-
1
-
-
0029586470
-
Primary cilia in normal and pathological tissues
-
Wheatley DN. Primary cilia in normal and pathological tissues. Pathobiology 1995;63:222-238.
-
(1995)
Pathobiology
, vol.63
, pp. 222-238
-
-
Wheatley, D.N.1
-
4
-
-
10644290199
-
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
-
Corey DP, Garcia-Anoveros J, Holt JR, et al. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 2004;432:723-730.
-
(2004)
Nature
, vol.432
, pp. 723-730
-
-
Corey, D.P.1
Garcia-Anoveros, J.2
Holt, J.R.3
-
5
-
-
0036901166
-
Intraflagellar transport and cilia-dependent diseases
-
Pazour GJ, Rosenbaum JL. Intraflagellar transport and cilia-dependent diseases. Trends Cell Biol 2002;12:551-555.
-
(2002)
Trends Cell Biol
, vol.12
, pp. 551-555
-
-
Pazour, G.J.1
Rosenbaum, J.L.2
-
6
-
-
16244368607
-
Intraflagellar transport and cilia-dependent renal disease: The ciliary hypothesis of polycystic kidney disease
-
Pazour GJ. Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease. J Am Soc Nephrol 2004;15:2528-2536.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 2528-2536
-
-
Pazour, G.J.1
-
7
-
-
85047681474
-
Assembly and motility of eukaryotic cilia and flagella. Lessons from Chlamydomonas reinhardtii
-
Silflow CD, Lefebvre PA. Assembly and motility of eukaryotic cilia and flagella. Lessons from Chlamydomonas reinhardtii. Plant Physiol 2001;127:1500-1507.
-
(2001)
Plant Physiol
, vol.127
, pp. 1500-1507
-
-
Silflow, C.D.1
Lefebvre, P.A.2
-
8
-
-
0035478337
-
The centrosome in vertebrates: More than a microtubule-organizing center
-
Rieder CL, Faruki S, Khodjakov A. The centrosome in vertebrates: more than a microtubule-organizing center. Trends Cell Biol 2001;11:413-419.
-
(2001)
Trends Cell Biol
, vol.11
, pp. 413-419
-
-
Rieder, C.L.1
Faruki, S.2
Khodjakov, A.3
-
9
-
-
0037225725
-
Basal body/centriole assembly and continuity
-
Beisson J, Wright M. Basal body/centriole assembly and continuity. Curr Opin Cell Biol 2003;15:96-104.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 96-104
-
-
Beisson, J.1
Wright, M.2
-
10
-
-
0038421025
-
Elucidation of basal body and centriole functions in Chlamydomonas reinhardtii
-
Dutcher SK. Elucidation of basal body and centriole functions in Chlamydomonas reinhardtii. Traffic 2003;4:443-451.
-
(2003)
Traffic
, vol.4
, pp. 443-451
-
-
Dutcher, S.K.1
-
11
-
-
0017162819
-
A human syndrome caused by immotile cilia
-
Afzelius BA. A human syndrome caused by immotile cilia. Science 1976;193:317-319.
-
(1976)
Science
, vol.193
, pp. 317-319
-
-
Afzelius, B.A.1
-
12
-
-
1642513854
-
Situs inversus, bronchiectasis, and sinusitis and its relation to immotile cilia: History of the diseases and their discoverers-Manes Kartagener and Bjorn Afzelius
-
Berdon WE, Willi U. Situs inversus, bronchiectasis, and sinusitis and its relation to immotile cilia: history of the diseases and their discoverers-Manes Kartagener and Bjorn Afzelius. Pediatr Radiol 2004;34:38-42.
-
(2004)
Pediatr Radiol
, vol.34
, pp. 38-42
-
-
Berdon, W.E.1
Willi, U.2
-
13
-
-
7944223873
-
Cilia-related diseases
-
Afzelius BA. Cilia-related diseases. J Pathol 2004;204:470-477.
-
(2004)
J Pathol
, vol.204
, pp. 470-477
-
-
Afzelius, B.A.1
-
14
-
-
4644225352
-
Primary ciliary dyskinesia: Genes, candidate genes and chromosomal regions
-
Geremek M, Witt M. Primary ciliary dyskinesia: genes, candidate genes and chromosomal regions. J Appl Genet 2004;45:347-361.
-
(2004)
J Appl Genet
, vol.45
, pp. 347-361
-
-
Geremek, M.1
Witt, M.2
-
15
-
-
0041845296
-
Cilia are at the heart of vertebrate left-right asymmetry
-
McGrath J, Brueckner M. Cilia are at the heart of vertebrate left-right asymmetry. Curr Opin Genet Dev 2003;13:385-392.
