Development and application of high throughput plasma stability assay for drug discovery

International Journal of Pharmaceutics

Volumn 297, Issue 1-2, 2005, Pages 110-119

  Di, Li ^a   Kerns, Edward H ^a   Hong, Yan ^a   Chen, Hong ^a  

^a PFIZER INC   (United States)

Author keywords

Enzymes; High throughput; HPLC; Hydrolysis; LC MS; Plasma stability; Prodrugs; Stability

Indexed keywords

ALBENDAZOLE; ANTITUSSIVE AGENT; BENFLUOREX; BUFFER; DILTIAZEM; DIMETHOXANATE; DIMETHYL SULFOXIDE; PIPEROCAINE; POLDINE METHYLSULFATE; PROPANTHELINE BROMIDE; UNCLASSIFIED DRUG; VINPOCETINE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DILUTION; DRUG SCREENING; DRUG STABILITY; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HYDROLYSIS; INCUBATION TIME; MALE; NONHUMAN; PH; PLASMA; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIMETHYL SULFOXIDE; DRUG COMPOUNDING; MALE; PHARMACEUTICAL PREPARATIONS; PLASMA; RATS; REPRODUCIBILITY OF RESULTS; SOLVENTS;

EID: 19344364710     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.03.022     Document Type: Article

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