Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development

Journal of NeuroVirology

Volumn 10, Issue 2, 2004, Pages 75-85

  Navas Martín, Sonia ^a   Weiss, Susan R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Coronavirus mutation; Replication; SARS; Vaccine

Indexed keywords

ANTIBIOTIC AGENT; CD8 ANTIGEN; CORTICOSTEROID; DNA VACCINE; METHYLPREDNISOLONE; RECOMBINANT VACCINE; RIBAVIRIN; VIRUS PROTEIN; VIRUS VACCINE;

ADOPTIVE TRANSFER; ANTIBIOTIC RESISTANCE; CLINICAL FEATURE; CORONAVIRUS; DEMYELINATING DISEASE; DIARRHEA; DISEASE COURSE; DYSPNEA; EPIDEMIC; FEVER; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNE RESPONSE; LISTERIA MONOCYTOGENES; LOWER RESPIRATORY TRACT INFECTION; LYMPHOCYTE TRANSFER; LYMPHOCYTOPENIA; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PATHOGENESIS; PLANT VIRUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM; VIRUS IDENTIFICATION; VIRUS REPLICATION; VIRUS TRANSMISSION; VIRUS VIRULENCE;

ANIMALS; HUMANS; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL VACCINES; VIRULENCE;

CORONAVIRUS; SARS CORONAVIRUS;

EID: 1942454290     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280490280292     Document Type: Review

References (138)

1. Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Fleming JO, Baker SC (1995). Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA. Virology 209: 337-346.
2. Anton IM, Sune C, Meloen RH, Borras-Cuesta F, Enjuanes L (1995). A transmissible gastroenteritis coronavirus nucleoprotein epitope elicits T helper cells that collaborate in the in vitro antibody synthesis to the three major structural viral proteins. Virology 212: 746-751.
3. Ashraf H (2003). WHO declares Beijing to be free of SARS. Lancet 361: 2212.
4. Baric RS, Nelson GW, Fleming JO, Deans RJ, Keck JG, Casteel N, Stohlman SA (1988). Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription. J Virol 62: 4280-4287.
5. Baric RS, Sullivan E, Hensley L, Yount B, Chen W (1999). Persistent infection promotes cross-species transmissibility of mouse hepatitis virus. J Virol 73: 638-649.
6. Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, Hammarstrom S, Holmes KV, Karlsson A, Kuroki M, Lin SH, Lucka L, Najjar SM, Neumaier M, Obrink B, Shively JE, Skubitz KM, Stanners CP, Thomas P, Thompson JA, Virji M, von Kleist S, Wagener C, Watt S, Zimmermann W (1999). Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res 252: 243-249.
7. Bergmann CC, Dimacali E, Stohl S, Marten N, Lai MM, Stohlman SA (1998). Viral evolution and CTL epitope stability during JHMV infection in the central nervous system. Adv Exp Med Biol 440: 751-757.
8. Bergmann CC, Marten NW, Hinton DR, Parra B, Stohlman SA (2001). CD8 T cell mediated immunity to neurotropic MHV infection. Adv Exp Med Biol 494: 299-308.
9. Bonavia A, Arbour N, Yong VW, Talbot PJ (1997). Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43. J Virol 71: 800-806.
10. Booth CM, Matukas LM, Tomlinson GA, Rachlis AR, Rose DB, Dwosh HA, Walmsley SL, Mazzulli T, Avendano M, Derkach P, Ephtimios IE, Kitai I, Mederski BD, Shadowitz SB, Gold WL, Hawryluck LA, Rea E, Chenkin JS, Cescon DW, Poutanen SM, Detsky AS (2003). Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA 289: 2801-2809.
11. Boots AM, Kusters JG, van Noort JM, Zwaagstra KA, Rijke E, van der Zeijst BA, Hensen EJ (1991). Localization of a T-cell epitope within the nucleocapsid protein of avian coronavirus. Immunology 74: 8-13.
12. Brian DA, Spaan WJM (1997). Recombination and coronavirus defective interfering RNAs. Semin Virol 8: 101-111.
13. Buchmeier MJ, Lane TE (1999). Viral-induced neurodegenerative disease. Curr Opin Microbiol 2: 398-402.
14. Cavanagh D, Mawditt K, Welchman Dde B, Britton P, Gough RE (2002). Coronaviruses from pheasants (Phasianus colchicus) are genetically closely related to coronaviruses of domestic fowl (infectious bronchitis virus) and turkeys. Avian Pathol 31: 81-93.
