Exploratory clinical testing of neuroscience drugs

Nature Neuroscience

Volumn 5, Issue 11s, 2002, Pages 1023-1025

  Choi, Dennis W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; CLINICAL MEDICINE; DRUG APPROVAL; DRUG SCREENING; NEOCORTEX; NEUROSCIENCE; NOTE; PRIORITY JOURNAL; SPINAL CORD INJURY;

ANIMALS; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM DISEASES; CLINICAL TRIALS; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG EVALUATION; HUMANS; NEUROPHARMACOLOGY; PATIENT SELECTION; PREDICTIVE VALUE OF TESTS;

EID: 0036830656     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn930     Document Type: Note

References (8)

1. Kundera, M. The Unbearable Lightness of Being (HarperCollins, New York, 1984).
2. Hill, R. NK (substance P) receptor antagonists - why are they not analgesic in humans? Trends Pharmacol. Sci. 21, 244-246 (2000).
3. Lee, J.M., Zipfel, G.J. & Choi, D.W. The changing landscape of ischaemic brain injury mechanisms. Nature 399, A7-A14 (1999).
4. Albers, G.W. Advances in intravenous thrombolytic therapy for treatment of acute stroke. Neurol. 57, S77-S81 (2001).
5. Curtis, V.A., Dixon, R.G., Morris, E.T., Bullmore, M.J., Williams, S.C.R., Sharma, T., Murray, R.M. & McGuire, P.K. Differential frontal activation in schizophrenia and bipolar illness during verbal fluency. J. Affect. Dis. 66, 111-121 (2001).
6. Drevets, W.C., Price, J.L., Bargett, M.E., Reich, T., Todd, R.D. & Raichle, M.E. Glucose metabolism in the amydala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacol. Biochem. Behav. 71, 431-447 (2002).
7. Fillit, H.M., O’Connell, A.W., Brown, W.M., Altsteil, L.D., Anand, R., Collins, K., Ferris, S.H., Khachaturian, Z.S., Kinoshita, J., Van Eldik, L. & Dewey, C.F. Barriers to drug discovery and development for Alzheimer’s disease. Alzheimer Dis. Assoc. Disorders 16, S1-S8 (2002).
8. Marcus, R., Wong, M., Heath, H. & Stock, J.L. Antiresorptive treatment of postmenopausal osteoporosis: comparison of study designs and outcomes in large clinical trials with fracture as an endpoint. Endocr. Rev. 23, 16-37 (2002).