Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae

Genetics

Volumn 169, Issue 4, 2005, Pages 1833-1844

  Karumbati, Anandi S ^a   Wilson, Thomas E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; URACIL DNA GLYCOSYLTRANSFERASE;

ANAPHASE; APN1 GENE; ARTICLE; CELL CYCLE S PHASE; CELL GROWTH; CHK1 PDS1 GENE; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DNA STRAND BREAKAGE; FUNGAL GENE; GENE IDENTIFICATION; GENE MUTATION; GENE REPRESSION; GENETIC EPISTASIS; GENETIC RECOMBINATION; GENETIC STABILITY; METAPHASE; NONHUMAN; PRIORITY JOURNAL; RAD1 GENE; TPP1 GENE;

ANAPHASE; CELL CYCLE PROTEINS; CELL DIVISION; CELL PROLIFERATION; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-BINDING PROTEINS; ENDONUCLEASES; EPISTASIS, GENETIC; FLOW CYTOMETRY; G2 PHASE; GENE DELETION; GENOME, FUNGAL; GENOTYPE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MODELS, GENETIC; MUTATION; NUCLEAR PROTEINS; NUCLEOTIDASES; PHENOTYPE; PLASMIDS; PROTEIN KINASES; S PHASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; URACIL-DNA GLYCOSIDASE;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 18844375357     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.104.035931     Document Type: Article

References (52)

