-
2
-
-
0141817911
-
Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate
-
R.B. Campbell, F. Liu, and A.H. Ross Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate J. Biol. Chem. 278 2003 33617 33620
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33617-33620
-
-
Campbell, R.B.1
Liu, F.2
Ross, A.H.3
-
3
-
-
0142137134
-
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
-
N.R. Leslie, D. Bennett, Y.E. Lindsay, H. Stewart, A. Gray, and C.P. Downes Redox regulation of PI 3-kinase signalling via inactivation of PTEN Eur. Mol. Biol. Org. J. 22 2003 5501 5510
-
(2003)
Eur. Mol. Biol. Org. J.
, vol.22
, pp. 5501-5510
-
-
Leslie, N.R.1
Bennett, D.2
Lindsay, Y.E.3
Stewart, H.4
Gray, A.5
Downes, C.P.6
-
4
-
-
0038245261
-
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: Evidence for activation by anionic phospholipids
-
G. McConnachie, I. Pass, S.M. Walker, and C.P. Downes Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids Biochem. J. 371 2003 947 955
-
(2003)
Biochem. J.
, vol.371
, pp. 947-955
-
-
McConnachie, G.1
Pass, I.2
Walker, S.M.3
Downes, C.P.4
-
5
-
-
0035199914
-
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
-
T. Virolle, E.D. Adamson, V. Baron, D. Birle, D. Mercola, T. Mustelin, and I. de Belle The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling Nat. Cell Biol. 3 2001 1124 1128
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1124-1128
-
-
Virolle, T.1
Adamson, E.D.2
Baron, V.3
Birle, D.4
Mercola, D.5
Mustelin, T.6
De Belle, I.7
-
6
-
-
0035873953
-
Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN
-
L. Patel, I. Pass, P. Coxon, C.P. Downes, S.A. Smith, and C.H. Macphee Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN Curr. Biol. 11 2001 764 768
-
(2001)
Curr. Biol.
, vol.11
, pp. 764-768
-
-
Patel, L.1
Pass, I.2
Coxon, P.3
Downes, C.P.4
Smith, S.A.5
MacPhee, C.H.6
-
8
-
-
0033621042
-
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
-
M-M. Georgescu, K.H. Kirsch, T. Akagi, T. Shishido, and H. Hanafusa The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region Proc. Natl Acad. Sci. USA 96 1999 10182 10187
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 10182-10187
-
-
Georgescu, M.-M.1
Kirsch, K.H.2
Akagi, T.3
Shishido, T.4
Hanafusa, H.5
-
9
-
-
0033946740
-
Phosphorylation of the PTEN tail regulates protein stability and function
-
F. Vazquez, S. Ramaswamy, N. Nakamura, and W.R. Sellers Phosphorylation of the PTEN tail regulates protein stability and function Mol. Cell. Biol. 20 2000 8969 8982
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8969-8982
-
-
Vazquez, F.1
Ramaswamy, S.2
Nakamura, N.3
Sellers, W.R.4
-
10
-
-
0035847102
-
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus: Implications for PTEN stability to proteasome-mediated degradation
-
J. Torres, and R. Pulido The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus: implications for PTEN stability to proteasome-mediated degradation J. Biol. Chem. 276 2001 993 998
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 993-998
-
-
Torres, J.1
Pulido, R.2
-
11
-
-
0036644058
-
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation
-
D. Birle, N. Bottini, S. Williams, H. Huynh, I. deBelle, E. Adamson, and T. Mustelin Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation J. Immunol. 169 2002 286 291
-
(2002)
J. Immunol.
, vol.169
, pp. 286-291
-
-
Birle, D.1
Bottini, N.2
Williams, S.3
Huynh, H.4
Debelle, I.5
Adamson, E.6
Mustelin, T.7
-
12
-
-
0042232478
-
Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: Implications for the control of protein stability and PTEN-protein interactions
-
J. Torres, J. Rodriguez, M.P. Myers, M. Valiente, J.D. Graves, N.K. Tonks, and R. Pulido Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions J. Biol. Chem. 278 2003 30652 30660
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30652-30660
-
-
Torres, J.1
Rodriguez, J.2
Myers, M.P.3
Valiente, M.4
Graves, J.D.5
Tonks, N.K.6
Pulido, R.7
-
13
-
-
0037444213
-
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels
-
K.A. Waite, and C. Eng BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels Hum. Mol. Genet. 12 2003 679 684
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 679-684
-
-
Waite, K.A.1
Eng, C.2
-
14
-
-
0042847299
-
Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells
-
W. Wu, X. Wang, W. Zhang, W. Reed, J.M. Samet, Y.E. Whang, and A.J. Ghio Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells J. Biol. Chem. 278 2003 28258 28263
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 28258-28263
-
-
Wu, W.1
Wang, X.2
Zhang, W.3
Reed, W.4
Samet, J.M.5
Whang, Y.E.6
Ghio, A.J.7
-
15
-
-
0034636038
-
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
-
X. Wu, K. Hepner, S. Castelino-Prabhu, D. Do, M.B. Kaye, and X.-J. Yuan Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 Proc. Natl Acad. Sci. USA 97 2000 4233 4238
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 4233-4238
-
-
Wu, X.1
Hepner, K.2
Castelino-Prabhu, S.3
Do, D.4
Kaye, M.B.5
Yuan, X.-J.6
-
16
-
-
0034647496
-
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase
-
Y. Wu, D. Dowbenko, S. Spencer, R. Laura, J. Lee, Q. Gu, and L.A. Lasky Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase J. Biol. Chem. 275 2000 21477 21485
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21477-21485
-
-
Wu, Y.1
Dowbenko, D.2
Spencer, S.3
Laura, R.4
Lee, J.5
Gu, Q.6
Lasky, L.A.7
-
17
-
-
0033958869
-
Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding
-
N.B. Adey, L. Huang, P.A. Ormonde, M.L. Baumgard, R. Pero, and D.V. Byreddy Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding Cancer Res. 60 2000 35 37
-
(2000)
Cancer Res.
