New strategy for antedrug application: Development of metalloproteinase inhibitors as antipsoriatic drugs

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 930-936

  Sawa, Masaaki ^a   Tsukamoto, Takako ^a   Kiyoi, Takao ^a   Kurokawa, Kiriko ^a   Nakajima, Fumio ^a   Nakada, Yuichiro ^a   Yokota, Koichi ^a   Inoue, Yoshimasa ^a   Kondo, Hirosato ^b   Yoshino, Kohichiro ^a  

^a Nippon Organon KK   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; ANTIPSORIASIS AGENT; DNA FRAGMENT; EPIDERMAL GROWTH FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; METALLOPROTEINASE INHIBITOR; N HYDROXY 2 [(2,2 DIFLUOROETHOXY)(4 METHOXYPHENYL)PHOSPHORYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; N HYDROXY 2 [(2,2,2 TRIFLUOROETHOXY)(4 METHOXYPHENYL)PHOSPHORYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHONAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DECOMPOSITION; DRUG SYNTHESIS; ENZYME INHIBITION; EPIDERMIS HYPERPLASIA; HUMAN; INFLAMMATION; MOUSE; NONHUMAN; PLASMA; PROTON NUCLEAR MAGNETIC RESONANCE; PSORIASIS;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; DRUG STABILITY; EPIDERMAL GROWTH FACTOR; GLYCOPROTEINS; GROWTH SUBSTANCES; HUMANS; HYDROXYLAMINES; HYPERPLASIA; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MICE; PROTEASE INHIBITORS; PSORIASIS; RECOMBINANT PROTEINS; SKIN; TETRADECANOYLPHORBOL ACETATE; TETRAHYDROISOQUINOLINES;

EID: 0037075119     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010349c     Document Type: Article

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