15. Chen DS, Asanaka M, Chen FS, Shively JE, Lai MM (1997). Human carcinoembryonic antigen and biliary glycoprotein can serve as mouse hepatitis virus receptors. J Virol 71: 1688-1691.
16. Chen DS, Asanaka M, Yokomori K, Wang F, Hwang SB, Li HP, Lai MM (1995). A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus. Proc Natl Acad Sci U S A 92: 12095-12099.
17. Chen W, Baric RS (1996). Molecular anatomy of mouse hepatitis virus persistence: coevolution of increased host cell resistance and virus virulence. J Virol 70: 3947-3960.
18. Chua MM, MacNamara K, San Mateo L, Shen H, Weiss SR (2004). Effects of an epitope specific CD8+ T cell response on murine coronavirus CNS disease: protection from virus replication and antigen spread and selection of epitope escape mutants. J Virol 78: 1150-1159.
19. Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW (2003). Treatment of SARS with human interferons. Lancet 362: 293-294.
20. de Haan CA, Masters PS, Shen X, Weiss S, Rottier PJ (2002a). The group-specific murine coronavirus genes are not essential, but their deletion, by reverse genetics, is attenuating in the natural host. Virology 296: 177-189.
21. de Haan CA, van Genne L, Stoop JN, Volders H, Rottier PJ (2003). Coronaviruses as vectors: position dependence of foreign gene expression. J Virol 77: 11312-11323.
22. de Haan CA, Volders H, Koetzner CA, Masters PS, Rottier PJ (2002b). Coronaviruses maintain viability despite dramatic rearrangements of the strictly conserved genome organization. J Virol 76: 12491-12502.
23. Domingo E, Biefricher C, Holland JJ, Eigen M (2001). Quasispecies and RNA virus evolution: principles and consequences. Austin, TX: Landes Bioscience.
24. Domingo E, Holland JJ (1997). RNA virus mutations and fitness for survival. Annu Rev Microbiol 51: 151-178.
25. Domingo E, Menendez-Arias L, Holland JJ (1997). RNA virus fitness. Rev Med Virol 7: 87-96.
26. Donnelly CA, Ghani AC, Leung GM, Hedley AJ, Fraser C, Riley S, Abu-Raddad LJ, Ho LM, Thach TQ, Chan P, Chan KP, Lam TH, Tse LY, Tsang T, Liu SH, Kong JH, Lau EM, Ferguson NM, Anderson RM (2003). Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. Lancet 361: 1761-1766.
27. Drake JW (1991). A constant rate of spontaneous mutation in DNA-based microbes. Proc Natl Acad Sci U S A 88: 7160-7164.
28. Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Muller S, Rickerts V, Sturmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW (2003a). Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 348: 1967-1976.
29. Drosten C, Preiser W, Gunther S, Schmitz H, Doerr HW (2003b). Severe acute respiratory syndrome: identification of the etiological agent. Trends Mol Med 9: 325-327.
30. Dveksler GS, Dieffenbach CW, Cardellichio CB, McCuaig K, Pensiero MN, Jiang GS, Beauchemin N, Holmes KV (1993). Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59. J Virol 67: 1-8.
31. Dveksler GS, Gagneten SE, Scanga CA, Cardellichio CB, Holmes KV (1996). Expression of the recombinant anchorless N-terminal domain of mouse hepatitis virus (MHV) receptor makes hamster of human cells susceptible to MHV infection. J Virol 70: 4142-4145.
32. Enjuanes LBD, Cavanagh D, Holmes K, Lai MMC, Laude H, Masters P, Rottier P, Sidell SG, Spaan WJM, Taguchi F, Talbot P (2000). Coronaviridae. In: Virus taxonomy classification and nomemclature of viruses. van Regenmortel MHV FC, Bishop DHL, Carsten EB, Estes MK, Lemon SM, McGeoch DJ, Maniloff J, Mayo MA, Pringle CR, Wickner RB (eds). San Diego: Academic Press, pp 835-849.
33. Escors D, Camafeita E, Ortego J, Laude H, Enjuanes L (2001). Organization of two transmissible gastroenteritis coronavirus membrane protein topologies within the virion and core. J Virol 75: 12228-12240.
