-
1
-
-
0027435899
-
Iron induced oxidative stress and mitochondrial dysfunction: Relevance to Parkinson's disease
-
HARLEY, A. et al. 1993. Iron induced oxidative stress and mitochondrial dysfunction: relevance to Parkinson's disease. Brain Res. 627: 349-353.
-
(1993)
Brain Res.
, vol.627
, pp. 349-353
-
-
Harley, A.1
-
2
-
-
0032975570
-
The role of iron in neurodegeneration: Prospects for pharmacotherapy of Parkinson's disease
-
JELLINGER, K.A. 1999. The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease. Drugs Aging 14: 115-140.
-
(1999)
Drugs Aging
, vol.14
, pp. 115-140
-
-
Jellinger, K.A.1
-
3
-
-
1642555537
-
Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases
-
SHOHAM, S. & M.B. YOUDIM. 2000. Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases. Cell. Mol. Biol. 46: 743-760.
-
(2000)
Cell. Mol. Biol.
, vol.46
, pp. 743-760
-
-
Shoham, S.1
Youdim, M.B.2
-
4
-
-
0031001278
-
Iron chelating therapy and the treatment of thalassemia
-
OLIVIERI, N.F. & G. BRITTENHAM. 1997. Iron chelating therapy and the treatment of thalassemia. Blood 89: 739-761.
-
(1997)
Blood
, vol.89
, pp. 739-761
-
-
Olivieri, N.F.1
Brittenham, G.2
-
5
-
-
0037411115
-
β-Thalassaemia: Emergence of new and improved chelators for treatment
-
WONG, C. & D.R. RICHARDSON. 2003. β-Thalassaemia: emergence of new and improved chelators for treatment. Int. J. Biochem. Cell Biol. 35: 1144-1149.
-
(2003)
Int. J. Biochem. Cell Biol.
, vol.35
, pp. 1144-1149
-
-
Wong, C.1
Richardson, D.R.2
-
6
-
-
0000723121
-
Iron transport in the central nervous system
-
Dekker. New York
-
BURDO, J.R. & J.R. CONNOR. 2002. Iron transport in the central nervous system. In Molecular and Cellular Iron Transport, pp. 487-508. Dekker. New York.
-
(2002)
Molecular and Cellular Iron Transport
, pp. 487-508
-
-
Burdo, J.R.1
Connor, J.R.2
-
7
-
-
0031567095
-
The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
-
RICHARDSON, D.R. & P. PONKA. 1997. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim. Biophys. Acta 1331: 1-40.
-
(1997)
Biochim. Biophys. Acta
, vol.1331
, pp. 1-40
-
-
Richardson, D.R.1
Ponka, P.2
-
8
-
-
0019860059
-
Transferrin biochemistry, physiology, and clinical significance
-
MORGAN, E. 1981. Transferrin biochemistry, physiology, and clinical significance. Mol. Aspects Med. 4: 1-123.
-
(1981)
Mol. Aspects Med.
, vol.4
, pp. 1-123
-
-
Morgan, E.1
-
9
-
-
0030755366
-
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
-
GUNSHIN, H. et al. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488.
-
(1997)
Nature
, vol.388
, pp. 482-488
-
-
Gunshin, H.1
-
10
-
-
0030763856
-
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
-
FLEMING, M.D. et al. 1997. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16: 383-386.
-
(1997)
Nat. Genet.
, vol.16
, pp. 383-386
-
-
Fleming, M.D.1
-
11
-
-
0021130764
-
Transferrin receptor on endothelium of brain capillaries
-
JEFFERIES, W.A. et al. 1984. Transferrin receptor on endothelium of brain capillaries. Nature 312: 162-163.
-
(1984)
Nature
, vol.312
, pp. 162-163
-
-
Jefferies, W.A.1
-
12
-
-
0023547088
-
Receptor-mediated transcytosis of transferrin across the blood brain barrier
-
FISHMAN, J.B. et al. 1987. Receptor-mediated transcytosis of transferrin across the blood brain barrier. J. Neurosci. Res. 18: 299-304.
-
(1987)
J. Neurosci. Res.
, vol.18
, pp. 299-304
-
-
Fishman, J.B.1
-
13
-
-
0027535206
-
Receptor-mediated endocytosis of transferrin at the blood-brain barrier
-
ROBERTS, R.L. et al. 1993. Receptor-mediated endocytosis of transferrin at the blood-brain barrier. J. Cell. Sci. 104: 521-532.
