메뉴 건너뛰기




Volumn 15, Issue 4, 2005, Pages 389-407

NR2B subtype-selective NMDA receptor antagonists: 2001-2004

Author keywords

CNS; Glutamate; Ion channel; NMDA; NR2B antagonists

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; AMINOCYCLOHEXANE DERIVATIVE; BESONPRODIL; CI 1041; CO 101244; CP 283 097; CYCLOHEXANE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; ELIPRODIL; EMD 95885; FIBRINOLYTIC AGENT; HALOPERIDOL; IFENPRODIL; IONOTROPIC RECEPTOR ANTAGONIST; KETAMINE; LEVODOPA; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUTROPHIL INHIBITORY FACTOR; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE DERIVATIVE; PHENOL DERIVATIVE; PIPERIDINE DERIVATIVE; PRAZOSIN; RECEPTOR SUBUNIT; RGH 896; RO 63 1908; RO 67 8867; TRAXOPRODIL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 18144428396     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.15.4.389     Document Type: Review
Times cited : (27)

References (99)
  • 1
    • 0036483593 scopus 로고    scopus 로고
    • The structure and function of glutamate receptor ion channels
    • MADDEN DR: The structure and function of glutamate receptor ion channels. Nat. Rev. Neurosci. (2002) 3(2):91-101.
    • (2002) Nat. Rev. Neurosci. , vol.3 , Issue.2 , pp. 91-101
    • Madden, D.R.1
  • 3
    • 0034845802 scopus 로고    scopus 로고
    • NMDA receptor pharmacology: Perspectives from molecular biology
    • LYNCH DR, GUTTMAN RP: NMDA receptor pharmacology: perspectives from molecular biology. Curr. Drug Targets (2001) 2(3):215-231.
    • (2001) Curr. Drug Targets , vol.2 , Issue.3 , pp. 215-231
    • Lynch, D.R.1    Guttman, R.P.2
  • 4
    • 0032467053 scopus 로고    scopus 로고
    • Glutamate in CNS disorders as a target for drug development: An update
    • PARSONS CG, DANYSZ W, QUACK G: Glutamate in CNS disorders as a target for drug development: an update. Drug News Perspect. (1998) 11(9):523-579.
    • (1998) Drug News Perspect. , vol.11 , Issue.9 , pp. 523-579
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 5
    • 0034852744 scopus 로고    scopus 로고
    • Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies
    • PALMER GC: Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies. Curr. Drug Targets (2001) 2(3):241-271.
    • (2001) Curr. Drug Targets , vol.2 , Issue.3 , pp. 241-271
    • Palmer, G.C.1
  • 6
    • 0035214976 scopus 로고    scopus 로고
    • Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging
    • LE DA, LIPTON SA: Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging. Drugs Aging (2001) 18(10):717-724.
    • (2001) Drugs Aging , vol.18 , Issue.10 , pp. 717-724
    • Le, D.A.1    Lipton, S.A.2
  • 7
    • 0142031078 scopus 로고    scopus 로고
    • Therapeutic N-methyl-D-aspartate receptor antagonists: Will reality meet expectation?
    • SMITH PF: Therapeutic N-methyl-D-aspartate receptor antagonists: will reality meet expectation? Curr. Opin. Invest. Drugs (2003) 4(7):826-832.
    • (2003) Curr. Opin. Invest. Drugs , vol.4 , Issue.7 , pp. 826-832
    • Smith, P.F.1
  • 8
    • 0344851901 scopus 로고    scopus 로고
    • Ketamine in chronic pain management: An evidence-based review
    • HOCKING G, COUSINS MJ: Ketamine in chronic pain management: an evidence-based review. Anesth. Analg. (2003) 97(6):1730-1739.
    • (2003) Anesth. Analg. , vol.97 , Issue.6 , pp. 1730-1739
    • Hocking, G.1    Cousins, M.J.2
  • 9
    • 0345735594 scopus 로고    scopus 로고
    • Evaluation of memantine for the treatment of Alzheimer's disease
    • FERRIS SH: Evaluation of memantine for the treatment of Alzheimer's disease. Expert Opin. Pharmacother. (2003) 4(12):2305-2313.
    • (2003) Expert Opin. Pharmacother. , vol.4 , Issue.12 , pp. 2305-2313
    • Ferris, S.H.1
  • 10
    • 1642474184 scopus 로고    scopus 로고
    • Paradigm shift in neuroprotective drug development: Clinically tolerated NMDA receptor inhibition by memantine
    • LIPTON SA, CHEN H-SV: Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine. Cell Death Differ. (2004) 11(1):18-20.
    • (2004) Cell Death Differ. , vol.11 , Issue.1 , pp. 18-20
    • Lipton, S.A.1    Chen, H.-S.V.2
  • 11
    • 0026766877 scopus 로고
    • Structures and properties of seven isoforms of NMDA receptor generated by alternative splicing
    • SUGIHARA H, MORIYOSHI K, ISHII T, MASU M, NAKANISHI S: Structures and properties of seven isoforms of NMDA receptor generated by alternative splicing. Biochem. Biophys. Res. Commun. (1992) 185(3):826-832.
    • (1992) Biochem. Biophys. Res. Commun. , vol.185 , Issue.3 , pp. 826-832
    • Sugihara, H.1    Moriyoshi, K.2    Ishii, T.3    Masu, M.4    Nakanishi, S.5
  • 12
    • 0035369112 scopus 로고    scopus 로고
    • NMDA receptor subunits: Diversity, development and disease
    • CULL-CANDY S, BRICKLEY S, FARRANT M: NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. (2001) 11(3):327-335.