34. Everard ML, Swarbrick A, Rigby AS, Milner AD (2001). The effect of ribavirin to treat previously healthy infants admitted with acute bronchiolitis on acute and chronic respiratory morbidity. Respir Med 95: 275-280.
35. Farsang A, Ros C, Renstrom LH, Baule C, Soos T, Belak S (2002). Molecular epizootiology of infectious bronchitis virus in Sweden indicating the involvement of a vaccine strain. Avian Pathol 31: 229-236.
36. Fischer F, Peng D, Hingley ST, Weiss SR, Masters PS (1997). The internal open reading frame within the nucleocapsid gene of mouse hepatitis virus encodes a structural protein that is not essential for viral replication. J Virol 71: 996-1003.
37. Fisman DN (2000). Hemophagocytic syndromes and infection. Emerg Infect Dis 6: 601-608.
38. Fleck F (2003). WHO says SARS outbreak is over, but fight should go on. BMJ 327: 70.
39. Fleming JO, Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Baker SC (1995). Mutations associated with viral sequences isolated from mice persistently infected with MHV-JHM. Adv Exp Med Biol 380: 591-595.
40. Fleming JO, Houtman JJ, Alaca H, Hinze HC, McKenzie D, Aiken J, Bleasdale T, Baker S (1993). Persistence of viral RNA in the central nervous system of mice inoculated with MHV-4. Adv Exp Med Biol 342: 327-332.
41. Gallagher TM (2001). Murine coronavirus spike glycoprotein. Receptor binding and membrane fusion activities. Adv Exp Med Biol 494: 183-192.
42. Glansbeek HL, Haagmans BL, te Lintelo EG, Egberink HF, Duquesne V, Aubert A, Horzinek MC, Rottier PJ (2002). Adverse effects of feline IL-12 during DNA vaccination against feline infectious peritonitis virus. J Gen Virol 83: 1-10.
43. Godfraind C, Langreth SG, Cardellichio CB, Knobler R, Coutelier JP, Dubois-Dalcq M, Holmes KV (1995). Tissue and cellular distribution of an adhesion molecule in the carcinoembryonic antigen family that serves as a receptor for mouse hepatitis virus. Lab Invest 73: 615-627.
44. Gombold JL, Hingley ST, Weiss SR (1993). Fusion-defective mutants of mouse hepatitis virus A59 contain a mutation in the spike protein cleavage signal. J Virol 67: 4504-4512.
45. Gonzalez JM, Gomez-Puertas P, Cavanagh D, Gorbalenya AE, Enjuanes L (2003). A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae. Arch Virol 148: 2207-2235.
46. Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, Luo SW, Li PH, Zhang LJ, Guan YJ, Butt KM, Wong KL, Chan KW, Lim W, Shortridge KF, Yuen KY, Peiris JS, Poon LL (2003). Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 302: 276-278.
47. Haring J, Perlman S (2001). Mouse hepatitis virus. Curr Opin Microbiol 4: 462-466.
48. Herrewegh AA, Smeenk I, Horzinek MC, Rottier PJ, de Groot RJ (1998). Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus. J Virol 72: 4508-4514.
49. Hingley ST, Gombold JL, Lavi E, Weiss SR (1994). MHV-A59 fusion mutants are attenuated and display altered hepatotropism. Virology 200: 1-10.
50. Hingley ST, Gombold JL, Lavi E, Weiss SR (1995). Hepatitis mutants of mouse hepatitis virus strain A59. Adv Exp Med Biol 380: 577-582.
51. Holland J, Domingo E (1998). Origin and evolution of viruses. Virus Genes 16: 13-21.
52. Holmes KV (1996). Coronaviridae: the viruses and their replication. In: Fields virology. Fields BN (ed). Philadelphia: Lippincott-Raven, pp. 1075-1103.
53. Holmes KV (2003). SARS-associated coronavirus. N Engl J Med 348: 1948-51.
54. Huelsenbeck JP, Ronquist F, Nielsen R, Bollback JP (2001). Bayesian inference of phylogeny and its impact on evolutionary biology. Science 294: 2310-2314.
55. Hung EC, Chim SS, Chan PK, Tong YK, Ng EK, Chiu RW, Leung CB, Sung JJ, Tam JS, Lo YM (2003). Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome. Clin Chem 49: 2108-2109.
