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Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 13, 2002, Pages 1719-1722

Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: Potency and plasma stability

(6) Borthwick, Alan D a Exall, Anne M a Haley, Terry M a Jackson, Deborah L a Mason, Andrew M a Weingarten, Gordon G a

a GLAXOSMITHKLINE (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LACTAM DERIVATIVE; PROTEINASE; VIRUS ENZYME; ANTIVIRUS AGENT; DANSYL CHLORIDE; DANSYLPROLINE; DRUG DERIVATIVE; LACTAM; PROLINE; PROTEINASE INHIBITOR; PYRROLIDINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; DRUG MECHANISM; DRUG POTENCY; DRUG STABILITY; HUMAN CYTOMEGALOVIRUS; PLASMA; BLOOD; CHEMISTRY; CYTOMEGALOVIRUS; ELECTROSPRAY MASS SPECTROMETRY; ENZYMOLOGY; HALF LIFE TIME; HUMAN; IC 50;

ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; DANSYL COMPOUNDS; DRUG STABILITY; HALF-LIFE; HUMAN; INHIBITORY CONCENTRATION 50; LACTAMS; PROLINE; PROTEASE INHIBITORS; PYRROLIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; HUMANS;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 0037042763 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(02)00294-9 Document Type: Article

Times cited : (29)

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