Roles of reactive oxygen species: Signaling and regulation of cellular functions

International Review of Cytology

Volumn 188, Issue , 1999, Pages 203-255

  Gamaley, I A ^a   Klyubin, I V ^a  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

Author keywords

Intracellular signaling; Reactive oxygen species; Redox state; Thiols; Transcriptional factors

Indexed keywords

ANTIOXIDANT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOL;

CELL FUNCTION; GENETIC TRANSCRIPTION; METABOLISM; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; EUKARYOTIC CELLS; GENE EXPRESSION; HUMANS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0032411042     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0074-7696(08)61568-5     Document Type: Article

References (343)

1. Abate, C, Patel, L., Rauscher, F. J., Ill, and Curran, T. (1990). Redox regulation of Fos and Jun DNA-binding activity in vitro. Science 249,1157-1161.
2. Ager, A., and Gordon, J. L. (1984). Differential effects of hydrogen peroxide on induces of endothelial cell function. J. Exp. Med. 159, 592-603.
3. Aitken, R. J., Fisher, H. M., Fulton, N., Gomez, E., Knox, W., Lewis, B., and Irvine, S. (1997). Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine. Mol. Reprod. Dev. 47, 468-482.
4. Akagi, M., Katakuse, Y., Fukuishi, N., Kan, T., and Akagi, R. (1994). Superoxide anioninduced histamine release from rat peritoneal mast cells. Biol. Pliaramcol. Bull. 17,732-734.
5. Allen, R. G. (1991). Oxygen-reactive species and antioxidant responses during development: The metabolic paradox of cellular differentiation. Proc. Soc. Exp. Biol. Med. 196,117-129.
6. Alien, R. G., and Venkatraj, V. S. (1992). Oxidants and antioxidants in development and differentiation. J. Nutr. 122, 631-635.
7. Alien, R. G., Keogh, B. P., Gerhard, G. S., Pignolo, R. J., Horton, J., and Cristofalo, V. J. (1995). Expression and regulation of Superoxide dismutase activity in human skin fibroblasts from donors of different ages. J. Cell Physiol. 165, 576-587.
8. Alien, R. G., Keogh, B. P., Tresini, M., Gerhard, G. S., Volker, G, Pignolo, R. J., Horton, J., and Cristofalo, V. J. (1997). Development and age-associated differences in electron transport potential and consequences for oxidant generation. J.Biol. Chem. 40,24805-24812.
9. Arnal, J. F., Tack, I., Besombes, J. P., Pipy, B., and Negre-Salvayre, A. (1996). Nitric oxide and Superoxide anion production during endothelial cell proliferation. Am. J. Physiol. 271, C1521-C1526.
10. Aust, S. D., Morehouse, L. A., and Thomas, G E. (1985). Role of metals in oxygen radical reactions. J. Free Rad. Biol. Med. 1, 3-25.
11. Azzi, A., Cantoni, O., Ozer, N., Boscoboinik, D., and Spycher, S. (1996). The role of hydrogen peroxide and RRR-alpha-tocopherol in smooth muscle cell proliferation. Cell Death Differ. 3, 79-90. [Review]
12. Bae, Y.S., Kang, S. W., Seo, M. S., Baines, I. G, Tekle, E., Chock, P. B., and Rhee, S. G. (1997). Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EOF receptor-mediated tyrosine phosphorylation. J. Biol. Chem. 272, 217-221.
13. Baeuerle, P. A., and Henkel, T. (1994). Function and activation of NF-kB in the immune system. Anna. Rev. Iinmunol. 12, 141-179.
14. Baker, A. M., Oberley, L. W., and Cohen, M. B. (1997). Expression of antioxidant enzymes in human prostatic adenocarcinoma. Prostrate 32, 229-233.
15. Baldrige, C. W., and Gerard, R. W. (1933). The extra respiration of phagocytosis. Am. J. Physiol. 103, 235-236.
16. Bannister, W. H., and Bannister, J. B. (eds.) (1980). "Biological and Clinical Aspects of Superoxide and Superoxide Dismutase." Elsevier, Amsterdam.
17. Basaga, H. S. (1990). Biochemical aspects of free radicals. Biochem. Cell Biol. 68, 989-998.
18. Bauer, V., Dike, M., Tanaka, H., Inoue, R., and Ito, Y. (1997). Hydrogen peroxide induced responses of cat tracheal smooth muscle cells. Br. J. Phannacol. 121, 867-874.
19. Beckman, J. S., and Crow, J. P. (1993). Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem. Soc. Trans. 21, 330-334.
20. Benov, L. C., Ribarov, S. R., and Monovich, O. H. (1992). Study of activated oxygen production by some thiols using chemiluminescence. Gen. Physiol. Biophys. 11, 195-202.
21. Bhunia, A. K., Han, H., Snowden, A., and Chatterjee, S. (1997). Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells. J. Biol. Chem. 272, 15642-15649.
22. Bielski, B. H. J. (1982). Chemistry of absorbic acid radicals. Adv. Chem. Ser. 200, 81-100.
23. Bielski, B. H. J., and Chan, P. C. (1973). Enzyme-catalysed free radical reactions with nicotinamide-adenine nucleotides: 1. Lactate dehydrogenase-catalyzed chain oxidation of bound NADH by Superoxide radicals. Arch. Biochem. Biophys. 159, 873-879.
24. 2- unsaturated fatty acids. J. Biol. Client. 258, 4759-4761.
25. 2 generation in FRTL-5 and porcine thyroid cells. Eur. J. Endocrinol. 130, 180-186.
26. 2: Senescence-like growth arrest or apoptosis? Cell Growth Differ. 8, 589-598.
27. Bolwell, G. P., Butt, V. S., Davies, D. R., and Zimmerlin, A. (1995). The origin of the oxidative burst in plants. Free Rad. Res. 23, 517-523.
28. Borg, D. C., and Shaich, K. M. (1987). Iron and iron derived radicals. In "Oxygen Radicals and Tissue Injury" (B. Halliwell, ed.), Proceedings of Brook Lodge Symposium, Augusta, MI, April 27-29, pp. 20-26. Upjohn Company, Bethesda.
29. Bouton, C., Raveau, M., and Drapier, J. C. (1996). Modulation of iron regulatory protein functions. Further insights into the role of nitrogen- and oxygen-derived reactive species. J. Biol Client. 271, 2300-2306.
30. Bradley, D. J., Kjellbom, P., and Lamb, C. J. (1992). Elicitor- and wound-induced oxidative cross-linking of a proline-rich plant cell wall protein: A novel, rapid defense response. Cell 70, 21-30.
31. Briviba, K., Roussyn, I., Sharov, V. W., and Sies, H. (1996). Attenuation of oxidant and nitration reactions of peroxynitrite by selenomethionine, selenocystine and Ebselen. Biochem. J. 319, 13-15.
32. Brumell, J. H., Burkhardt, A. L., Bolen, J. B., and Grinstein, S. (1996). Endogenous reactive oxygen intermediates activate tyrosine kinases in human neutrophils. J. Biol. Chem. 271, 1455-1461.
33. Brune, B., and Lapetina, E. G. (1995). Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase as a target for nitric oxide signaling. Genet. Eng. N. Y. 17, 149-164.
34. Brunori, M., and Rotilio, G. (1984). Biochemistry of oxygen radical species. Methods Enzytnol. 105, 22-29.
35. Burdon, R. H., Alliangana, D., and Gill, V. (1995). Hydrogen peroxide and the proliferation of BHK-21 cells. Free Rad. Res. 23, 471-486.
36. Burdon, R. H., Gill, V., and Alliangana, D. (1996). Hydrogen peroxide in relation to proliferation and apoptosis in BHK-21 hamster fibroblasts. Free Rad. Res. 24, 81-93.
37. Burke, T. M., and Wolin, M. S. (1987). Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation. Am. J. Physiol. 252, H4721-H4732.
38. Burton, G. W., Cheeseman, K. H., Doba, T., Ingold, K. U., and Slatler, T. F. (1983). Vitamin E as an antioxidant in vitro and in vivo. Giba Found. Symp. 101, 4-14.
39. Buvet, R. (1982). Energetics of the chemical coupling between ATP production and oxygen reduction comparison with electrochemical date. Bioelectrochem. Bloenerget. 9, 299-305.
