Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3′ phosphatases

Molecular and Cellular Biology

Volumn 21, Issue 21, 2001, Pages 7191-7198

  Vance, J R ^a   Wilson, T E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA 3' PHOSPHATASE; EXONUCLEASE; GENE PRODUCT; HYDROGEN PEROXIDE; MESYLIC ACID METHYL ESTER; PHOSPHATASE; PROTEIN TOP1; PROTEIN TPP1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME MECHANISM; GENE DELETION; GENE FUNCTION; GENE MUTATION; LETHALITY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

ALKYLATING AGENTS; BASE SEQUENCE; BLEOMYCIN; CARBON-OXYGEN LYASES; CELL SURVIVAL; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA, FUNGAL; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDODEOXYRIBONUCLEASES; GENE DELETION; HYDROGEN PEROXIDE; KINETICS; METHYL METHANESULFONATE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDASES; OXYGEN; PHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 0034785884     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.21.7191-7198.2001     Document Type: Article

References (28)

1. Phosphoesterase domains associated with DNA polymerases of diverse origins
2. The Saccharomyces ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis
3. A plant 3′-phosphoesterase involved in the repair of DNA strand breaks generated by oxidative damage
4. Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
5. The importance of repairing stalled replication forks
6. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
7. The Ogg1 protein of Saccharomyces cerevisiae: A 7,8-dihydro-8-oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity
8. Intragenic suppression of an active site mutation in the human apurinic/apyridimic endonuclease
9. Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3′-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage
10. Yeast DNA 3′-repair diesterase is the major cellular apurinic/apyrimidinic endonuclease: Substrate specificity and kinetics
11. Yeast DNA diesterase for 3′-fragments of deoxyribose: Purification and physical properties of a repair enzyme for oxidative DNA damage
12. Identification of APN2: The Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites
13. Molecular characterization of a human DNA kinase
14. Oxidative DNA damage and mutagenesis
15. DNA topoisomerase-targeting antitumor drugs can be studied in yeast
16. Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae
17. Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes
18. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin, neocarzinostatin and other enediynes
19. Partial purification of Pde1 from Saccharomyces cerevisiae: Enzymatic redundancy for the repair of 3′ terminal DNA lesions and abasic sites in yeast
20. Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae
21. Conserved sequence motifs among bacterial, eukaryotic, and archaeal phosphatases that define a new phosphohydrolase superfamily
22. 3′-Phosphodiesterase and 3′.5′ exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage
23. A convenient synthesis of oligonucleotides with a 3′ phosphoglycolate and 3′ phosphoglycaldehyde terminus
24. Uncoupling of 3′-phosphatase and 5′-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3′-phosphatase (TPP1)
25. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair
26. Prokaryotic base excision repair
27. A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases