viglietto G and Fusco A. (1998). Int. J. Oncol., 13, 665-668.
44. Sette C, Bevilacqua A, Bianchini A, Mangia F, Geremia R and Rossi P. (1997). Development, 124, 2267-2274.
45. Skotheim RI and Lothe RA. (2003). APMIS, 111, 136-150.
46. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP and Mak TW. (1998). Cell, 95, 29-39.
47. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH and Tavtigian SV. (1997). Nat. Genet., 15, 356-362.
48. Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M and Mak TW. (1998). Curr. Biol., 8, 1169-1178.
49. Tashiro H, Blazes MS, Wu R, Cho KR, Bose S, Wang SI, Li J, Parsons R and Ellenson LH. (1997). Cancer Res., 57, 3935-3940.
50. Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WK, Fujii G, Berson A and Steck PA. (1997). Cancer Res., 57, 5221-5225.
51. Torres J and Pulido R. (2001). J. Biol. Chem., 276, 993-998.
52. Ulbright TM. (1993). Am. J. Surg. Pathol., 17, 1075-1091.
53. Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A and Santoro M. (2002). Nat. Med., 8, 1136-1144.
54. Viglietto G, Romano A, Maglione D, Rambaldi M, Paoletti I, Lago C, Califano D, Monaco C, Mineo A, Santelli G, Manzo G, Botti G, Chiappetta G and Persico MG. (1996). Oncogene, 13, 577-587.
55. Vos A, Oosterhuis JW, de Jong B, Buist J and Schraffordt Koops H. (1990). Cancer Genet. Cytogenet., 46, 75-81.
56. Wang SI, Puc J, Li J, Bruce JN, Cairns P, Sidransky D and Parsons R. (1997). Cancer Res., 57, 4183-4186.
57. Wu W, Wang X, Zhang W, Reed W, Samet JM, Whang YE and Ghio AJ. (2003). J. Biol. Chem., 278, 28258-28263.
58. Wu Y, Dowbenko D, Pisabarro MT, Dillard-Telm L, Koeppen H and Lasky LA. (2001). J. Biol. Chem., 276, 21745-21753.
59. Zhou XP, Gimm O, Hampel H, Niemann T, Walker MJ and Eng V. (2000). Am. J. Pathol., 157, 1123-1128.