Extracellular toxicity of 6-hydroxydopamine on PC12 cells

Neuroscience Letters

Volumn 283, Issue 3, 2000, Pages 193-196

  Blum, David ^a,b   Torch, Sakina ^b   Nissou, Marie France ^b   Benabid, Alim Louis ^c   Verna, Jean Marc ^b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b HÔPITAL MICHALLON   (France)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

6 Hydroxydopamine; Cell death; Neurotoxicity; Oxidative stress; Parkinson's disease; PC12 cells

Indexed keywords

ACETYLCYSTEINE; CATALASE; DESIPRAMINE; GLUTATHIONE; NEUROTOXIN; OXIDOPAMINE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; CELL DEATH; CELL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; DRUG TOXICITY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0034646802     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)00948-4     Document Type: Article

References (16)

1. 2 in chromaffin cells. Eur. J. Pharmacol. 293:1995;55-64.
2. Baunez C., Nieoullon A., Amalric M. In rat model of parkinsonism, lesions of the subthalamic nucleus reverses increases of reaction time but induce a dramatic premature responding deficit. J. Neurosci. 15:1995;6531-6541.
3. Blum D., Wu Y., Nissou M.F., Arnaud S., Benabid A.L., Verna J.M. p53 and Bax activation in 6-OHDA-induced apoptosis in PC12 cells. Brain Res. 751:1997;139-142.
4. Chritin M., Blanchard V., Raisman-Vozari R., Feuerstein C., Agid Y., Javoy-Agid F., Savasta M. DA uptake sites D1 and D2 receptors, D2 and preproenkephalin mRNAs and fos immunoreactivity in rat striatal subregions after partial dopaminergic degeneration. Eur. J. Neurosci. 8:1996;2511-2520.
5. Decker D.E., Althaus J.S., Buxser S.E., Von Voigtlander P.F., Ruppel P.L. Competitive irreversible inhibition of dopamine uptake by 6-hydroxydopamine. Res. Comm. Chem. Pathol. Pharmacol. 79:1993;195-208.
6. Gerlach M., Riederer P. Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man. J. Neural Transm. 103:1996;987-1041.
7. Glinka Y., Gassen M., Youdim M.B.H. Mechanism of 6-hydroxydopamine neurotoxicity. J. Neural Transm. 50:1997;55-66.
8. Graham D.G., Tiffany S.M., Bell W.R., Gutknecht W.F. Autooxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine 6-hydroxydopamine, and related compounds toward C1300 Neuroblastoma cells in vitro. Mol. Pharmacol. 14:1978;644-653.
9. Hirsch E.C., Faucheux B., Damier P., Mouatt-Prigent A., Agid Y. Neuronal vulnerability in Parkinson's disease. J. Neural Transm. 50:1997;79-88.
10. Jonsson G., Sachs C. Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons. Eur. J. Pharmacol. 9:1970;141-155.
11. Lotharius J., Dugan L.L., O'Malley K. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J. Neurosci. 19:1999;1284-1293.
12. Okamura H., Yokoyama C., Ibata Y. Lateral gradient of the susceptibility of midbrain dopaminergic neurons to neonatal 6-hydroxydopamine toxicity. Exp. Neurol. 136:1995;136-142.
13. Tifany-Castiglioni E., Saneto R.P., Proctor P.H., Perez-Polo J.R. Participation of active oxygen species in 6-hydroxydopamine toxicity to a human neuroblastoma cell line. Biochem. Pharmacol. 31:1982;181-188.
14. Walkinshaw G., Waters C.M. Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neuroscience. 63:1994;975-987.
15. Woodgate A., MacGibbon G., Walton M., Dragunow M. The toxicity of 6-hydroxydopamine on PC12 and P19 cells. Mol. Brain Res. 69:1999;84-92.
16. +, apoptosis induced by 6-OHDA in PC12 cells is independent of mitochondrial inhibition. Neurosci. Lett. 221:1996;69-71.