, vol.60
, pp. 35-37
-
-
Adey, N.B.1
Huang, L.2
Ormonde, P.A.3
Baumgard, M.L.4
Pero, R.5
Byreddy, D.V.6
-
18
-
-
0037174815
-
PTEN associates with the vault particles in HeLa cells
-
Z. Yu, N. Fotouhi-Ardakani, L. Wu, M. Maoui, S. Wang, D. Banville, and S-H. Shen PTEN associates with the vault particles in HeLa cells J. Biol. Chem. 277 2002 40247 40252
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40247-40252
-
-
Yu, Z.1
Fotouhi-Ardakani, N.2
Wu, L.3
Maoui, M.4
Wang, S.5
Banville, D.6
Shen, S.-H.7
-
19
-
-
0041450058
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and - Independent mechanisms
-
D.J. Freeman, A.G. Li, G. Wei, H.H. Li, N. Kertesz, and R. Lesche PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and - independent mechanisms Cancer Cell 3 2003 117 130
-
(2003)
Cancer Cell
, vol.3
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
Li, H.H.4
Kertesz, N.5
Lesche, R.6
-
20
-
-
1642512636
-
Synergy in tumor suppression by direct interaction of Neutral Endopeptidase with PTEN
-
M. Sumitomo, A. Iwase, R. Zheng, D. Navarro, D. Kaminetzky, and R. Shen Synergy in tumor suppression by direct interaction of Neutral Endopeptidase with PTEN Cancer Cell 5 2004 67 78
-
(2004)
Cancer Cell
, vol.5
, pp. 67-78
-
-
Sumitomo, M.1
Iwase, A.2
Zheng, R.3
Navarro, D.4
Kaminetzky, D.5
Shen, R.6
-
21
-
-
2442498583
-
Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase
-
L. Mahimainathan, and G.G. Choudhury Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase J. Biol. Chem. 279 2004 15258 15268
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15258-15268
-
-
Mahimainathan, L.1
Choudhury, G.G.2
-
22
-
-
5044229903
-
Regulation of androgen receptor signaling by PTEN tumor suppressor through distinct mechanisms in prostate cancer cells
-
H.-K. Li, Y.-C. Hu, D.K. Lee, C. Chang, Regulation of androgen receptor signaling by PTEN tumor suppressor through distinct mechanisms in prostate cancer cells. Mol. Endocrinol. 18 (2004) 2409-2423.
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 2409-2423
-
-
Li, H.-K.1
Hu, Y.-C.2
Lee, D.K.3
Chang, C.4
-
23
-
-
0035394373
-
Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383
-
T. Tolkacheva, M. Boddapati, A. Sanfiz, K. Tsuchida, A.C. Kimmelman, and A.M. Chan Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383 Cancer Res. 61 2001 4985 4989
-
(2001)
Cancer Res.