-
(1993)
J. Cell. Sci.
, vol.104
, pp. 521-532
-
-
Roberts, R.L.1
-
14
-
-
0025354340
-
Developmental changes in transferrin and iron uptake by the brain in the rat
-
TAYLOR, E.M. & E.H. MORGAN. 1990. Developmental changes in transferrin and iron uptake by the brain in the rat. Dev. Brain Res. 55: 35-42.
-
(1990)
Dev. Brain Res.
, vol.55
, pp. 35-42
-
-
Taylor, E.M.1
Morgan, E.H.2
-
15
-
-
0033597780
-
Molecular cloning of transferrin receptor 2: A new member of the transferrin receptor-like family
-
KAWABATA, H. et al. 1999. Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family. J. Biol. Chem. 274: 20826-20832.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20826-20832
-
-
Kawabata, H.1
-
16
-
-
0034595856
-
Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo
-
KAWABATA, H. et al. 2000. Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo. J. Biol. Chem. 275: 16618-16625.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16618-16625
-
-
Kawabata, H.1
-
17
-
-
0027944830
-
Two saturable mechanisms of iron uptake from transferrin in human melanoma cells: The effect of transferrin concentration, chelators, and metabolic probes on transferrin and iron uptake
-
RICHARDSON, D.R. & E. BAKER. 1994. Two saturable mechanisms of iron uptake from transferrin in human melanoma cells: the effect of transferrin concentration, chelators, and metabolic probes on transferrin and iron uptake. J. Cell. Physiol. 161: 160-168.
-
(1994)
J. Cell. Physiol.
, vol.161
, pp. 160-168
-
-
Richardson, D.R.1
Baker, E.2
-
18
-
-
0029953577
-
Transferrin receptor-independent uptake of diferric transferrin by human hepatoma cells with antisense inhibition of receptor expression
-
TRINDER, D. et al. 1996. Transferrin receptor-independent uptake of diferric transferrin by human hepatoma cells with antisense inhibition of receptor expression. Hepatology 23: 1512-1520.
-
(1996)
Hepatology
, vol.23
, pp. 1512-1520
-
-
Trinder, D.1
-
19
-
-
0017700831
-
Low molecular weight intracellular iron transport compounds
-
JACOBS, A. 1977. Low molecular weight intracellular iron transport compounds. Blood 50: 433-439.
-
(1977)
Blood
, vol.50
, pp. 433-439
-
-
Jacobs, A.1
-
20
-
-
0032533549
-
Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts
-
RADISKY, D.C. & J. KAPLAN. 1998, Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts. Biochem. J. 336: 201-205.
-
(1998)
Biochem. J.
, vol.336
, pp. 201-205
-
-
Radisky, D.C.1
Kaplan, J.2
-
21
-
-
0029865751
-
Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: Examination of the intermediates involved in iron metabolism
-
RICHARDSON, D.R. et al. 1996. Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism. Blood 87: 3477-3488.
-
(1996)
Blood
, vol.87
, pp. 3477-3488
-
-
Richardson, D.R.1
-
22
-
-
0030608152
-
The ferritins: Molecular properties, iron storage function, and cellular regulation
-
HARRISON, P.M. & P. AROSIO. 1996. The ferritins: molecular properties, iron storage function, and cellular regulation. Biochim. Biophys. Acta 1275: 161-203.
-
(1996)
Biochim. Biophys. Acta
, vol.1275
, pp. 161-203
-
-
Harrison, P.M.1
Arosio, P.2
-
23
-
-
0029758487
-
Molecular control of vertebrate iron metabolism: MRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
-
HENTZE, M.W. & L.C. KÜHN. 1996. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl. Acad. Sci. USA 93: 8175-8182.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 8175-8182
-
-
Hentze, M.W.1
Kühn, L.C.2
-
24
-
-
0037316787
-
Huntingtin in health and disease
-
YOUNG, A.B. 2003. Huntingtin in health and disease. J. Clin. Invest. 111: 299-302.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 299-302
-
-
Young, A.B.1
-
25
-
-
0034703860
-
Huntingtin: An iron regulated protein essential for normal nuclear and perinuclear organelles
-
HILDITCH-MAGUIRE, P. et al. 2000. Huntingtin: an iron regulated protein essential for normal nuclear and perinuclear organelles. Hum. Mol. Genet. 9: 2789-2797.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2789-2797
-
-
Hilditch-Maguire, P.1
-
26
-
-
0036048876
-
Recent developments in the pathology of Parkinson's disease
-
JELLINGER, K.A. 2002. Recent developments in the pathology of Parkinson's disease. J. Neural Transm. Suppl. 62: 347-376.
