Intracrinology: Role of the family of 17β-hydroxysteroid dehydrogenases in human physiology and disease

Journal of Molecular Endocrinology

Volumn 25, Issue 1, 2000, Pages 1-16

  Labrie, F ^a   Luu The, V ^a   Lin, S X ^a   Simard, J ^a   Labrie, C ^a   El Alfy, M ^a   Pelletier, G ^a   Belanger, A ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE;

ANDROGEN SYNTHESIS; ENZYME ACTIVITY; ESTROGEN SYNTHESIS; HUMAN; PRIORITY JOURNAL; REVIEW; STEROIDOGENESIS; TARGET ORGAN;

EID: 0033852685     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0250001     Document Type: Review

References (101)

1. Steroidal regulation of oestradioI-17β-dehydrogenase activity of the human breast cancer cell line MCF-7
2. Effects of human breast fibroblasts on growth and 17β-estradiol dehydrogenase activity in MCF-7 cells in culture
3. Paracrine influence of human breast stromal fibroblasts on breast epithelial cells: Secretion of a polypeptide which stimulates reductive 17β-estradiol dehydrogenase activity
4. Interleukin 6 is secreted by breast fibroblasts and stimulates 17β-oestradiol oxidoreductase activity of MCF-7 cells; possible paracrine regulation of breast 17-oestradiol levels
5. Control of secretion and the function of C19-CΔ steroids of the human adrenal gland
6. Molecular cloning of a novel widely expressed human 80 kDa 17β-hydroxysteroid dehydrogenase IV
7. Downregulation of Ke6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease
8. Crystal structure of human estrogenic 17β- hydroxysteroid dehydrogenase complexed with 17β-estradiol
9. Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: Unique importance of extra-testicular androgens in men
10. Maximum androgen-blockade with medical or surgical castration in advanced prostate cancer: A meta-analysis of nine published randomized controlled trials and 4128 patients using Flutamide
11. Endogenous hormones and breast cancer risk
12. Expression cloning and characterization of oxidative 17β- and 3α-hydroxysteroid dehydrogenase from rat and human prostate
13. Potent stimulatory effect of interleukin-lα on apolipoprotein D and gross cystic disease fluid protein-15 expression in human breast-cancer cells
14. Interleukin-6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin-lα on apolipoprotein D and GCDFP-15 expression in human breast cancer cells
15. Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells
16. Morphogenesis of benign prostatic hyperplasia and prostatic carcinoma
17. The relationship between 17β-hydroxysteroid dehydrogenase activity and oestrogen concentrations in human breast tumours and in normal breast tissue
18. Human 17β-hydroxysteroid dehydrogenase: Overproduction using a baculovirus expression system and characterization
19. Fadrozole HCL (CGS-16949A) versus megestrol acetate treatment of post-menopausal patients with metastatic breast carcinoma: Results of 2 randomized double-blind controlled multiinstitutional trials
20. Maximum androgen blockade in advanced prostate cancer: A meta-analysis of published randomized controlled trials using nonsteroidal antiandrogens
21. Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase
22. Effect of combined treatment using radiotherapy and the antiestrogen EM-800 on ZR-75-1 human mammary carcinoma growth in nude mice
23. Androgen receptor-mediated stimulation of 17β-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells
24. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma
25. The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
26. Adrenarche: A survey of rodents, domestic animals and primates
27. The role of estrogens in growth regulation of breast cancer
28. Autocrine and paracrine growth factors in the normal and neoplastic breast
29. Expression and function of the cytokine receptor superfamily on breast cancer
30. Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor
31. Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase
32. Expression of human 17β-hydroxysteroid dehydrogenase in mammalian cells
33. Localization of type 5 17β-hydroxysreroid dehydrogenase, 3β-hydroxysteroid dehydrogenase and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry
34. Characterization of Ke6, a new 17 beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues
35. Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
36. Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2·20 <#ri> resolution
37. DHEA and DHT recognition by human estrogenic 17β-hydrosteroid dehydrogenase: C18/C19 steroid discrimination and enzyme-induced strain
38. Steroid sulfation: Current concepts
39. Recombinant human 11-cis retinol dehydrogenase expresses high 3-hydroxysteroid 9-oxydative activity
40. Macrophages in human breast disease: a quantitative immunohistochemical study
41. Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes
42. A discussion of the roles of estrogen and progestin in human mammary carcinogenesis
43. Determination of cDNA, gene structure and chromosomal localization of the novel human 17 beta-hydroxysteroid dehydrogenase type 7 (1)
44. Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate
45. Intracrinology
46. Intracrinology: Its impact on prostate cancer
47. Screening and hormonal therapy of localized prostate cancer show major benefits on survival
48. New hormonal therapy in prostatic carcinoma: Combined treatment with an LHRH agonist and an antiandrogen