-
(2003)
Curr Opin Genet Dev
, vol.13
, pp. 385-392
-
-
McGrath, J.1
Brueckner, M.2
-
16
-
-
0038784537
-
Two populations of node monocilia initiate left-right asymmetry in the mouse
-
McGrath J, Somlo S, Makova S, et al. Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell 2003;114:61-73.
-
(2003)
Cell
, vol.114
, pp. 61-73
-
-
McGrath, J.1
Somlo, S.2
Makova, S.3
-
17
-
-
0037019287
-
Determination of left-right patterning of the mouse embryo by artificial nodal flow
-
Nonaka S, Shiratori H, Saijoh Y, et al. Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 2002;418:96-99.
-
(2002)
Nature
, vol.418
, pp. 96-99
-
-
Nonaka, S.1
Shiratori, H.2
Saijoh, Y.3
-
18
-
-
1642564276
-
To beat or not to beat: Roles of cilia in development and disease
-
Ibanez-Tallon I, Heintz N, Omran H. To beat or not to beat: roles of cilia in development and disease. Hum Mol Genet 2003;12:R27-R35.
-
(2003)
Hum Mol Genet
, vol.12
-
-
Ibanez-Tallon, I.1
Heintz, N.2
Omran, H.3
-
19
-
-
0021707121
-
Immotile cilia syndrome associated with polycystic kidney
-
Saeki H, Kondo S, Morita T, et al. Immotile cilia syndrome associated with polycystic kidney. J Urol 1984;132:1165-1166.
-
(1984)
J Urol
, vol.132
, pp. 1165-1166
-
-
Saeki, H.1
Kondo, S.2
Morita, T.3
-
21
-
-
2942521612
-
Cilia and flagella revealed: From flagellar assembly in Chlamydomonas to human obesity disorders
-
Snell WJ, Pan J, Wang Q. Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders. Cell 2004;117:693-697.
-
(2004)
Cell
, vol.117
, pp. 693-697
-
-
Snell, W.J.1
Pan, J.2
Wang, Q.3
-
22
-
-
0027286361
-
A motility in the eukaryotic flagellum unrelated to flagellar beating
-
Kozminski KG, Johnson KA, Forscher P, et al. A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc Natl Acad Sci USA 1993;90:5519-5523.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 5519-5523
-
-
Kozminski, K.G.1
Johnson, K.A.2
Forscher, P.3
-
23
-
-
0345255945
-
Intraflagellar transport
-
Scholey JM. Intraflagellar transport. Annu Rev Cell Dev Biol 2003;19:423-443.
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 423-443
-
-
Scholey, J.M.1
-
24
-
-
1642382220
-
Intraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body
-
Qin H, Diener DR, Geimer S, et al. Intraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body. J Cell Biol 2004;164:255-266.
-
(2004)
J Cell Biol
, vol.164
, pp. 255-266
-
-
Qin, H.1
Diener, D.R.2
Geimer, S.3
-
25
-
-
0035851915
-
Intraflagellar transport balances continuous turnover of outer doublet microtubules: Implications for flagellar length control
-
Marshall WF, Rosenbaum JL. Intraflagellar transport balances continuous turnover of outer doublet microtubules: implications for flagellar length control. J Cell Biol 2001;155:405-414.
-
(2001)
J Cell Biol
, vol.155
, pp. 405-414
-
-
Marshall, W.F.1
Rosenbaum, J.L.2
-
26
-
-
0037744859
-
The intraflagellar transport machinery of Chlamydomonas reinhardtii
-
Cole DG. The intraflagellar transport machinery of Chlamydomonas reinhardtii. Traffic 2003;4:435-442.
-
(2003)
Traffic
, vol.4
, pp. 435-442
-
-
Cole, D.G.1
-
27
-
-
0029990194
-
Inner dynein arms but not outer dynein arms require the activity of kinesin homologue protein KHP1(FLA10) to reach the distal part of flagella in Chlamydomonas
-
Piperno G, Mead K, Henderson S. Inner dynein arms but not outer dynein arms require the activity of kinesin homologue protein KHP1(FLA10) to reach the distal part of flagella in Chlamydomonas. J Cell Biol 1996;133:371-379.
-
(1996)
J Cell Biol
, vol.133
, pp. 371-379
-
-
Piperno, G.1
Mead, K.2
Henderson, S.3
-
28
-
-
0035916823
-
An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons
-
Qin H, Rosenbaum JL, Barr MM. An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons. Curr Biol 2001;11:457-461.