    • (2001) Curr. Opin. Neurobiol. , vol.11 , Issue.3 , pp. 327-335
    • Cull-Candy, S.1    Brickley, S.2    Farrant, M.3
  • 13
    • 0037074985 scopus 로고    scopus 로고
    • Excitatory glycine receptor containing the NR3 family of NMDA receptor subunits
    • CHATTERTON JE, AWOBULUYI M, PREMKUMAR LS et al.: Excitatory glycine receptor containing the NR3 family of NMDA receptor subunits. Nature (2002) 415(6873):793-798.
    • (2002) Nature , vol.415 , Issue.6873 , pp. 793-798
    • Chatterton, J.E.1    Awobuluyi, M.2    Premkumar, L.S.3
  • 14
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • MONYER H, BURNASHEV N, LAURIE DJ, SAKMANN B, SEEBURG PH: Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron (1994) 12(3):529-540.
    • (1994) Neuron , vol.12 , Issue.3 , pp. 529-540
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakmann, B.4    Seeburg, P.H.5
  • 15
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanism at recombinant heteromeric receptors
    • WILLIAMS K: Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanism at recombinant heteromeric receptors. Mol. Pharmacol. (1993) 44(4):851-859.
    • (1993) Mol. Pharmacol. , vol.44 , Issue.4 , pp. 851-859
    • Williams, K.1
  • 16
    • 0032987252 scopus 로고    scopus 로고
    • Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: Correlation with restricted localization of NR2B subunit in dorsal horn
    • BOYCE S, WYATT A, WEBB JK et al.: Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localization of NR2B subunit in dorsal horn. Neuropharmacology (1999) 38(5):611-623.
    • (1999) Neuropharmacology , vol.38 , Issue.5 , pp. 611-623
    • Boyce, S.1    Wyatt, A.2    Webb, J.K.3
  • 17
    • 0037216407 scopus 로고    scopus 로고
    • The N-methyl-D-aspartate receptor subunit NR2B: Localization, functional properties, regulation, and clinical applications
    • LOFTIS JM, JANOWSKY A: The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical applications. Pharmacol. Therap. (2003) 97(1):55-85.
    • (2003) Pharmacol. Therap. , vol.97 , Issue.1 , pp. 55-85
    • Loftis, J.M.1    Janowsky, A.2
  • 18
    • 0344304828 scopus 로고    scopus 로고
    • Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the Ro 25-6981 binding pocket
    • MALHERBE P, MUTEL V, BROGER C et al.: Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the Ro 25-6981 binding pocket. J. Pharmacol Exp. Ther. (2003) 307(3):897-905.
    • (2003) J. Pharmacol Exp. Ther. , vol.307 , Issue.3 , pp. 897-905
    • Malherbe, P.1    Mutel, V.2    Broger, C.3
  • 19
    • 0347416999 scopus 로고    scopus 로고
    • NMDA receptor subunit gating-uncovered
    • GIBB AJ: NMDA receptor subunit gating-uncovered. Trends Neurosci. (2004) 27(1):7-10.
    • (2004) Trends Neurosci. , vol.27 , Issue.1 , pp. 7-10
    • Gibb, A.J.1
  • 20
    • 0037312558 scopus 로고    scopus 로고
    • Activation of NR1/NR2B NMDA receptors
    • BANKE TG, TRAYNELIS SF: Activation of NR1/NR2B NMDA receptors. Nat. Neurosci. (2003) 6(2):144-152.
    • (2003) Nat. Neurosci. , vol.6 , Issue.2 , pp. 144-152
    • Banke, T.G.1    Traynelis, S.F.2
  • 21
    • 0036122295 scopus 로고    scopus 로고
    • Studies on the subtype selectivity of CP-101,606: Evidence for two classes of NR2B-selective NMDA receptor antagonists
    • CHAZOT PL, LAWRENCE S, THOMPSON CL: Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists. Neuropharmacology (2002) 42(3):319-324.
    • (2002) Neuropharmacology , vol.42 , Issue.3 , pp. 319-324
    • Chazot, P.L.1    Lawrence, S.2    Thompson, C.L.3
  • 22
    • 0029100602 scopus 로고
    • (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino) -1-propanol: A potent new neuroprotectant which blocks N-methyl-D-aspartate responses
    • CHENARD BL, BORDNER J, BUTLER TW et al.: (1S,2 S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino) -1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J. Med. Chem. (1995) 38(16):3138-3145.
    • (1995) J. Med. Chem. , vol.38 , Issue.16 , pp. 3138-3145
    • Chenard, B.L.1    Bordner, J.2    Butler, T.W.3
  • 23
    • 0031443289 scopus 로고    scopus 로고
    • Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit
    • Characterization in vitro
    • FISCHER G, MUTEL V, TRUBE G et al.: Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J. Pharmacol. Exp. Ther. (1997) 283(3):1285-1292.
    • (1997) J. Pharmacol. Exp. Ther. , vol.283 , Issue.3 , pp. 1285-1292
    • Fischer, G.1    Mutel, V.2    Trube, G.3
  • 24
    • 0033517366 scopus 로고    scopus 로고
    • Genetic enhancement of learning and memory in mice
    • TANG Y-P, SHIMIZU E, DUBE GR et al.: Genetic enhancement of learning and memory in mice. Nature (1999) 401(6748):63-69.
    • (1999) Nature , vol.401 , Issue.6748 , pp. 63-69
    • Tang, Y.-P.1    Shimizu, E.2    Dube, G.R.3
  • 25
    • 0032437540 scopus 로고    scopus 로고
    • Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behavior
    • DOYLE KM, FEERICK S, KIRKBY DL, EDDLESTON A, HIGGINS GA: Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behavior. Behav. Pharmacol. (1998) 9(8):671-681.
