메뉴 건너뛰기




Volumn 83, Issue 2, 2002, Pages 320-330

Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease

Author keywords

Ferritin; Iron; Iron regulatory proteins; Melanized neurones; Mesencephalon; Parkinson's disease

Indexed keywords

FERRITIN; IRON; IRON REGULATORY FACTOR; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; MESSENGER RNA; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

EID: 0036798434     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01118.x     Document Type: Article
Times cited : (102)

References (53)
  • 1
    • 0030805622 scopus 로고    scopus 로고
    • A generalized increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease
    • Alam Z. I., Daniel S. E., Lees A. J., Marsden D. C., Jenner P. and Halliwell B. (1997a) A generalized increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J. Neurochem. 69, 1326-1329.
    • (1997) J. Neurochem. , vol.69 , pp. 1326-1329
    • Alam, Z.I.1    Daniel, S.E.2    Lees, A.J.3    Marsden, D.C.4    Jenner, P.5    Halliwell, B.6
  • 2
    • 0030878073 scopus 로고    scopus 로고
    • Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxy-guanine levels in substantia nigra
    • Alam Z. I., Jenner A., Daniel S. E., Lees A. J., Cairns N., Marsden C. D., Jenner P. and Halliwell B. (1997b) Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxy-guanine levels in substantia nigra. J. Neurochem. 69, 1196-1203.
    • (1997) J. Neurochem. , vol.69 , pp. 1196-1203
    • Alam, Z.I.1    Jenner, A.2    Daniel, S.E.3    Lees, A.J.4    Cairns, N.5    Marsden, C.D.6    Jenner, P.7    Halliwell, B.8
  • 4
    • 0029433318 scopus 로고
    • Cellular management of iron in the brain
    • Connor J. R. and Menzies S. L. (1995) Cellular management of iron in the brain. J. Neurol. Sci. 134, 33-44.
    • (1995) J. Neurol. Sci. , vol.134 , pp. 33-44
    • Connor, J.R.1    Menzies, S.L.2
  • 5
    • 0029092802 scopus 로고
    • A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains
    • Connor J. R., Snyder B. S., Arosio P., Loeffler D. A. and LeWitt P. (1995) A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains. J. Neurochem. 65, 717-724.
    • (1995) J. Neurochem. , vol.65 , pp. 717-724
    • Connor, J.R.1    Snyder, B.S.2    Arosio, P.3    Loeffler, D.A.4    LeWitt, P.5
  • 6
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
    • Dexter D. T., Wells F. R., Lees A. J., Agid F., Agid Y., Jenner P. and Marsden C. D. (1989) Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52, 1830-1836.
    • (1989) J. Neurochem. , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3    Agid, F.4    Agid, Y.5    Jenner, P.6    Marsden, C.D.7
  • 7
    • 0025821265 scopus 로고
    • Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia
    • Dexter D. T., Carayon A., Javoy-Agid F., Agid Y., Wells F. R., Daniel S. E., Lees A. J., Jenner P. and Marsden D. (1991) Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114, 1953-1975.
    • (1991) Brain , vol.114 , pp. 1953-1975
    • Dexter, D.T.1    Carayon, A.2    Javoy-Agid, F.3    Agid, Y.4    Wells, F.R.5    Daniel, S.E.6    Lees, A.J.7    Jenner, P.8    Marsden, D.9
  • 8
    • 0030197587 scopus 로고    scopus 로고
    • Modulation by nitric oxide of metalloprotein regulatory activities
    • Drapier J. C. and Bouton C. (1996) Modulation by nitric oxide of metalloprotein regulatory activities. Bioessays 18, 549-556.
    • (1996) Bioessays , vol.18 , pp. 549-556
    • Drapier, J.C.1    Bouton, C.2
  • 9
    • 0014240538 scopus 로고
    • Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue
    • Earle K. M. (1968) Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue. J. Neuropathol. Exp. Neurol. 27, 1-14.
    • (1968) J. Neuropathol. Exp. Neurol. , vol.27 , pp. 1-14
    • Earle, K.M.1
  • 10
    • 0033586471 scopus 로고    scopus 로고
    • Blood vessels change in the mesencephalon of patients with Parkinson's disease
    • Faucheux B. A., Bonnet A. M., Agid Y. and Hirsch E. C. (1999) Blood vessels change in the mesencephalon of patients with Parkinson's disease. Lancet 353, 981-982.
    • (1999) Lancet , vol.353 , pp. 981-982
    • Faucheux, B.A.1    Bonnet, A.M.2    Agid, Y.3    Hirsch, E.C.4
  • 11
    • 0034009915 scopus 로고    scopus 로고
    • Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson's disease
    • Foley P. and Riederer P. (2000) Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson's disease. J. Neurol. 247, II82-II94.
    • (2000) J. Neurol. , vol.247
    • Foley, P.1    Riederer, P.2
  • 13
    • 0026746512 scopus 로고
    • Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminium in Parkinson's disease: A LAMMA study
    • Good P. F., Olanow C. W. and Perl D. P. (1992) Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminium in Parkinson's disease: a LAMMA study. Brain Res. 593, 343-346.
    • (1992) Brain Res. , vol.593 , pp. 343-346
    • Good, P.F.1    Olanow, C.W.2    Perl, D.P.3
  • 15
    • 0028998624 scopus 로고
    • Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease
    • Gorell J. M., Ordidge R. J., Brown G. G., Deniau J. C., Buderer N. M. and Helpern J. A. (1995) Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology 45, 1138-1143.
    • (1995) Neurology , vol.45 , pp. 1138-1143
    • Gorell, J.M.1    Ordidge, R.J.2    Brown, G.G.3    Deniau, J.C.4    Buderer, N.M.5    Helpern, J.A.6
  • 16
    • 0029662001 scopus 로고    scopus 로고
    • An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys
    • Goto K., Mochizuki H., Imai H., Akiyama H. and Mizuno Y. (1996) An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys. Brain Res. 724, 125-128.
    • (1996) Brain Res. , vol.724 , pp. 125-128
    • Goto, K.1    Mochizuki, H.2    Imai, H.3    Akiyama, H.4    Mizuno, Y.5
  • 17
    • 0011798071 scopus 로고
    • Histochemically distinct compartments in the striatum of human, monkey and cat demonstrated by acetylcholinesterase stain
    • Graybiel A. M. and Ragsdale C. W. (1978) Histochemically distinct compartments in the striatum of human, monkey and cat demonstrated by acetylcholinesterase stain. Proc. Natl Acad. Sci. USA 75, 1723-1726.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 1723-1726
    • Graybiel, A.M.1    Ragsdale, C.W.2
  • 18
    • 0029034338 scopus 로고
    • Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels
    • Guo B., Brown F. M., Phillips J. D., Yu Y. and Leibold E. A. (1995) Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. J. Biol. Chem. 270, 16529-16535.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16529-16535
    • Guo, B.1    Brown, F.M.2    Phillips, J.D.3    Yu, Y.4    Leibold, E.A.5
  • 19
    • 84961042345 scopus 로고
    • The effect of age on the non-haemin iron in the human brain
    • Hallgren B. and Sourander P. (1958) The effect of age on the non-haemin iron in the human brain. J. Neurochem. 3, 41-51.
    • (1958) J. Neurochem. , vol.3 , pp. 41-51
    • Hallgren, B.1    Sourander, P.2
  • 20
    • 0030608152 scopus 로고    scopus 로고
    • The ferritins: Molecular properties, iron storage function and cellular regulation
    • Harrison P. M. and Arosio P. (1996) The ferritins: molecular properties, iron storage function and cellular regulation. Biochim. Biophys. Acta 1275, 161-203.
    • (1996) Biochim. Biophys. Acta , vol.1275 , pp. 161-203
    • Harrison, P.M.1    Arosio, P.2
  • 21
    • 0030607202 scopus 로고    scopus 로고
    • Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: A nuclear microscopy study
    • He Y., Thong P. S. P., Lee T., Leong S. K., Shi C. Y., Wong P. T. H., Yuan S. Y. and Watt F. (1996) Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: a nuclear microscopy study. Brain Res. 735, 149-153.
    • (1996) Brain Res. , vol.735 , pp. 149-153
    • He, Y.1    Thong, P.S.P.2    Lee, T.3    Leong, S.K.4    Shi, C.Y.5    Wong, P.T.H.6    Yuan, S.Y.7    Watt, F.8
  • 22
    • 0027717217 scopus 로고
    • Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements
    • Henderson B. R., Seiser C. and Kühn L. C. (1993) Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements. J. Biol. Chem. 268, 27327-27334.
    • (1993) J. Biol. Chem. , vol.268 , pp. 27327-27334
    • Henderson, B.R.1    Seiser, C.2    Kühn, L.C.3
  • 23
    • 0029758487 scopus 로고    scopus 로고
    • Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
    • Hentze M. W. and Kühn L. C. (1996) Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl Acad. Sci. USA 93, 8175-8182.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8175-8182