, vol.61
, pp. 4985-4989
-
-
Tolkacheva, T.1
Boddapati, M.2
Sanfiz, A.3
Tsuchida, K.4
Kimmelman, A.C.5
Chan, A.M.6
-
24
-
-
0035966127
-
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
-
F. Vazquez, S.R. Grossman, Y. Takahashi, M.V. Rokas, N. Nakamura, and W.R. Sellers Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex J. Biol. Chem. 276 2001 48627 48630
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48627-48630
-
-
Vazquez, F.1
Grossman, S.R.2
Takahashi, Y.3
Rokas, M.V.4
Nakamura, N.5
Sellers, W.R.6
-
25
-
-
0030837555
-
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
-
M.P. Myers, J.P. Stolarov, C. Eng, J. Li, S.I. Wang, and M.H. Wigler P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase Proc. Natl Acad. Sci. USA 94 1997 9052 9057
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 9052-9057
-
-
Myers, M.P.1
Stolarov, J.P.2
Eng, C.3
Li, J.4
Wang, S.I.5
Wigler, M.H.6
-
26
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
T. Maehama, and J.E. Dixon The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J. Biol. Chem. 273 1998 13375 13378
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
27
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
-
J-O. Lee, H. Yang, M.-M. Georgescu, A. Di Cristofano, T. Maehama, and Y. Shi Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Cell 99 1999 323 334
-
(1999)
Cell
, vol.99
, pp. 323-334
-
-
Lee, J.-O.1
Yang, H.2
Georgescu, M.-M.3
Di Cristofano, A.4
Maehama, T.5
Shi, Y.6
-
28
-
-
0037205230
-
Tumor suppressor PTEN mediates sensing of chemoattractant gradients
-
M. Iijima, and P. Devreotes Tumor suppressor PTEN mediates sensing of chemoattractant gradients Cell 109 2002 599 610
-
(2002)
Cell
, vol.109
, pp. 599-610
-
-
Iijima, M.1
Devreotes, P.2
-
29
-
-
0037205265
-
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
-
S. Funamoto, R. Meili, S. Lee, L. Parry, and R.A. Firtel Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis Cell 109 2002 611 623
-
(2002)
Cell
, vol.109
, pp. 611-623
-
-
Funamoto, S.1
Meili, R.2
Lee, S.3
Parry, L.4
Firtel, R.A.5
-
30
-
-
1942501586
-
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-biphosphate binding motif is critical for chemotaxis
-
M. Iijima, Y.E. Huang, H.R. Luo, F. Vazquez, and P.N. Devreotes Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-biphosphate binding motif is critical for chemotaxis J. Biol. Chem. 279 2004 16606 16613
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 16606-16613
-
-
Iijima, M.1
Huang, Y.E.2
Luo, H.R.3
Vazquez, F.4
Devreotes, P.N.5
-
31
-
-
0035146778
-
Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues
-
J. Torres, S. Navarro, I. Roglá, F. Ripoll, A. Lluch, and J. García-Conde Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues Eur. J. Cancer 37 2001 114 121
-
(2001)
Eur. J. Cancer
, vol.37
, pp. 114-121
-
-
Torres, J.1
Navarro, S.2
Roglá, I.3
Ripoll, F.4
Lluch, A.5
García-Conde, J.6
-
32
-
-
0032516885
-
A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
-
K. Hirao, Y. Hata, N. Ide, M. Takeuchi, M. Irie, and I. Yao A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins J. Biol. Chem. 273 1998 21105 21110
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21105-21110
-
-
Hirao, K.1
Hata, Y.2
Ide, N.3
Takeuchi, M.4
Irie, M.5
Yao, I.6
-
33
-
-
0027360184
-
A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette
-
P.D. Walden, and N.J. Cowan A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette Mol. Cell. Biol. 13 1993 7625 7635
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 7625-7635
-
-
Walden, P.D.1
Cowan, N.J.2
-
34
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
M.P. Myers, I. Pass, I.H. Batty, J. Van der Kaay, J.P. Stolarov, and B.A. Hemmings The lipid phosphatase activity of PTEN is critical for its tumor supressor function Proc. Natl Acad. Sci. USA 95 1998 13513 13518
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
Van Der Kaay, J.4
Stolarov, J.P.5
Hemmings, B.A.6
-
35
-
-
1242284600
-
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
-
M. Raftopoulou, S. Etienne-Manneville, A. Self, S. Nicholls, and A. Hall Regulation of cell migration by the C2 domain of the tumor suppressor PTEN Science 303 2004 1179 1181
-
(2004)
Science
, vol.303
, pp. 1179-1181
-
-
Raftopoulou, M.1
Etienne-Manneville, S.2
Self, A.3
Nicholls, S.4
Hall, A.5
-
36
-
-
0032574718
-
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
-
Y.E. Whang, X. Wu, H. Suzuki, R.E. Reiter, C. Tran, and R.L. Vessella Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression Proc. Natl Acad. Sci. USA 95 1998 5246 5250
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 5246-5250
-
-
Whang, Y.E.1
Wu, X.2
Suzuki, H.3
Reiter, R.E.4
Tran, C.5
Vessella, R.L.6
-
37
-
-
0032898096
-
P.T.E.N is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies
-
P.L. Dahia, R.C. Aguiar, J. Alberta, J.B. Kum, S. Caron, and H. Sill P.T.E.N is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies Hum. Mol. Genet. 8 1999 185 193
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 185-193
-
-
Dahia, P.L.1
Aguiar, R.C.2
Alberta, J.3
Kum, J.B.4
Caron, S.5
Sill, H.6
-
38
-
-
0032857217
-
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
-
A. Perren, L.P. Weng, A.H. Boag, U. Ziebold, K. Thakore, and P.L. Dahia Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast Am. J. Pathol. 155 1999 1253 1260
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 1253-1260
-
-
Perren, A.1
Weng, L.P.2
Boag, A.H.3
Ziebold, U.4
Thakore, K.5
Dahia, P.L.6
-
39
-
-
0033561655
-
Differential expression of MMAC/PTEN in glioblastoma multiforme: Relationship to localization and prognosis
-
T. Sano, H. Lin, X. Chen, L.A. Langford, D. Koul, and M.L. Bondy Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis Cancer Res. 19 1999 1820 1824
-
(1999)
Cancer Res.
, vol.19
, pp. 1820-1824
-
-
Sano, T.1
Lin, H.2
Chen, X.3
Langford, L.A.4
Koul, D.5
Bondy, M.L.6
|