56. Jia W, Karaca K, Parrish CR, Naqi SA (1995). A novel variant of avian infectious bronchitis virus resulting from recombination among three different strains. Arch Virol 140: 259-271.
57. Jonassen CM, Jonassen TO, Grinde B (1998). A common RNA motif in the 3′ end of the genomes of astroviruses, avian infectious bronchitis virus and an equine rhinovirus. J Gen Virol 79( Pt 4): 715-718.
58. Keck JG, Matsushima GK, Makino S, Fleming JO, Vannier DM, Stohlman SA, Lai MM (1988a). In vivo RNA-RNA recombination of coronavirus in mouse brain. J Virol 62: 1810-1813.
59. Keck JG, Soe LH, Makino S, Stohlman SA, Lai MM (1988b). RNA recombination of murine coronaviruses: recombination between fusion-positive mouse hepatitis virus A59 and fusion-negative mouse hepatitis virus 2. J Virol 62: 1989-1998.
60. Koo M, Bendahmane M, Lettieri GA, Paoletti AD, Lane TE, Fitchen JH, Buchmeier MJ, Beachy RN (1999). Protective immunity against murine hepatitis virus (MHV) induced by intranasal or subcutaneous administration of hybrids of tobacco mosaic virus that carries an MHV epitope. Proc Natl Acad Sci U S A 96: 7774-7779.
61. Koolen MJ, Borst MA, Horzinek MC, Spaan WJ (1990). Immunogenic peptide comprising a mouse hepatitis virus A59 B-cell epitope and an influenza virus T-cell epitope protects against lethal infection. J Virol 64: 6270-6273.
62. Koren G, King S, Knowles S, Phillips E (2003). Ribavirin in the treatment of SARS: a new trick for an old drug? Chin Med Assoc J 168: 1289-1292.
63. Kottier SA, Cavanagh D, Britton P (1995a). Experimental evidence of recombination in coronavirus infectious bronchitis virus. Virology 213: 569-580.
64. Kottier SA, Cavanagh D, Britton P (1995b). First experimental evidence of recombination in infectious bronchitis virus. Recombination in IBV. Adv Exp Med Biol 380: 551-556.
65. Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ (2003). A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 348: 1953-1966.
66. Kunz J, Krause D, Kremer M, Dermietzel R (1994). The 140-kDa protein of blood-brain barrier-associated pericytes is identical to aminopeptidase N. J Neurochem 62: 2375-2386.
67. La Monica N, Yokomori K, Lai MM (1992). Coronavirus mRNA synthesis: identification of novel transcription initiation signals which are differentially regulated by different leader sequences. Virology 188: 402-407.
68. Lai KN, Leung JC, Metz CN, Lai FM, Bucala R, Lan HY (2003). Role for macrophage migration inhibitory factor in acute respiratory distress syndrome. J Pathol 199: 496-508.
69. Lai MM (1992). RNA recombination in animal and plant viruses. Microbiol Rev 56: 61-79.
70. Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, Ahuja A, Yung MY, Leung CB, To KF, Lui SF, Szeto CC, Chung S, Sung JJ (2003). A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 348: 1986-1994.
71. Leparc-Goffart I, Hingley ST, Chua MM, Jiang X, Lavi E, Weiss SR (1997). Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein. Virology 239: 1-10.
72. Leung WK, To KF, Chan PK, Chan HL, Wu AK, Lee N, Yuen KY, Sung JJ (2003). Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology 125: 1011-1017.
73. Li L, Wo J, Shao J, Zhu H, Wu N, Li M, Yao H, Hu M, Dennin RH (2003a). SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients. J Clin Virol 28: 239-244.
74. Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M (2003b). Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426: 450-454.
75. Lin MT, Hinton DR, Marten NW, Bergmann CC, Stohlman SA (1999). Antibody prevents virus reactivation within the central nervous system. J Immunol 162: 7358-7368.
76. Lipman MM, Cotler SJ (2003). Antiviral therapy for hepatitis C. Curr Treat Options Gastroenterology 6: 445-453.
77. Liu C, Kokuho T, Kubota T, Watanabe S, Inumaru S, Yokomizo Y, Onodera T (2001). DNA mediated immunization with encoding the nucleoprotein gene of porcine transmissible gastroenteritis virus. Virus Res 80: 75-82.