    • (1998) Behav. Pharmacol. , vol.9 , Issue.8 , pp. 671-681
    • Doyle, K.M.1    Feerick, S.2    Kirkby, D.L.3    Eddleston, A.4    Higgins, G.A.5
  • 26
    • 0142026804 scopus 로고    scopus 로고
    • The effect of (±)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze
    • GUSCOTT MR, CLARKE HF, MURRAY F, GRIMWOOD S, BRISTOW LJ, HUTSON PH: The effect of (±)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze. Eur. J. Pharmacol. (2003) 476(3):193-199.
    • (2003) Eur. J. Pharmacol. , vol.476 , Issue.3 , pp. 193-199
    • Guscott, M.R.1    Clarke, H.F.2    Murray, F.3    Grimwood, S.4    Bristow, L.J.5    Hutson, P.H.6
  • 27
    • 0036720776 scopus 로고    scopus 로고
    • Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl) -piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist
    • GILL R, ALANINE A, BOURSON B et al.: Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl) -piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist. J. Pharmacol. Exp. Ther. (2002) 302(3):940-948.
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , Issue.3 , pp. 940-948
    • Gill, R.1    Alanine, A.2    Bourson, B.3
  • 28
    • 0037370176 scopus 로고    scopus 로고
    • Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: Evidence for an involvement of NR2B NMDA receptors in response inhibition
    • HIGGINS GA, BALLARD TM, HUWYLER J, KEMP JA, GILL R: Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition. Neuropharmacology (2003) 44(3):324-341.
    • (2003) Neuropharmacology , vol.44 , Issue.3 , pp. 324-341
    • Higgins, G.A.1    Ballard, T.M.2    Huwyler, J.3    Kemp, J.A.4    Gill, R.5
  • 29
    • 0344289521 scopus 로고    scopus 로고
    • 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4- (4-methylbenzyl)piperidine: A novel potent selective NR1/2B NMDA receptor antagonist
    • ZHOU Z-L, CAI SX, WHITTEMORE ER et al.: 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4- (4-methylbenzyl)piperidine: A novel, potent, and selective NR1/2B NMDA receptor antagonist. J. Med. Chem. (1999) 42(15):2993-3000.
    • (1999) J. Med. Chem. , vol.42 , Issue.15 , pp. 2993-3000
    • Zhou, Z.-L.1    Cai, S.X.2    Whittemore, E.R.3
  • 30
    • 0035840856 scopus 로고    scopus 로고
    • NMDA receptors as targets for drug action in neuropathic pain
    • PARSONS CG: NMDA receptors as targets for drug action in neuropathic pain. Eur. J. Pharmacol. (2001) 429(1-3):71-78.
    • (2001) Eur. J. Pharmacol. , vol.429 , Issue.1-3 , pp. 71-78
    • Parsons, C.G.1
  • 31
    • 0036386818 scopus 로고    scopus 로고
    • Novel approaches to targeting glutamate receptors for the treatment of chronic pain: Review article
    • CHIZH BA: Novel approaches to targeting glutamate receptors for the treatment of chronic pain: review article. Amino Acids (2002) 23(1-3):169-176.
    • (2002) Amino Acids , vol.23 , Issue.1-3 , pp. 169-176
    • Chizh, B.A.1
  • 32
    • 0141458065 scopus 로고    scopus 로고
    • The role of N-methyl-D-aspartate (NMDA) receptors in pain: A review
    • PETRENKO AB, YAMAKURA T, BABA H, SHIMOJI K: The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review: Anesth. Analg. (2003) 97(4):1108-1116.
    • (2003) Anesth. Analg. , vol.97 , Issue.4 , pp. 1108-1116
    • Petrenko, A.B.1    Yamakura, T.2    Baba, H.3    Shimoji, K.4
  • 33
    • 0036525709 scopus 로고    scopus 로고
    • The NR2B subunit of glutamate receptors as a potential target for relieving chronic pain: Prospects and concerns
    • GURWITZ D, WEIZMAN A: The NR2B subunit of glutamate receptors as a potential target for relieving chronic pain: prospects and concerns. Drug Discov. Today (2002) 7(7):403-406.
    • (2002) Drug Discov. Today , vol.7 , Issue.7 , pp. 403-406
    • Gurwitz, D.1    Weizman, A.2
  • 34
    • 0030771671 scopus 로고    scopus 로고
    • Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist
    • TANIGUCHI K, SHINJO K, MIZUTANI M et al.: Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br. J. Pharmacol. (1997) 122(5):809-812.
    • (1997) Br. J. Pharmacol. , vol.122 , Issue.5 , pp. 809-812
    • Taniguchi, K.1    Shinjo, K.2    Mizutani, M.3
  • 35
    • 0035577313 scopus 로고    scopus 로고
    • NMDA receptor antagonists as analgesics: Focus on the NR2B subtype
    • CHIZH BA, HEADLEY PM, TZSCHENTKE TM: NMDA receptor antagonists as analgesics: focus on the NR2B subtype. Trends Pharmacol. Sci. (2001) 22(12):636-642.
    • (2001) Trends Pharmacol. Sci. , vol.22 , Issue.12 , pp. 636-642
    • Chizh, B.A.1    Headley, P.M.2    Tzschentke, T.M.3
  • 36
    • 0036830627 scopus 로고    scopus 로고
    • NMDA receptor pathways as drug targets
    • KEMP JA, MCKERNAN RM: NMDA receptor pathways as drug targets. Nat. Neurosci. (2002) 5(suppl.):1039-1042.
    • (2002) Nat. Neurosci. , vol.5 , Issue.SUPPL. , pp. 1039-1042
    • Kemp, J.A.1    Mckernan, R.M.2
  • 37
    • 1242351945 scopus 로고    scopus 로고
    • The NMDA receptor NR2B subunit: A valid therapeutic target for multiple CNS pathologies
    • CHAZOT PL: The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. Curr. Med. Chem. (2004) 11(3):389-396.
