7-Hydroxylated derivatives of dehydroepiandrosterone: What are they good for ?

Endocrine Regulations

Volumn 31, Issue 4, 1997, Pages 211-218

  Hampl, R ^a   Morfin, R ^b   Starka, L ^a  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

^b Bioinformatique et Chimie Moléculaire   (France)

Author keywords

7 Hydroxy dehydroepiandrosterone; Antiglucocorticoid effects; Dehydroepiandrosterone; Review

Indexed keywords

EID: 0000868180     PISSN: 12100668     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. AKWA Y, YOUNG J, KABBADJ K et al: Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain. J Steroid Biochem Molec Biol 40, 71-81, 1991
2. AKWA Y, MORFIN R, ROBEL P, BAULIEU EE: Neurosteroids metabolism: 7a-hydroxylation of pregnenolone and dehydroepiandrosterone by rat brain microsomes. Biochem J 288, 959-964, 1992
3. AKWA Y, SANANES N, GOUEZOU M et al: Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density. J Cell Biol 121, 135-143, 1993
4. ARANEO B, DAYNES R: Dehydroepiandrosterone functions as more than an anti-glucocorticoid in preserving immunocompetence after thermal injury. Endocrinology 136, 393-401, 1995
5. BARNESS G, ADCOCK J: Anti-inflammatory actions of steroids: molecular mechanisms. TiPS Rev 14, 436-441, 1993
6. BAULIEU EE, EMILIOZZI R, CORPECHOT C: Isolement dans le plasma veineux périphérique et surrénalien de 1 ester-sulfate de 5-androsténe-3β-ol-7,17-dione. Experientia 17, 110-111, 1961
7. BAULIEU EE: Dehydroepiandrosterone (DHEA): a fountain of youth. J Clin Endocrinol Metab 81, 3147-3151, 1996
8. CAIRNS BA, YAMAMOTO H, SMITH D et al: Dehydroepiandrosterone fails to improve immunoglobulin synthesis and lymphocyte mitogenic response after burn injury. J Burn Care Rehabil 15, 509-514, 1994.
9. COUCH RAF, SKINNER SJM, TOBLER CJP, DOOUS TW: The in vitro synthesis of 7-hydroxy-dehydroepiandrosterone by human mammary tissues. Steroids 26, 1-15, 1977
10. DOOSTZADEH J, MORFIN R: Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7α-hydroxylation in mouse tissues. Steroids 61, in press, 1996
11. DOOSTZADEH J, FLINOIS JP, BEAUNE P, MORFIN R: Pregnenolone-7β-hydroxylaling activity of human cytochrome P450-1A1. J Steroid Biochem Molec Biol, in press, 1997a
12. DOOSTZADEH J, URBAN P, POMPON D, MORFIN R: Pregnenolone-7β-hydroxylating activities of yeast-expressed mouse cytochrome P450-1A1 and mouse-tissue microsomes. Europ J Biochem, in press, 1997b
13. EBELING P, KOIVISTO VA: Physiological importance of dehydroepiandrosterone. Lancet 343, 1479-1481, 1994
14. 14C]-dehydroepiandrosterone into 7-oxygenated derivatives by normal male and female skin tissue. J Invest Dermatol 52, 357-361, 1969
15. FUKUSHIMA DK, KEMP AD, SCHNEIDER R et al: Studies in steroid metabolism XXV. Isolation and characterization of new urinary steroids. J Biol Chem 210, 129-137, 1954
16. GRIPPING TG: Dinosaurs and steroids. J Clin Endocrinol Metab 77, 1450-1451, 1993
17. HAMPL R, STARKA L: In vitro metabolic transformations of 7α-hydroxydehydroepi-androsterone in rat liver, adrenal and testis. Endocrin Exper 1, 5-13, 1967
18. HEINRICHS WL, MUSHEN RL, COLAS S: The 7β-hydroxylation of 3β-hydroxyandrost-5-en-17-one by hepatic microsomes. Steroids 9, 23-40, 1967
19. HOLSZTYNSKA EL, WAXMAN DJ: Cytochrome P-450 cholesterol 7α-hydroxylase: Inhibition of enzyme deactivation by structuraly diverse calmodulin antagonists and phosphate inhibitors. Arch Biochem Biophys 256, 543-549, 1987
20. INANO H, TSUNO K, TAMAOKI BI: Identification of 7α-hydroxylated androgens as the metabolites of androstenedione by testicular microsomal fraction of rats. Biochemistry 9, 2253-2260, 1970
21. KALIMI M, SHAFAGOI Y, LORIA R et al: Antiglucocorticoid effects of dehydroepiandrosterone (DHEA). Molec Cell Biochem 131, 99-104, 1994
22. KHALIL MW, STRUTT B, VACHON D, KILLINGER DW: Metabolism of dehydroepiandrosterone by cultured human adipose stromal cells: identification of 7α-hydroxydehydroepiandrosterone as a major metabolite using high performance liquid chromatography and mass spectrometry. J Steroid Biochem Molec Biol 46, 585-595, 1993
23. KHALIL MW, STRUITT B, VACHON D, KILLINGER DW: Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7α-hydroxydehydroepiandrosterone by human adipose stromal cells. J Steroid Biochem Molec Biol 48, 545-552, 1994