    • Hentze, M.W.1    Kühn, L.C.2
  • 24
    • 0031947244 scopus 로고    scopus 로고
    • Iron metabolism and Parkinson's disease
    • Hirsch E. C. and Faucheux B. A. (1998) Iron metabolism and Parkinson's disease. Mov. Disord. 13, 39-45.
    • (1998) Mov. Disord. , vol.13 , pp. 39-45
    • Hirsch, E.C.1    Faucheux, B.A.2
  • 25
    • 0023740954 scopus 로고
    • Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • Hirsch E., Graybiel A. M. and Agid Y. A. (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334, 345-348.
    • (1988) Nature , vol.334 , pp. 345-348
    • Hirsch, E.1    Graybiel, A.M.2    Agid, Y.A.3
  • 26
    • 0026034279 scopus 로고
    • Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: An x-ray microanalysis
    • Hirsch E. C., Brandel J. P., Galle P., Javoy-Agid F. and Agid Y. (1991) Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J. Neurochem. 56, 446-451.
    • (1991) J. Neurochem. , vol.56 , pp. 446-451
    • Hirsch, E.C.1    Brandel, J.P.2    Galle, P.3    Javoy-Agid, F.4    Agid, Y.5
  • 27
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration?
    • Hirsch E. C., Hunot S., Damier P. and Faucheux B. (1998) Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann. Neurol. 44, S115-S120.
    • (1998) Ann. Neurol. , vol.44
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 28
    • 0014082977 scopus 로고
    • Parkinsonism: Onset, progression and mortality
    • Hoehn M. M. and Yahr M. D. (1967) Parkinsonism: onset, progression and mortality. Neurology 17, 427-442.
    • (1967) Neurology , vol.17 , pp. 427-442
    • Hoehn, M.M.1    Yahr, M.D.2
  • 29
    • 0030057235 scopus 로고    scopus 로고
    • Demonstration and characterization of the iron regulatory protein in human brain
    • Hu J. and Connor J. R. (1996) Demonstration and characterization of the iron regulatory protein in human brain. J. Neurochem. 67, 838-844.
    • (1996) J. Neurochem. , vol.67 , pp. 838-844
    • Hu, J.1    Connor, J.R.2
  • 31
    • 0033121299 scopus 로고    scopus 로고
    • FcεRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-α in glial cells
    • Hunot S., Dugas N., Faucheux B., Hartmann A., Tardieu M., Debré P., Agid Y., Dugas B. and Hirsch E. C. (1999) FcεRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-α in glial cells. J. Neurosci. 19, 3340-3347.
    • (1999) J. Neurosci. , vol.19 , pp. 3340-3347
    • Hunot, S.1    Dugas, N.2    Faucheux, B.3    Hartmann, A.4    Tardieu, M.5    Debré, P.6    Agid, Y.7    Dugas, B.8    Hirsch, E.C.9
  • 34
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • Jenner P. and Olanow C. W. (1998) Understanding cell death in Parkinson's disease. Ann. Neurol. 44, S72-S84.
    • (1998) Ann. Neurol. , vol.44
    • Jenner, P.1    Olanow, C.W.2
  • 35
    • 0018850985 scopus 로고
    • A simple, rapid, and sensitive DNA assay procedure
    • Labarca C. and Paigen K. (1980) A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102, 344-352.
    • (1980) Anal. Biochem. , vol.102 , pp. 344-352
    • Labarca, C.1    Paigen, K.2
  • 36
    • 0024121621 scopus 로고
    • Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs
    • Leibold E. A. and Munro H. N. (1988) Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs. Proc. Natl Acad. Sci. USA 85, 2171-2175.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 2171-2175
    • Leibold, E.A.1    Munro, H.N.2
  • 38
    • 0035920165 scopus 로고    scopus 로고
    • Regulation of the 75-kDa subunit of mitochondrial Complex I by iron
    • Lin E., Graziano J. H. and Freyers G. A. (2001) Regulation of the 75-kDa subunit of mitochondrial Complex I by iron. J. Biol. Chem. 276, 27685-27692.
    • (2001) J. Biol. Chem. , vol.276 , pp. 27685-27692
    • Lin, E.1    Graziano, J.H.2    Freyers, G.A.3
  • 42
    • 0031975341 scopus 로고    scopus 로고
    • A point mutation in the bulge of the iron-responsive element of the L ferritin gene in two families with the hereditary hyperferritinemia-cataract syndrome
    • Martin M. E., Fargion S., Brissot P., Pellat B. and Beaumont C. (1998) A point mutation in the bulge of the iron-responsive element of the L ferritin gene in two families with the hereditary hyperferritinemia-cataract syndrome. Blood 91, 319-323.