    • (2004) Curr. Med. Chem. , vol.11 , Issue.3 , pp. 389-396
    • Chazot, P.L.1
  • 38
    • 0032966426 scopus 로고    scopus 로고
    • Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpine-treated rat
    • NASH JE, HILL MP, BROTCHIE JM: Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpine-treated rat. Exp. Neurol. (1999) 155(1):42-48.
    • (1999) Exp. Neurol. , vol.155 , Issue.1 , pp. 42-48
    • Nash, J.E.1    Hill, M.P.2    Brotchie, J.M.3
  • 39
    • 0037273830 scopus 로고    scopus 로고
    • Glutamate receptors and Parkinson's disease: Opportunities for intervention
    • MARINO M, VALENTI O, CONN PJ: Glutamate receptors and Parkinson's disease: opportunities for intervention. Drugs Aging (2003) 20(5):377-397.
    • (2003) Drugs Aging , vol.20 , Issue.5 , pp. 377-397
    • Marino, M.1    Valenti, O.2    Conn, P.J.3
  • 40
    • 0033834442 scopus 로고    scopus 로고
    • Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson's disease
    • NASH JE, FOX SH, HENRY B et al.: Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson's disease. Exp. Neurol. (2000) 165(1):136-142.
    • (2000) Exp. Neurol. , vol.165 , Issue.1 , pp. 136-142
    • Nash, J.E.1    Fox, S.H.2    Henry, B.3
  • 41
    • 0034067617 scopus 로고    scopus 로고
    • Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-D-aspartate receptors
    • STEECE-COLLIER K, CHAMBERS LK, JAW-TSAI SS, MENNITI, FS, GREENMYRE JT: Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-D-aspartate receptors. Exp. Neurol. (2000) 163(1):239-243.
    • (2000) Exp. Neurol. , vol.163 , Issue.1 , pp. 239-243
    • Steece-Collier, K.1    Chambers, L.K.2    Jaw-Tsai, S.S.3    Menniti, F.S.4    Greenmyre, J.T.5
  • 42
    • 1842664189 scopus 로고    scopus 로고
    • Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease
    • LÖSCHMANN P-A, DE GROOTE C, SMITH L et al.: Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp. Neurol. (2004) 187(1):86-93.
    • (2004) Exp. Neurol. , vol.187 , Issue.1 , pp. 86-93
    • Löschmann, P.-A.1    De Groote, C.2    Smith, L.3
  • 43
    • 3042833166 scopus 로고    scopus 로고
    • The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease
    • NASH JE, RAVENSCROFT P, MCGUIRE S, CROSSMAN AR, MENNITI FS, BROTCHIE JM: The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease. Exp. Neurol. (2004) 188(2):471-479.
    • (2004) Exp. Neurol. , vol.188 , Issue.2 , pp. 471-479
    • Nash, J.E.1    Ravenscroft, P.2    Mcguire, S.3    Crossman, A.R.4    Menniti, F.S.5    Brotchie, J.M.6
  • 44
    • 3042662151 scopus 로고    scopus 로고
    • NR2B selective NMDA receptor antagonist CP-101,606 prevents levodopa-induced motor response alterations in hemiparkinsonian rats
    • WESSEL RH, AHMED SM, MENNITI FS, DUNBAR GL, CHASE TN, OH JD: NR2B selective NMDA receptor antagonist CP-101,606 prevents levodopa-induced motor response alterations in hemiparkinsonian rats. Neuropharmacology (2004) 47(2):184-194.
    • (2004) Neuropharmacology , vol.47 , Issue.2 , pp. 184-194
    • Wessel, R.H.1    Ahmed, S.M.2    Menniti, F.S.3    Dunbar, G.L.4    Chase, T.N.5    Oh, J.D.6
  • 45
    • 1542360582 scopus 로고    scopus 로고
    • Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys
    • HADJ TAHAR A, GRÉGOIRE L, DARRÉ A, BÉLANGER N, MELTZER L, BÉDARD PJ: Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys. Neurobiol. Dis. (2004) 15(2):171-176.
    • (2004) Neurobiol. Dis. , vol.15 , Issue.2 , pp. 171-176
    • Hadj Tahar, A.1    Grégoire, L.2    Darré, A.3    Bélanger, N.4    Meltzer, L.5    Bédard, P.J.6
  • 46
    • 0032797570 scopus 로고    scopus 로고
    • Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys
    • BLANCHET PJ, KONITSIOTIS S, WHITTEMORE ER, ZHOU ZL, WOODWARD RM, CHASE TN: Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys. J. Pharmacol. Exp. Ther. (1999) 290(3):1034-1040.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , Issue.3 , pp. 1034-1040
    • Blanchet, P.J.1    Konitsiotis, S.2    Whittemore, E.R.3    Zhou, Z.L.4    Woodward, R.M.5    Chase, T.N.6
  • 47
    • 2942517754 scopus 로고    scopus 로고
    • Relevance of the MPTP primate model in the study of dyskinesia priming mechanisms
    • BLANCHET PJ, CALON F, MORISSETTE M et al.: Relevance of the MPTP primate model in the study of dyskinesia priming mechanisms. Parkinsonism Rel. Dis. (2004) 10(5):297-304.
    • (2004) Parkinsonism Rel. Dis. , vol.10 , Issue.5 , pp. 297-304
    • Blanchet, P.J.1    Calon, F.2    Morissette, M.3
  • 48
    • 2342654311 scopus 로고    scopus 로고
    • The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression
    • BARTON ME, WHITE HS: The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression. Epilepsy Res. (2004) 59(1):1-12.