-
(2001)
Curr Biol
, vol.11
, pp. 457-461
-
-
Qin, H.1
Rosenbaum, J.L.2
Barr, M.M.3
-
29
-
-
0038158086
-
A novel MAP kinase regulates flagellar length in Chlamydomonas
-
Berman SA, Wilson NF, Haas NA, et al. A novel MAP kinase regulates flagellar length in Chlamydomonas. Curr Biol 2003;13:1145-1149.
-
(2003)
Curr Biol
, vol.13
, pp. 1145-1149
-
-
Berman, S.A.1
Wilson, N.F.2
Haas, N.A.3
-
30
-
-
0242509225
-
Defective flagellar assembly and length regulation in LF3 null mutants in Chlamydomonas
-
Tam LW, Dentier WL, Lefebvre PA. Defective flagellar assembly and length regulation in LF3 null mutants in Chlamydomonas. J Cell Biol 2003;163:597-607.
-
(2003)
J Cell Biol
, vol.163
, pp. 597-607
-
-
Tam, L.W.1
Dentier, W.L.2
Lefebvre, P.A.3
-
31
-
-
1642406286
-
An aurora kinase is essential for flagellar disassembly in Chlamydomonas
-
Pan J, Wang Q, Snell WJ. An aurora kinase is essential for flagellar disassembly in Chlamydomonas. Dev Cell 2004;6:445-451.
-
(2004)
Dev Cell
, vol.6
, pp. 445-451
-
-
Pan, J.1
Wang, Q.2
Snell, W.J.3
-
32
-
-
6344226513
-
Regulation of flagellar assembly by glycogen synthase kinase 3 in Chlamydomonas reinhardtii
-
Wilson NF, Lefebvre PA. Regulation of flagellar assembly by glycogen synthase kinase 3 in Chlamydomonas reinhardtii. Eukaryot Cell 2004;3:1307-1319.
-
(2004)
Eukaryot Cell
, vol.3
, pp. 1307-1319
-
-
Wilson, N.F.1
Lefebvre, P.A.2
-
33
-
-
0242625186
-
The microtubule plus end-tracking protein EB1 is localized to the flagellar tip and basal bodies in Chlamydomonas reinhardtii
-
Pedersen LB, Geimer S, Sloboda RD, et al. The microtubule plus end-tracking protein EB1 is localized to the flagellar tip and basal bodies in Chlamydomonas reinhardtii. Curr Biol 2003;13:1969-1974.
-
(2003)
Curr Biol
, vol.13
, pp. 1969-1974
-
-
Pedersen, L.B.1
Geimer, S.2
Sloboda, R.D.3
-
34
-
-
0034658368
-
EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability
-
Tirnauer JS, Bierer BE. EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. J Cell Biol 2000;149:761-766.
-
(2000)
J Cell Biol
, vol.149
, pp. 761-766
-
-
Tirnauer, J.S.1
Bierer, B.E.2
-
35
-
-
17144394537
-
The LF1 Gene of Chlamydomonas reinhardtii encodes a novel protein required for flagellar length control
-
Nguyen RL, Tam LW, Lefebvre PA. The LF1 Gene of Chlamydomonas reinhardtii encodes a novel protein required for flagellar length control. Genetics 2004.
-
(2004)
Genetics
-
-
Nguyen, R.L.1
Tam, L.W.2
Lefebvre, P.A.3
-
36
-
-
6344270057
-
Aurora kinases in spindle assembly and chromosome segregation
-
Ducat D, Zheng Y. Aurora kinases in spindle assembly and chromosome segregation. Exp Cell Res 2004;301:60-67.
-
(2004)
Exp Cell Res
, vol.301
, pp. 60-67
-
-
Ducat, D.1
Zheng, Y.2
-
37
-
-
0141592294
-
Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails
-
Sarpal R, Todi SV, Sivan-Loukianova E, et al. Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails. Curr Biol 2003;13:1687-1696.
-
(2003)
Curr Biol
, vol.13
, pp. 1687-1696
-
-
Sarpal, R.1
Todi, S.V.2
Sivan-Loukianova, E.3
-
38
-
-
0141480791
-
Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm
-
Han YG, Kwok BH, Kernan MJ. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr Biol 2003;13:1679-1686.
-
(2003)
Curr Biol
, vol.13
, pp. 1679-1686
-
-
Han, Y.G.1
Kwok, B.H.2
Kernan, M.J.3
-
39
-
-
0142104375
-
Cell motility: Deaf Drosophila keep the beat
-
Witman GB. Cell motility: deaf Drosophila keep the beat. Curr Biol 2003;13:R796-R798.