-
(2002)
J. Neural Transm. Suppl.
, vol.62
, pp. 347-376
-
-
Jellinger, K.A.1
-
27
-
-
0036591852
-
Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease
-
TABNER, B.J. et al. 2002. Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radical Biol. Med. 32: 1076-1083.
-
(2002)
Free Radical Biol. Med.
, vol.32
, pp. 1076-1083
-
-
Tabner, B.J.1
-
28
-
-
0036152892
-
Iron and Parkinson's disease
-
WOLOZIN, B. & N. GOLTS. 2002. Iron and Parkinson's disease. Neuroscientist 8: 22-32.
-
(2002)
Neuroscientist
, vol.8
, pp. 22-32
-
-
Wolozin, B.1
Golts, N.2
-
29
-
-
0036670712
-
Aggregation and neurotoxicity of alpha-synuclein and related peptides
-
EL-AGNAF, O.M. & G.B. IRVINE. 2002. Aggregation and neurotoxicity of alpha-synuclein and related peptides. Biochem. Soc. Trans. 30: 559-565.
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 559-565
-
-
El-Agnaf, O.M.1
Irvine, G.B.2
-
30
-
-
0036798434
-
Lack of up-regulatjon of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease
-
FAUCHEUX, B.A. et al. 2002. Lack of up-regulatjon of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease. J. Neurochem. 83: 320-330.
-
(2002)
J. Neurochem.
, vol.83
, pp. 320-330
-
-
Faucheux, B.A.1
-
31
-
-
0037216723
-
Mouse brains deficient in H-ferritin have normal iron concentration, but a protein profile of iron deficiency and increased evidence of oxidative stress
-
THOMPSON, K. et al. 2003. Mouse brains deficient in H-ferritin have normal iron concentration, but a protein profile of iron deficiency and increased evidence of oxidative stress. J. Neurosci. Res. 71: 46-63.
-
(2003)
J. Neurosci. Res.
, vol.71
, pp. 46-63
-
-
Thompson, K.1
-
32
-
-
0035138456
-
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
-
LAVAUTE, T. et al. 2001. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat. Genet. 27: 209-214.
-
(2001)
Nat. Genet.
, vol.27
, pp. 209-214
-
-
LaVaute, T.1
-
33
-
-
0036869157
-
Polymorphisms in iron-responsive binding protein 2 and lack of association with sporadic Parkinson's disease
-
LEE, P.L. et al. 2002. Polymorphisms in iron-responsive binding protein 2 and lack of association with sporadic Parkinson's disease. Mov. Disord. 17: 1302-1304.
-
(2002)
Mov. Disord.
, vol.17
, pp. 1302-1304
-
-
Lee, P.L.1
-
34
-
-
0036306510
-
Association study between iron-related genes polymorphisms and Parkinson's disease
-
BORIE, C. et al. 2002. Association study between iron-related genes polymorphisms and Parkinson's disease. J. Neurol. 249: 801-804.
-
(2002)
J. Neurol.
, vol.249
, pp. 801-804
-
-
Borie, C.1
-
35
-
-
0035941201
-
Metal triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein: A possible molecular NK between Parkinson's disease and heavy metal exposure
-
UVERSKY, V.N. et al. 2001. Metal triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein: a possible molecular NK between Parkinson's disease and heavy metal exposure. J. Biol. Chem. 276: 44284-44296.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44284-44296
-
-
Uversky, V.N.1
-
36
-
-
0035241245
-
Neuroimaging in basal ganglia disorders: Perspectives for transcranial ultrasound
-
BECKER, G. & D. BERG. 2001. Neuroimaging in basal ganglia disorders: perspectives for transcranial ultrasound. Mov. Disord. 16: 23-32.
-
(2001)
Mov. Disord.
, vol.16
, pp. 23-32
-
-
Becker, G.1
Berg, D.2
-
37
-
-
0035227581
-
Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease?
