Single nucleotide polymorphisms of thrifty genes for energy metabolism: Evolutionary origins and prospects for intervention to prevent obesity-related diseases

Biochemical and Biophysical Research Communications

Volumn 295, Issue 2, 2002, Pages 207-222

  Kagawa, Yasuo ^a,b   Yanagisawa, Yoshiko ^a   Hasegawa, Kyoko ^a   Suzuki, Hisano ^a   Yasuda, Kazuto ^a   Kudo, Hideki ^a   Abe, Mieko ^a   Matsuda, Sanae ^a   Ishikawa, Yuko ^a   Tsuchiya, Noriko ^a   Sato, Aya ^a,b   Umetsu, Kazuo ^c   Kagawa, Yoshiko ^a  

^a KAGAWA NUTRITION UNIVERSITY   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c YAMAGATA UNIVERSITY   (Japan)

Author keywords

Diabetes; Energy metabolism; mtDNA; SNP

Indexed keywords

DNA; LEPTIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN SUBUNIT; UNCOUPLING PROTEIN 3;

AGRICULTURE; DIABETIC DIET; DISEASE PREDISPOSITION; ENERGY METABOLISM; GENE FREQUENCY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HUMAN; HYPOTHESIS; MOLECULAR EVOLUTION; NATURAL SELECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; RACE DIFFERENCE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SPECIES DIFFERENCE; STARVATION;

EVOLUTION, MOLECULAR; GENOME, HUMAN; GENOTYPE; HUMANS; OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; STARVATION;

EID: 18444418534     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00680-0     Document Type: Article

References (95)