-
(2003)
Curr Biol
, vol.13
-
-
Witman, G.B.1
-
40
-
-
0042971367
-
Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport subunit gene
-
Brown JM, Fine NA, Pandiyan G, et al. Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport subunit gene. Mol Biol Cell 2003;14:3192-3207.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 3192-3207
-
-
Brown, J.M.1
Fine, N.A.2
Pandiyan, G.3
-
41
-
-
4544383179
-
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney
-
Sun Z, Amsterdam A, Pazour GJ, et al. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 2004;131:4085-4093.
-
(2004)
Development
, vol.131
, pp. 4085-4093
-
-
Sun, Z.1
Amsterdam, A.2
Pazour, G.J.3
-
42
-
-
2942596578
-
Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons
-
Tsujikawa M, Malicki J. Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons. Neuron 2004;42:703-716.
-
(2004)
Neuron
, vol.42
, pp. 703-716
-
-
Tsujikawa, M.1
Malicki, J.2
-
43
-
-
0242582130
-
Murine models of polycystic kidney disease: Molecular and therapeutic insights
-
Guay-Woodford LM. Murine models of polycystic kidney disease: molecular and therapeutic insights. Am J Physiol Renal Physiol 2003;285:F1034-F1049.
-
(2003)
Am J Physiol Renal Physiol
, vol.285
-
-
Guay-Woodford, L.M.1
-
44
-
-
0031750484
-
Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons
-
Cole DG, Diener DR, Himelblau AL, et al. Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons. J Cell Biol 1998;141:993-1008.
-
(1998)
J Cell Biol
, vol.141
, pp. 993-1008
-
-
Cole, D.G.1
Diener, D.R.2
Himelblau, A.L.3
-
45
-
-
0033598394
-
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
-
Barr MM, Sternberg PW. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature 1999;401:386-389.
-
(1999)
Nature
, vol.401
, pp. 386-389
-
-
Barr, M.M.1
Sternberg, P.W.2
-
46
-
-
0034735526
-
Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
-
Pazour GJ, Dickert BL, Vucica Y, et al. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 2000;151:709-718.
-
(2000)
J Cell Biol
, vol.151
, pp. 709-718
-
-
Pazour, G.J.1
Dickert, B.L.2
Vucica, Y.3
-
47
-
-
0037884961
-
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease
-
Lin F, Hiesberger T, Cordes K, et al. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci USA 2003;100:5286-5291.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5286-5291
-
-
Lin, F.1
Hiesberger, T.2
Cordes, K.3
-
48
-
-
0347357836
-
Polycystic kidney disease
-
Wilson PD. Polycystic kidney disease. N Engl J Med 2004;350:151-164.
-
(2004)
N Engl J Med
, vol.350
, pp. 151-164
-
-
Wilson, P.D.1
-
49
-
-
0029069583
-
The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains
-
Hughes J, Ward CJ, Peral B, et al. The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Nat Genet 1995;10:151-160.
-
(1995)
Nat Genet
, vol.10
, pp. 151-160
-
-
Hughes, J.1
Ward, C.J.2
Peral, B.3
-
50
-
-
15844385078
-
PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
-
Mochizuki T, Wu G, Hayashi T, et al. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 1996;272:1339-1342.
-
(1996)
Science
, vol.272
, pp. 1339-1342
-
-
Mochizuki, T.1
Wu, G.2
Hayashi, T.3
-
51
-
-
0142106807
-
Role of polycystins in renal tubulogenesis
-
Boletta A, Germino GG. Role of polycystins in renal tubulogenesis. Trends Cell Biol 2003;13:484-492.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 484-492
-
-
Boletta, A.1
Germino, G.G.2
-
52
-
-
0036707893
-
Genetics and pathogenesis of polycystic kidney disease
-
Igarashi P, Somlo S. Genetics and pathogenesis of polycystic kidney disease. J Am Soc Nephrol 2002;13:2384-2398.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 2384-2398
-
-
Igarashi, P.1
Somlo, S.2
-
53
-
-
18344366124
-
PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription- factor domains and parallel beta-helix 1 repeats
-
Onuchic LF, Furu L, Nagasawa Y, et al. PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet 2002;70:1305-1317.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 1305-1317
-
-
Onuchic, L.F.1
Furu, L.2
Nagasawa, Y.3
-
54
-
-
0036509712
-
The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein
-
Ward CJ, Hogan MC, Rossetti S, et al. The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. Nat Genet 2002;30:259-269.
-
(2002)
Nat Genet
, vol.30
, pp. 259-269
-
-
Ward, C.J.1
Hogan, M.C.2
Rossetti, S.3
-
55
-
-
2142659368
-
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice
-
Hiesberger T, Bai Y, Shao X, et al. Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J Clin Invest 2004;113:814-825.