    • (2004) Epilepsy Res. , vol.59 , Issue.1 , pp. 1-12
    • Barton, M.E.1    White, H.S.2
  • 49
    • 0034859802 scopus 로고    scopus 로고
    • The NMDA receptor complex: A promising target for novel antiepileptic strategies
    • KOHL BK, DANNHARDT G: The NMDA receptor complex: a promising target for novel antiepileptic strategies. Curr. Med. Chem. (2001) 8(11):1275-1289.
    • (2001) Curr. Med. Chem. , vol.8 , Issue.11 , pp. 1275-1289
    • Kohl, B.K.1    Dannhardt, G.2
  • 50
    • 0041779415 scopus 로고    scopus 로고
    • NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol-withdrawal in primary cultures of rat cortical neurones
    • NAGY J, HORVÁTH C, FARKAS S, KOLOK S, SZOMBATHELYI Z: NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol-withdrawal in primary cultures of rat cortical neurones. Neurochem. Int. (2004) 44(1):17-23.
    • (2004) Neurochem. Int. , vol.44 , Issue.1 , pp. 17-23
    • Nagy, J.1    Horváth, C.2    Farkas, S.3    Kolok, S.4    Szombathelyi, Z.5
  • 51
    • 3242770741 scopus 로고    scopus 로고
    • Renaissance of NMDA receptor antagonists: Do they have a role in the pharmacotherapy for alcoholism?
    • NAGY J: Renaissance of NMDA receptor antagonists: do they have a role in the pharmacotherapy for alcoholism? Invest. Drugs J. (2004) 7(4):339-350.
    • (2004) Invest. Drugs J. , vol.7 , Issue.4 , pp. 339-350
    • Nagy, J.1
  • 53
    • 0030901530 scopus 로고    scopus 로고
    • N-methyl-D-aspartate antagonists for stroke and head trauma
    • WOOD PL, HAWKINSON JE: N-methyl-D-aspartate antagonists for stroke and head trauma. Expert Opin. Investig. Drugs (1997) 6(4):389-397.
    • (1997) Expert Opin. Investig. Drugs , vol.6 , Issue.4 , pp. 389-397
    • Wood, P.L.1    Hawkinson, J.E.2
  • 54
    • 0004923753 scopus 로고    scopus 로고
    • The neuroprotectant properties of glutamate antagonists and antiglutamatergic drugs
    • PEDERSEN V, SCHMIDT WJ: The neuroprotectant properties of glutamate antagonists and antiglutamatergic drugs. Neurotox. Res. (2000) 2(2-3):179-204.
    • (2000) Neurotox. Res. , vol.2 , Issue.2-3 , pp. 179-204
    • Pedersen, V.1    Schmidt, W.J.2
  • 55
    • 0037183734 scopus 로고    scopus 로고
    • Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis
    • WILLIAMS AJ, DAVE JR, LU XM, LING G, TORTELLA FC: Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis. Eur. J. Pharmacol. (2002) 452(1):135-136.
    • (2002) Eur. J. Pharmacol. , vol.452 , Issue.1 , pp. 135-136
    • Williams, A.J.1    Dave, J.R.2    Lu, X.M.3    Ling, G.4    Tortella, F.C.5
  • 56
    • 4143117789 scopus 로고    scopus 로고
    • Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease
    • HYND MR, SCOTT HL, DODD PR: Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease. J. Neurochem. (2004) 90(4):913-919.
    • (2004) J. Neurochem. , vol.90 , Issue.4 , pp. 913-919
    • Hynd, M.R.1    Scott, H.L.2    Dodd, P.R.3
  • 57
    • 0036830656 scopus 로고    scopus 로고
    • Exploratory clinical testing of neuroscience drugs
    • CHOI DW: Exploratory clinical testing of neuroscience drugs. Nat. Neurosci. (2002) 5(suppl.):1023-1025.
    • (2002) Nat. Neurosci. , vol.5 , Issue.SUPPL. , pp. 1023-1025
    • Choi, D.W.1
  • 58
    • 0033392424 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury
    • MERCHANT RE, BULLOCK MR, CARMACK CA et al.: A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury. Ann. NY Acad. Sci. (1999) 890:42-50.
    • (1999) Ann. NY Acad. Sci. , vol.890 , pp. 42-50
    • Merchant, R.E.1    Bullock, M.R.2    Carmack, C.A.3
  • 59
    • 0033387727 scopus 로고    scopus 로고
    • An open-label study of CP-101,606 in subjects with a severe traumatic head injury or spontaneous intracerebral hemorrhage
    • BULLOCK MR, MERCHANT RE, CARMACK CA et al.: An open-label study of CP-101,606 in subjects with a severe traumatic head injury or spontaneous intracerebral hemorrhage. Ann. NY Acad. Sci. (1999) 890:51-58.
    • (1999) Ann. NY Acad. Sci. , vol.890 , pp. 51-58
    • Bullock, M.R.1    Merchant, R.E.2    Carmack, C.A.3
  • 60
    • 18144430830 scopus 로고    scopus 로고
    • The NR2B subunit-selective NMDA receptor antagonist, CP-101,606, reduces spontaneous pain intensity in patients with central and peripheral neuropathic pain
    • Program No. 814.9. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience online
    • SANG CN, WEAVER JJ, JINGA L, WOUDEN J, SALTARELLI MD: The NR2B subunit-selective NMDA receptor antagonist, CP-101,606, reduces spontaneous pain intensity in patients with central and peripheral neuropathic pain. Program No. 814.9. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience (2003) online.
    • (2003)
    • Sang, C.N.1    Weaver, J.J.2    Jinga, L.3    Wouden, J.4    Saltarelli, M.D.5
  • 61
    • 0032914455 scopus 로고    scopus 로고
    • Antagonists selective for NMDA receptors containing the NR2B subunit
    • CHENARD BL, MENNITI FS: Antagonists selective for NMDA receptors containing the NR2B subunit. Curr. Pharm. Des. (1999) 5(5):381-404.