-
ANDERSEN, J.K. 2001. Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? Novartis Found. Symp. 235: 11-20.
-
(2001)
Novartis Found. Symp.
, vol.235
, pp. 11-20
-
-
Andersen, J.K.1
-
38
-
-
0037188472
-
The galvanization of β-amyloid in Alzheimer's disease
-
BUSH, A.I. & R.E. TANZI. 2002. The galvanization of β-amyloid in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 99: 7317-7319.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7317-7319
-
-
Bush, A.I.1
Tanzi, R.E.2
-
39
-
-
0021256895
-
Alzheimer's disease: Initial report of purification and characterization of a novel cerebrovascular protein
-
GLENNER, G.G. & C.W. WONG. 1984. Alzheimer's disease: initial report of purification and characterization of a novel cerebrovascular protein. Biochem. Biophys. Res. Commun. 120: 885-890.
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
40
-
-
0029063033
-
Amyloid beta-binding protein in vitro and in normal human cerebrospinal fluid
-
GOLABECK, A. et al. 1995. Amyloid beta-binding protein in vitro and in normal human cerebrospinal fluid. Neurosci. Lett. 191: 79-82.
-
(1995)
Neurosci. Lett.
, vol.191
, pp. 79-82
-
-
Golabeck, A.1
-
41
-
-
0033986037
-
Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains
-
SU, S.W. et al. 2000. Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains. Brain Res. 852: 274-278.
-
(2000)
Brain Res.
, vol.852
, pp. 274-278
-
-
Su, S.W.1
-
42
-
-
0033855331
-
Chelation and intercalation: Complementary properties in a compound for the treatment of Alzheimer's disease
-
CHERNY, R.A. et al. 2000. Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J. Struct. Biol. 130: 209-216.
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 209-216
-
-
Cherny, R.A.1
-
43
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
CHERNY, R.A. et al. 2002. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30: 665-676.
-
(2002)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
-
44
-
-
0032557425
-
Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis
-
ATWODD, C.S. et al. 1998. Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis. J. Biol. Chem. 273: 12817-12826.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12817-12826
-
-
Atwodd, C.S.1
-
45
-
-
0033844944
-
Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42
-
ATWODD, C.S. et al. 2000. Characterization of copper interactions with Alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta 1-42. J. Neurochem. 75: 1219-1233.
-
(2000)
J. Neurochem.
, vol.75
, pp. 1219-1233
-
-
Atwodd, C.S.1
-
46
-
-
0035827681
-
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
-
CURTAIN, C.C. et al. 2001. Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. J. Biol. Chem. 276: 20466-20473.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20466-20473
-
-
Curtain, C.C.1
-
47
-
-
0037174856
-
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)
-
OPAZO, C. et al. 2002. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J. Biol. Chem. 277: 40302-40308.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40302-40308
-
-
Opazo, C.1
-
48
-
-
0027980901
-
Rapid induction of Alzheimer A beta amyloid formation by zinc
-
BUSH, A.I. et al. 1994. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265: 1464-1467.
-
(1994)
Science
, vol.265
, pp. 1464-1467
-
-
Bush, A.I.1
-
49
-
-
0033587478
-
Histidine-13 is a critical residue in the zinc-ion induced aggregation of the A beta peptide in Alzheimer's disease
-
LIU, S.T. et al. 1999. Histidine-13 is a critical residue in the zinc-ion induced aggregation of the A beta peptide in Alzheimer's disease. Biochemistry 38: 9373-9378.
-
(1999)
Biochemistry
, vol.38
, pp. 9373-9378
-
-
Liu, S.T.1
-
50
-
-
0037188530
-
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice
-
LEE, J-Y. et al. 2002. Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc. Natl. Acad. Sci. USA 99: 7705-7710.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7705-7710
-
-
Lee, J.-Y.1
-
51
-
-
0036860349
-
Metal completing agents as therapies for Alzheimer's disease
-
BUSH, A.I. 2002. Metal completing agents as therapies for Alzheimer's disease. Neurobiol. Aging 23: 1031-1038.
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 1031-1038
-
-
Bush, A.I.1
-
52
-
-
0035865905
-
Redox-active iron mediated beta-amyloid toxicity
-
ROTTKAMP, C.A. et al. 2001. Redox-active iron mediated beta-amyloid toxicity. Free Radical Biol. Med. 30: 447-450.
-
(2001)
Free Radical Biol. Med.