-
(2004)
J Clin Invest
, vol.113
, pp. 814-825
-
-
Hiesberger, T.1
Bai, Y.2
Shao, X.3
-
56
-
-
4243144134
-
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
-
Cano DA, Murcia NS, Pazour GJ, et al. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 2004;131:3457-3467.
-
(2004)
Development
, vol.131
, pp. 3457-3467
-
-
Cano, D.A.1
Murcia, N.S.2
Pazour, G.J.3
-
57
-
-
0002227861
-
Nephronopthisis-medullary cystic kidney disease
-
Avner ED, Harmon WE, Niaudet P (eds.) Lipincott, Williams and Williams: Philadelphia
-
Hildebrandt F. Nephronopthisis-medullary cystic kidney disease. In: Avner ED, Harmon WE, Niaudet P (eds.) Pediatric Nephrology, 5th edn. Lipincott, Williams and Williams: Philadelphia, 2004, pp 665-673.
-
(2004)
Pediatric Nephrology, 5th Edn.
, pp. 665-673
-
-
Hildebrandt, F.1
-
58
-
-
9844224478
-
A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis
-
Saunier S, Calado J, Heilig R, et al. A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis. Hum Mol Genet 1997;6:2317-2323.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 2317-2323
-
-
Saunier, S.1
Calado, J.2
Heilig, R.3
-
59
-
-
0030868540
-
A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1
-
Hildebrandt F, Otto E, Rensing C, et al. A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1. Nat Genet 1997;17:149-153.
-
(1997)
Nat Genet
, vol.17
, pp. 149-153
-
-
Hildebrandt, F.1
Otto, E.2
Rensing, C.3
-
60
-
-
0041592700
-
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination
-
Otto EA, Schermer B, Obara T, et al. Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet 2003;34:413-420.
-
(2003)
Nat Genet
, vol.34
, pp. 413-420
-
-
Otto, E.A.1
Schermer, B.2
Obara, T.3
-
61
-
-
0042093746
-
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis
-
Olbrich H, Fliegauf M, Hoefele J, et al. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet 2003;34:455-459.
-
(2003)
Nat Genet
, vol.34
, pp. 455-459
-
-
Olbrich, H.1
Fliegauf, M.2
Hoefele, J.3
-
62
-
-
0036842902
-
A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution
-
Otto E, Hoefele J, Ruf R, et al. A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution. Am J Hum Genet 2002;71:1161-1167.
-
(2002)
Am J Hum Genet
, vol.71
, pp. 1161-1167
-
-
Otto, E.1
Hoefele, J.2
Ruf, R.3
-
63
-
-
18644368159
-
The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin
-
Mollet G, Salomon R, Gribouval O, et al. The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin. Nat Genet 2002;32:300-305.
-
(2002)
Nat Genet
, vol.32
, pp. 300-305
-
-
Mollet, G.1
Salomon, R.2
Gribouval, O.3
-
64
-
-
0037317302
-
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
-
Nauli SM, Alenghat FJ, Luo Y, et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 2003;33:129-137.
-
(2003)
Nat Genet
, vol.33
, pp. 129-137
-
-
Nauli, S.M.1
Alenghat, F.J.2
Luo, Y.3
-
65
-
-
0036785149
-
The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
-
Yoder BK, Hou X, Guay-Woodford LM. The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol 2002;13:2508-2516.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 2508-2516
-
-
Yoder, B.K.1
Hou, X.2
Guay-Woodford, L.M.3
-
66
-
-
10744220950
-
Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia
-
Ward CJ, Yuan D, Masyuk TV, et al. Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia. Hum Mol Genet 2003;12:2703-2710.
-
(2003)
Hum Mol Genet
, vol.12
, pp. 2703-2710
-
-
Ward, C.J.1
Yuan, D.2
Masyuk, T.V.3
-
67
-
-
1542378854
-
The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area
-
Wang S, Luo Y, Wilson PD, et al. The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area. J Am Soc Nephrol 2004;15:592-602.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 592-602
-
-
Wang, S.1
Luo, Y.2
Wilson, P.D.3
-
68
-
-
10744222228
-
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells
-
Zhang MZ, Mai W, Li C, et al. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci USA 2004;101:2311-2316.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2311-2316
-
-
Zhang, M.Z.1
Mai, W.2
Li, C.3
-
69
-
-
0037115494
-
Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle
-
Morgan D, Eley L, Sayer J, et al. Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. Hum Mol Genet 2002;11:3345-3350.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 3345-3350
-
-
Morgan, D.1
Eley, L.2
Sayer, J.3
-
70
-
-
0037959910
-
The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia
-
Watanabe D, Saijoh Y, Nonaka S, et al. The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. Development 2003;130:1725-1734.