    • (1999) Curr. Pharm. Des. , vol.5 , Issue.5 , pp. 381-404
    • Chenard, B.L.1    Menniti, F.S.2
  • 62
    • 0036250086 scopus 로고    scopus 로고
    • NR2B selective NMDA receptor antagonists
    • NIKAM SS, MELTZER LT: NR2B selective NMDA receptor antagonists. Curr. Pharm. Des. (2002) 8(10):845-855.
    • (2002) Curr. Pharm. Des. , vol.8 , Issue.10 , pp. 845-855
    • Nikam, S.S.1    Meltzer, L.T.2
  • 63
    • 0031969962 scopus 로고    scopus 로고
    • 3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits
    • 3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J. Neurochem. (1998) 70(5):2147-2155.
    • (1998) J. Neurochem. , vol.70 , Issue.5 , pp. 2147-2155
    • Mutel, V.1    Buchy, D.2    Klingelschmidt, A.3
  • 64
    • 0026088184 scopus 로고
    • 1-adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds
    • 1-adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds. J. Med. Chem. (1991) 34(10):3085-3090.
    • (1991) J. Med. Chem. , vol.34 , Issue.10 , pp. 3085-3090
    • Chenard, B.L.1    Shalaby, I.A.2    Koe, B.K.3
  • 66
    • 14444271319 scopus 로고    scopus 로고
    • (3R,4S)-3-[4-(4-Fluorophenyl)-4-hydroxypiperidin-1-yl]chroman- 4,7-diol: A conformationally restricted analog of the NR2B subtype-selective NMDA antagonist (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy- 4-phenylpiperidino)-propanol
    • BUTLER TW, BLAKE JF, BORDNER J et al.: (3R,4S)-3-[4-(4-Fluorophenyl)-4-hydroxypiperidin- 1-yl]chroman-4,7-diol: a conformationally restricted analog of the NR2B subtype-selective NMDA antagonist (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy- 4-phenylpiperidino)-propanol. J. Med. Chem. (1998) 41(7):1172-1184.
    • (1998) J. Med. Chem. , vol.41 , Issue.7 , pp. 1172-1184
    • Butler, T.W.1    Blake, J.F.2    Bordner, J.3
  • 68
    • 15644370726 scopus 로고    scopus 로고
    • Structure-activity relationships for a series of bis(phenylalkyl)amines: Potent subtype-selective inhibitors of N-methyl-D-aspartate receptors
    • TAMIZ AP, WHITTEMORE ER, ZHOU Z-L et al.: Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J. Med. Chem. (1998) 41(18):3499-3506.
    • (1998) J. Med. Chem. , vol.41 , Issue.18 , pp. 3499-3506
    • Tamiz, A.P.1    Whittemore, E.R.2    Zhou, Z.-L.3
  • 69
    • 0034624676 scopus 로고    scopus 로고
    • Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (±)-3-(4-hydroxyphenyl)pyrrolidines: Selective antagonists at the 1A/2B NMDA receptor subtype
    • GUZIKOWSKI AP, TAMIZ AP, ACOSTA-BURRUEL M et al.: Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (±)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype. J. Med. Chem. (2000) 43(5):984-994.
    • (2000) J. Med. Chem. , vol.43 , Issue.5 , pp. 984-994
    • Guzikowski, A.P.1    Tamiz, A.P.2    Acosta-Burruel, M.3
  • 70
    • 0031985248 scopus 로고    scopus 로고
    • State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist
    • KEW JNC, TRUBE G, KEMP JA: State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br. J. Pharmacol. (1998) 123(3):463-472.
    • (1998) Br. J. Pharmacol. , vol.123 , Issue.3 , pp. 463-472
    • Kew, J.N.C.1    Trube, G.2    Kemp, J.A.3
  • 71
    • 0033693599 scopus 로고    scopus 로고
    • CP-101606 (Pfizer Inc)
    • CHAZOT PL: CP-101606 (Pfizer Inc). Curr. Opin. Invest. Drugs (2000) 1(3):370-374.
    • (2000) Curr. Opin. Invest. Drugs , vol.1 , Issue.3 , pp. 370-374
    • Chazot, P.L.1
  • 73
    • 17944377190 scopus 로고    scopus 로고
    • Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4- (4-methyl-benzyl)-piperidin-4-ol: A novel NR1/2B subtype selective NMDA receptor antagonist
    • PINARD E, ALANINE A, BOURSON A et al.: Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4- (4-methyl-benzyl)-piperidin-4-ol: A novel NR1/2B subtype selective NMDA receptor antagonist. Bioorg. Med. Chem. Lett. (2001) 11(16):2173-2176.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , Issue.16 , pp. 2173-2176
    • Pinard, E.1    Alanine, A.2    Bourson, A.3
  • 74
    • 0038384650 scopus 로고    scopus 로고
    • Efficient enantioselective synthesis of the NMDA 2B receptor antagonist Ro 67-8867
    • SCALONE M, WALDMEIER P: Efficient enantioselective synthesis of the NMDA 2B receptor antagonist Ro 67-8867. Org. Proc. Res. Dev. (2003) 7(3):418-425.