, vol.30
, pp. 447-450
-
-
Rottkamp, C.A.1
-
53
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
-
ROGERS, J.T. et al. 2002. An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript. J. Biol. Chem. 277: 45518-45528.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45518-45528
-
-
Rogers, J.T.1
-
54
-
-
0036975682
-
Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease
-
DE FELICE, F.G. & ST. FERREIRA. 2002. Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease. Cell. Mol. Neurobiol. 22: 545-563.
-
(2002)
Cell. Mol. Neurobiol.
, vol.22
, pp. 545-563
-
-
De Felice, F.G.1
Ferreira, S.T.2
-
55
-
-
18444399243
-
Treatment of Alzheimer's disease with clioquinol
-
REGLAND, B. et al. 2001 Treatment of Alzheimer's disease with clioquinol. Dement. Geriatr. Cogn. Disord. 12: 408-414.
-
(2001)
Dement. Geriatr. Cogn. Disord.
, vol.12
, pp. 408-414
-
-
Regland, B.1
-
57
-
-
0016726066
-
The neuropathology of subacute myelo-optico-neuropathy (SMONS) in the humans: With special reference to the quinoform intoxication
-
SHIRAKI, H. 1975. The neuropathology of subacute myelo-optico-neuropathy (SMONS) in the humans: with special reference to the quinoform intoxication. Jpn. J. Med. Sci. Biol. 28: 101-164.
-
(1975)
Jpn. J. Med. Sci. Biol.
, vol.28
, pp. 101-164
-
-
Shiraki, H.1
-
58
-
-
0031761894
-
Clioquinol-zinc chelate: A candidate causative agent of subacute myelo-optic neuropathy
-
ARBISER, J.L. et al. 1998. Clioquinol-zinc chelate: a candidate causative agent of subacute myelo-optic neuropathy. Mol. Med. 4: 665-670.
-
(1998)
Mol. Med.
, vol.4
, pp. 665-670
-
-
Arbiser, J.L.1
-
59
-
-
0342700237
-
Recent advances in the molecular pathogenesis of Friedreich ataxia
-
PUCCIO, H. & M. KOENIG. 2000. Recent advances in the molecular pathogenesis of Friedreich ataxia. Hum. Mol. Genet. 9: 887-892.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 887-892
-
-
Puccio, H.1
Koenig, M.2
-
60
-
-
0035122450
-
Frataxin: Its role in iron metabolism and the pathogenesis of Friedreich's ataxia
-
BECKER, E. & D.R. RICHARDSON. 2001. Frataxin: its role in iron metabolism and the pathogenesis of Friedreich's ataxia. Int. J. Biochem. Cell Biol. 33: 1-10.
-
(2001)
Int. J. Biochem. Cell Biol.
, vol.33
, pp. 1-10
-
-
Becker, E.1
Richardson, D.R.2
-
61
-
-
0033582421
-
The yeast frataxin homologue mediates mitochondrial iron efflux: Evidence for a mitochondrial iron cycle
-
RADISKY, D.C. et al. 1999. The yeast frataxin homologue mediates mitochondrial iron efflux: evidence for a mitochondrial iron cycle. J. Biol. Chem. 274: 4497-4499.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 4497-4499
-
-
Radisky, D.C.1
-
62
-
-
0037093206
-
Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: Characterisation of frataxin expression compared to molecules involved in iron metabolism and hemoglobinisation
-
BECKER, E. et al. 2002. Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterisation of frataxin expression compared to molecules involved in iron metabolism and hemoglobinisation. Blood 99: 3813-3822.
-
(2002)
Blood
, vol.99
, pp. 3813-3822
-
-
Becker, E.1
-
63
-
-
0037101845
-
The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins
-
MÜIILENHOFF, U. et al. 2002. The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins. Hum. Mol. Genet. 11: 2025-2036.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 2025-2036
-
-
Müiilenhoff, U.1
-
64
-
-
0037447390
-
Iron use for haem synthesis is under the control of the yeast frataxin homologue (Yfh1)
-
LESUISSE, E. et al. 2003. Iron use for haem synthesis is under the control of the yeast frataxin homologue (Yfh1). Hum. Mol. Genet. 12: 879-889.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 879-889
-
-
Lesuisse, E.1
-
65
-
-
0036569986
-
Molecular basis of cellular iron toxicity
-
EATON, J.W. & M. QIAN. 2002. Molecular basis of cellular iron toxicity. Free Radical Biol. Med. 32: 833-840.