    • (1998) Blood , vol.91 , pp. 319-323
    • Martin, M.E.1    Fargion, S.2    Brissot, P.3    Pellat, B.4    Beaumont, C.5
  • 43
    • 0028266425 scopus 로고
    • Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys
    • Mochizuki H., Imai H., Endo K., Yokomizo K., Murata Y., Hattori N. and Mizuno Y. (1994) Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys. Neurosci. Lett. 168, 251-253.
    • (1994) Neurosci. Lett. , vol.168 , pp. 251-253
    • Mochizuki, H.1    Imai, H.2    Endo, K.3    Yokomizo, K.4    Murata, Y.5    Hattori, N.6    Mizuno, Y.7
  • 44
    • 0032160381 scopus 로고    scopus 로고
    • IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F
    • Muckenthaler M., Gray N. K. and Hentze M. W. (1998) IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F. Mol. Cell 2, 383-388.
    • (1998) Mol. Cell , vol.2 , pp. 383-388
    • Muckenthaler, M.1    Gray, N.K.2    Hentze, M.W.3
  • 45
    • 0033215094 scopus 로고    scopus 로고
    • Regulation of iron metabolism in murine J774 macrophages: Role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide
    • Mulero V. and Brock J. H. (1999) Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide. Blood 94, 2383-2389.
    • (1999) Blood , vol.94 , pp. 2383-2389
    • Mulero, V.1    Brock, J.H.2
  • 47
    • 2142828035 scopus 로고    scopus 로고
    • Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzeimer's diseased brains
    • Pinero D. J. and Connor J. R. (2000) Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzeimer's diseased brains. Cell. Mol. Biol. 46, 761-776.
    • (2000) Cell. Mol. Biol. , vol.46 , pp. 761-776
    • Pinero, D.J.1    Connor, J.R.2
  • 48
    • 0031963449 scopus 로고    scopus 로고
    • Function and regulation of transferrin and ferritin
    • Ponka P., Beaumont C. and Richardson D. R. (1998) Function and regulation of transferrin and ferritin. Semin. Hematol. 35, 35-54.
    • (1998) Semin. Hematol. , vol.35 , pp. 35-54
    • Ponka, P.1    Beaumont, C.2    Richardson, D.R.3
  • 49
    • 0026625534 scopus 로고
    • Distribution of iron in different brain regions and subcellular compartments in Parkinson's disease
    • Riederer P., Dirr A., Goetz M., Sofic E., Jellinger K. and Youdim M. B. H. (1992) Distribution of iron in different brain regions and subcellular compartments in Parkinson's disease. Ann. Neurol. 32, S101-S104.
    • (1992) Ann. Neurol. , vol.32
    • Riederer, P.1    Dirr, A.2    Goetz, M.3    Sofic, E.4    Jellinger, K.5    Youdim, M.B.H.6
  • 50
    • 0030885482 scopus 로고    scopus 로고
    • Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
    • Smith M. A., Harris P. L. R., Sayre L. M. and Perry G. (1997) Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl Acad. Sci. USA 94, 9866-9868.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9866-9868
    • Smith, M.A.1    Harris, P.L.R.2    Sayre, L.M.3    Perry, G.4
  • 52
    • 0031031536 scopus 로고    scopus 로고
    • Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and nonhuman primates: An in situ hybridization study of cytochrome oxidase subunit I mRNA
    • Vila M., Levy R., Herrero M. T., Ruberg M., Faucheux B., Obeso J. A., Agid Y. and Hirsch E. C. (1997) Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and nonhuman primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA. J. Neurosci. 17, 765-773.
    • (1997) J. Neurosci. , vol.17 , pp. 765-773
    • Vila, M.1    Levy, R.2    Herrero, M.T.3    Ruberg, M.4    Faucheux, B.5    Obeso, J.A.6    Agid, Y.7    Hirsch, E.C.8
  • 53
    • 0035103932 scopus 로고    scopus 로고
    • Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: Consequences for iron storage and neurodegenerative processes
    • Zecca L., Gallorini M., Schünemann V., Trautwein A. X., Gerlach M., Riederer P., Vezzoni P. and Tampellini D. (2001) Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes. J. Neurochem. 76, 1766-1773.
    • (2001) J. Neurochem. , vol.76 , pp. 1766-1773
    • Zecca, L.1    Gallorini, M.2    Schünemann, V.3    Trautwein, A.X.4    Gerlach, M.5    Riederer, P.6    Vezzoni, P.7    Tampellini, D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.