    • (2003) Org. Proc. Res. Dev. , vol.7 , Issue.3 , pp. 418-425
    • Scalone, M.1    Waldmeier, P.2
  • 75
    • 12444275570 scopus 로고    scopus 로고
    • Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists
    • BORZA I, KOLOK S, GERE A et al.: Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2003) 13(21):3859-3861.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , Issue.21 , pp. 3859-3861
    • Borza, I.1    Kolok, S.2    Gere, A.3
  • 76
    • 0033532652 scopus 로고    scopus 로고
    • Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: potent subtype-selective inhibitors of N-methyl-D-aspartate (NMDA) receptors
    • TAMIZ AP, WHITTEMORE ER, WOODWARD RM, UPASANI RB, KEANA JFW: Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: potent subtype-selective inhibitors of N-methyl-D-aspartate (NMDA) receptors. Bioorg. Med. Chem. Lett. (1999) 9(11):1619-1624.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , Issue.11 , pp. 1619-1624
    • Tamiz, A.P.1    Whittemore, E.R.2    Woodward, R.M.3    Upasani, R.B.4    Keana, J.F.W.5
  • 77
    • 18144369148 scopus 로고    scopus 로고
    • RGH-896 is a novel potent and selective NR2B-NMDA antagonist with efficacy in neuropathic pain models
    • Program No. 382.8. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience online
    • FARKAS S, HORVATH C, NAGY J et al.: RGH-896 is a novel potent and selective NR2B-NMDA antagonist with efficacy in neuropathic pain models. Program No. 382.8. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience (2003) online.
    • (2003)
    • Farkas, S.1    Horvath, C.2    Nagy, J.3
  • 78
    • 11144355020 scopus 로고    scopus 로고
    • NR2B-selective N-methyl-D-aspartate antagonists: Synthesis and evaluation of 5-substituted benzimidazoles
    • MCCAULEY JA, THEBERGE CR, ROMANO JJ et al.: NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J. Med. Chem. (2004) 47(8):2089-2096.
    • (2004) J. Med. Chem. , vol.47 , Issue.8 , pp. 2089-2096
    • Mccauley, J.A.1    Theberge, C.R.2    Romano, J.J.3
  • 79
    • 1842408328 scopus 로고    scopus 로고
    • EMD 95885, a new eliprodil analog with higher affinity for the N-methyl-D-aspartate (NMDA) receptor
    • LEIBROCK J, PRÜCHER H, RAUTENBERG W: EMD 95885, a new eliprodil analog with higher affinity for the N-methyl-D-aspartate (NMDA) receptor. Pharmazie (1997) 52(6):479-480.
    • (1997) Pharmazie , vol.52 , Issue.6 , pp. 479-480
    • Leibrock, J.1    Prücher, H.2    Rautenberg, W.3
  • 80
    • 0033168012 scopus 로고    scopus 로고
    • Subtype-selective N-methyl-D-aspartate receptor antagonists: Synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines
    • WRIGHT JL, GREGORY TF, BIGGE CF et al.: Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines. J. Med. Chem. (1999) 42(13):2469-2477.
    • (1999) J. Med. Chem. , vol.42 , Issue.13 , pp. 2469-2477
    • Wright, J.L.1    Gregory, T.F.2    Bigge, C.F.3
  • 81
    • 0033523611 scopus 로고    scopus 로고
    • Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists
    • WRIGHT JL, GREGORY TF, BOXER PA et al.: Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists. Bioorg. Med. Chem. Lett. (1999) 9(19):2815-2818.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , Issue.19 , pp. 2815-2818
    • Wright, J.L.1    Gregory, T.F.2    Boxer, P.A.3
  • 82
    • 0034618553 scopus 로고    scopus 로고
    • Subtype-selective N-methyl-D-aspartate receptor antagonists: Synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines
    • WRIGHT JL, GREGORY TF, KESTEN SR et al.: Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J. Med. Chem. (2000) 43(18):3408-3419.
    • (2000) J. Med. Chem. , vol.43 , Issue.18 , pp. 3408-3419
    • Wright, J.L.1    Gregory, T.F.2    Kesten, S.R.3
  • 83
    • 1242293897 scopus 로고    scopus 로고
    • Subtype selective NMDA receptor antagonists: Evaluation of some novel alkynyl analogues
    • KORNBERG BE, NIKAM SS, WRIGHT JL et al.: Subtype selective NMDA receptor antagonists: evaluation of some novel alkynyl analogues. Bioorg. Med. Chem. Lett. (2004) 14(5):1213-1216.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , Issue.5 , pp. 1213-1216
    • Kornberg, B.E.1    Nikam, S.S.2    Wright, J.L.3
  • 84
    • 0034026350 scopus 로고    scopus 로고
    • Subtype-selective N-methyl-D-aspartate receptor antagonists: Benzimidazalone and hydantoin as phenol replacements
    • SCHELKUN RM, YUEN P-W, SERPA K et al.: Subtype-selective N-methyl-D-aspartate receptor antagonists: benzimidazalone and hydantoin as phenol replacements. J. Med. Chem. (2000) 43(9):1892-1897.
    • (2000) J. Med. Chem. , vol.43 , Issue.9 , pp. 1892-1897
    • Schelkun, R.M.1    Yuen, P.-W.2    Serpa, K.3
  • 85
    • 0034689520 scopus 로고    scopus 로고
    • Parallel synthesis of a series of subtype-selective NMDA receptor antagonists
    • GREGORY TF, WRIGHT JL, WISE LD et al.: Parallel synthesis of a series of subtype-selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2000) 10(6):527-529.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , Issue.6 , pp. 527-529
    • Gregory, T.F.1    Wright, J.L.2    Wise, L.D.3
  • 86
    • 3042634224 scopus 로고    scopus 로고
    • Oxamides as novel NR2B selective NMDA receptor antagonists
    • BARTA-SZALAI G, BORZA I, BOZÓ E et al.: Oxamides as novel NR2B selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2004) 14(15):3953-3956.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , Issue.15 , pp. 3953-3956
    • Barta-Szalai, G.1    Borza, I.2    Bozó, E.3
  • 87
    • 0026702866 scopus 로고
    • (5S)-3-Aryl-5-(1-piperidinylmethyl)-2-oxazolidinones, a new class of potential neuroleptics with a high affinity for sigma receptors
    • PRÜCHER H, GOTTSCHLICH R, HASSE A, STOHER M, SEYFRIED C: (5S)-3-Aryl-5-(1-piperidinylmethyl)-2-oxazolidinones, a new class of potential neuroleptics with a high affinity for sigma receptors. Bioorg. Med. Chem. Lett. (1992) 2(2):165-170.
