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The authors show that renal monocilia are mechanosensors able to sense fluid flow. Further, they demonstrate that polycystin 1 and 2 on the ciliary membrane are mechanotransducers and generate a calcium signal in response to fluid flow
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Nauli S.M., Alenghat F.J., Luo Y., Williams E., Vassilev P., Li X., Elia A.E., Lu W., Brown E.M., Quinn S.J.et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 33:2003;129-137 The authors show that renal monocilia are mechanosensors able to sense fluid flow. Further, they demonstrate that polycystin 1 and 2 on the ciliary membrane are mechanotransducers and generate a calcium signal in response to fluid flow.
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(2003)
Nat Genet
, vol.33
, pp. 129-137
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Nauli, S.M.1
Alenghat, F.J.2
Luo, Y.3
Williams, E.4
Vassilev, P.5
Li, X.6
Elia, A.E.7
Lu, W.8
Brown, E.M.9
Quinn, S.J.10
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44
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0037019298
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Conserved function for embryonic nodal cilia
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This study shows that a ciliated structure which expresses lrd is conserved in zebrafish, Xenopus, chick and mice
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Essner J.J., Vogan K.J., Wagner M.K., Tabin C.J., Yost H.J., Brueckner M. Conserved function for embryonic nodal cilia. Nature. 418:2002;37-38 This study shows that a ciliated structure which expresses lrd is conserved in zebrafish, Xenopus, chick and mice.
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(2002)
Nature
, vol.418
, pp. 37-38
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Essner, J.J.1
Vogan, K.J.2
Wagner, M.K.3
Tabin, C.J.4
Yost, H.J.5
Brueckner, M.6
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45
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0037020041
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Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning
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+-ATPase mRNA precedes the development of monocilia in Xenopus
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+-ATPase mRNA precedes the development of monocilia in Xenopus.
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(2002)
Cell
, vol.111
, pp. 77-89
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Levin, M.1
Thorlin, T.2
Robinson, K.R.3
Nogi, T.4
Mercola, M.5
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