N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: A novel antagonist at the 1A/2B NMDA receptor subtype

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 2, 1998, Pages 199-200

  Tamiz, Amir P ^a   Whittemore, Edward R ^b   Schelkun, Robert M ^c   Yuen, Po Wai ^c   Woodward, Richard M ^b   Cai, Sui Xiong ^b   Weber, Eckard ^b   Keana, John F W ^a,b  

^a UNIVERSITY OF OREGON   (United States)

^b Department of Pharmacokinetics and Drug Metabolism   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE;

ARTICLE; CHEMICAL MODIFICATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; OOCYTE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

CINNAMATES; EXCITATORY AMINO ACID ANTAGONISTS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032548457     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10215-3     Document Type: Article

References (7)

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5. 1H NMR spectra for all intermediates and final compounds were consistent with the assigned structures. All final compounds gave satisfactory C, H, N analyses.
6. 6. Dean, W. D.; Blum, D. M. J. Org. Chem. 1993, 58, 7916.
7. 7. Ilyin, V. I.; Whittemore, E. R.; Guastella, J.; Weber, E.; Woodward, R. M. Mol. Pharmacol. 1996, 50, 1541.