-
(2003)
Development
, vol.130
, pp. 1725-1734
-
-
Watanabe, D.1
Saijoh, Y.2
Nonaka, S.3
-
71
-
-
0036177603
-
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
-
Hou X, Mrug M, Yoder BK, et al. Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest 2002;109:533-540.
-
(2002)
J Clin Invest
, vol.109
, pp. 533-540
-
-
Hou, X.1
Mrug, M.2
Yoder, B.K.3
-
72
-
-
0036086844
-
Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium
-
Yoder BK, Tousson A, Millican L, et al. Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium. Am J Physiol Renal Physiol 2002;282:F541-F552.
-
(2002)
Am J Physiol Renal Physiol
, vol.282
-
-
Yoder, B.K.1
Tousson, A.2
Millican, L.3
-
73
-
-
0037377655
-
Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice
-
Brown NE, Murcia NS. Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice. Kidney Int 2003;63:1220-1229.
-
(2003)
Kidney Int
, vol.63
, pp. 1220-1229
-
-
Brown, N.E.1
Murcia, N.S.2
-
74
-
-
0035159015
-
Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia
-
Taulman PD, Haycraft CJ, Balkovetz DF, et al. Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol Biol Cell 2001;12:589-599.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 589-599
-
-
Taulman, P.D.1
Haycraft, C.J.2
Balkovetz, D.F.3
-
75
-
-
0034700483
-
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
-
Hanaoka K, Qian F, Boletta A, et al. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 2000;408:990-994.
-
(2000)
Nature
, vol.408
, pp. 990-994
-
-
Hanaoka, K.1
Qian, F.2
Boletta, A.3
-
76
-
-
1542283793
-
A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells
-
Roitbak T, Ward CJ, Harris PC, et al. A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells. Mol Biol Cell 2004;15:1334-1346.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1334-1346
-
-
Roitbak, T.1
Ward, C.J.2
Harris, P.C.3
-
77
-
-
0041831249
-
The renal cell primary cilium functions as a flow sensor
-
Praetorius HA, Spring KR. The renal cell primary cilium functions as a flow sensor. Curr Opin Nephrol Hypertens 2003;12:517-520.
-
(2003)
Curr Opin Nephrol Hypertens
, vol.12
, pp. 517-520
-
-
Praetorius, H.A.1
Spring, K.R.2
-
78
-
-
0035498717
-
Bending the MDCK cell primary cilium increases intracellular calcium
-
Praetorius HA, Spring KR. Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 2001;184:71-79.
-
(2001)
J Membr Biol
, vol.184
, pp. 71-79
-
-
Praetorius, H.A.1
Spring, K.R.2
-
80
-
-
0037557518
-
Removal of the MDCK cell primary cilium abolishes flow sensing
-
Praetorius HA, Spring KR. Removal of the MDCK cell primary cilium abolishes flow sensing. J Membr Biol 2003;191:69-76.
-
(2003)
J Membr Biol
, vol.191
, pp. 69-76
-
-
Praetorius, H.A.1
Spring, K.R.2
-
81
-
-
0033635231
-
Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells
-
Boletta A, Qian F, Onuchic LF, et al. Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells. Mol Cell 2000;6:1267-1273.
-
(2000)
Mol Cell
, vol.6
, pp. 1267-1273
-
-
Boletta, A.1
Qian, F.2
Onuchic, L.F.3
-
82
-
-
0035859888
-
Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2
-
Benzing T, Gerke P, Hopker K, et al. Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. Proc Natl Acad Sci USA 2001;98:9784-9789.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9784-9789
-
-
Benzing, T.1
Gerke, P.2
Hopker, K.3
-
83
-
-
0034630157
-
Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells
-
Donaldson JC, Dempsey PJ, Reddy S, et al. Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res 2000;256:168-178.
-
(2000)
Exp Cell Res
, vol.256
, pp. 168-178
-
-
Donaldson, J.C.1
Dempsey, P.J.2
Reddy, S.3
-
85
-
-
0037018850
-
The ion channel polycystin-2 is required for left-right axis determination in mice
-
Pennekamp P, Karcher C, Fischer A, et al. The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol 2002;12:938-943.