    • (1992) Bioorg. Med. Chem. Lett. , vol.2 , Issue.2 , pp. 165-170
    • Prücher, H.1    Gottschlich, R.2    Hasse, A.3    Stoher, M.4    Seyfried, C.5
  • 88
    • 0030867518 scopus 로고    scopus 로고
    • Antagonism of N-methyl-D-aspartate receptors by σ-site ligands: Potency, subtype-selectivity and mechanisms of inhibition
    • WHITTEMORE ER, ILYIN VI: WOODWARD RM: Antagonism of N-methyl-D-aspartate receptors by σ-site ligands: potency, subtype-selectivity and mechanisms of inhibition. J. Pharmacol. Exp. Ther. (1997) 282(1):326-338.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , Issue.1 , pp. 326-338
    • Whittemore, E.R.1    Ilyin, V.I.2    Woodward, R.M.3
  • 89
    • 0037430678 scopus 로고    scopus 로고
    • 2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists
    • BÜTTELMANN B, ALANINE A, BOURSON A et al.: 2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2003) 13(5):829-832.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , Issue.5 , pp. 829-832
    • Büttelmann, B.1    Alanine, A.2    Bourson, A.3
  • 90
    • 0038363787 scopus 로고    scopus 로고
    • 4-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists
    • BÜTTELMANN B, ALANINE A, BOURSON A et al.: 4-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2003) 13(10):1759-1762.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , Issue.10 , pp. 1759-1762
    • Büttelmann, B.1    Alanine, A.2    Bourson, A.3
  • 91
    • 0037119827 scopus 로고    scopus 로고
    • 4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists
    • PINARD E, ALANINE A, BOURSON A et al.: 4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2002) 12(18):2615-2619.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , Issue.18 , pp. 2615-2619
    • Pinard, E.1    Alanine, A.2    Bourson, A.3
  • 92
    • 0037294026 scopus 로고    scopus 로고
    • Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists
    • CURTIS NR, DIGGLE HJ, KULAGOWSKI JJ et al.: Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2003) 13(4):693-696.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , Issue.4 , pp. 693-696
    • Curtis, N.R.1    Diggle, H.J.2    Kulagowski, J.J.3
  • 93
    • 0032548457 scopus 로고    scopus 로고
    • N-(4-Hydroxyphenethyl)-4-chlorocinnamamide: A novel antagonist at the 1A/2B NMDA receptor subtype
    • TAMIZ AP, WHITTEMORE ER, SCHELKUN RM et al.: N-(4-Hydroxyphenethyl)-4-chlorocinnamamide: a novel antagonist at the 1A/2B NMDA receptor subtype. Bioorg. Med. Chem. Lett. (1998) 8(2):199-200.
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , Issue.2 , pp. 199-200
    • Tamiz, A.P.1    Whittemore, E.R.2    Schelkun, R.M.3
  • 94
    • 13044287353 scopus 로고    scopus 로고
    • Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists
    • TAMIZ AP, CAI SX, ZHOU Z-L et al.: Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists. J. Med. Chem. (1999) 42(17):3412-3420.
    • (1999) J. Med. Chem. , vol.42 , Issue.17 , pp. 3412-3420
    • Tamiz, A.P.1    Cai, S.X.2    Zhou, Z.-L.3
  • 95
    • 0001248267 scopus 로고    scopus 로고
    • Chemoselective reactions of amidines: Selective formation of iminopyrimidine regioisomers
    • MCCAULEY JA, THEBERGE CR, LIVERTON NJ: Chemoselective reactions of amidines: selective formation of iminopyrimidine regioisomers. Org. Lett. (2000) 2(21):3389-3391.
    • (2000) Org. Lett. , vol.2 , Issue.21 , pp. 3389-3391
    • Mccauley, J.A.1    Theberge, C.R.2    Liverton, N.J.3
  • 96
    • 0037293059 scopus 로고    scopus 로고
    • Orally efficacious NR2B-selective NMDA receptor antagonists
    • CLAIBORNE CF, MCCAULEY JA, LIBBY BE et al.: Orally efficacious NR2B-selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2003) 13(4):697-700.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , Issue.4 , pp. 697-700
    • Claiborne, C.F.1    Mccauley, J.A.2    Libby, B.E.3
  • 97
    • 3242665260 scopus 로고    scopus 로고
    • Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux
    • BEDNAR B, CUNNINGHAM ME, KISS L et al.: Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux. J. Neurosci. Meth. (2004) 137(2):247-255.
    • (2004) J. Neurosci. Meth. , vol.137 , Issue.2 , pp. 247-255
    • Bednar, B.1    Cunningham, M.E.2    Kiss, L.3
  • 98
    • 0041330444 scopus 로고    scopus 로고
    • 1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists
    • ALANINE A, BOURSON A, BÜTTELMANN Bet al.: 1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. (2003) 13(19):3155-3159.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , Issue.19 , pp. 3155-3159
    • Alanine, A.1    Bourson, A.2    Büttelmann, B.3
  • 99
    • 0033851790 scopus 로고    scopus 로고
    • Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors
    • DONEYAN SD, MCCABE RT: Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol. Pharmacol. (2000) 58(3):614-623.
    • (2000) Mol. Pharmacol. , vol.58 , Issue.3 , pp. 614-623
    • Doneyan, S.D.1    Mccabe, R.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.