24. KILLINGER DW, STRUTT B, RONCARI DA, KHALIL MW: Estrone formation from dehydroepiandrosterone in cultured human breast adipose stromal cells. J Steroid Biochem Molec Biol 52, 195-201, 1995
25. A receptor. Hormone Behav 28, 537-544, 1994
26. LISBOA BP, GUSTAFSSON JA, SJOVAL J: Hydroxylation of testosterone in rat liver microsomes. Europ J Steroids 4, 496-502, 1968
27. LORIA RM, INGE TH, CÖOK SS et al: Protection against lethal infection with the native steroid dehydroepiandrosterone (DHEA). J Med Virol 26, 301-314, 1988
28. MACDONALD PC, DOMBROSKI RA, GASSY ML: Recurrent secretion of progesterone in large amounts: An endocrine/metabolic disorder unique to young women? Endocrine Rev 12, 372-401, 1991
29. MASCHLER I, BALL P, BAYERKOHLER G et al: Identification of 6α- and 7α-hydroxyestrone as major metabolites of estrone and estradiol in porcine uterus. Steroids 41, 597-607, 1983
30. MOHAN PF, CLEARY MP: Studies on nuclear binding of dehydroepiandrosterone in hepatocytes. Steroids 57, 244-247, 1992
31. MORFIN R, COURCHAY G: Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice. J Steroid Biochem Molec Biol 50, 91-100, 1994
32. MORFIN R, YOUNG J, CORPECHOT C et al: Neurosteroids: pregnenolone in human sciatic nerves. Proc Natl Acad Sci USA 89, 6790-6793, 1992
33. MURPHY LJ: Growth factors and steroid hormone action in endometrial cancer (General review). J Steroid Biochem Molec Biol 48, 419-423, 1994
34. NASMAN B, OLSSON T, SECKL JR et al: Abnormalities in adrenal androgens, but not of glucocorticoids, in early Alzheimer's disease. Psychoneuroendocrinol 20, 83-94, 1995
35. OKADA M, FUKUSHIMA DK, GALLAGHER TF: Isolation and characterisation of 3β-hydroxy-5-ene-steroids in adrenal carcinoma. J Biol Chem 234, 1688-1692, 1959
36. PADGETT DA, LORIA RM: In vitro potentiation of lymphocyte activation by dehydroepi-androsterone, androstenediol and androstenetriol. J Immunol 153, 1544-1552, 1994
37. SCHNEIDER JJ, LEWBART ML: Fractionation and isolation of steroid conjugates. Recent Progr Hormone Res 15, 201-230, 1959
38. SKINNER SJM, COUCH RAF, THAMBYAH S et al: The relationship of plasma 7a-hydroxy dehydroepiandrosterone to disease stage and adrenal androgens in breast cancer patients. Europ J Cancer 16, 223-228, 1980
39. SKINNER SJM, TOBLER CJP, COUCH RAF: A radioimmunoassay for 7a-hydroxy dehydroepiandrosterone in human plasma. Steroids 30, 315-330, 1977
40. STARKA L, HAMPL R: Die Isolation des 7-Hydroxydehydroepiandrosteron-Sulphates aus dem menschlichen Plasma. Naturwiss 51, 164-165, 1964
41. STARKA L, KUTOVA J: 7-Hydroxylation of dehydroepiandrosterone by rat liver homogenate. Biochim Biophys Acta 56, 76-82, 1962
42. STARKA L, SULCOVA J, ILINK K: Die Harnauscheidung von 7-Hydroxy-dehydro-epiandrosteronsulfat. Clin Chim Acta 7, 309-316, 1961
43. STARKA L: 7-Hydroxylierung von Dehydroepiandrosteron in menschlichen Nebenierenrinde und Leber. Naturwiss 52, 499-501, 1965
44. SULCOVA J, STARKA L: Extrahepatic 7-hydroxylation of dehydroepiandrosterone. Experientia 19, 632-635, 1963
45. SULCOVA J, STARKA L: Characterisation of microsomal dehydroepiandrosterone 7-hydroxylase from rat liver. Steroids 12, 113-116, 1968
46. SULCOVA J, STARKA L: 7-Hydroxylation of dehydroepiandrosterone in human testis and epididymis in vitro Experientia 28, 1361-1362, 1972
47. SULCOVA J, JIRASEK JE, CARLSTED-DUKE J, STARKA L: Activity of 7-hydroxylase of dehydroepiandrosterone in human amniotic epithelium. J Steroid Biochem 7, 101-104, 1976
48. SULCOVA J, STARKA L, JIRASEK JE: 7-Hydroxylation of dehydroepiandrosterone by the steroidogenic tissues and the liver of human embryo in the first trimester of pregnancy in vitro. Gen Comp Endocr 9, 497-498, 1967
49. TRUSS M, BEATO M: Steroid hormone receptors: interaction with deoxyribonucleic acids and transcription factors. Endocrine Rev 14, 459-479, 1993
50. TUNN S, CLAUS S, SCHULZE H et al: 5a-Androstane-3β,17β-diol hydroxylating enzymes in stroma and epithelium of human benign prostatic hyperplasia (BPH). J Steroid Biochem 28, 257-265, 1987
51. VAN CANTFORT J, RENSON J, GIELEN J: Rat-liver cholesterol 7α-hydroxylase. Eur J Biochem 55, 23-31, 1975
52. VAN CANTFORT J, GIELEN J: Cholesterol 7α-hydroxylase. Eur J Biochem 55, 33-40, 1975
53. WEKSLER MC: Hormone replacement for men. British Medical Journal 312, 859-860, 1996