-
(2002)
Free Radical Biol. Med.
, vol.32
, pp. 833-840
-
-
Eaton, J.W.1
Qian, M.2
-
66
-
-
0030846021
-
Regulation of mitochondrial iron accumulation by Yfh1p, a putative homologue of frataxin
-
BABCOCK, M. et al. 1997. Regulation of mitochondrial iron accumulation by Yfh1p, a putative homologue of frataxin. Science 276: 1709-1712.
-
(1997)
Science
, vol.276
, pp. 1709-1712
-
-
Babcock, M.1
-
67
-
-
0035138072
-
Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect, and Fe-S enzyme deficiency followed by intramitochondrial iron deposits
-
PUCCIO, H. et al. 2001. Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect, and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet. 27: 181-186.
-
(2001)
Nat Genet.
, vol.27
, pp. 181-186
-
-
Puccio, H.1
-
68
-
-
0031253821
-
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia
-
ROTIG, A. et al. 1997. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat. Genet. 17: 215-217.
-
(1997)
Nat. Genet.
, vol.17
, pp. 215-217
-
-
Rotig, A.1
-
69
-
-
0033054177
-
The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis
-
WONG, A. et al. 1999. The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis. Hum. Mol. Genet. 8: 425-430.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 425-430
-
-
Wong, A.1
-
70
-
-
0033533071
-
Effect of idebenone on cardiomyopathy in Friedreich's ataxia: A preliminary study
-
RUSTIN, P. et al. 1999. Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study. Lancet 354: 477-479.
-
(1999)
Lancet
, vol.354
, pp. 477-479
-
-
Rustin, P.1
-
71
-
-
0035020940
-
Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia
-
LODI, R. et al. 2001. Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia. Ann. Neurol. 49: 590-596.
-
(2001)
Ann. Neurol.
, vol.49
, pp. 590-596
-
-
Lodi, R.1
-
72
-
-
0036221156
-
Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia
-
HAUSSE, A.O. et al. 2002. Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia. Heart 87: 346-349.
-
(2002)
Heart
, vol.87
, pp. 346-349
-
-
Hausse, A.O.1
-
73
-
-
0028158768
-
The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell
-
RICHARDSON, D.R. et al. 1994. The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell. Cancer Res. 54: 685-689.
-
(1994)
Cancer Res.
, vol.54
, pp. 685-689
-
-
Richardson, D.R.1
-
74
-
-
0018394556
-
Mobilization of iron from reticulocytes: Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent
-
PONKA, P. et al. 1979. Mobilization of iron from reticulocytes: identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent. FEBS Lett. 97: 317-321.
-
(1979)
FEBS Lett.
, vol.97
, pp. 317-321
-
-
Ponka, P.1
-
75
-
-
0035978474
-
Development of potential iron chelators for the treatment of Friedreich's ataxia: Ligands that mobilize mitochondrial iron
-
RICHARDSON, D.R. et al. 2001. Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron. Biochim. Biophys. Acta 1536: 133-140.
-
(2001)
Biochim. Biophys. Acta
, vol.1536
, pp. 133-140
-
-
Richardson, D.R.1
-
76
-
-
0037317490
-
Friedreich's ataxia: Iron chelators that target the mitochondrion as a therapeutic strategy
-
RICHARDSON, D.R. 2003. Friedreich's ataxia: iron chelators that target the mitochondrion as a therapeutic strategy. Exp. Opin. Invest. Drugs 12: 235-245.
-
(2003)
Exp. Opin. Invest. Drugs
, vol.12
, pp. 235-245
-
-
Richardson, D.R.1
-
77
-
-
0018567483
-
Effective iron chelation following oral administration of an isoniazid pyridoxal hydrazone
-
HOY, T. et al. 1979. Effective iron chelation following oral administration of an isoniazid pyridoxal hydrazone. Br. J. Haematol. 43: 443-449.
-
(1979)
Br. J. Haematol.
, vol.43
, pp. 443-449
-
-
Hoy, T.1
-
78
-
-
0025194404
-
Pyridoxal isonicotinoyl hydrazone: An effective chelator after oral administration
-
BRITTENHAM, G.M. 1990. Pyridoxal isonicotinoyl hydrazone: an effective chelator after oral administration. Semin. Hematol. 27: 112-116.