1. 1, mtDNA, UCP, and ROS
2. Overweight and obesity in the United States: Prevalence and trends 1960-1994
3. Descriptive epidemiology of body mass index in Japanese adults in a representative sample from the National Nutrition Survey 1990-1994
4. The thrifty genotype in 1998
5. Type 2 diabetes, the thrifty phenotype - An overview
6. Impact of Westernization on the nutrition of Japanese: Changes in physique, cancer, longevity and centenarians
7. Cold-induced thermoregulation and biological aging
8. Construction and analysis of a human-chimpanzee comparative clone map
9. Mitochondrial disease and polymorphism in the genes for energy transduction
10. mtDNA polymorphism in east asian populations, with special reference to the peopling of Japan
11. Mitochondrial DNA variation in human populations and implications for detection of mitochondrial DNA mutations of pathological significance
12. The origin and dispersal of mordern humans: Inferred from mitochondrial DNA
13. Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis
14. Retroviruses, ascorbate, and mutations, in the evolution of Homo sapiens
15. Human pigmentation genes: Identification, structure and consequences of polymorphic variation
16. The evolution of human skin coloration
17. M235T angiotensinogen gene polymorphism and cardiovascular renal risk
18. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men
19. Age and gender effects on glucose utilization in skeletal muscle and brown adipose tissue of cold-exposed rats
20. Keilin's respiratory chain concept and its chemiosmotic consequences
21. Reconstitution of oxidative phosphorylation
22. The ATP synthase - A splendid molecular machine
23. Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism
24. Chronic docosahexa-enoic acid intake enhances expression of the gene for uncoupling protein 3 and affects pleiotropic mRNA levels in skeletal muscle of aged C57BL/6NJcl mice
25. Energy metabolism in uncoupling protein 3 gene knockout mice
26. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
27. Nutrition, thyroid function and basal metabolism of the Evenki of central Siberia
28. Lactose intolerance
29. Genetic link between Asians and native Americans: Evidence from HLA genes and haplotypes
30. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice
31. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
32. Genetic versus environmental aetiology of the metabolic syndrome among male and female twins
33. Genetic and environmental influences on total-body and central abdominal fat: The effect of physical activity in female twins
34. Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs
35. The importance of genealogy in determining genetic association with complex traits
36. Nutrition, oxidative damage, telomere shortening, and cellular senescence: Individual or connected agents of aging?
37. The relationships of animal age and caloric intake to cellular replication in vivo and in vitro: A review
38. Uncoupling protein 3 and peroxisome proliferator-activated receptor γ 2 contribute to obesity and diabetes in Palauans
39. Sodium intake and blood pressure in two Polynesian populations
40. The effect of Indian or Anglo dietary preference on the incidence of diabetes in Pima Indians
41. Heritability of obesity-related traits among Nigerians, Jamaicans and US black people
42. Incidence of non-insulin-dependent diabetes mellitus and its risk factors in Japanese-Americans living in Hawaii and Los Angeles
43. Developmental aspects in the pathogenesis of type 2 diabetes
44. Decline in incidence of epidemic glucose intolerance in Nauruans: Implications for the thrifty genotype
45. Effects of the FABP2 A54T mutation on triglyceride metabolism of viscerally obese men
46. The polymorphism at codon 54 of the FABP2 gene increases fat absorption in human intestinal explants
47. A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels
48. Positional cloning of the mouse obese gene and its human homologue
49. Identification and expression cloning of a leptin receptor, OB-R
50. Obesity and the regulation of energy balance
51. Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression
52. A genetic variation in the 5′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity
53. A novel polymorphism in the proximal UCP3 promoter region: Effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians
54. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
55. Variation in the calpain-10 gene affects blood glucose levels in the British population
56. Mitochondrial function in normal and diabetic β-cells
57. The Trp64Arg mutation of the adrenergic beta-3 receptor gene impairs insulin secretion: A twin study
58. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction and type 2 diabetes
59. y mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid
60. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
61. Antiatherogenic mitochondrial genotype in patients with type 2 diabetes
62. Meta-analysis of the association of Trp64Arg polymorphism of beta 3-adrenergic receptor gene with body mass index
63. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
64. 1998 Clinical practice guidelines for the management of diabetes in Canada
65. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study
66. Improvements in circulating cholesterol, antioxidants, and homocysteine after dietary intervention in an Australian Aboriginal community
67. Angiotensinogen genotype, sodium reduction, weight loss, and prevention of hypertension. Trials of hypertension prevention, phase II
68. Secondary prevention of cardiovascular diseases of outpatients of the Nutrition Clinic
69. Polymorphisms of uncoupling protein (UCP) and beta 3-adrenoreceptor genes in obese people submitted to a low calorie diet
70. Mutation of beta 3-adrenergic-receptor gene and response to treatment of obesity
71. APOE genotype as a risk factor for ischemic cerebrovascular disease: A meta-analysis
72. The dietary approaches to stop hypertension (DASH) clinical trial: Implications for lifestyle modifications in the treatment of hypertensive patients
73. Genetic variation at the uncoupling protein 1, 2, and 3 loci and the response to long-term overfeeding
74. Ten years of life: Is it a matter of choice?
75. Coronary heart diseases mortality among Seventh-Day Adventists with differing dietary habits
76. Eicosapentaenoic acids of the serum lipids of Japanese islanders with low incidence of cardiovascular diseases
77. Relationship between anthropometric state by BMI and single nucleotide polymorphism (SNP) of genes concerning the energy metabolism of healthy inhabitants in Ozato, Okinawa
78. Association of the Ala54-Thr polymorphism in the intestinal fatty acid-binding protein with 2-h postchallenge insulin levels in the Framingham Offspring Study
79. Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study
80. Genetics of body-weight regulation
81. Synergistic effect of polymorphisms in uncoupling protein 1 and beta 3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects
82. Differential regulation of exonic regulatory elements for muscle-specific alternative splicing during myogenesis and cardiogenesis
83. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
84. Muscle-specific exonic splicing silencer for exon exclusion in human ATP synthase γ-subunit pre-mRNA
85. Leptin stimulates fatty acid oxidation by acting AMP-activated protein kinase
86. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population
87. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
88. Gene therapy by mitochondrial transfer
89. Inter-mitochondrial complementation: Mitochondria- specific system preventing mice from expression of disease phenotypes by mutant mtDNA
90. Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians
91. Single nucleotide polymorphisms and the future of genetic epidemiology