40. Buvet R., and Le Port, L. (1984). Chemical coupling between oxygen reduction and ATP production. Bioelectrochem. Bioenerget. 12, 167-172.
41. Cadet, J., and Berger, M. (1985). Radiation-induced decomposition of the purine bases within DNA and related model compounds. Int. J. Radiat. Biol. 47, 127-143.
42. Cadet, J., Ancelmino, C., Douki, T., and Voituriez, L. (1992). Photochemistry of nucleic acids in cells. J. Photochem. Photobiol. B 15, 277-298.
43. Calvayrac, R., Laval-Martin, D., Hubert, M., Best-Belpomme, M., and Vuillaume, M. (1985). ATP-production and catalytic-type activities in etiolated or green Euglena gracilis. Comp. Biochem. Physiol. B 81,1009-1017.
44. Campbell, D. L., Stamler, J. S., and Strauss, H. C. (1996). Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and Snitrosothiols. J. Gen. Physiol. 108, 277-293.
45. Carlin, G., and Djursater, R. (1988). Peroxidation of phospholipids promoted by myeloperoxidase. Free Rad. Res. Commun. 4, 251-257.
46. Carson, D. A., Seto, S., and Wasson, B. (1986). Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency. J. Exp. Med. 163, 746-751.
47. 2+- and reduced nicotinamide adenine dinucleotide phosphate-dependent hydrogen peroxide generating system is induced by thyrotropin in porcine thyroid cells. Endocrinology 137, 1007-1012.
48. Cerutti, P. A. (1985). Prooxidant states and tumor promotion. Science 227, 375-381.
49. Chance, B., Sies, H., and Boveris, A. (1979). Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59, 527-605.
50. Chandra, S., Martin, G. B., and Low, P. S. (1996). The Pto kinase mediates a signalling pathway leading to the oxidative burst in tomato. Proc. Natl. Acad. Sei. USA 93,13393-13397.
51. 558. Biochem. J. 306, 141-145.
52. 4. Regulation of superoxidation and mitogenesis. J. Biol. Chem. 272, 9854-9859.
53. Christman, M. F., Storz, G., and Ames, B. N. (1989). OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. Proc. Natl. Acad. Sei. USA 86, 3484-3488.
54. Christman, M. F., Morgan, R. W., Jacobson, F. S., and Ames, B. N. (1995). Positive control of a regulon for defences against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Cell 41, 753-762.
55. Colton, C. A., and Chernyshev, O. N. (1996). Inhibition of microglial Superoxide anion production by isoproterenol and dexamethasone. Neurochetn. Int. 29, 43-53.
56. Crane, F. L., Sun, I. L., Clark, M. G., Grebing, C., and Low, H. (1985). Transport membrane redox systems in growth and development. Biochim. Biophys. Ada 811, 233-264.
57. Cross, A. R., and Jones, O. T. G. (1991). Enzymic mechanisms of Superoxide production. Biochim. Biohys. Acta 1057, 281-298.
58. 2 sensor protein in the rat carotid body. Biochem. J. 272, 743-747.
59. Cui, X. L., and Douglas, J. G. (1997). Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells. Proc. Natl. Acad. Sei. USA 94, 3771-3776.
60. Dai, J., Meij, J. T., Dhalla, V., and Panagia, V. (1995). Involvement of thiol groups in the impairment of cardiac sarcoplasmic reticular phospholipase D activity by oxidants. J. Lipid Mediat. Cell Signal. 11, 107-118.
61. Dana, R., Leto, T. L., Malech, H. L., and Levy, R. (1998). Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. J. Biol. Chem. 273, 441-445.
62. Darden, A. G., Ries, W. L., Wolf, W. C, Rodriguiz, R. M., and Key, L. L., Jr. (1996). Osteoclastic Superoxide production and bone resorption: Stimulation and inhibition by modulators of NADPH oxidase. J. Bone Mineral Res. 11, 671-675.
63. Davies, K. J. A., and Goldberg, A. L. (1987). Oxygen radicals stimulate intracellular proteolysis and peroxidation by independent mechanisms in erythrocytes.7. Biol. Chem. 262,8220-8226.
64. phox-based NADH oxidase in vascular smooth muscle. Biochem. J. 329, 653-657.
65. De Lamirande, E., and Gagnon, C. (1993). Human sperm hyperactivation and capacitation as parts of an oxidative process. Free Rad. Biol. Med. 14, 157-166.
66. Delgado, W., and Calderon, R. (1979). Acatalasia in two Peruvian siblings. J. Oral Pathol. 6, 358-368.
67. Del Rio, L. A., Sandalio, L. M., and Palma, J. M. (1990). A new cellular function for peroxisomes related to oxygen free radicals? Experientia 46, 989-992.
68. 2 generator in thyroid plasma membrane: Inhibition by diphenyleneiodonium. Biochem. J. 301, 75-81.
69. Demple, B. (1991). Regulation of bacterial oxidative stress genes. Anna. Rev. Genet. 25, 315-337.
70. Demple, B. (1996). Redox signaling and gene control in the Escherichia colisoxRS oxidative stress regulon - A review. Gene 179, 53-57.
71. + channels. J. Neurosci. 17, 4942-4955.
72. Ding, H., and Demple, B. (1997). In vivo kinetics of a redox-regulated transcriptional switch. Proc. Nail. Acad. Sei. USA 94, 8445-8449.
73. Ding, Z., Li, S., and Wu, Z. (1992). Platelet-activating factor mediates hydrogen peroxide induced endothelial-leukocyte adhesion. J. Med. Coll. 7, 236-241.
74. Doha, T., Burton, G. W., and Ingold, K. M. (1985). Antioxidant and coantioxidant activity of vitamin C. The effect of vitamin C either alone or in the presence of vitamin E or a water soluble vitamin E analog, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim. Biophys. Acta 835, 298-303.
75. Doke, N. (1983). Involvement of Superoxide anion generation in the hypersensitive response of potato tuber tissues to infection with an incompatible race of Pliytophtliora infestons and to the hyphal wall components. Pliysiol. Plant Pathol. 23, 359-367.
76. Dupuy, C, Virion, A., Ohayon, R., Kaniewski, J., Deme, D., and Pommier, J. (1991). Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane. J. Biol. Client. 266, 3739-3743.
77. Dusi, S., Delia Bianca, V., Donini, M., Nadalini, K. A., and Rossi, F. (1996). Mechanisms of stimulation of the respiratory burst by TNF in nonadherent neutrophils: Its independence of lipidic transmembrane signaling and dependence on protein tyrosine phosphorylation and cytoskeleton. J. linnmnol. 157, 4615-4623.
78. Dwyer, S. C, Legendre, L., Low, P. S., and Leto, T. L. (1996). Plant and human neutrophil oxidative burst complexes contain immunologically related proteins. Biochim. Biophys. Acta 1289, 231-237.
79. Ellerby, L. M., Ellerby, H. M., Park, S. M., Holleran, A. L., Murphy, A. N., Fiskum, G., Kane, D. J., Testa, M. P., Kayalar, C, and Bredesen, D. E. (1996). Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J. Neurochem. 67, 1259-1267.
80. Elliott, S. J., Meszaros, J. G., and Schilling, W. P. (1992). Effect of oxidant stress on calcium signaling in vascular endothelial cells. Free Rad. Biol. Med. 13, 635-650.
81. Emmendorffer, A., Roesler, J., Eisner, J., Raeder, E., Lohmann Matthes, M. L., and Meier, B. (1993). Production of oxygen radicals by fibroblasts and neutrophils from a patient with x-linked chronic granulomatous disease. Eur. J. Haematol. 51, 223-227.
82. English, D. (1996). Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signalling. Cell. Signal. 8, 341-347.
83. Fenton, H. J. H., and Jackson, H. (1899). The oxidation of polyhydric alcohols in the presence of iron. J. Citent. Soc. Trans. 75, 1-11.
84. Ferrari, D., Wesselborg, S., Bauer, M. K. A., and Schulze-Osthoff, K. (1997). Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65. J. Cell. Biol. 139,1635-1643.
85. Fialkow, L., Chan, C. K., Grinstein, S., and Downey, G. P. (1993). Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen intermediates. J. Biol. Client. 268, 17131-17137.