1. AGARWAL, R., Z. TANG, H. YU and O. COHEN-FIX, 2003 Two distinct pathways for inhibiting Pds1 ubiquitination in response to DNA damage. J. Biol. Chem. 278: 45027-45033.
2. ALLEN, J. B., Z. ZHOU, W. SIEDE, E. C. FRIEDBERG and S. J. ELLEDGE, 1994 The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8: 2401-2415.
3. BLANKLEY, R. T., and D. LYDALL, 2004 A domain of Rad9 specifically required for activation of Chk1 in budding yeast. J. Cell Sci. 117: 601-608.
4. CALDECOTT, K. W., 2001 Mammalian DNA single-strand break repair: an X-ra(y)ted affair. BioEssays 23: 447-455.
5. CHABES, A., B. GEORGIEVA, V. DOMKIN, X. ZHAO, R. ROTHSTEIN et al., 2003 Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell 112: 286-287.
6. CLARKE. D. J., M. SEGAL, C. A. ANDREWS, S. G. RUDYAK, S. JENSEN et al., 2003 S-phase checkpoint controls mitosis via an APC-independent Cdc20p function. Nat. Cell Biol. 5: 928-935.
7. COLAIACOVO, M. P., F. PAQUES and J. E. HABER, 1999 Removal of one nonhomologous DNA end during gene conversion by a RAD1- and MSH2-independent pathway. Genetics 151: 1409-1423.
8. CRAVEN, R. J., P. W. GREENWELL, M. DOMINSKA and T. D. PETES, 2002 Regulation of genome stability by TELl and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161: 493-507.
9. DAVIES, A. A., E. C. FRIEDBERG, A. E. TOMKINSON, R. D. WOOD and S. C. WEST, 1995 Role of the Radl and Rad10 proteins in nucleotide excision repair and recombination. J. Biol. Chem. 270: 24638-24641.
10. EVERT, B. A., T. B. SALMON, B. SONG, L. JINGJING, W. SIEDE et al., 2004 Spontaneous DNA damage in Saccharomyces cerevisiae elicits phenotypic properties similar to cancer cells. J. Biol. Chem. 279: 22585-22594.
11. FOIANI, M., M. FERRARI, G. LIBERI, M. LOPES, C. LUCCA et al., 1998 S-phase DNA damage checkpoint in budding yeast. Biol. Chem. 379: 1019-1023.
12. FOIANI, M., A. PELLICIOLI, M. LOPES, C. LUCCA, M. FERRARI et al., 2000 DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae. Mutat. Res. 451: 187-196.
13. FRIEDBERG, E. C., G. C. WALKER and W. SIEDE, 1995 DNA Repair and Mutagenesis. ASM Press, Washington, DC.
14. FRIEDBERG, E. C., L. D. MCDANIEL and R. A. SCHULTZ, 2004 The role of endogenous and exogenous DNA damage and mutagenesis. Curr. Opin. Genet. Dev. 14: 5-10.
15. GARDNER, R. D., and D. J. BURKE, 2000 The spindle checkpoint: two transitions, two pathways. Trends Cell Biol. 10: 154-158.
16. GUILLET, M., and S. BOITEUX, 2002 Endogenous DNA abasic sites cause cell death in the absence of Apnl, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae. EMBO J. 21: 2833-2841.
17. GUILLET, M., and S. BOITEUX, 2003 Origin of endogenous DNA abasic sites in Saccharomyces cereuisiae. Mol. Cell. Biol. 23: 8386-8394.
18. GUILLET, M., and S. BOITEUX, 2004 Abasic sites in DNA: repair and biological consequences in Saccharomyces cereuisiae. DNA Repair 3: 1-12.
19. GUZDER, S. N., C. TORRES-RAMOS, R. E. JOHNSON, L. HARACSKA, L. PRAKASH et al., 1992 Requirement of yeast Rad1-Rad10 nuclease for the removal of 3′-blocked termini from DNA strand breaks induced by reactive oxygen species. Genes Dev. 18: 2283-2291.
20. HOEIJMAKERS, J. H., 2001 Genome maintenance mechanisms for preventing cancer. Nature 411: 366-374.
21. HUANG, D., and D. KOSHLAND, 2003 Chromosome integrity in Saccharomyces cereuisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev. 17: 1741-1754.
22. JOHNSON, R. E., C. A. TORRES-RAMOS, T. IZUMI, S. MITRA, S. PRAKASH et al., 1998 Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev. 12: 3137-3143.
23. KARUMBATI, A. S., R. A. DESHPANDE, A. JILANI, J. R. VANCE, D. RAMOTAR et al., 2003 The role of yeast DNA 3′-phosphatase Tpp1 and Rad1/Rad10 endonuclease in processing spontaneous and induced base lesions. J. Biol. Chem. 278: 31434-31443.
24. KATOU, Y., Y. KANOH, M. BANDO, H. NOGUCHI, H. TANAKA et al., 2003 S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424: 1078-1083.
25. KOLODNER, R. D., C. D. PUTNAM and K. MYUNG, 2002 Maintenance of genome stability in Saccharomyces cerevisiae. Science 297: 552-557.
26. LONGHESE, M. P., M. CLERICI and G. LUCCHINI, 2003 The S-phase checkpoint and its regulation in Saccharomyces cerevisiae. Mutat. Res. 532: 41-58.
27. LOPES, M., C. COTTA-RAMUSINO, A. PELLICIOLI, G. LIBERI, P. PLEVANI et al., 2001 The DNA replication checkpoint response stabilizes stalled replication forks. Nature 412: 557-561.
28. MAJKA, J., and P. M. BURGERS, 2003 Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc. Natl. Acad. Sci. USA 100: 2249-2254.
29. MCVEY, M., M. KAEBERLEIN, H. A. TISSENBAUM and L. GUARENTE, 2001 The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics 157: 1531-1542.
30. MELO, J., and D. TOCZYSKI, 2002 A unified view of the DNA-damage checkpoint. Curr. Opin. Cell Biol. 14: 237-245.
31. NAGAO, K., Y. ADACHI and M. YANAGIDA, 2004 Separase-mediated cleavage of cohesin at interphase is required for DNA repair. Nature 430: 1044-1048.
32. NASMYTH, K., 2001 Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis. Annu. Rev. Genet. 35: 673-745.
33. PAQUES, F., and J. E. HABER, 1999 Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63: 349-404.
34. RHIND, N., and P. RUSSELL, 2000 Checkpoints: it takes more than time to heal some wounds. Curr. Biol. 10: R908-R911.
35. ROUSE, J., 2004 Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J. 23: 1188-1197.
36. ROUSE, J., and S. P. JACKSON, 2002 Interfaces between the detection, signaling, and repair of DNA damage. Science 297: 547-551.
37. SANCHEZ, Y., B. A. DESANY, W. J. JONES, Q. LIU, B. WANG et al., 1996 Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271: 357-360.
38. SANCHEZ, Y., J. BACHANT, H. WANG, F. HU, D. LIU et al., 1999 Control of the DNA damage checkpoint by Chkl and Rad53 protein kinases through distinct mechanisms. Science 286: 1166-1171.
39. SORGER, P. K., and E. S. GILLETT, 2001 Tracing the pathway of spindle assembly checkpoint signaling. Dev. Cell 1: 162-164.
40. SWANSON, R. L., N. J. MOREY, P. W. DOETSCH and S. JINKS-ROBERTSON, 1999 Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. Mol. Cell. Biol. 19: 2929-2935.
41. TOH, G. W., and N. F. LOWNDES, 2003 Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem. Soc. Trans. 31: 242-246.
42. VANCE, J. R., and T. E. WILSON, 2001a Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-spedfic DNA 3′ phosphatases. Mol. Cell. Biol. 21: 7191-7198.
43. VANCE, J. R., and T. E. WILSON, 2001b Uncoupling of 3′-phosphatase and 5′-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3′-phosphatase (Tpp1). J. Biol. Chem. 276: 15073-15081.
44. VANCE, J. R., and T. E. WILSON, 2002 Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage. Proc. Natl. Acad. Sci. USA 99: 13669-13674.
45. WANG, H., D. LIU, Y. WANG, J. QIN and S. J. ELLEDGE, 2001 Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev. 15: 1361-1372.
46. WEINERT, T., E. LITTLE, L. SHANKS, A. ADMIRE, R. GARDNER et al., 2000 Details and concerns regarding the G2/M DNA damage checkpoint in budding yeast. Cold Spring Harbor Symp. Quant. Biol. 65: 433-441.
47. WEINERT, T. A., G. L. KISER, L. H. HARTWELL and R. J. CRAVEN, 1994 Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8: 652-665.
48. YAMAMOTO, A., V. GUACCI and D. KOSHLAND, 1996 Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J. Cell Biol. 133: 99-110.
49. ZEGERMAN, P., and J. F. DIFFLEY, 2003 Lessons in how to hold a fork. Nat. Struct. Biol. 10: 778-779.
50. ZHAO, X., and R. ROTHSTEIN, 2002 The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1. Proc. Natl. Acad. Sci. USA 99: 3746-3751.
51. ZHAO, X., E. G. MULLER and R. ROTHSTEIN, 1998 A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2: 329-340.
52. ZHU, Y., and W. XIAO, 2001 Two alternative cell cycle checkpoint pathways differentially control DNA damage-dependent induction of MAG1 and DDI1 expression in yeast. Mol. Genet. Genomics 266: 436-444.