Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease

Journal of Neurochemistry

Volumn 90, Issue 4, 2004, Pages 913-919

  Hynd, Matthew R ^a   Scott, Heather L ^a   Dodd, Peter R ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Excitotoxicity; Glutamate; Human brain; Polyamine; Receptor subunit isoforms

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CELL LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; WESTERN BLOTTING;

ALZHEIMER DISEASE; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; HUMANS; PROTEIN ISOFORMS; RECEPTORS, N-METHYL-D-ASPARTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 4143117789     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02548.x     Document Type: Article

References (26)

1. Albin R. L. and Greenamyre J. T. (1992) Alternative excitotoxic hypotheses. Neurology 42, 733-738.
2. Bliss T. V. P. and Collingridge G. L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
3. Brun A. (1983) An overview of light and electron microscopic changes, in Alzheimer's Disease: the Standard Reference (Reisberg B., ed.), pp. 37-47. Free Press, New York.
4. Brun A. and Englund E. (1981) Regional pattern of degeneration in Alzheimer's Disease: neuronal loss and histopathological grading. Histopathology 5, 549-564.
5. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
6. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
7. Constantine-Paton M. (1990) NMDA receptor as a mediator of activity-dependent synaptogenesis in the developing brain. Cold Spring Harb. Symp. Quant. Biol. 55, 431-443.
8. Dingledine R., Borges K., Bowie D. and Traynelis S. F. (1999) The glutamate receptor ion channels. Pharmacol. Rev. 51, 7-61.
9. Dodd P. R., Hardy J. A., Baig E. B., Kidd A. M., Bird E. D., Watson W. E. J. and Johnston G. A. R. (1986) Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain. Neurochem. Pathol. 4, 177-198.
10. Hollmann M. and Heinemann S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108.
11. Hynd M. R., Scott H. L. and Dodd P. R. (2001) Glutamate NMDA receptor NR1 subunit mRNA expression in Alzheimer's disease. J. Neurochem. 78, 175-182.
12. Hynd M. R., Scott H. L. and Dodd P. R. (2003) Quantitation of NMDA receptor NR2 mRNA transcripts in human brain by competitive RT-PCR. Brain Res. Prot. 11, 67-79.
13. Hynd M. R., Scott H. L. and Dodd P. R. (2004) Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease. J. Neurochem. 89, 240-247.
14. Ishii T., Moriyoshi K., Sugihara H. et al. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268, 2836-2843.
15. Khachaturian Z. S. (1985) Diagnosis of Alzheimer's disease. Arch. Neurol. 42, 1097-1105.
16. Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B. and Seeburg P. H. (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217-1221.
17. Monyer H., Burnashev N., Laurie D. J., Sakmann B. and Seeburg P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.
18. Olney J. W. (1994) Excitatory transmitter neurotoxicity. Neurobiol. Aging 15, 259-260.
19. Premkumar L. S., Qin F. and Auerbach A. (1997) Subconductance states of a mutant NMDA receptor channel kinetics, calcium, and voltage dependence. J. Gen. Physiol. 109, 181-189.
20. NMDA receptor is differentially responsive to conantokins in normal and Alzheimer disease human cerebral cortex. J Neurochem. 81, 765-779.
21. Tannenberg R. K., Scott H. L., Westphalen R. I. and Dodd P. R. (2004) The identification and characterization of excitotoxic nerve-endings in Alzheimer disease. Curr. Alzheimer Res. 1, 11-25.
22. Watanabe M., Inoue Y., Sakimura K. and Mishina M. (1992) Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport 3, 1138-1140.
23. Watanabe M., Inoue Y., Sakimura K. and Mishina M. (1993) Distinct spatio-temporal distributions of the NMDA receptor channel subunit mRNAs in the brain. Ann. N. Y. Acad. Sci. 707, 463-466.
24. Wilkinson L., Hill M. and Vang E. (1992) SYSTAT: Statistics. SYSTAT Inc., Evanston.
25. Winer B. J., Brown D. R. and Michels K. M. (1991) Statistical Principles in Experimental Design. McGraw-Hill, Sydney.
26. Young A. B. (1993) Role of excitotoxins in heredito-degenerative neurologic diseases. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 71, 175-189.