Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic β-cells via reduced nuclear factor binding to the A5/core and Z element

Molecular Endocrinology

Volumn 19, Issue 5, 2005, Pages 1343-1360

  Pino, Maria F ^a,f   Ye, Diana Z ^b   Linning, Katrina D ^a   Green, Christopher D ^c   Wicksteed, Barton ^d   Poitout, Vincent ^d,e   Olson, L Karl ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c Michigan State University   (United States)

^d PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A2 LIKE BINDING FACTOR; BINDING PROTEIN; CELL EXTRACT; GLUCOSE; INSULIN; NUCLEAR FACTOR; PALINDROMIC DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; VIRUS T ANTIGEN;

ANIMAL CELL; ARTICLE; BASE PAIRING; CELL LINE; CELL NUCLEUS; CELL TRANSFORMATION; DNA STRUCTURE; E BOX ELEMENT; ENHANCER REGION; GENE OVEREXPRESSION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; RAT; REGULATOR GENE; REPORTER GENE; SIMIAN VIRUS 40; SITE DIRECTED MUTAGENESIS; Z ELEMENT;

5' FLANKING REGION; ANIMALS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GLUCOSE; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MAF TRANSCRIPTION FACTORS, LARGE; PROMOTER REGIONS (GENETICS); RATS; TRANS-ACTIVATORS;

SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 17844368863     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2003-0493     Document Type: Article

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