-
(1990)
Semin. Hematol.
, vol.27
, pp. 112-116
-
-
Brittenham, G.M.1
-
79
-
-
0024920255
-
Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium(II), magnesium(II), and zinc(II)
-
RICHARDSON, D.R. et al. 1989. Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium(II), magnesium(II), and zinc(II). Biol. Metals 2: 161-167.
-
(1989)
Biol. Metals
, vol.2
, pp. 161-167
-
-
Richardson, D.R.1
-
80
-
-
0000424901
-
Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part 2, Formation constants with iron(III) and iron(II)
-
VITOLO, L.M.W. et al. 1990. Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part 2, Formation constants with iron(III) and iron(II). Inorg. Chim. Acta 170: 171-176.
-
(1990)
Inorg. Chim. Acta
, vol.170
, pp. 171-176
-
-
Vitolo, L.M.W.1
-
81
-
-
0000166947
-
Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part 1. Ionisation characteristics of the ligands and their relevance to biological properties
-
RICHARDSON, D.R. et al. 1990. Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part 1. Ionisation characteristics of the ligands and their relevance to biological properties. Inorg. Chim. Acta 170: 165-170.
-
(1990)
Inorg. Chim. Acta
, vol.170
, pp. 165-170
-
-
Richardson, D.R.1
-
82
-
-
0026081935
-
The release of iron and transferrin by the human malignant melanoma cell
-
RICHARDSON, D.R. & E. BAKER. 1991. The release of iron and transferrin by the human malignant melanoma cell. Biochim. Biophys. Acta 1091: 294-302.
-
(1991)
Biochim. Biophys. Acta
, vol.1091
, pp. 294-302
-
-
Richardson, D.R.1
Baker, E.2
-
83
-
-
0028535112
-
The iron metabolism of the human neuroblastoma cell: Lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis
-
RICHARDSON, D.R. & P. PONKA. 1994. The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis. J. Lab. Clin. Med. 124: 660-671.
-
(1994)
J. Lab. Clin. Med.
, vol.124
, pp. 660-671
-
-
Richardson, D.R.1
Ponka, P.2
-
84
-
-
0028891974
-
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferarive agents
-
RICHARDSON, D.R. et al. 1995. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferarive agents. Blood 86: 4295-4306.
-
(1995)
Blood
, vol.86
, pp. 4295-4306
-
-
Richardson, D.R.1
-
85
-
-
0033230124
-
Development of novel aroylhydrazone ligands for iron chelation therapy: The 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) analogues
-
BECKER, E. & D.R. RICHARDSON. 1999. Development of novel aroylhydrazone ligands for iron chelation therapy: the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) analogues. J. Lab. Clin. Med. 134: 510-521.
-
(1999)
J. Lab. Clin. Med.
, vol.134
, pp. 510-521
-
-
Becker, E.1
Richardson, D.R.2
-
86
-
-
0032055861
-
Pyridoxal isonicotinoyl hydrazone and its analogues: Potential orally effective iron-chelating agents for the treatment of iron overload disease
-
RICHARDSON, D.R. & P. PONKA. 1998. Pyridoxal isonicotinoyl hydrazone and its analogues: potential orally effective iron-chelating agents for the treatment of iron overload disease. J. Lab. Clin. Med. 131: 306-315.
-
(1998)
J. Lab. Clin. Med.
, vol.131
, pp. 306-315
-
-
Richardson, D.R.1
Ponka, P.2
-
87
-
-
0037356211
-
Structural variations and formation constants of first-row transition metal complexes of biologically active aroylhydrazones
-
ARMSTRONG, C.M. et al. 2003. Structural variations and formation constants of first-row transition metal complexes of biologically active aroylhydrazones. Eur. J. Inorg. Chem. 2003(6): 1145-1156.
-
(2003)
Eur. J. Inorg. Chem.
, vol.2003
, Issue.6
, pp. 1145-1156
-
-
Armstrong, C.M.1
-
88
-
-
0035161372
-
Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): Serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy
-
BERNHARDT, P.V. et al. 2001. Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy. J. Biol. Inorg. Chem. 6: 801-809.
-
(2001)
J. Biol. Inorg. Chem.
, vol.6
, pp. 801-809
-
-
Bernhardt, P.V.1
|