86. Fridovich, I. (1975). Superoxide dismutases. Aniiu. Rev. Biochem. 44, 147-159.
87. Fridovich, I. (1986). Biological effects of the Superoxide radical. Arch. Biochem. Biophys. 247, 1-11.
88. Fujitani, Y., Kasai, K., Ohtani, S., Nishimura, K., Yamada, M., and Utsumi, K. (1997). Effect of oxygen concentration and free radicals on in vitro development of in vitro-produced bovine embryos. J. Anim. Sei. 75, 483-489.
89. Fukuishi, N., Sakaguchi, M., Matsuura, S., Nakagawa, C., Akagi, R., and Akagi, M. (1997). The mechanisms of compound 48/80-induced Superoxide generation mediated by A-kinase in rat peritoneal mast cells. Biochein. Mol. A/erf. 61, 107-113.
90. Furth, J. J., Alien, R. G., Tresini, M., Keogh, B. P., and Cristofalo, V. J. (1997). Abundance of alfa 1(1) and alfa l(III) procollagen and p21 mRNAs in fibroblasts cultured from fetal and postnatal dermis. Mccli. Ageing Dev. 97,131-142.
91. Gaboury, J. P., Anderson, D. C., and Kubes, P. (1994). Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo. Am. J. Physiol. 266, H637-H642.
92. Gamaley, I. A., Kaulin, A. B., and Kirpichnikova, K. M. (1991). Changes in membrane potential, cytoplasmic Ca2t, and fluorescein anion transport across the plasma membrane of macrophages under low concentrations of O2~ and H2O2- Tsitologia (Russian) 33,79-85.
93. Gamaley, I. A., Kirpichnikova, K. M., and Klyubin, I. V. (1994). Activation of murine macrophages by hydrogen peroxide. Cell. Signal. 6, 949-957.
94. Gamaley, I. A., Kirpichnikova, K. M., and Klyubin, I. V. (1998). Superoxide release is involved in membrane potential changes in mouse peritoneal macrophages. Free Rad. Biol. Med. 24, 168-174.
95. Gamberini, M., and Leite, L. C. (1997). Proliferation of mouse fibroblasts induced by 1,2-dimethylhydrazine auto-oxidation: Role of iron and free radicals. Biochein. Biophys. Res. Commun. 234, 44-47.
96. Gardner, P. R., and Fridovich, I. (1991). Superoxide sensitivity of the Eschericliia coli 6-phosphogluconate dehydratase. J. Biol. Cliem. 266, 1478-1483.
97. Gardner, P. R., and Fridovich, I. (1992). Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of Superoxide radical. J. Biol. Cliem. 267, 8757-8763.
98. 2 modification of (Na,K)-ATPase. J. Biol. Cliem. 259, 7712-7718.
99. Gaudu, P., and Weiss, B. (1996). SoxR a [2Fe-2S] transcription factor, is active only in its oxidized form. Proc. Natl. Acad. Sei. USA 93, 10094-10098.
100. Gaudu, P., Moon, N., and Weiss, B. (1997). Regulation of the soxRS oxidative stress regulon. Reversible oxidation of the Fe-S centers of soxR in vivo. J. Biol. Client. 272, 5082-5086.
101. Giulivi, C., and Davies, K. J. A. (1990). A novel antioxidant role for hemoglobin. The comproportionation of ferrilhemoglobin with oxy hemoglobin. J. Biol. Cliem. 265, 19453-19460.
102. Goldman, R., and Zor, U. (1994). Activation of macrophage Ptdlns-PLC by phorbol ester and vanadate: Involvement of reactive oxygen species and tyrosine phosphorylation. Biochem. Biophys. Res. Commun. 199, 334-338.
103. 2- FEES Lett. 309, 190-192.
104. Goldman, R., Moshonov, S., and Zor, U. (1998). Generation of reactive oxygen species in a human keratinocyte cell line: Role of calcium. Arch. Biochein. Biophys. 350, 10-18.
105. Gong, K. W., Zhu, G. Y., Wang, L. H., and Tang, C. S. (1996). Effect of active oxygen species on intimai proliferation in rat aorta after arterial injury. J. Vase. Res. 33, 42-46.
106. Gonzalezrubio, M., Voit, S., Rodriguezpuyol, D., Weber, M., and Marx, M. (1996). Oxidative stress induces tyrosine phosphorylation of pdgf alpha-receptors and beta-receptors and pp60(c-src) in mesangial cells. Kidney Int. 50, 164-173.
107. 6 reductase. Relationship with the NADPH-dependent H2O2-generating system. Eur. J. Biochein. 240, 807-814.
108. 2+: Studies with phenylarsine oxide in thyroid plasma membrane. Biochein. J. 321, 383-388.
109. Green, M. J., and Hill, H. A. O. (1984). Chemistry of dioxygen. Methods Enzymol. 105,3-22.
110. Greiber, S., Munzel, T., Kastner, S., Muller, B., Schollmeyer, P., and Pavenstadt, H. (1998). NAD(P)H oxidase activity in cultured human podocytes: Effects of adenosine triphosphate. Kidney Int. 53, 654-663.
111. Gus'kova, R. A., Ivanov, I. L, Koltover, V. K., Akhobadze, V. V., and Rubin, A. B. (1984). Permeability of bilayer lipid membranes for Superoxide (C2~) radicals. Biochim. Biophys. Acta 778, 579-585.
112. Gutteridge, J. M. (1994). Biological origin of free radicals, and mechanisms of antioxidant protection. Chem. Biol. Interact. 91, 133-140.
113. Haber, F., and Weiss, J. (1934). The catalytic decomposition of hydrogen peroxide by iron salts. Proc. R. Soc. London A 147, 332-351.
114. +) pump current: Role of protein and nonprotein sulfhydryl redox status. Am. J. Physiol. 269, H297-H307.
115. Hainaut, P., and Milner, J. (1993). Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. Cancer Res. 53, 4469-4473.
116. Halliwell, B., and Gutterrige, J. M. C. (1984). Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219,1-4.
117. Hamblin, M. R., and Newman, E. L. (1994). On the mechanism of the tumor-localising effect in photodynamic therapy. J. Photochem. Photobiol. 23, 3-8.
118. Hancock, J. T., Maly, F. E., and Jones, O. T. (1989). Properties of the superoxide-generating oxidase of B-lymphocyte cell lines. Determination of Michaelis parameters. Biochem. J. 262, 373-375.
119. Hanciick, J. T., Henderson, L. M., and Jones, O. T. (1990). Superoxide generation by EBV-transformed B lymphocytes. Activation by IL-1 beta, TNF-alpha and receptor independent stimuli. Immunology 71, 213-217.
120. Harman, D. (1982). The free-radical theory of aging. In "Free Radicals in Biology" (W. A. Pryor, ed.), Vol. 5, pp. 255-271. Academic, New York.
121. Hassan, N. M., and Fridovich, I. (1979). Paraquat and Esherichia coli. Mechanisrti of production of extracellular Superoxide radical. J. Biol. Chem. 254,10846-10852.
122. 2-induced filamin redistribution in endothelial cells. J. Cell. Biochem. 68, 511-524.
123. Hausladen, A., Privalle, C. T., Keng, T., DeAngelo, J., and Stamler, J. S. (1996). Nitrosative stress: Activation of the transcription factor oxyR. Cell 86, 719-729.
124. Hayashi, T., Ueno, Y., and Okamoto, T. (1993). Oxidoreductive regulation of nuclear factor kB. Involvement of a cellular reducing catalyst thioredoxin. J. Biol. Chem. 268,11380-11388.
125. 2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells. Biochem. J. 288, 631-635.
126. Henderson, B. W., and Dougherty, T. J. (1992). How does photodynamic therapy work? Photochem. Photobiol. 53, 145-157.
127. Henderson, L. M., and Chappell, J. B. (1996). NADPH oxidase of neutrophils. Biochim. Biophys. Acta 1273, 87-107.
128. Hentze, M. W., Rouault, T. A., Harford, J. B., and Klausner, R. D. (1989). Oxidationreduction and the molecular mechanism of a regulatory RNA-protein interaction. Science 244, 357-359.
129. 2 for vascular smooth muscle cells is mediated by an increase of the affinity of basic fibroblast growth factor for its receptor. FEBS Lett. 395, 43-47.
130. Hinshaw, D. B., Sklar, L. A., Bohl, B., Schraufstatter, I. U, Hyslop, P. A., Rossi, M. W., Spragg, R. G., and Cochrane, C. G. (1986). Cytoskeletal and morphological impact of cellular oxidant injury. Am. J. Palhol 123, 454-464.
