The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination

Genetics

Volumn 157, Issue 4, 2001, Pages 1531-1542

  McVey, M ^a   Kaeberlein, M ^a   Tissenbaum, H A ^a   Guarente, L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELICASE;

AGING; ARTICLE; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; DNA DAMAGE; GENE MUTATION; MITOSIS INHIBITION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CELL CYCLE; CELL CYCLE PROTEINS; DNA HELICASES; MITOSIS; MUTAGENESIS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0035049599     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

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2. Semi-dominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence pre-diets a protein with similarities to procaryotic RecA proteins
3. Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae
4. Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae
5. Interaction between yeast sgs1 helicase and DNA topoisomerase III
6. Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
7. Elimination of replication block protein Fobl extends the life span of yeast mother cells
8. Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1δ of Saccharomyces cerevisiae
9. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
10. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
11. Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases
12. The many interfaces of Mre11
13. Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast
14. Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast
15. DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage
16. RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae
17. Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae
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19. The SIR2/3/ 4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
20. RecQ family helicases: Roles in cancer and aging
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24. Model for homologous recombination during transfer of DNA into mouse L cells: Role for DNA ends in the recombination process
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28. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
29. Multiple pathways of recombination reduced by double-strand breaks in Saccharomyces cerevisiae
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32. The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
33. The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway
34. RuvAB acts at arrested replication forks
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39. DNA length dependence of the single-strand annealing pathway and the role of Saccharomyces cerevisiae RAD59 in double-strand break repair
40. The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs
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42. DNA topoisomerases
43. Failure to unwind causes cancer. Genome stability
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45. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
46. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
47. Yeast DNA ligase IV mediates non-homologous DNA end joining