-
(2002)
Curr Biol
, vol.12
, pp. 938-943
-
-
Pennekamp, P.1
Karcher, C.2
Fischer, A.3
-
86
-
-
0346403328
-
A flagellar polycystin-2 homolog required for male fertility in Drosophila
-
Watnick TJ, Jin Y, Matunis E, et al. A flagellar polycystin-2 homolog required for male fertility in Drosophila. Curr Biol 2003;13:2179-2184.
-
(2003)
Curr Biol
, vol.13
, pp. 2179-2184
-
-
Watnick, T.J.1
Jin, Y.2
Matunis, E.3
-
87
-
-
2342508500
-
A transcriptional network in polycystic kidney disease
-
Gresh L, Fischer E, Reimann A, et al. A transcriptional network in polycystic kidney disease. EMBO J 2004;23:1657-1668.
-
(2004)
EMBO J
, vol.23
, pp. 1657-1668
-
-
Gresh, L.1
Fischer, E.2
Reimann, A.3
-
88
-
-
4644282724
-
Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm
-
Menezes LF, Cai Y, Nagasawa Y, et al. Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm. Kidney Int 2004;66:1345-1355.
-
(2004)
Kidney Int
, vol.66
, pp. 1345-1355
-
-
Menezes, L.F.1
Cai, Y.2
Nagasawa, Y.3
-
89
-
-
1942502194
-
Cell biology of normal and abnormal ciliogenesis in the ciliated epithelium
-
Hagiwara H, Ohwada N, Takata K. Cell biology of normal and abnormal ciliogenesis in the ciliated epithelium. Int Rev Cytol 2004;234:101-141.
-
(2004)
Int Rev Cytol
, vol.234
, pp. 101-141
-
-
Hagiwara, H.1
Ohwada, N.2
Takata, K.3
-
91
-
-
0036175934
-
The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells
-
Nickel C, Benzing T, Sellin L, et al. The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest 2002;109:481-489.
-
(2002)
J Clin Invest
, vol.109
, pp. 481-489
-
-
Nickel, C.1
Benzing, T.2
Sellin, L.3
-
92
-
-
85047694216
-
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus
-
Chauvet V, Xin T, Husson H, et al. Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest 2004;114:1433-1443.
-
(2004)
J Clin Invest
, vol.114
, pp. 1433-1443
-
-
Chauvet, V.1
Xin, T.2
Husson, H.3
-
93
-
-
1842579395
-
The oligogenic properties of Bardet-Biedl syndrome
-
Katsanis N. The oligogenic properties of Bardet-Biedl syndrome. Hum Mol Genet 2004;13:R65-R71.
-
(2004)
Hum Mol Genet
, vol.13
-
-
Katsanis, N.1
-
94
-
-
0142104970
-
Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome
-
Ansley SJ, Badano JL, Blacque OE, et al. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 2003;425:628-633.
-
(2003)
Nature
, vol.425
, pp. 628-633
-
-
Ansley, S.J.1
Badano, J.L.2
Blacque, O.E.3
-
95
-
-
20244381625
-
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression
-
Kim JC, Badano JL, Sibold S, et al. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet 2004;36:462-470.
-
(2004)
Nat Genet
, vol.36
, pp. 462-470
-
-
Kim, J.C.1
Badano, J.L.2
Sibold, S.3
-
96
-
-
2942625562
-
Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly
-
Mykytyn K, Mullins RF, Andrews M, et al. Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly. Proc Natl Acad Sci USA 2004;101:8664-8669.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8664-8669
-
-
Mykytyn, K.1
Mullins, R.F.2
Andrews, M.3
-
97
-
-
4444254983
-
Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse
-
Kulaga HM, Leitch CC, Eichers ER, et al. Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. Nat Genet 2004;36:994-998.
-
(2004)
Nat Genet
, vol.36
, pp. 994-998
-
-
Kulaga, H.M.1
Leitch, C.C.2
Eichers, E.R.3
-
98
-
-
1442274810
-
Establishing a connection between cilia and Bardet-Biedl syndrome
-
Mykytyn K, Sheffield VC. Establishing a connection between cilia and Bardet-Biedl syndrome. Trends Mol Med 2004;10:106-109.
-
(2004)
Trends Mol Med
, vol.10
, pp. 106-109
-
-
Mykytyn, K.1
Sheffield, V.C.2
-
99
-
-
2342501364
-
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene
-
Li JB, Gerdes JM, Haycraft CJ, et al. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell 2004;117:541-552.
-
(2004)
Cell
, vol.117
, pp. 541-552
-
-
Li, J.B.1
Gerdes, J.M.2
Haycraft, C.J.3
-
100
-
-
3042738924
-
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport
-
Blacque OE, Reardon MJ, Li C, et al. Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev 2004;18:1630-1642.