131. Hiran, T. S., Moulton, P. J., and Hancock, J. T. (1997). Detection of Superoxide and NADPH oxidase in porcine articular chondrocytes. Free Rad. Biol. Med. 23, 736-743.
132. Hirota, K., Matsui, M., Iwata, S., Nishiyama, A., Mori, K., and Yodoi, J. (1997). AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl. Acad. Sei. USA 94, 3633-3638.
133. Hishikawa, K., Oemar, B. S., Yang, Z., and Luscher, T. F. (1997). Pulsatile stretch stimulates Superoxide production and activates nuclear factor-kappa B in human coronary smooth muscle. Circ. Res. 81, 797-803.
134. Holmgren, A. (1985). Thioredoxin. Annu. Rev. Biochem. 54, 237-271.
135. Holmgren, A. (1989). Thioredoxin and glutaredoxin systems. J. Biol. Cliem. 264,13963-13966.
136. Homandberg, G. A., Hui, F., and Wen, C. (1996). Fibronectin fragment mediated cartilage chondrolysis. I. Suppression by anti-oxidants. Biochim. Biophys. Ada 1317, 134-142.
137. Hsieh, H. J., Cheng, C. C, Wu, S. T., Chiu, J. J., Wung, B. S., and Wang, D. L. (1998). Increase of reactive oxygen species (ROS) in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression. J. Cell Physiol. 175,156-162.
138. Huang, L. E., Zhang, H., Bae, S. W., and Liu, A. Y. (1994). Thiol reducing reagents inhibit the heat shock response. Involvement of a redox mechanism in the heat shock signal transduction pathway. J. Biol. Chem. 269, 30718-30725.
139. Huie, R. E., and Padmaja, S. (1993). The reaction of NO with Superoxide. Free Rad. Res. Commun. 18, 195-199.
140. Hwang, C., Sinskey, A. J., and Lodish, H. F. (1992). Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257, 1496-1502.
141. liyama, K., Lam, T., and Stone, B. A. (1994). Covalent cross-links in the cell wall. Plant Physiol. 104, 315-320.
142. Ikebuchi, Y., Masumoto, N., Tasaka, K., Koike, K., Kasahara, K., Miyake, A., and Tanizawa, O. (1991). Superoxide anion increases intracellular pH, intracellular free calcium, and arachidonate release in human amnion cells. J. Biol. Cliem. 266, 13233-13237.
143. Ikeda, H., Koga, Y., Oda, T., Kuwano, K., Nakayama, H., Ueno, T., Toshima, H., Michael, L. H., and Entman, M. L. (1994). Free oxygen radicals contribute to platelet aggregation and cyclic flow variations in stenosed and endothelium-injured canine coronary arteries. J. Am. Coll. Cardiol. 24,1749-1756.
144. Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., and Goldschmidt-Clermont, P. J. (1997). Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275, 1649-1652.
145. 2+-dependent protein tyrosine kinase. J. Neiirochem. 69, 729-736.
146. Iwata, S., Hori, T., Sato, N., Hirota, K., Sasada, T., Mitsui, A., Hirakawa, T., and Yodoi, J. (1997). Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: Possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state. J. Immitnol. 158, 3108-3117.
147. Jabs, T., Tschope, M., Colling, C, Hahlbrock, K., and Scheel, D. (1997). Elicitor-stimulated ion fluxes and Oa" from the oxidative burst are essential components in triggering defense gene activation and phytoalexin synthesis in parsley. Proc. Natl. Acad. Sei. USA 94,4800-4805.
148. Jabr, R. L, and Cole, W. C. (1995). Oxygen-derived free radical stress activates nonselective cation current in guinea pig ventricular myocytes. Role of sulfhydryl groups. Circ. Res. 76, 812-824.
149. Jaeschke, H. (1991a). Reactive oxygen and ischemia/reperfusion injury of the liver. Chem. Biol. Interact. 79,115-136.
150. Jaeschke, H. (1991b). Vasicular oxidant stress and hepatic ischemia/reperfusion injury. Free Rad. Res. Commun. 12-13, 737-743.
151. Jakobek, J. L., and Lindgren, P. B. (1993). Generalized induction of defense responses in bean is not correlated with the induction of the hypersensitive reactions. Plant Cell 5,49-56.
152. Janolino, V. G., and Swaisgood, H. E. (1987). Sulfhydryl oxidase-catalyzed formation of disulfide bonds in reduced ribonuclease. Arch. Biochem. Biophys. 258, 265-271.
153. Jones, O. T. G. (1994). The regulation of Superoxide production by the NADPH oxidase of neutrophils and other mammalian cells. BioEssays 16, 919-923.
154. Jones, S. A., Wood, J. D., Coffey, M. J., and Jones, O. T. (1994). The functional expression of p47-p/;o.r and p67-phox may contribute to the generation of Superoxide by an NADPH oxidase-like system in human fibroblasts. FEES Lett. 355, 178-182.
155. Jones, S. A., Hancock, J. T., Jones, O. T., Neubauer, A., and Topley, N. (1995). The expression of NADPH oxidase components in human glomerular mesangial cells: Detection of protein and mRNA for p47phox, p67phox, and p22phox. J. Am. Soc. Nephrol. 5, 1483-1491.
156. Jones, S. A., O'Donnell, V. B., Wood, J. D., Broughton, J. P., Hughes, E. J., and Jones, O. T. (1996). Expression of phagocyte NADPH oxidase components in human endothelial cells. Am. J. Physiol. 271, H1626-H1634.
157. Jori, G., Moan, J., and Star, W. M. (1993). Responses of tumour tissues to photodynamic therapy. Proc. Pholodyn. Ther. Cancer 2078, 286-291.
158. Jung, R., Nam, Y.-W., Saalbaoh, L, Müuntz, K., and Nielsen, N. C. (1997). Role of the sulfhydryl redox state and disulfide bonds in processing and assembly of US seeds globulins. Plant Cell 9, 2037-2050.
159. Junod, A. F. (1987). Effects of oxygen intermediates on cellular functions. Am. Rev. Respir. Dis. 135, S32-S34.
160. 2+-pump activity by oxygen free radicals. Am. J. Physiol. 256, H368-H374.
161. Kaneko, M., Chapman, D. C, Ganguly, P. K., Beamish, R. E., and Dhalla, N. S. (1991). Modification of cardiac adrenergic receptors by oxygen free radicals. Am. J. Physiol. 260, H821-H826.
162. Kaul, N., and Forman, H. J. (1996). Activation of NF-kappa-b by the respiratory burst of macrophages. Free Rad. Biol. Med. 21, 401-405.
163. Keller, T., Damude, H. G., Werner, D., Doerner, P., Dixon, R., and Lamb, C. (1998). A plant homolog of neutrophil NADPH oxidase gp91p/io.r subunit gene encodes a plasma membrane protein with Ca2t binding motifs. Plant Cell 10, 255-266.
164. Kellogg, E. W., and Fridovich, I. (1977). Liposome oxidation and erythrocyte lysis by enzymically generated Superoxide and hydrogen peroxide. J. Biol. Cliem. 252, 6721-6728.
165. Keogh, B. P., Alien, R. G., Pignolo, R. J., Horton, J., Tresini, M., and Cristofalo, V. J. (1996a). Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages. J. Cell. Physiol. 167, 512-522.
166. Keogh, B. P., Tresini, M., Cristofalo, V. J., and Alien, R. G. (1996b). Effects of cellular aging on the induction of c-fos by antioxidant treatments. Mech. Ageing Dev. 86, 151-160.
167. Klegeris, A., and McGeer, P. L. (1994). Rat brain microglia and peritoneal macrophages show similar responses to respiratory burst stimulants. J. Neuroimmunol. 53, 83-90.
168. Klessig, D. F., and Malamy, J. (1994). The salicylic acid signal in plants. Plant Mol. Biol. 26,1439-1458.
169. 2. FEBS Lett. 407, 230-234.
170. Klyubin, I. V., Kirpichnikova, K. M., and Gamaley, I. A. (1996). Hydrogen peroxide-induced chemotaxis of mouse peritoneal neutrophils. Eur. J. Cell Biol. 70, 347-351.
