Antibody is required for clearance of infectious murine hepatitis virus A59 from the central nervous system, but not the liver

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5254-5263

  Matthews, A E ^a   Weiss, S R ^a   Shlomchik, M J ^a   Hannum, L G ^a   Gombold, J L ^a   Paterson, Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIGEN; IMMUNOGLOBULIN M; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; INOCULATION; LIVER; MOUSE; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS IMMUNITY; VIRUS INFECTION; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN;

EID: 0035500650     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5254     Document Type: Article

References (73)

1. The organ tropism of mouse hepatitis virus A59 in mice is dependent on dose and route of inoculation
2. Persistence of mouse hepatitis virus A59 RNA in a slow virus demyelinating infection in mice as detected by in situ hybridization
3. Pathogenesis of mouse hepatitis virus-induced demyelination
4. + T cells are not major effectors of mouse hepatitis virus A59-induced demyelinating disease
5. + T cells
6. + T cells and RANTES in virus-induced central nervous system inflammation and demyelination
7. Contributions of fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system
8. Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system
9. Protection of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones
10. Dissociation of demyelination and viral clearance in congenitally immunodeficient mice infected with murine coronavirus JHM
11. Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in vivo by monoclonal antibody
12. Monoclonal antibodies to the matrix (El) glycoprotein of mouse hepatitis virus protect mice from encephalitis
13. Hemagglutinin-esterase-specific monoclonal antibodies alter the neuropathogenicity of mouse hepatitis virus
14. Fas (CD95)-dependent cell-mediated immunity to Listeria monocytogenes
15. T cell-dependent IFN-γ exerts an antiviral effect in the central nervous system but not in peripheral solid organs
16. Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells
17. Patterns of oligodendrocyte pathology in coronavirus-induced subacute demyelinating encephalomyelitis in the Lewis rat
18. Immunity to viruses in B cell-deficient mice: Influence of antibodies on virus persistence and on T cell memory
19. Antibody-mediated clearance of alphavirus infection from neurons
20. H locus
21. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
22. Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells
23. Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA
24. MHV-A59 fusion mutants are attenuated and display altered hepatotropism
25. + T cells
26. Experimental demyelination produced by the A59 strain of mouse hepatitis virus
27. Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein
28. + T cells
29. Successful T cell priming in B cell-deficient mice
30. + T cell activation and tolerance induction in B cell knockout mice
31. CD8 T cell memory in B cell-deficient mice
32. + T cell memory in the absence of B cells and Ig
33. Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: Failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT/muMT mice
34. Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease
35. Localization of virus and antibody response in mice infected persistently with MHV-JHM
36. Pathogenesis of coronavirus-induced infections
37. Nervous tissue as an immune compartment: The dialect of the immune response in the CNS
38. Antigen-dependent intrathecal antibody synthesis in the normal rat brain: Tissue entry and local retention of antigen-specific B cells
39. Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns
40. Type 1 and type 2 cytokines in antiviral defense
41. - T cell epitope on nucleocapsid protein which induces different T-helper cell subsets
42. FcR γ chain deletion results in pleiotrophic effector cell defects
43. Antibody prevents virus reactivation within the central nervous system
44. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class 11-deficient mice and B cell-deficient mice
45. + T cell subsets to Plasmodium chabaudi in B cell-deficient mice
46. Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection
47. B cells and antibodies in the pathogenesis of myelin injury in Semliki Forest virus encephalomyelitis
48. Cooperation of B cells and T cells is required for survival of mice infected with vesicular stomatitis virus
49. B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality
50. + T cells during viral persistence in the central nervous system
51. Regulation of brain-derived T cells during acute central nervous system inflammation
52. Immune therapy of a persistent and disseminated viral infection
53. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system
54. Normal cerebrospinal fluid suppresses the in vitro development of cytotoxic T cells: Role of the brain microenvironment in CNS immune regulation
55. Gangliosides suppress the proliferation of autoreactive cells in experimental allergic encephalomyelitis: Ganglioside effects on IL-2 activity
56. CTL access to tissue antigen is restricted in vivo
57. + T cells by the normal liver
58. On the function of pit cells, the liver-specific natural killer cells
59. Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo
60. + T cells in mouse hepatitis virus infection in mice
61. + cytotoxic T cells in recovery from mouse hepatitis virus infection
62. IFN-γ is required for viral clearance from central nervous system oligodendroglia
63. Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection
64. Protective T cell-independent antiviral antibody responses are dependent on complement
65. The immune response in viral encephalitis
66. Antibody-induced restriction of viral gene expression in measles encephalitis in rats
67. Induction of demyelination by a temperature-sensitive mutant of the coronavirus MHV-A59 is associated with restriction of viral replication in the brain
68. Enzyme-linked immunosorbent assay for detection of antibodies to murine hepatitis virus
69. Long term intraparenchymal Ig secretion after acute viral encephalitis in mice
70. Antiviral antibody production in parenchymatous organs of lymphocytic choriomeningitis virus carrier mice: Enumeration of antibody-producing cells and immunohistochemical investigation of mononuclear cell infiltrates
71. Diagnostic usefulness of cerebrospinal fluid in multiple sclerosis
72. Anatomical environment as a determinant in viral immunity
73. Bone marrow is a major site of long-term antibody production after acute viral infection