-
(2004)
Genes Dev
, vol.18
, pp. 1630-1642
-
-
Blacque, O.E.1
Reardon, M.J.2
Li, C.3
-
102
-
-
0345561551
-
Selective targeting of somatostatin receptor 3 to neuronal cilia
-
Handel M, Schulz S, Stanarius A, et al. Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience 1999;89:909-926.
-
(1999)
Neuroscience
, vol.89
, pp. 909-926
-
-
Handel, M.1
Schulz, S.2
Stanarius, A.3
-
103
-
-
0034725792
-
Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain
-
Brailov I, Bancila M, Brisorgueil MJ, et al. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brain Res 2000;872:271-275.
-
(2000)
Brain Res
, vol.872
, pp. 271-275
-
-
Brailov, I.1
Bancila, M.2
Brisorgueil, M.J.3
-
104
-
-
0041921143
-
Leptin-target neurones of the rat hypothalamus express somatostatin receptors
-
Stepanyan Z, Kocharyan A, Pyrski M, et al. Leptin-target neurones of the rat hypothalamus express somatostatin receptors. J Neuroendocrinol 2003;15:822-830.
-
(2003)
J Neuroendocrinol
, vol.15
, pp. 822-830
-
-
Stepanyan, Z.1
Kocharyan, A.2
Pyrski, M.3
-
105
-
-
0242581681
-
Hedgehog signalling in the mouse requires intraflagellar transport proteins
-
Huangfu D, Liu A, Rakeman AS, et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 2003;426:83-87.
-
(2003)
Nature
, vol.426
, pp. 83-87
-
-
Huangfu, D.1
Liu, A.2
Rakeman, A.S.3
-
106
-
-
0021795601
-
Analysis of the morphology and function of primary cilia in connective tissues: A cellular cybernetic probe?
-
Poole CA, Flint MH, Beaumont BW. Analysis of the morphology and function of primary cilia in connective tissues: a cellular cybernetic probe? Cell Motil 1985;5:175-193.
-
(1985)
Cell Motil
, vol.5
, pp. 175-193
-
-
Poole, C.A.1
Flint, M.H.2
Beaumont, B.W.3
-
107
-
-
0037227766
-
The vertebrate primary cilium is a sensory organelle
-
Pazour GJ, Witman GB. The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol 2003;15:105-110.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 105-110
-
-
Pazour, G.J.1
Witman, G.B.2
-
108
-
-
0017765641
-
Evidence for role of flagella as sensory transducers in mating of Chlamydomonas reinhardii
-
Solter KM, Gibor A. Evidence for role of flagella as sensory transducers in mating of Chlamydomonas reinhardii. Nature 1977;265:444-445.
-
(1977)
Nature
, vol.265
, pp. 444-445
-
-
Solter, K.M.1
Gibor, A.2
-
109
-
-
0036226297
-
Kinesin-II is required for flagellar sensory transduction during fertilization in Chlamydomonas
-
Pan J, Snell WJ. Kinesin-II is required for flagellar sensory transduction during fertilization in Chlamydomonas. Mol Biol Cell 2002;13:1417-1426.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 1417-1426
-
-
Pan, J.1
Snell, W.J.2
-
110
-
-
0037744851
-
Protein transport and signal transduction during fertilization in Chlamydomonas
-
Pan J, Misamore MJ, Wang Q, et al. Protein transport and signal transduction during fertilization in Chlamydomonas. Traffic 2003;4:452-459.
-
(2003)
Traffic
, vol.4
, pp. 452-459
-
-
Pan, J.1
Misamore, M.J.2
Wang, Q.3
-
111
-
-
0042357310
-
Flagellar adhesion between mating type plus and mating type minus gametes activates a flagellar protein-tyrosine kinase during fertilization in Chlamydomonas
-
Wang Q, Snell WJ. Flagellar adhesion between mating type plus and mating type minus gametes activates a flagellar protein-tyrosine kinase during fertilization in Chlamydomonas. J Biol Chem 2003;278:32936-32942.
-
(2003)
J Biol Chem
, vol.278
, pp. 32936-32942
-
-
Wang, Q.1
Snell, W.J.2
-
112
-
-
1342302882
-
Ultra-structural, tomographic and confocal imaging of the chondrocyte primary cilium in situ
-
Jensen CG, Poole CA, McGlashan SR, et al. Ultra-structural, tomographic and confocal imaging of the chondrocyte primary cilium in situ. Cell Biol Int 2004;28:101-110.
-
(2004)
Cell Biol Int
, vol.28
, pp. 101-110
-
-
Jensen, C.G.1
Poole, C.A.2
McGlashan, S.R.3
|