Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4- hydroxybenzyl)piperidines, and (±)-3-(4-hydroxyphenyl)pyrrolidines: Selective antagonists at the 1A/2B NMDA receptor subtype

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 984-994

  Guzikowski, Anthony P ^a,d   Tamiz, Amir P ^e   Acosta Burruel, Manuel ^d   Hong Bae, Soo ^d   Cai, Sui Xiong ^b,d   Hawkinson, Jon E ^c,d   Keana, John F W ^e   Kesten, Suzanne R ^f   Shipp, Christina T ^e   Tran, Minhtam ^d   Whittemore, Edward R ^d   Woodward, Richard M ^d   Wright, Jon L ^f   Zhou, Zhang Lin ^d  

^a Marker Gene Technologies Inc   (United States)

^b Cytovia Inc   (United States)

^c ELAN PHARMACEUTICALS   (United States)

^d Department of Pharmacokinetics and Drug Metabolism   (United States)

^e UNIVERSITY OF OREGON   (United States)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; DOPAMINE 2 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PIPERIDINE DERIVATIVE; PRAZOSIN; PYRROLIDINE DERIVATIVE; RACLOPRIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; OOCYTE; SEIZURE; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; ANTICONVULSANTS; CEREBRAL CORTEX; CORPUS STRIATUM; ELECTROSHOCK; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICE; OOCYTES; PIPERIDINES; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES; XENOPUS LAEVIS;

EID: 0034624676     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990428c     Document Type: Article

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