78. Look AT, Ashmun RA, Shapiro LH, Peiper SC (1989). Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. J Clin Invest 83: 1299-1307.
79. Luytjes W, Bredenbeek PJ, Noten AF, Horzinek MC, Spaan WJ (1988). Sequence of mouse hepatitis virus A59 mRNA 2: indications for RNA recombination between coronaviruses and influenza C virus. Virology 166: 415-422.
80. Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, Khattra J, Asano JK, Barber SA, Chan SY, Cloutier A, Coughlin SM, Freeman D, Girn N, Griffith OL, Leach SR, Mayo M, McDonald H, Montgomery SB, Pandoh PK, Petrescu AS, Robertson AG, Schein JE, Siddiqui A, Smailus DE, Stott JM, Yang GS, Plummer F, Andonov A, Artsob H, Bastien N, Bernard K, Booth TF, Bowness D, Czub M, Drebot M, Fernando L, Flick R, Garbutt M, Gray M, Grolla A, Jones S, Feldmann H, Meyers A, Kabani A, Li Y, Normand S, Stroher U, Tipples GA, Tyler S, Vogrig R, Ward D, Watson B, Brunham RC, Krajden M, Petric M, Skowronski DM, Upton C, Roper RL (2003). The genome sequence of the SARS-associated coronavirus. Science 300: 1399-1404.
81. Marten NW, Stohlman SA, Atkinson RD, Hinton DR, Fleming JO, Bergmann CC (2000). Contributions of CD8+ T cells and viral spread to demyelinating disease. J Immunol 164: 4080-4088.
82. Marten NW, Stohlman SA, Bergmann CC (2001). MHV infection of the CNS: mechanisms of immune-mediated control. Virol Immunol 14: 1-18.
83. Martin J, Navas S, Quiroga JA, Pardo M, Carreno V (1998). Effects of the ribavirin-interferon alpha combination on cultured peripheral blood mononuclear cells from chronic hepatitis C patients. Cytokine 10: 635-644.
84. Martina BE, Haagmans BL, Kuiken T, Fouchier RA, Rimmelzwaan GF, Van Amerongen G, Peiris JS, Lim W, Osterhaus AD (2003). Virology: SARS virus infection of cats and ferrets. Nature 425: 915.
85. Matthews AE, Weiss SR, Shlomchik MJ, Hannum LG, Gombold JL, Paterson Y (2001). Antibody is required for clearance of infectious murine hepatitis virus A59 from the central nervous system, but not the liver. J Immunol 167: 5254-5263.
86. Myint SH (1994). Human coronaviruses - a brief review. Rev Med Virol 4: 35-46.
87. Navas-Martín S, Weiss SR (2003). SARS: lessons learned from other coronaviruses. J Virol Immunol In press.
88. Nedellec P, Dveksler GS, Daniels E, Turbide C, Chow B, Basile AA, Holmes KV, Beauchemin N (1994). Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses. J Virol 68: 4525-4537.
89. Nicholls JM, Poon LL, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY, Peiris JS (2003). Lung pathology of fatal severe acute respiratory syndrome. Lancet 361: 1773-1778.
90. Nie QH, Luo XD, Zhang JZ, Su Q (2003). Current status of severe acute respiratory syndrome in China. World J Gastroenterol 9: 1635-1645.
91. Olsen CW, Corapi WV, Jacobson RH, Simkins RA, Saif LJ, Scott FW (1993). Identification of antigenic sites mediating antibody-dependent enhancement of feline infectious peritonitis virus infectivity. J Gen Virol 74(Pt 4): 745-749.
92. Ortego J, Sola I, Almazan F, Ceriani JE, Riquelme C, Balasch M, Plana J, Enjuanes L (2003). Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence. Virology 308: 13-22.
93. Parry J (2003). WHO investigates China's fall in SARS cases. BMJ 326: 1285.
94. Peiris JS, Chu CM, Cheng VC, Chan KS, Hung IF, Poon LL, Law KI, Tang BS, Hon TY, Chan CS, Chan KH, Ng JS, Zheng BJ, Ng WL, Lai RW, Guan Y, Yuen KY (2003a). Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 361: 1767-1772.
95. Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY (2003b). Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361: 1319-1325.
96. Perlman S, Pewe L (1998). Role of CTL mutants in demyelination induced by mouse hepatitis virus, strain JHM. Adv Exp Med Biol 440: 515-519.