171. 558 in B-cell lineage of human lymphocytes. Blood 75, 458-461.
172. Koivu, J., and Myllylä, R. (1987). Interchain disulfide bond formation in types I and II protocollagen. Evidence for a protein disulfide isomerase catalyzing long formation.J. Dial. Chem. 262, 6159-6164.
173. 2. Proc. Natl. Acad. Sei. USA 94, 11233-11237.
174. Kono, Y., and Fridovich, I. (1982). Superoxide radical inhibits catalase. J. Biol. Cliem. 257, 5751-5754.
175. Koshida, H., and Kotake, Y. (1994). Nitric oxide does not contribute to superoxide-mediated sulfhydryl oxidation in human polymorphonuclear leukocytes. Life Sei. 55, 463-470.
176. 2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase. J. Clin. Invest. 89, 1006-1013.
177. 2 generation
178. 2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines. Biochem. J. 307, 543-548.
179. 2 generation in human adipocyte plasma membranes is mediated by Galphai2. J. Biol. Cliem. 272, 10135-10143.
180. 2 induced hyperpolarization of pancreatic B-cells. Pflugers Arch. 426, 552-554.
181. Kummer, W., and Acker, H. (1995). Immunohistochemical demonstration of four subunits of neutrophil N AD(P)H oxidase in type I cells of carotid body. J. Appl. Physiol. 78,1904-1909.
182. Kuo, C. F., Mashino, T., and Fridovich, I. (1987). α,β-Dihidroxyisovalerate dehydratase. A Superoxide-sensitive enzyme. J. Biol. Cliem. 262, 4724-4727.
183. Kuo, S. S., Saad, A. H., Koong, A. C., Hahn, G. M., and Giaccia, A. J. (1993). Potassiumchannel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells. Proc. Natl. Acad. Sei. USA 90, 908-912.
184. Lander, H. M., Sehajpal, P. K., and Novogrodsky, A. (1993). Nitric oxide signaling: A possible role for G proteins. J. Immunol. 151, 7182-7187.
185. Leusen, J. H. W., Verhoeven, A. J., and Roos, D. (1996). Interactions between the components of the human NADPH oxidase: A review about the intrigues in the phox family. Front. Biosci. 1, d72-d90.
186. Levine, A., Tenhaken, R., Dixon, R., and Lamb, C. (1994). H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response. Cell 79, 583-593.
187. Levine, R. L., Mosoni, L., Berlett, B. S., and Stadtman, E. R. (1996). Methionine residues as endogenous antioxidants in proteins. Proc. Natl. Acad. Sei. USA 93, 15036-15040.
188. Li, P. F., Dietz, R., and Harsdorf, R. (1997). Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells. Circulation 96, 3602-3609.
189. Lippman, R. D. (1982). A new method that investigates Superoxide versus respiration in vitro using bioluminescence and Sepharose-bound adenosine derivatives. J. Biochem. Biophys. Methods 6, 81-87.
190. Liu, G., and Pessah, I. N. (1994). Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydryls. J. Biol. Chem. 269, 33028-33034.
191. Liu, H., Lightfoot, R., and Stevens, J. L. (1996). Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols. J. Biol. Chem. 271, 4805-4812.
192. Liu, S. M., and Sundqvist, T. (1995). Effects of hydrogen peroxide and phorbol myristate acetate on endothelial transport and F-actin distribution. Exp. Cell Res. 217, 1-7.
193. Lo, Y. Y., and Cruz, T. F. (1995). Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes.J. Biol. Chem. 270,11727-11730.
194. Lo, Y. Y., Conquer, J. A., Grinstein, S., and Cruz, T. F. (1998). Interleukin-1β induction of c-fos and collagenase expression in articular chondrocytes: Involvement of reactive oxygen species. J. Cell. Biochem. 69,19-29.
195. Lopez-Barneo, J., Benot, A. R., and Urena, J. (1993). Oxygen sensing and the electrophysiology of arterial chemoreceptor cells. NIPS 8, 191-195.
196. Los, M., Droge, W., Stricker, K., Baeuerle, P. A., and Schulze-Osthoff, K. (1995). Hydrogen peroxide as a potent activator of T lymphocyte functions. Eur. J. Immunol. 25, 159-165.
197. Low, P. S., and Merida, J. R. (1996). The oxidative burst in plant defense-Function and signal transduction. Physiol. Plant. 96, 533-542. [Review]
198. 2 is inhibited by L-NAME and removal of extracellular calcium. J. Physiol. 475,65P-66P.
199. Mailer, K. (1990). Superoxide radical as electron donor for oxidative phosphorylation of ADP. Biochem. Biophys. Res. Commun. 170, 59-64.
200. Makino, N., Mochizuki, Y., Bannai, S., and Sugita, Y. (1994). Kinetic studies on the removal of extracellular hydrogen peroxide by cultured fibroblasts. J. Biol. Chem. 269, 1020-1025.
201. Maly, F. E., Quilliam, L. A., Dorseuil, O., Der, C. J., and Bokoch, G. M. (1994). Activated or dominant inhibitory mutants of RaplA decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes. J. Biol. Chem. 269, 18743-18746.
202. Maresca, M., Colao, C., and Leoncini, G. (1992). Generation of hydrogen peroxide in resting and activated platelets. Cell. Biochem. Fund. 10, 79-85.
203. Marini, M., Frabetti, F., Musiani, D., and Franceschi, C. (1996). Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytes. Int. J. Rad. Biol. 70, 337-350.
204. Marshall, C., Mamary, A. J., Verhoeven, A. J., and Marshall, B. E. (1996). Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. Am. J. Respir. Cell Mol. Biol. 15, 633-644.
205. Marumo, T., Schini-Kerth, V. B., Fisslthaler, B., and Busse, R. (1997). Platelet-derived growth factor-stimulated Superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells. Circulation 96, 2361-2367.
206. Mathai, J. C., and Sitaramam, V. (1994). Stretch sensitivity of transmembrane mobility of hydrogen peroxide through voids in the bilayer. Role of cardiolipin. J. Biol. Chem. 269, 17784-17793.
207. Mathews, J. R., Wakasugi, N., Virelizier, J.-L., Yodoi, J., and Hay, R. T. (1991). Thioredoxin regulates the DNA binding activity of NF-kB by reduction of a disulflde bond involving cysteine 62. Nucleic Acids Res. 20, 3821-3830.
208. McCord, J. M. (1990). Is Superoxide dismutase a stress protein? In "Stress Proteins in Inflammation" (R. Burbon, C. Rice-Evans, D. Blake, and V. Winrow, eds.), pp. 125-134. Richelien, London.
209. McCord, J. M., and Russell, W. J. (1988). Superoxide inactivates creatine phosphokinase during reperfusion of ischemie heart. In "Oxy-radicals in Molecular Biology and Pathology" (P. A. Cerutti, I. Fridovitch, and J. M. McCord, eds.), pp. 27-35. A. R. Liss, New York.
210. McDuffee, A. T., Senisterra, G., Huntley, S., Lepock, J. R., Sekhar, K. R., Meredith, M. L., Borrelli, M. J., Morrow, J. D., and Freeman, M. L. (1997). Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response. J. Cell. Physiol. 171, 143-151.
211. Meier, B., Cross, A. R., Hancock, J. T., Kaup, F. J., and Jones, O. T. (1991). Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. Biochem. J. 275, 241-245.
212. 558 molecules involved in the fibroblast and polymorphonuclear leucocyte superoxide-generating NADPH oxidase systems are structurally and genetically distinct. Biochem. J. 289, 481-486.
213. Meister, A. (1983). Selective modification of glutathione metabolism. Science 220, 472-477.
214. Meister, A., and Anderson, M. E. (1983). Glutathione. Annu. Rev. Biochem. 79, 711-760.
215. Metodiewa, D., and Dunford, H. B. (1989). The reactions of horseradish peroxidase, lactoperoxidase, and myeloperoxidase with enzymatically generated Superoxide. Arch. Biochem. Biophys. 272, 245-253.
216. Michaelis, M. L., Bigelow, D. J., Schoneich, G, Williams, T. D., Ramonda, L., Yin, D., Huhmer, A. F. R., Yao, Y., Gao, J., and Squier, T. G (1996). Decreased plasma membrane calcium transport activity in aging brain. Life Sei. 59, 405-412.
