Structure-activity relationship for a series of 2-substituted 1,2,3,4- tetrahydro-9H-pyrido[3,4-b]indoles: Potent subtype-selective inhibitors of N- methyl-D-aspartate (NMDA) receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 11, 1999, Pages 1619-1624

  Tamiz, Amir P ^a   Whittemore, Edward R ^b   Woodward, Richard M ^b   Upasani, Ravindra B ^b   Keana, John F W ^a  

^a UNIVERSITY OF OREGON   (United States)

^b Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXY 2 (4 PHENYLBUTYL) 1,2,3,4 TETRAHYDROPYRIDO[3,4 B]INDOLE; BETA CARBOLINE 3 CARBOXYLIC ACID; IFENPRODIL; INDOLE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TRAXOPRODIL; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; NERVE CELL DEGENERATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; INDOLES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PYRIDINES; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

ANIMALIA;

EID: 0033532652     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00248-6     Document Type: Article

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