Characterization of the dehydroepiandrosterone (DHEA) metabolism via oxysterol 7α-hydroxylase and 17-ketosteroid reductase activity in the human brain

Journal of Neurochemistry

Volumn 83, Issue 3, 2002, Pages 713-726

  Steckelbroeck, Stephan ^a,b   Watzka, Matthias ^a   Lütjohann, Dieter ^a   Makiola, Paul ^a   Nassen, Alexander ^a   Hans, Volkmar H J ^a   Clusmann, Hans ^a   Reissinger, Annette ^a   Ludwig, Michael ^a   Siekmann, Lothar ^a   Klingmüller, Dietrich ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

17 hydroxysteroid dehydrogenase; CYP39A1; CYP7A1; Neurosteroids

Indexed keywords

17 HYDROXYSTEROID DEHYDROGENASE; 17 OXOSTEROID; GLUCOCORTICOID; KETOCONAZOLE; OXYSTEROL; OXYSTEROL 7ALPHA HYDROXYLASE; PRASTERONE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN TISSUE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; NEOCORTEX; NERVE STIMULATION; NEUROMODULATION; NEUROTOXICITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPORAL LOBE; WHITE MATTER;

17-HYDROXYSTEROID DEHYDROGENASES; ADOLESCENT; ADULT; AGED; ANIMALS; BRAIN; BRAIN CHEMISTRY; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, THIN LAYER; CYTOCHROME P-450 ENZYME SYSTEM; DEHYDROEPIANDROSTERONE; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROGEN-ION CONCENTRATION; INFANT; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; NADP; ORGAN SPECIFICITY; RATS; RATS, WISTAR; RNA, MESSENGER; STEROID HYDROXYLASES; TEMPORAL LOBE;

RODENTIA;

EID: 18644369470     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01187.x     Document Type: Article

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