217. Miles, A. M., Bohle, D. S., Glassbrenner, P. A., Hansert, B., Wink, D. A., and Grisham, M. B. (1996). Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide. J. Biol. Chein. 271, 40-47.
218. Moan, J., and Berg, K. (1991). The photodegradation of porphyrines in cells can be used to estimate the lifetime of singlet oxygen. Photochem. Photobiol. S3, 549-553.
219. 2 sensor. Am. J. Physiol. 267, L823-L831.
220. 2 modulate Superoxide anion production in bovine cardiac myocytes: Potential role of NADH oxidase. Circulation 96, 614-620.
221. 2 mechanisms of guanylate cyclase activation in oxygen-dependent responses of rat pulmonary circulation. Am. J. Physiol. 268, L546-L550.
222. Morel, F., Doussiere, J., and Vignais, P. V. (1991). The superoxide-generating oxidase of phagocytic cells. Physiological, molecular and pathological aspects. Eur. J. Biochem. 201, 523-546.
223. Moriguchi, T., Seres, T., Ravichandran, V., Sasada, M., and Johnston, R. B., Jr. (1996). Diamide primes neutrophils for enhanced release of Superoxide anion: Relationship to S-thiolation of cellular proteins. J. Leukocyte Biol. 60, 191-198.
224. Morikawa, K., and Morikawa, S. (1996). Immunomodulatory effect of recombinant human Superoxide dismutase (SOD) on human B lymphocyte function in vitro. Cell. Immunol. 172, 70-76.
225. phox subunit. Biochem. J. 329, 449-451.
226. Murphy, H. S., Shayman, J. A., Till, G. O., Mahrougui, M., Owens, G B., Ryan, U. S., and Ward, P. A. (1992). Superoxide responses of endothelial cells to C5a and TNF-alpha: Divergent signal transduction pathways. Am. J. Physiol. 263, L151-L59.
227. Myrset, A. H., Bostad, A., Jamin, N., Lirsac, P. N., Toma, F., and Gabrielsen, O. S. (1993). DNA and redox state induced conformational changes in the DNA-binding domain of the Myb oncoprotein. EMBO J. 12, 4625-4633.
228. Nakayama, T., Kodama, M., and Nagata, G (1984). Generation of hydrogen peroxide and superoxide anion radical from cigarette smoke. Cann 75, 95-98.
229. Natarajan, V., Taher, M. M., Roehm, B., Parinandi, N. L., Schmid, H. H., Kiss, Z., and Garcia, J. G. (1993). Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide. J. Biol. Chem. 268, 930-937.
230. Nathan, C. F., Silverstein, S. O., Brukner, L. H., and Cohn, Z. A. (1979). Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.J. Exp. Med. 149, 100-113.
231. 2+ and the stimulation of non-lyposomal proteolic system. J. Biol. Client. 261, 14628-14635.
232. 2+ is mediated by the activation of non-lyposomal proteolic system. FEBS Lett. 209,139-144.
233. Nishio, E., and Watanabe, Y. (1997). The involvement of reactive oxygen species and arachidonic acid in alpha 1-adrenoceptor-induced smooth muscle cell proliferation and migration. Br. J. Pharmacol. 121, 665-670.
234. Nose, K., and Ohba, M. (1996). Functional activation of the egr-1 (early growth response-1) gene by hydrogen peroxide. Biochem. J. 316, 381-383.
235. Oberley, L. W., and Oberley, T. D. (1984). The role of Superoxide dismutase and the gene amplification in carcirogenesis. J. Theor. Biol. 106, 403-422.
236. O'Donnell-Tormey, J., DeBoer, C. J., and Nathan, C. F. (1985). Resistance of human tumor in vitro oxidative cytolysis. J. Clin. Invest. 76, 80-86.
237. Ohba, M., Shibanuma, M., Kuroki, T., and Nose, K. (1994). Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J. Cell Biol. 126, 1079-1088.
238. Costing, R. S., van Bree, L., van Iwaarden, J. F., van Golde, L. M. G., and Verhoef, J. (1990). Impairment of phagocytic functions of alveolar macrophages by hydrogen peroxide. Am. J. Physiol. 259, L87-L94.
239. Orrenius, S., McConkey, D. J., and Nicotera, P. (1988). Mechanisms of oxidant-induced damage. In "UCLA Symposium on Molecular Cell Biology New Series," Vol. 82, Oxyradicals in Molecular Biology and Pathology, pp. 327-339. A. R. Liss, New York.
240. Packer, J. E., Slater, T. F., and Willson, R. L. (1979). Direct observation of a free radical interaction between vitamin E and vitamin C. Nature (London) 278, 737-738.
241. Packer, L., Wilt, E. H., and Tritschler, H. J. (1995). Alpha-Iipoic acid as a biological antioxidant. Free Rad. Biol. Med. 19, 227-250.
242. Pan, Z. H., Bahring, R., Grantyn, R,. and Lipton, S. A. (1995). Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells. J. Nettrosci. 15, 1384-1391.
243. 2) control mammalian iron metabolism by different pathways. Mol. Cell Biol. 16, 3781-3788.
244. Paraskeva, E., and Hentze, M. W. (1996). Iron-sulphur clusters as genetic regulatory switches: The bifunctional iron regulatory protein-1. FEBS Lett. 389, 40-43. [Review]
245. Parks, D. A., and Granger, D. N. (1986). Xanthine oxidase: Biochemistry, distribution and physiology. Ada Physiol. Scand. Suppl. 548, 87-99.
246. Peover, M. E., and White, B. S. (1966). Electrolytic reduction of oxygen in aprotic solvents: The Superoxide ion. Electrochim. Acta 11, 1061-1067.
247. Pignatelli, P., Pulcinelli, F. M., Pier, L. L., Gazzaniga, P. P., and Violi, F. (1998). Hydrogen peroxide is involved in collagen-induced platelet activation. Blood 91, 484-490.
248. Pratico, D., luliano, L., Pulcinelli, F. M., Bonavita, M. S., Gazzaniga, P. P., and Violi, F. (1992). Hydrogen peroxide triggers activation of human platelets selectively exposed to nonaggregating concentrations of arachidonic acid and collagen. J. Lab. Clin. Med. 119, 364-370.
249. Pryor, W. A. (1976). The role of free radical reactions in biological systems. In "Free Radicals in Biology" (W. A. Pryor, ed.), Vol. 1, pp. 1-43. Academic Press, New York.
250. Pryor, W. A. (1986). Oxy-radicals and related species: Their formation, lifetimes, and reactions. Annu. Rev. Physiol. 48, 657-667.
251. Radeke, H. H., Cross, A. R., Hancock, J. T., Jones, O. T., Nakamura, M., Kaever, V., and Resch, K. (1991). Functional expression of NADPH oxidase components (alpha- and betasubunits of cytochrome bxa and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells. J. Biol. Chem. 266, 21025-21029.
252. Rainwater, R., Parks, D., Anderson, M. E., Tegtmeyer, P., and Mann, K. (1995). Role of cysteine residues in regulation of p53 function. Mol Cell Biol. 15, 3892-3903.
253. Rao, G. N. (1996). Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases. Oncogene 13, 713-719.
254. Rao, G. N., and Berk, B. C. (1992). Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ. Res. 70, 593-599.
255. 2 in vascular smooth muscle cells. Biochim. Biophys. Acta 1265, 67-72.
256. Rao, G. N., Glasgow, W. C, Eling, T. E., and Runge, M. S. (1996). Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. J. Biol. Cliem. 271, 27760-27764.
257. - uptake by thyrotropin through the cyclic adenosine 3′,5′-monophosphate cascade. Endocrinology 136, 965-973.
258. Ravichandran, V., Seres, T., Moriguchi, T., Thomas, J. A., and Johnston, R. B., Jr. (1994). S-thiolation of glyceraldehyde-3-phosphate dehydrogenase induced by the phagocytosisassociated respiratory burst in blood monocytes. J. Biol. Chem. 269, 25010-25015.
259. 2+ release from liver mitochondria. Specific versus nonspecific pathways. Ann. N. Y. Acad. Sei. 663,262-268.
260. Rowe, G. T., Manson, N. T., Caplan, M., and Hess, M. L. (1983). Hydrogen peroxide and hydroxyl radical mediation of activated leukocyte depresssion of cardiac sarcoplasmic reticulum. Circ. Res. 53, 584-591.