49. Complete androgen blockade for the treatment of prostate cancer
50. Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in advanced prostate cancer: A marked improvement in response and survival
51. Androgens and breast cancer
52. Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues
53. Intracrinology: The basis for the rational design of endocrine therapy at all stages of prostate cancer European Urology
54. History of LHRH agonists and combination therapy in prostate cancer
55. The 3β-hydroxysteroid dehydrogenase/isomerase gene family: lessons from type II 3β-HSD congenital deficiency
56. Physiological changes in DHEA are not reflected by the serum levels of active androgens and estrogens but of their metabolites: intracrinology
57. Effect of 12-month DHEA replacement therapy on bone, vaginum, and endometrium in postmenopausal women
58. The key role of 17β-HSDs in sex steroid biology
59. DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: Its role during aging
60. Long-term combined androgen blockade alone for localized prostate cancer
61. Molecular cloning and amino acid sequence of the porcine 17 beta-estradiol dehydrogenase
62. Subunit identity of the dimeric 17β-hydroxysteroid dehydrogenase from human placenta
63. 3D-structure of human estrogenic 1713-HSD1: Binding with various steroids
64. Characterization of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: Evidence of two mRNA species with distinct 5' termini in human placenta
65. Structure of two in tandem human I7β-hydroxysteroid dehydrogenase genes
66. Dehydroepiandrosterone and estrone 17-ketosteroid reductases in MCF-7 human breast cancer cells
67. The production of progesterone androgens and estrogens by granulosa cells, thecal tissue and stromal tissue from human ovaries in vitro
68. 3H]estradiol by normal breast and breast tumor tissues in postmenopausal women
69. Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues
70. Widespread tissue distribution of steroid sulfatase, 3β-hydroxysteroid dehydrogenase/A5-A4 isomerase (3β-HSD), 17β-HSD 5α-reductase and aromatase activities in the rhesus monkey
71. Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (ml 7 HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat
72. Expression of mouse 17 beta-hydroxysteroid dehydrogenase/ 17-ketosteroid reductase type 7 in the ovary, uterus, and placenta: Localization from implantation to late pregnancy
73. Importance of estrogen sulfates in breast cancer
74. Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA
75. Genomic organization and DNA sequences of human 17β-hydroxysteroid dehydrogenase genes and flanking regions: Localization of multiple Alu sequences and putative cis-acting elements
76. Two 17 beta-hydroxysteroid dehydrogenases (17β HSDs) of estradiol biosynthesis: 17β HSD type 1 and type 7
77. Stimulation of cell proliferation and estrogenic response by adrenal C19-AS-steroids in the ZR-75-1 human breast cancer cell line
78. Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line
79. Antiestrogenic properties of keoxifene, trans-4-hydroxytamoxifen and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells
80. Progestin induction of I7β-hydroxysteroid dehydrogenase enzyme protein in the T-47D human breast cancer cell line
81. 17β-hydroxysteroid dehydrogenase gene expression in human breast cancer cells: Regulation of expression by a progestin
82. Maximum androgen blockade in advanced prostate cancer: an overview of the randomized trials
83. Regulation of aromatase and sulphatase in breast tumours cells
84. Testosterone, dihydrotestosterone and estradiol levels in portmenopausal breast cancer tissue
85. Breast cancer and the role of cytokines in regulating estrogen synthesis: An emerging hypothesis
86. Inhibition of proliferation and clonal growth of human breast cancer cells by interleukin 13
87. Molecular biology and genetics of the 3β-hydroxysteroid dehydrogenase/A5-A4 isomerase gene family
88. Expression of the CYP19 (aromatase) gene, an unusual case of alternative promoter usage
89. Novel aspects of hormone action: intracellular ligand supply and its control by a series of tissue-specific enzymes
90. Multiple form of 17β-hydroxysteroid oxidoreductase in human breast tissue
91. Interleukin 6 decreases cell-cell association and increases motility of ductaI breast carcinoma cells
92. Decreased adherence of interleukin 6-treated breast carcinoma cells can lead to separation from neighbors after mitosis
93. Inhibition of colon and breast carcinoma ceil growth by interleukin-4
94. Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells
95. Endogenous concentrations and subcellular distribution of estrogens in normal and malignant human breast cancer tissues
96. Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women
97. Flow cytometric analysis of tumour infiltrating lymphocytes in breast cancer
98. Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity
99. Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter
100. Monte Carlo-minimized energy profile of estradiol in the ligand-binding tunnel of 17 beta-hydroxysteroid dehydrogenase: Atomic mechanisms of steroid recognition
101. Crystallization and preliminary X-ray diffraction analysis of the complex of human placental 17β-hydroxysteroid dehydrogenase with NADP+