Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

Journal of Clinical Investigation

Volumn 114, Issue 10, 2004, Pages 1433-1443

  Chauvet, Veronique ^a   Tian, Xin ^a   Husson, Herve ^b   Grimm, David H ^a   Wang, Tong ^a   Hieseberger, Thomas ^c   Igarashi, Peter ^c   Bennett, Anton M ^a   Ibraghimov Beskrovnaya, Oxana ^b   Somlo, Stefan ^a   Caplan, Michael J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENZYME CORPORATION   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCYSTIN 1; POLYCYSTIN 2; MEMBRANE PROTEIN; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN; PROTEIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; INTRACELLULAR TRANSPORT; KIDNEY POLYCYSTIC DISEASE; MALE; MECHANICAL STIMULATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; CHO CELL; CRICETULUS; CYTOLOGY; DOG; EMBRYO; EPITHELIUM CELL; GENE DELETION; GENETICS; HAMSTER; KIDNEY TUBULE; MECHANICAL STRESS; METABOLISM; PATHOLOGY; PRENATAL DEVELOPMENT; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; DOGS; EMBRYO; EPITHELIAL CELLS; KIDNEY TUBULES; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEINS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSCRIPTION FACTOR AP-1; TRPP CATION CHANNELS;

EID: 85047694216     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI21753     Document Type: Article

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