261. Salimath, B. P., and Savitha, G. (1992). Mechanism of inhibition by cyclic AMP of protein kinase C-triggered respiratory burst in Ehrlich ascites tumour cells. Cell. Signal. 4,651-663.
262. Sanchez-Fernandez, R., Fricker, M., Corben, L. B., White, N. S., Sheard, N., Leaver, C. J., Van Montagu, M., Inze, D., and May, M. J. (1997). Cell proliferation and hair tip growth in the Arabidopsis root are under mechanistically different forms of redox control. Proc. Natl. Acad. Sei. USA 94, 2745-2750.
263. Sandau, K., Pfeilschifter, J., and Brune, B. (1997). The balance between nitric oxide and Superoxide determines apoptotic and necrotic death of rat mesangial cells. J. Imimtnol. 158, 4938-4946.
264. Sato, N., Iwata, S., Nakamura, K., Hori, T., Mori, K., and Yodoi, J. (1995). Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis. J. Imimtnol. 154, 3194-3203.
265. Satriano, J., and Schlondorff, D. (1994). Activation and attenuation of transcription factor NF-KB in mouse glomerular mesangial cells in response to tumor necrosis factor-alpha, immunoglobulin G, and adenosine 3' :5'-cyclic monophosphate. Evidence for involvement of reactive oxygen species. J. Clin. Invest. 94, 1629-1636.
266. Satriano, J. A., Shuldiner, M., Hora, K., Xing, Y., Shan, Z., and Schlondorff, D. (1993). Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase. J. Clin. Invest. 92, 1564-1571.
267. Saul, R. L., Gee, P., and Ames, B. N. (1987). Free radicals, DNA damage, and aging. In "Modern Theories of Aging" (H. R. Warner, ed.), pp. 113-129. Raven Press, New York.
268. Sawada, M., Sester, U., and Carlson, J. C. (1992). Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat. J. Cell. Biochem. 48, 296-304.
269. 2+ signals. J. Biol. Chem. 268, 16688-16692.
270. Schmidt, K. N., Amstad, P., Cerutti, P., and Baeuerle, P. A. (1995). The roles of hydrogen peroxide and Superoxide as messengers in the activation of transcription factor NF-kappa B. Chem. Biol. 2, 13-22.
271. Schraufstatter, I. U., Hinshaw, D. B., Hyslop, P. A., Spragg, R. G., and Cochrane, C. G. (1986a). Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphateribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J. Clin. Invest. 77,1312-1320.
272. Schraufstatter, I. U., Hinshaw, D. B., Hyslop, P. A., Spragg, R. G., Sklar, L. A., and Cochrane, C. G. (1986b). Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase. Proc. Nail. Acad. Sei. USA 83, 4908-4912.
273. Schraufstatter, I. U., Hyslop, P. A., Jackson, J., and Cochrane, C. C. (1987). Oxidant injury of cells. Int. J. Tissue React. 9, 317-324.
274. Schreck, R., Rieber, P., and Baeuerle, P. A. (1991). Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EM BO J. 10, 2247-2258.
275. Schubert, J., and Wilmer, J. W. (1991). Does hydrogen peroxide exist "free" in biological systems? Free Rad. Biol. Med. 11, 545-555.
276. Schuppe Koistinen, I., Moldeus, P., Bergman, T., and Cotgreave, I. A. (1994). S-thiolation of human endothelial cell glyceraldehyde-3-phosphate dehydrogenase after hydrogen peroxide treatment. Eur. J. Biochem. 221, 1033-1037.
277. Sen, C. K., and Packer, L. (1996). Antioxidant and redox regulation of gene transcription. FASEB J. 10, 709-720.
278. Sen, C. K., Kolosova, L, Hanninen, O., and Orlov, S. N. (1995). Inward potassium transport systems in skeletal muscle derived cells are highly sensitive to oxidant exposure. Free Rad. Biol. Med. 18, 795-800.
279. Shrimpton, C. N., Glucksman, M. J., Lew, R. A., Tullai, J. W., Margulies, E. H., Roberts, J. L., and Smith, A. I. (1997). Thiol activation of endopeptidase EC 3.4.24.15. A novel mechanism for the regulation of catalytic activity. J. Biol. Chem. 272, 17395-17399.
280. Sies, H. (1997). Oxidative stress: Oxidants and antioxidants. Exp. Physiol. 82, 291-295.
281. Siflinger Birnboim, A., Goligorsky, M. S., Del Vecchio, P. J., and Malik, A. B. (1992). Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability. Lab. Invest. 67, 24-30.
282. Simon, R. H., Scoggin, C. H., and Patterson, D. (1981). Hydrogen peroxide causes the fatal injury to human flbroblasts exposed to oxygen radicals. J. Biol. Chem. 256, 7181-7186.
283. Smith, R. M., and Curnutte, J. T. (1991). Molecular basis of chronic granulomatous disease. Blood 77, 673-686.
284. + channels. Stroke 28, 2290-2294.
285. Soboll, S, Griindel, S., Harris, J., Kolb-Bachofen, V., Sies, H., and Ketterer, B. (1995). The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a nonaqueous technique of liver cell fractionation. Biochem. J. 311, 889-894.
286. Spragg, R. G., Schraufstatter, I. U., Hyslop, P. A., Hinshaw, D. B., and Cochrane, C. G. (1987). Oxidant injury of cultured cells: Biochemical consequences. Prog. Clin. Biol. Res. 236A, 253-258.
287. Steinbeck, M. J., Appel, W. H., Jr., Verhoeven, A. J., and Karnovsky, M. J. (1994). NADPH-oxidase expression and in situ production of Superoxide by osteoclasts actively resorbing bone. J. Cell. Biol. 126, 765-772.
288. Storz, G., Tartaglia, L. A., and Ames, B. N. (1990). Transcriptional regulator of oxidative stress inducible genes: Direct activation by oxidation. Science 248, 189-194.
289. 2 on protein tyrosine phosphatase activity in HER14 cells. Free Rad. Biol. Med. 16, 399-403.
290. Sun, Y. (1990). Free radicals, antioxidant enzymes, and carcinogenesis. Free Rad. Biol. Med. 8, 583-599.
291. Sun, Y., and Oberley, L. W. (1996). Redox regulation of transcriptional activators. Free Rad. Biol. Med. 21, 335-348. [Review].
292. 2 for platelet-derived growth factor signal transduction. Science 270, 296-299.
293. Sundaresan, M., Yu, Z. X., Ferrans, V. J., Sulciner, D. J., Gutkind, J. S., Irani, K., GoldschmidtClermont, P. J., and Finkel, T. (1996). Regulation of reactive-oxygen-species generation in fibroblasts by Racl. Biochem. J. 318, 379-382.
294. Sundqvist, T. (1991). Bovine aortic endoothelial cells release hydrogen peroxide. J. Cell. Physiol. 148, 152-156.
295. Suzuki, M., Asako, H., Kubes, P., Jennings, S., Grisham, M. B., and Granger, D. N. (1991). Neutrophil-derived oxidants promote leukocyte adherence in postcapillary venules. Microvase. Res. 42, 125-138.
296. Suzuki, Y. J., and Ford, G. D. (1994). Mathematical model supporting the Superoxide theory of oxygen toxicity. Free Rad. Biol. Med. 16, 63-72.
297. Suzuki, Y. J., Edmondson, J. D., and Ford, G. D. (1992). Inactivation of rabbit muscle creatine kinase by hydrogen peroxide. Free Rad. Res. Commun. 16,131-136.
298. + channels by reactive oxygen species. Proc. Natl. Acad. Sei. USA 94,11698-11703.
299. Tenhaken, R., Levine, A., Brisson, L. F., Dixon, R. A., and Lamb, C. (1995). Function of the oxidative burst in hypersensitive disease resistance. Proc. Nat!. Acad. Sei. USA 92, 4158-4163.
300. 2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1. J. Biol. Chem. 270, 30334-30338.
301. Thannickal, V. J., Hassoun, P. M., White, A. C, and Fanburg, B. L. (1993). Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1. Am. J. Physiol. 265, L622-L626.
302. Thanos, D., and Maniatis, T. (1995). NF-kB: A lesson in family values. Cell 80, 529-532.
303. Thelen, M., Dewald, B., and Baggiolini, M. (1993). Neutrophil signal transduction and activation of the respiratory burst. Physiol. Rev. 73, 797-821.