97. Perlman S, Wu GF (2001). Selection of and evasion from cytotoxic T cell responses in the central nervous system. Adv Virus Res 56: 219-242.
98. Pewe L, Heard SB, Bergmann C, Dailey MO, Perlman S (1999). Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: quantitative estimate of TCR diversity in the infected central nervous system. J Immunol 163: 6106-6113.
99. Pewe L, Wu GF, Barnett EM, Castro RF, Perlman S (1996). Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease. Immunity 5: 253-262.
100. Poutanen SM, Low DE, Henry B, Finkelstein S, Rose D, Green K, Tellier R, Draker R, Adachi D, Ayers M, Chan AK, Skowronski DM, Salit I, Simor AE, Slutsky AS, Doyle PW, Krajden M, Petric M, Brunham RC, McGeer AJ (2003). Identification of severe acute respiratory syndrome in Canada. N Engl J Med 348: 1995-2005.
101. Pratelli A, Tinelli A, Decaro N, Cirone F, Elia G, Roperto S, Tempesta M, Buonavoglia C (2003). Efficacy of an inactivated canine coronavirus vaccine in pups. New Microbiol 26: 151-155.
102. Prentice E, Denison MR (2001). The cell biology of coronavirus infection. Adv Exp Med Biol 494: 609-614.
103. Reilley B, Van Herp M, Sermand D, Dentico N (2003). SARS and Carlo Urbani. N Engl J Med 348: 1951-1952.
104. Rest JS, Mindell DP (2003). SARS associated coronavirus has a recombinant polymerase and coronaviruses have a history of host-shifting. Infect Genet Evol 3: 219-225.
105. Robitaille J, Izzi L, Daniels E, Zelus B, Holmes KV, Beauchemin N (1999). Comparison of expression patterns and cell adhesion properties of the mouse biliary glycoproteins Bbgp1 and Bbgp2. Eur J Biochem 264: 534-544.
106. Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, Penaranda S, Bankamp B, Maher K, Chen MH, Tong S, Tamin A, Lowe L, Frace M, DeRisi JL, Chen Q, Wang D, Erdman DD, Peret TC, Burns C, Ksiazek TG, Rollin PE, Sanchez A, Liffick S, Holloway B, Limor J, McCaustland K, Olsen-Rasmussen M, Fouchier R, Gunther S, Osterhaus AD, Drosten C, Pallansch MA, Anderson LJ, Bellini WJ (2003). Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 300: 1394-1399.
107. Rowe CL, Baker SC, Nathan MJ, Fleming JO (1997a). Evolution of mouse hepatitis virus: detection and characterization of spike deletion variants during persistent infection. J Virol 71: 2959-2969.
108. Rowe CL, Baker SC, Nathan MJ, Sgro JY, Palmenberg AC, Fleming JO (1998). Quasispecies development by high frequency RNA recombination during MHV persistence. Adv Exp Med Biol 440: 759-765.
109. Rowe CL, Fleming JO, Nathan MJ, Sgro JY, Palmenberg AC, Baker SC (1997b). Generation of coronavirus spike deletion variants by high-frequency recombination at regions of predicted RNA secondary structure. J Virol 71: 6183-6190.
110. Schickli JH, Wentworth DE, Zelus BD, Holmes KV, Sawicki SG (1998). Selection in persistently infected murine cells of an MHV-A59 variant with extended host range. Adv Exp Med Biol 440: 735-741.
111. Schickli JH, Zelus BD, Wentworth DE, Sawicki SG, Holmes KV (1997). The murine coronavirus mouse hepatitis virus strain A59 from persistently infected murine cells exhibits an extended host range. J Virol 71: 9499-9507.
112. Siddell SG (1995). The Coronaviridae. New York: Plenum Press.
113. Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LL, Guan Y, Rozanov M, Spaan WJ, Gorbalenya AE (2003). Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J Mol Biol 331: 991-1004.
114. Steinhauer DA, Domingo E, Holland JJ (1992). Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase. Gene 122: 281-288.
115. Takamura K, Matsumoto Y, Shimizu Y (2002). field study of bovine coronavirus vaccine enriched with hemagglutinating antigen for winter dysentery in diary cows. Can J Vet Res 66: 278-281.
