Design and synthesis of pyrrolidine-5,5′-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability

Journal of Medicinal Chemistry

Volumn 46, Issue 21, 2003, Pages 4428-4449

  Borthwick, Alan D ^a   Davies, Dave E ^a   Ertl, Peter F ^a   Exall, Anne M ^a   Haley, Terry M ^a   Hart, Graham J ^a   Jackson, Deborah L ^a   Parry, Nigel R ^a   Patikis, Angela ^b   Trivedi, Naimisha ^a   Weingarten, Gordon G ^a   Woolven, James M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Department of Drug Metabolism ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[4 (1,3 BENZOTHIAZOL 2 YL) 6 METHYL 5 OXOHEXAHYDROPYRROLO[3,2 B]PYRROL 1 YL]CARBONYL] N (4 ISOPROPYLPHENYL)PYRROLIDINE 1 CARBOXAMIDE; 5 OXOHEXAHYDROPYRROLO[3,2 B]PYRROLE DERIVATIVE; 6 HYDROXYMETHYLBENZOTHIAZOLE DERIVATIVE; AMIDE; ANTIVIRUS AGENT; GANCICLOVIR; PROTEINASE INHIBITOR; PYRROLIDINE 5,5' LACTAM DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIRALITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; BRAIN; CELLS, CULTURED; CYTOMEGALOVIRUS; DOGS; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE; GANCICLOVIR; GUINEA PIGS; HALF-LIFE; HUMANS; INDICATORS AND REAGENTS; KINETICS; LACTAMS; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEASE INHIBITORS; PYRROLES; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 10744223326     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030810w     Document Type: Article

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