304. 2-terminal kinase). Eur. J. Biochem. 244, 587-595.
305. Tsinkalovsky, O. R., and Laerum, O. D. (1994). Flow cytometric measurement of the production of reactive oxygen intermediate in activated rat mast cells. Acta Pathol. Microbiol. Immunol. Scand. 102, 474-480.
306. Turner, C. P., Toye, A. M., and Jones, O. T. (1998). Keratinocyte Superoxide generation. Free Rad. Biol. Med. 24, 401-407.
307. 2 in plasma and mitochondrial membranes of rat cardiomyocytes. Respir. Physiol. 90,351-362.
308. phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J. Biol. Chem. 271, 23317-23321.
309. Vaca, C. E., Wilhelm, J., and Harms-Rihsdahl, M. (1988). Interaction of lipid peroxidation products with DNA. A review. Mutat. Res. Rev. Genet. Toxicol. 195, 137-149.
310. 2. Mol. Cell. Biochem. 129, 57-65.
311. van Wyngaarden, K. E., and Pauwels, E. K. (1995). Hormesis: Are low doses of ionizing radiation harmful or beneficial? Ear. J. Nucl. Med. 22, 481-486.
312. 2-mediated cytotoxicity of rat pulmonary endothelial cells. Changes in adenosine triphosphate and purine products and effects of protective interventions. Lab. Invest. 63, 683-689.
313. Vepa, S., Scribner, W. M., and Natarajan, V. (1997). Activation of protein phosphorylation by oxidants in vascular endothelial cells: Identification of tyrosine phosphorylation ofcaveolin. Free Rad. Biol. Med. 22, 25-35.
314. Vera-Estrella, R., Higgins, V. J., and Blumwald, E. (1994). Plant defense response to fungal pathogens. II. G-protein-mediated changes in host plasma membrane redox reactions. Plant Physiol. 106, 97-102.
315. Vercellotti, G. M., Dobson, M., Schorer, A. E., and Moldow, C. F. (1988). Endothelial cell heterogeneity: Antioxidant profiles determine vulnerability to oxidant injury. Proc. Soc. Exp. Biol. Med. 187, 181-189.
316. Vermeer, C. (1990). γ-Carboxyglutamate-containing proteins and the vitamin K dependent carboxylase. Biochem. J. 266, 625-636.
317. 2+ changes in endothelial cells induced by low doses of reactive oxygen species: Role of hydrogen peroxide. Mol. Cell. Biochem. 171,11-21.
318. Vuillaume, M. (1987). Reduced oxygen species, mutation, induction and cancer initiation. Mutat. Res. 186, 43-72.
319. Vuillaume, M., Calvayrac, R., and Best-Belpomme, M. (1982). Biological model for the possible importance of hydrogen peroxide. Bioelectrochem. Bioenerget. 9, 527-534.
320. + channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. Proc. Natl. Acad. Sei. USA 93,13182-13187.
321. Wasylyk, C., and Wasylyk, B. (1993). Oncogenic conversion of Ets affects redox regulation in-vivo and in-vitro. Nucleic Acids Res. 21, 523-529.
322. Watson, R. W., Rotstein, O. D., Nathens, A. B., Dackiw, A. P., and Marshall, J. C. (1996). Thiol-mediated redox regulation of neutrophil apoptosis. Surgery 120, 150-157.
323. Wayner, D. D. M., Burton, G. W., Ingold, K. U., and Locke, S. (1985). Quantitative measurement of the total peroxyl radical trapping antioxidant capability of human blood plasma by controlled peroxidation. The important contribution made by plasma proteins. FEBS Lett. 187, 33-37.
324. Weber, C., Erl, W., Pietsch, A., Strobel, M., Ziegler-Heitbrock, H. W., and Weber, P. C. (1994). Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-l in endothelial cells stimulated to generate radicals. Arterioscler. Thromb. 14, 1665-1673.
325. Wei, E. P., Kontos, H. A., and Beckman, J. S. (1996). Mechanisms of cerebral vasodilation by Superoxide, hydrogen peroxide, and peroxynitrite. Am. J. Physiol. 271, H1262-H1266.
326. Williamson, J. D., Stoop, J. M, Massel, M. O., Conkling, M. A., and Pharr, D. M. (1995). Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein EL13. Proc. Natl. Acad. Sei. USA 92, 7148-7152.
327. Winn, J. S., Guille, J., Gebicki, J. M., and Day, R. O. (1991). Hydrogen peroxide modulation of the respiratory burst of human neutrophils. Biochem. Pharmacol. 41, 31-36.
328. Wojtaszek, P. (1997). Oxidative burst: An early plant response to pathogen infection. Biochem. J. 332, 681-692.
329. Wood, P. M. (1988). The potential diagram for oxygen at pH 7. Biochem. J. 253, 287-289.
330. Wung, B. S., Cheng, J. J., Hsieh, H. J., Shyy, Y. J., and Wang, D. L. (1997). Cyclic straininduced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Cir. Res. 81, 1-7.
331. Xanthoudakis, S., Miao, G., Wang, F., Pan, Y.-C, and Curran, T. (1992). Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 11,3323-3335.
332. Yan, S. R., and Berton, G. (1996). Regulation of Src family tyrosine kinase activities in adherent human neutrophils. Evidence that reactive oxygen intermediates produced by adherent neutrophils increase the activity of the p58c-fgr and p53/561yn tyrosine kinases. J. BioL Chem. 271, 23464-23471.
333. Yang, M., Nazhat, N. B., Jiang, X., Kelsey, S. M., Blake, D. R., Newland, A. C, and Morris, C. J. (1996). Adriamycin stimulates proliferation of human lymphoblastic leukaemic cells via a mechanism of hydrogen peroxide (H2O2) production. Br. J. Haematol. 95, 339-344.
334. Yao, S. K., Ober, J. C, Gonenne, A., Clubb, F. J., Jr., Krishnaswami, A., Ferguson, J. J., Anderson, H. V., Gorecki, M., Buja, L. M., and Willerson J. T. (1993). Active oxygen species play a role in mediating platelet aggregation and cyclic flow variations in severely stenosed and endothelium-injured coronary arteries. Circ. Res. 73, 952-967.
335. Yokoyama, Y., Beckman, J. S., Beckman, T. K., Wheat, J. K., Cash, T. G., Freeman, B. A., and Parks, D. A. (1990). Circulating xantine oxidaze: Potential mediator of ischemic injury. Am. J. Pliysiol. 258, G564-G70.
336. 2-sensing protein (NADPH oxidase) in chemoreceptor cells. Microsc. Res. Tech. 37, 101-106.
337. Yuan, G., Kaneko, M., Masuda, H., Hon, R. B., Kobayashi, A., and Yamazaki, N. (1992). Decrease in heart mitochondrial creatine kinase activity due to oxygen free radicals. Biochim. Biophys. Acta 1140, 78-84.
338. Zarebska, Z. (1994). Cell membrane, a target for PUVA therapy. J. Pliotochem. Photobiol. 23, 101-109.
339. Zhang, Z., Collinge, D. B., and Thordal-Christiansen, H. (1995). Germin-like oxalate oxidase, a H2O2-producing enzyme, accumulates in barley attacked by the powdery mildew fungus. Plant J. 8, 139-145.
340. Zhao, Y., and Davis, H. W. (1998). Hydrogen peroxide-induced cytoskeletal rearrangement in cultured pulmonary endothelial cells. J. Cell. Pliysiol. 174, 370-379.
341. Zhong, W., Oberley, L. W., Oberley, T. D., Yan, T., Domann, F. E., and St. Clair, D. K. (1996). Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese Superoxide dismutase in rat glioma cells. Cell Growth Differ. 7, 1175-1186.
342. Ziegler, D. M., Duffel, M. W., and Poulsen, L. L. (1979). Studies on the nature and regulation of the cellular thio : disulphide potential. Ciba Found. Synip. 72,191-204.
343. Zulueta, J. J., Yu, F. S., Hertig, I. A., Thannickal, V. J., and Hassoun, P. M. (1995). Release of hydrogen peroxide in response to hypoxia-reoxygenation: Role of an NAD(P)H oxidaselike enzyme in endothelial cell plasma membrane. Am. J. Respir. Cell Mol. Biol. 12,41-49.