116. Talbot PJ (1995). Implication of viruses in multiple sclerosis. Med Sci 11: 837-843.
117. To KF, Chan PK, Chan KF, Lee WK, Lam WY, Wong KF, Tang NL, Tsang DN, Sung RY, Buckley TA, Tam JS, Cheng AF (2001). Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol 63: 242-246.
118. Tsui PT, Kwok ML, Yuen H, Lai ST (2003). Severe acute respiratory syndrome: clinical outcome and prognostic correlates. Emerg Infect Dis 9: 1064-1069.
119. van der Veen RC (1996). Immunogenicity of JHM virus proteins: characterization of a CD4+ T cell epitope on nucleocapsid protein which induces different T-helper cell subsets. Virology 225: 339-346.
120. Vennema H, Godeke GJ, Rossen JW, Voorhout WF, Horzinek MC, Opstelten DJ, Rottier PJ (1996). Nucleocapsid-independent assembly of coronavirus-like particles by co-expression of viral envelope protein genes. EMBO J 15: 2020-2028.
121. Wang X, Khan MI (2000). Molecular characterization of an infectious bronchitis virus strain isolated from an outbreak in vaccinated layers. Avian Dis 44: 1000-1006.
122. Wang X, Schnitzlein WM, Tripathy DN, Girshick T, Khan MI (2002). Construction and immunogenicity studies of recombinant fowl poxvirus containing the S1 gene of Massachusetts 41 strain of infectious bronchitis virus. Avian Dis 46: 831-838.
123. Weiss R, Scott FW (1981). Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorragic fever. Comp Immunol Microbiol Infect Dis 4: 175-189.
124. Wentworth DE, Holmes KV (2001a). Addition of a single glycosylation site to hAPN blocks human coronavirus-229E receptor activity. Adv Exp Med Biol 494: 199-204.
125. Wentworth DE, Holmes KV (2001b). Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation. J Virol 75: 9741-9752.
126. World Health Organization (WHO) (2003). Severe acute respiratory syndrome (SARS): multi-country outbreak.
127. Wu GF, Dandekar AA, Pewe L, Perlman S (2000a). CD4 and CD8 T cells have redundant but not identical roles in virus induced demyelination. J Immunol 165: 2278-2286.
128. Wu GF, Dandekar AA, Pewe L, Perlman S (2001). The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination. Adv Exp Med Biol 494: 341-347.
129. Wu GF, Pewe L, Perlman S (2000b). Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase. J Virol 74: 7683-7686.
130. Wu HY, Guy JS, Yoo D, Vlasak R, Urbach E, Brian DA (2003). Common RNA replication signals exist among group 2 coronaviruses: evidence for in vivo recombination between animal and human coronavirus molecules. Virology 315: 174-183.
131. Xu X, Liu Y, Weiss S, Arnold E, Sarafianos SG, Ding J (2003). Molecular model of SARS coronavirus polymerase: implications for biochemical functions sand drug design. Nucleic Acids Res 31: 7117-7130.
132. Xue S, Jaszewski A, Perlman S (1995). Identification of a CD4+ T cell epitope within the M protein of a neurotropic coronavirus. Virology 208: 173-179.
133. Xue S, Perlman S (1997). Antigen specificity of CD4 T cell response in the central nervous system of mice infected with mouse hepatitis virus. Virology 238: 68-78.
134. Yeager CL, Ashmun RA, Williams RK, Cardellichio CB, Shapiro LH, Look AT, Holmes KV (1992). Human aminopeptidase N is a receptor for human coronavirus 229E. Nature 357: 420-422.
135. Yount B, Curtis KM, Fritz EA, Hensley LE, Jahrling PB, Prentice E, Denison MR, Geisbert TW, Baric RS (2003). Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A 100: 12995-13000.
136. Yu L, Liu W, Schnitzlein WM, Tripathy DN, Kwang J (2001). Avian Dis 45: 340-348.
137. Yu X, Bi W, Weiss SR, Leibowitz JL (1994). Mouse hepatitis virus gene 5b protein is a new virion envelope protein. Virology 202: 1018-1023.
138. Zhong NS, Zheng BJ, Li YM, Poon, Xie ZH, Chan KH, Li PH, Tan SY, Chang Q, Xie JP, Liu XQ, Xu J, Li DX, Yuen KY, Peiris, Guan Y (2003). Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet 362: 1353-1358.